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About 65,338 results

Immune Checkpoint Inhibitors Have Clinical Activity in Patients With Recurrent Chordoma.
https://doi.org/10.1097/CJI.0000000000000431
Journal of Immunotherapy (Hagerstown, Md. : 1997); Bishop AJ, Amini B et. al.

Aug 10th, 2022 - The aim of this study is to evaluate the outcomes and tolerance of immune checkpoint inhibitors (ICIs) for patients with recurrent chordoma. We reviewed the records of 17 patients with recurrent chordomas who received ICIs for progressing disease as part of their treatment between 2016 and 2020. Response was assessed using response evaluation criteria in solid tumors 1.1 criteria. The Kaplan-Me...

Brain Ependymoma Imaging
https://emedicine.medscape.com/article/340362-overview

Aug 9th, 2022 - Practice Essentials Ependymoma is a central nervous system (CNS) neoplasm composed of glial cells that have differentiated along ependymal lines. These lesions occur most commonly in the ependymal lining of the ventricles, but they also arise in the filum terminale and in the central spinal cord. [1, 2, 3, 4, 5] Ependymoma may arise anywhere within the neuroaxis in children and in adults. The t...

Xanthomatous Giant Cell Renal Cell Carcinoma: Another Morphologic Form of TSC-associate...
https://doi.org/10.1097/PAS.0000000000001940
The American Journal of Surgical Pathology; Argani P, Matoso A et. al.

Aug 9th, 2022 - Over the past decade, several distinct novel renal epithelial neoplasms driven by underlying tuberous sclerosis comples (TSC)/mammalian target of rapamycin (MTOR) pathway mutations have been described. We report herein two distinctive TSC2-mutated renal cell carcinomas which do not fit any previously described entity. The two renal carcinomas occurred in young patients (ages 10 and 31 y), and w...

Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Clinicopathologic Study of 94 Cases...
https://doi.org/10.1097/PAS.0000000000001933
The American Journal of Surgical Pathology; Devins KM, Young RH et. al.

Aug 9th, 2022 - Embryonal rhabdomyosarcoma of the uterine cervix (cERMS) is rare and frequently associated with DICER1 mutations. We report 94 tumors that arose in patients aged 7 to 59 (median=23) years and presented with vaginal bleeding (52), protruding vaginal mass (17), cervical polyp (8), or expelled tumor fragments per vagina (5). Nine had DICER1 syndrome, 8 of whom had other syndromic manifestations in...

Lymph node positive pseudomyxoma peritonei.
https://doi.org/10.1016/j.ejso.2022.07.018
European Journal of Surgical Oncology : the Journal of Th... Sugarbaker PH, Chang D

Aug 9th, 2022 - Appendiceal mucinous neoplasms are routinely accompanied by peritoneal metastases at the time of diagnosis of the primary appendiceal tumor. In contrast, liver metastases and lymph node metastases are unusual. From an extensive database, patients with lymph node metastases identified at the time of primary appendiceal cancer resection were selected for special study. The clinical, treatment-rel...

Pediatric Plasma Cell Neoplasms: A Population-Based Study.
https://doi.org/10.1016/j.clml.2022.07.003
Clinical Lymphoma, Myeloma & Leukemia; Loap P, Vignon M et. al.

Aug 9th, 2022 - Plasma cell neoplasms are exceptionally rare in the pediatric population; the demographic characteristics and the clinical outcomes of plasma cell neoplasms in this population are currently poorly understood. The aim of this study was to provide a comprehensive analysis of pediatric plasma cell neoplasms, based on the United-States Surveillance, Epidemiology, and End Results (SEER) program regi...

Update on aneurysmal bone cyst: pathophysiology, histology, imaging and treatment.
https://doi.org/10.1007/s00247-022-05396-6
Pediatric Radiology; Restrepo R, Zahrah D et. al.

Aug 9th, 2022 - Aneurysmal bone cyst (ABC) is a benign but locally aggressive lesion that predominantly affects children and young adults. ABC, which accounts for approximately 70% of the cases, is now recognized to be a true neoplasm, whereas ABC-like changes associated to other bone neoplasms (also referred in the literature as secondary ABC) accounts for the remaining 30%. The solid variant of ABC is also c...

Natural history of intracholecystic papillary neoplasm (ICPN): a rare case of ICPN whos...
https://doi.org/10.1186/s12876-022-02454-z
BMC Gastroenterology; Koike D, Kato H et. al.

Aug 9th, 2022 - The natural history of intracholecystic papillary neoplasm (ICPN), especially the speed of growth from small benign to a carcinomatous lesion, is quite unrevealed. Here, we report an extremely rare case of ICPN, in which the papillary lesion was observed transforming from small and benign to malignant using abdominal ultrasound (AUS) over 2 years during routine health checks. A 44-year-old man ...

Follicular dendritic cell sarcoma of gastrointestinal tract with two emerging distinct ...
https://doi.org/10.1186/s13000-022-01246-z
Diagnostic Pathology; Gui H, Chaudhari J et. al.

Aug 9th, 2022 - Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm of mesenchymal origin. FDCS of gastrointestinal tract (GI) are exceedingly uncommon. We report the first case of classic type FDCS in a 34-year-old male with Birt-Hogg-Dubé syndrome, which presented as a mass at the ileo-cecal junction. He received no further treatment after resection and remained disease free for 3.5 years. We further...

Brain Ependymoma Imaging
http://emedicine.medscape.com/article/340362-overview

Aug 9th, 2022 - Practice Essentials Ependymoma is a central nervous system (CNS) neoplasm composed of glial cells that have differentiated along ependymal lines. These lesions occur most commonly in the ependymal lining of the ventricles, but they also arise in the filum terminale and in the central spinal cord. [1, 2, 3, 4, 5] Ependymoma may arise anywhere within the neuroaxis in children and in adults. The t...

