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About 2,849,183 results

Structures of honeybee-infecting Lake Sinai virus reveal domain functions and capsid as...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892032
Nature Communications; Chen NC, Wang CH et. al.

Feb 3rd, 2023 - Understanding the structural diversity of honeybee-infecting viruses is critical to maintain pollinator health and manage the spread of diseases in ecology and agriculture. We determine cryo-EM structures of T = 4 and T = 3 capsids of virus-like particles (VLPs) of Lake Sinai virus (LSV) 2 and delta-N48 LSV1, belonging to tetraviruses, at resolutions of 2.3-2.6 Å in various pH environments. Str...

Effect of PFOA exposure on diminished ovarian reserve and its metabolism.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890749
Reproductive Biology and Endocrinology : RB&E; Shen H, Gao M et. al.

Feb 3rd, 2023 - Owing to its difficulty in degrading and ease of accumulation in the body, perfluorooctanoic acid (PFOA) has a detrimental effect on reproduction. This study aimed to examine the effect of PFOA concentration in follicular fluid during ovulation stimulation on embryo quality and the impact of PFOA exposure on the metabolic components of follicular fluid. This was a single-center prospective stud...

Sunitinib efficacy with minimal toxicity in patient-derived retinoblastoma organoids.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890748
Journal of Experimental & Clinical Cancer Research : CR; Srimongkol A, Laosillapacharoen N et. al.

Feb 3rd, 2023 - Recurrence of retinoblastoma (RB) following chemoreduction is common and is often managed with local (intra-arterial/intravitreal) chemotherapy. However, some tumors are resistant to even local administration of maximum feasible drug dosages, or effective tumor control and globe preservation may be achieved at the cost of vision loss due to drug-induced retinal toxicity. The aim of this study w...

Comparison of the prognostic value of stromal tumor-infiltrating lymphocytes and CD3 + ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890788
World Journal of Surgical Oncology; Wang W, Zhang Y et. al.

Feb 3rd, 2023 - To compare the prognostic value of tumor-infiltrating lymphocytes (TILs) and CD3 + cells and CD20 + cells between schistosomal colorectal cancer (SCRC) and non-schistosomal CRC (NSCRC). Although schistosomiasis has been basically eliminated, it has not been completely extinction in China, and occasional outbreaks occur in Europe recently. The role of immune cells in the immune microenvironment ...

Gene expression profiles and bioinformatics analysis in lung samples from ovalbumin-ind...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893693
BMC Pulmonary Medicine; Song Y, Jiang J et. al.

Feb 3rd, 2023 - Asthma is characterized by chronic inflammation and airway remodeling. However, limited study is conducted on the gene expression profiles of ovalbumin (OVA) induced asthma in mice. Here, we explored the gene expression profiles in lung tissues from mice with OVA-induced asthma using microarray and bioinformatics analysis. For establishment of OVA-induced asthma model, mice first received intra...

Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893613
Fluids and Barriers of the CNS; Kim H, Noh M et. al.

Feb 3rd, 2023 - Age-related changes in the cerebrovasculature, including blood-brain barrier (BBB) disruption and vascular dementia, are emerging as potential risks for many neurodegenerative diseases. Therefore, the endothelial cells that constitute the cerebrovasculature may play key roles in preventing brain injury. Our previous study showed that CU06-1004, an endothelial cell dysfunction blocker, prevented...

Transcriptional reprogramming of skeletal muscle stem cells by the niche environment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892560
Nature Communications; Lazure F, Farouni R et. al.

Feb 3rd, 2023 - Adult stem cells are indispensable for tissue regeneration, but their function declines with age. The niche environment in which the stem cells reside plays a critical role in their function. However, quantification of the niche effect on stem cell function is lacking. Using muscle stem cells (MuSC) as a model, we show that aging leads to a significant transcriptomic shift in their subpopulatio...

Changes in the meibomian glands in postmenopausal women with primary acquired nasolacri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890874
BMC Ophthalmology; Jin H, Zhang H

Feb 3rd, 2023 - Primary acquired nasolacrimal duct obstruction (PANDO) is frequently encountered in perimenopausal women, causing tear flow stagnation and resulting in a variety of ocular discomfort symptoms. However, little is known about the alterations in the meibomian gland in postmenopausal women with PANDO. Hence, this study investigated the changes in the meibomian gland and ocular surface in postmenopa...

