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About 2,794,515 results

Hymenolepis diminuta Infection Affects Apoptosis in the Small and Large Intestine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368115
International Journal of Environmental Research and Publi... Kapczuk P, Kosik-Bogacka D et. al.

Aug 13th, 2022 - The rat tapeworm Hymenolepis diminuta has been shown to cause alterations in gastrointestinal tissues. Since hymenolepiasis induces a number of reactions in the host, it is reasonable to assume that it may also be involved in the mechanisms of apoptosis in the intestines. Individual research tasks included an examination of the effect of H. diminuta infection on; (i) the cellular localization o...

Dexmedetomidine Attenuates LPS-Stimulated Alveolar Type II Cells' Injury through Upregu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357803
Canadian Respiratory Journal; Chen X, Hu J et. al.

Aug 13th, 2022 - Dexmedetomidine (DEX), which is reported to be a newly discovered, novel α-2 adrenoceptor agonist, is known to exhibit anti-inflammatory properties in several diseases. DEX regulates inflammation-related signaling pathways and genes through interactions with several miRNAs. This study verified that expression levels of miR-140-3p were diminished when alveolar type II cells were exposed to LPS. ...

CAV-1 Overexpression Exacerbates the Manifestation in EPAC-1-Induced Chronic Postsurgic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357801
Pain Research & Management; Hua Q, Shen S et. al.

Aug 13th, 2022 - Caveolae (CAV) are an invaginated microcapsule with the shape of Ω on the surface of the cell membrane. Caveolin-1 (CAV-1) is involved in neuropathic pain, and adenosine monophosphate (AMP)-exchange protein directly activated by cAMP1 (EPAC-1) is a potential therapeutic target for chronic pain. However, whether EPAC-1 promotes chronic postsurgical pain (CPSP) through CAV-1 has not been reported...

Application of Mesoporous Silica Nanoparticle-Chitosan-Loaded BMP-2 in the Repair of Bo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357812
Journal of Immunology Research; Yi M, Nie Y et. al.

Aug 13th, 2022 - In order to test the effectiveness of nanoparticle- (NP-) loaded bone morphogenetic protein 2 (BMP-2) in chronic osteomyelitis (CO) complicated with bone defect, a new nanodrug delivery system composed of mesoporous silica NP (MSN) and chitosan were used to load BMP-2 and transfer it to the target region. Bone marrow mesenchymal stem cells (BMSCs) were purchased and cultivated to detect the ost...

Investigation of the "Nose-to-Brain" Pathways in Intranasal HupA Nanoemulsions and Eval...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359405
International Journal of Nanomedicine; Jiang Y, Jiang Y et. al.

Aug 13th, 2022 - While developing huperzine A (HupA) to explore new approaches to treating Alzheimer's disease (AD), intranasal administration was proposed as an alternative route to deliver drugs into the brain. This study aimed to prepare nanoemulsions (NEs) of HupA to investigate their potential "nose-to-brain" pathways and to evaluate their pharmacokinetic and brain-targeting parameters. HupA-NE and Lf-HupA...

BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Ge...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359861
Journal of Immunology Research; Sang X, Zhang Y et. al.

Aug 13th, 2022 - AML (acute myeloid leukemia) is a common hematological malignancy in children with poor treatment effects and poor prognosis. Recent studies have shown that as a novel BRD4 (bromodomain containing 4) PROTACs (proteolysis targeting chimeras) degrader, GNE-987 can slow down the growth of various tumors and increase apoptosis, with promising clinical prospects. However, the function and molecular ...

Nrf2/p‑Fyn/ABCB1 axis accompanied by p‑Fyn nuclear accumulation plays pivotal roles in ...
https://doi.org/10.3892/or.2022.8386
Oncology Reports; Tamari S, Menju T et. al.

Aug 13th, 2022 - Adjuvant cisplatin‑vinorelbine is a standard therapy for stage II/III lung cancer. However, a poor survival rate of patients with lung cancer is attributed to vinorelbine resistance arising from ATP‑binding cassette (ABC) sub‑family B member 1 (ABCB1) and phosphorylated Fyn (p‑Fyn) overexpression. However, the underlying mechanisms remain unclear. NF‑E2‑related factor 2 (Nrf2) regulates the ABC...

Arsenic Mobilization and Transformation by Ammonium-Generating Bacteria Isolated from H...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368665
International Journal of Environmental Research and Publi... Jiang Z, Shen X et. al.

Aug 13th, 2022 - Arsenic (As) mobilization in groundwater involves biogeochemical cycles of carbon, iron, and sulfur. However, few studies have focused on the role of nitrogen-metabolizing bacteria in As mobilization, as well as in the transformation between inorganic and organic As in groundwater. In this study, the nitrogen and As metabolisms of Citrobacter sp. G-C1 and Paraclostridium sp. G-11, isolated from...

The Effect of Global Warming on Complex Disorders (Mental Disorders, Primary Hypertensi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368177
International Journal of Environmental Research and Publi... Natur S, Damri O et. al.

Aug 13th, 2022 - Multiple studies imply a strong relationship between global warming (GW) and complex disorders. This review summarizes such reports concentrating on three disorders-mental disorders (MD), primary hypertension, and type 2 diabetes (T2D). We also attempt to point at potential mechanisms mediating the effect of GW on these disorders. Concerning mental disorders, immediate candidates are brain leve...

Rosinidin Protects against Cisplatin-Induced Nephrotoxicity via Subsiding Proinflammato...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368304
International Journal of Environmental Research and Publi... Gilani SJ, Bin-Jumah MN et. al.