Brain Ependymoma Imaging
https://emedicine.medscape.com/article/340362-print

Aug 9th, 2022 - Ependymoma is a central nervous system (CNS) neoplasm composed of glial cells that have differentiated along ependymal lines. These lesions occur most commonly in the ependymal lining of the ventricles, but they also arise in the filum terminale and in the central spinal cord.[1, 2, 3, 4, 5] Ependymoma may arise anywhere within the neuroaxis in children and in adults. The treatment of choice is...

Characterization of TRPV4-mediated signaling pathways in an optimized human choroid ple...
https://doi.org/10.1152/ajpcell.00193.2022
American Journal of Physiology. Cell Physiology; Hulme L, Hochstetler A et. al.

Aug 9th, 2022 - The objectives of these studies were 2-fold: (1) to characterize the human choroid plexus papilloma (HIBCPP) cell line as a model of the blood-cerebrospinal fluid barrier (BCSFB) via morphology, tightness, and polarization of transporters in choroid plexus epithelia (CPe), and (2) to utilize Ussing-style electrophysiology to elucidate signaling pathways associated with the activation of the tra...

Exploring the pathological relationships between adamantinomatous craniopharyngioma and...
https://doi.org/10.1007/s11060-022-04084-7
Journal of Neuro-oncology; Li S, Wu B et. al.

Aug 9th, 2022 - Identifying relationships between craniopharyngiomas (CPs) and contiguous structures, and tumor origin are crucial for treatments. This study attempted to explore the relationships and tumor origin. CPs that underwent endoscopic surgeries were enrolled. The interfacial specimens of CPs attaching the hypothalamus, pituitary stalk (PS), pituitary grand (PG), optic chiasma (OC) and brain tissue (B...

A Rare Case of Synchronous Intraductal Papillary Mucinous Neoplasm-Associated Pancreati...
https://doi.org/10.12659/AJCR.935242
The American Journal of Case Reports; Shupp B, Liaquat H et. al.

Aug 9th, 2022 - BACKGROUND Synchronous malignancies are primary cancers that are diagnosed in a single individual within a 2-month period. Synchronous malignancies are uncommon, involving only 2.4-8% of all cancer cases, with a very low number of cases of simultaneous gastric and pancreatic cancer. Although cases of synchronous malignancies do exist, synchronous pancreatic adenocarcinoma and signet ring cell (...

Pineal Tumors
http://emedicine.medscape.com/article/249945-overview

Aug 8th, 2022 - Practice Essentials Anatomy and pathophysiology The pineal gland develops during the second month of gestation as a diverticulum in the diencephalic roof of the third ventricle. It is flanked by the posterior and habenular commissures in the rostral portion of the midbrain directly below the splenium of the corpus callosum. The velum interpositum is found rostral and dorsal to the pineal gland ...

Pineal Tumors
https://emedicine.medscape.com/article/249945-print

Aug 8th, 2022 - Practice Essentials Anatomy and pathophysiology The pineal gland develops during the second month of gestation as a diverticulum in the diencephalic roof of the third ventricle. It is flanked by the posterior and habenular commissures in the rostral portion of the midbrain directly below the splenium of the corpus callosum. The velum interpositum is found rostral and dorsal to the pineal gland ...

Pineal Tumors
https://emedicine.medscape.com/article/249945-overview

Aug 8th, 2022 - Practice Essentials Anatomy and pathophysiology The pineal gland develops during the second month of gestation as a diverticulum in the diencephalic roof of the third ventricle. It is flanked by the posterior and habenular commissures in the rostral portion of the midbrain directly below the splenium of the corpus callosum. The velum interpositum is found rostral and dorsal to the pineal gland ...

Durvalumab plus tremelimumab in advanced or metastatic soft tissue and bone sarcomas: a...
https://doi.org/10.1016/S1470-2045(22)00392-8
The Lancet. Oncology; Somaiah N, Conley AP et. al.

Aug 8th, 2022 - Few standard treatment options are available for patients with metastatic sarcomas. We did this trial to evaluate the efficacy, safety, and changes in the tumour microenvironment for durvalumab, an anti-PD-L1 drug, and tremelimumab, an anti-CTLA-4 drug, across multiple sarcoma subtypes. In this single-centre phase 2 trial, done at The University of Texas MD Anderson Cancer Center (Houston, TX U...

Adenomyoepithelioma of the breast with unusual confounding diagnostic feature: a case r...
https://doi.org/10.1186/s13256-022-03507-3
Journal of Medical Case Reports; Al Mulla L, Abdelhadi M et. al.

Aug 8th, 2022 - Adenomyoepithelioma of the breast is an uncommon subtype of breast neoplasm that occurs in adults over a wide age range but most commonly in middle-aged and older adults. It usually presents as a solitary palpable mass or is detected on breast radiographic images. Histologically, it is a biphasic tumor with proliferation of both the epithelial and myoepithelial components of the glands, with va...

A novel fusion variant LSM14A::NR4A3 in extraskeletal myxoid chondrosarcoma.
https://doi.org/10.1002/gcc.23090
Genes, Chromosomes & Cancer; Ngo C, Verret B et. al.

Aug 7th, 2022 - Extraskeletal myxoid chondrosarcoma (EMC) is a very rare soft tissue neoplasm of uncertain lineage characterized by the pathognomonic rearrangement of the NR4A3 gene, which in most cases is fused with EWSR1. Other NR4A3 fusion partners have been described, namely TAF15, FUS, TCF12 and TGF. Some studies suggest that EMCs with non-EWSR1 variant fusion are associated with high grade morphology and...