Aug 13th, 2022 - Rosinidin is a flavonoid anthocyanin pigmentation found in shrub flowers such as Catharanthus roseus and Primula rosea. The molecular docking studies predicted that rosinidin has adequate structural competency, making it a viable medicinal candidate for the treatment of a wide range of disorders. The current study intends to assess rosinidin nephroprotective efficacy against nephrotoxicity indu...

Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenoc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359862
Disease Markers; Xiong F, Guo T et. al.

Aug 13th, 2022 - Pancreatic ductal adenocarcinoma (PDAC) is one of the highest-grade malignancies in the world. More effective biomarkers and treatment plans are necessary to improve the diagnosis rate and clinical outcome. The oncogenesis of PDAC is influenced by several factors, including chronic pancreatitis (CP). Keratin 8 (KRT8) is an important member of the keratin protein family and plays a role in regul...

MicroRNA-29a-3p Regulates SH-SY5Y Cell Proliferation and Neurite Growth through Interac...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359856
Disease Markers; Gao W, Yang H et. al.

Aug 13th, 2022 - The effects of microRNA-29a-3p in the proliferation process of nerve cells are unclear. The purpose of this study is to delve into the regulatory role of microRNA-29a-3p, via interaction with phosphatase and tension homolog (PTEN), in the SH-SY5Y cell proliferation process. Different expressions of microRNA-29a-3p in the SH-SY5Y cells were constructed by transfected miRNA-29a-3p mimic and inhib...

MW‑9, a chalcones derivative bearing heterocyclic moieties, attenuates experimental aut...
https://doi.org/10.3892/mmr.2022.12824
Molecular Medicine Reports; Liu B, Mao Z et. al.

Aug 13th, 2022 - Previous studies have indicated that MW‑9, a chalcones derivative bearing heterocyclic moieties, has considerable anti‑inflammatory activity in vitro. Whether MW‑9 may be used to treat inflammation‑based diseases, such as multiple sclerosis, remains unknown. The present study was designed to determine the effect and underlying mechanism of MW‑9 in experimental autoimmune encephalomyelitis (EAE)...

The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359389
Drug Design, Development and Therapy; Yang X, Wu X et. al.

Aug 13th, 2022 - Chronic myelogenous leukemia (CML) is a hematological malignancy with increased proliferation of cells of the myeloid series. This can disrupt normal hematopoiesis. The 1-(2-(dimethylamino)acetyl)-rocaglaol (MQ-16) is a new synthetic flavagline compound that showed promising activity in chronic myeloid leukemia K562 cells. This study aims to analyze the underlying mechanisms of MQ-16 against CM...

miR‑519d‑3p released by human blastocysts negatively regulates endometrial epithelial c...
https://doi.org/10.3892/ijmm.2022.5179
International Journal of Molecular Medicine; Wang X, Miao S et. al.

Aug 13th, 2022 - Successful embryo implantation requires a competent embryo, a receptive endometrium and synchronized communication between them. The selection of embryos with the highest implantation potential remains a challenge in the field of assisted reproductive technology. Moreover, little is known about the precise molecular mechanisms underlying embryo‑endometrium crosstalk. MicroRNAs (miRNAs/miRs) hav...

Prediction of Dichloroethene Concentration in the Groundwater of a Contaminated Site Us...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367752
International Journal of Environmental Research and Publi... Xia F, Jiang D et. al.

Aug 13th, 2022 - Chlorinated aliphatic hydrocarbons (CAHs) are widely used in agriculture and industries and have become one of the most common groundwater contaminations. With the excellent performance of the deep learning method in predicting, LSTM and XGBoost were used to forecast dichloroethene (DCE) concentrations in a pesticide-contaminated site undergoing natural attenuation. The input variables included...

Effect of Humic Acid on the Growth and Metabolism of Candida albicans Isolated from Sur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368076
International Journal of Environmental Research and Publi... Cudowski A, Pietryczuk A et. al.

Aug 13th, 2022 - The aim of this study was to determine the effect of humic acid on the growth and metabolism of Candida albicans, a common waterborne pathogenic yeast. At 10-20 mg/L, humic acid caused the greatest increase in biomass and compactness of proteins and monosaccharides, both in cells and in extracellular secretion of the yeast. At higher humic acid concentrations (40-80 mg/L), C. albicans cells sti...

Family with sequence similarity 134 member B-mediated reticulophagy ameliorates hepatoc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254142
World Journal of Gastroenterology; Guo YX, Han B et. al.

Aug 12th, 2022 - Endoplasmic reticulum (ER) stress-related hepatocyte apoptosis is responsible for multiple hepatic diseases. Previous studies have revealed that endoplasmic reticulophagy (ER-phagy) promotes the selective clearance of damaged ER fragments during ER stress, playing a crucial role in maintaining ER homeostasis and inhibiting apoptosis. Family with sequence similarity 134 member B (FAM134B) is a r...

Infliximab trough level combined with inflammatory biomarkers predict long-term endosco...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9254140
World Journal of Gastroenterology; Cao WT, Huang R et. al.

Aug 12th, 2022 - Infliximab trough level (ITL) severely affects therapeutic outcomes of Crohn's disease (CD) patients under infliximab (IFX). Recently, frontier research has focused on identifying ITL based on different therapeutic targets. Although previous studies have elaborated clinical value of ITL monitoring on short-term outcomes in CD patients during therapy, studies contraposing the predictive value of...

PTEN inhibits AMPK to control collective migration.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372137
Nature Communications; Peglion F, Capuana L et. al.

Aug 12th, 2022 - Pten is one of the most frequently mutated tumour suppressor gene in cancer. PTEN is generally altered in invasive cancers such as glioblastomas, but its function in collective cell migration and invasion is not fully characterised. Herein, we report that the loss of PTEN increases cell speed during collective migration of non-tumourous cells both in vitro and in vivo. We further show that loss...