Characterisation of tumour-immune phenotypes and PD-L1 positivity in squamous bladder c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890720
BMC Cancer; Jung M, Rose M et. al.

Feb 3rd, 2023 - Immune checkpoint inhibitor (ICI) therapy has become a viable treatment strategy in bladder cancer. However, treatment responses vary, and improved biomarkers are needed. Crucially, the characteristics of immune cells remain understudied especially in squamous differentiated bladder cancer (sq-BLCA). Here, we quantitatively analysed the tumour-immune phenotypes of sq-BLCA and correlated them wi...

PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derive...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893610
BMC Medicine; Park KC, Kim JM et. al.

Feb 3rd, 2023 - Cancer cells have developed molecular strategies to cope with evolutionary stressors in the dynamic tumor microenvironment. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) is a metabolic rheostat that regulates diverse cellular adaptive behaviors, including growth and survival. However, the mechanistic role of PGC1α in regulating cancer cell viability under metabolic and gen...

Inhibition of EZH2 mitigates peritoneal fibrosis and lipid precipitation in peritoneal ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897791
Renal Failure; Wang Q, Sun J et. al.

Feb 2nd, 2023 - Peritoneal fibrosis caused by long-term peritoneal dialysis (PD) is the main reason why patients withdraw from PD treatment. Lipid accumulation in the peritoneum was shown to participate in fibrosis, and klotho is a molecule involved in lipid metabolism. GSK343 (enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) inhibitor) has been verified to inhibit epithelial mesenchymal transd...

An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897762
Drug Delivery; Wang N, Ma J et. al.

Feb 2nd, 2023 - Rheumatoid arthritis (RA), an autoimmune disease, is characterized by inflammatory cell infiltration that damages cartilage, disrupts bone, and impairs joint function. The therapeutic efficacy of RA treatments with the severely affected side remains unsatisfactory despite current treatment methods that primarily focus on anti-inflammatory activity, largely because of the complicatedly pathologi...

TIPE2 deletion improves the therapeutic potential of adoptively transferred NK cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896240
Journal for Immunotherapy of Cancer; Bi J, Huang C et. al.

Feb 2nd, 2023 - To enhance the efficacy of adoptive NK cell therapy against solid tumors, NK cells must be modified to resist exhaustion in the tumor microenvironment (TME). However, the molecular checkpoint underlying NK cell exhaustion in the TME remains elusive. We analyzed the correlation between TIPE2 expression and NK cell functional exhaustion in the TME both in humans and mice by single-cell transcript...

A split ribozyme that links detection of a native RNA to orthogonal protein outputs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892565
Nature Communications; Gambill L, Staubus A et. al.

Feb 2nd, 2023 - Individual RNA remains a challenging signal to synthetically transduce into different types of cellular information. Here, we describe Ribozyme-ENabled Detection of RNA (RENDR), a plug-and-play strategy that uses cellular transcripts to template the assembly of split ribozymes, triggering splicing reactions that generate orthogonal protein outputs. To identify split ribozymes that require templ...

Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in pertur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891901
Nature Communications; Li F, Fang J et. al.

Feb 2nd, 2023 - The quickly accumulating ribosome profiling data is an insightful resource for studying the critical details of translation regulation under various biological contexts. Rocaglamide A (RocA), an antitumor heterotricyclic natural compound, has been shown to inhibit translation initiation of a large group of mRNA species by clamping eIF4A onto poly-purine motifs in the 5' UTRs. However, reanalysi...

Dosage differences in 12-OXOPHYTODIENOATE REDUCTASE genes modulate wheat root growth.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892559
Nature Communications; Gabay G, Wang H et. al.

Feb 2nd, 2023 - Wheat, an essential crop for global food security, is well adapted to a wide variety of soils. However, the gene networks shaping different root architectures remain poorly understood. We report here that dosage differences in a cluster of monocot-specific 12-OXOPHYTODIENOATE REDUCTASE genes from subfamily III (OPRIII) modulate key differences in wheat root architecture, which are associated wi...

The pleiotropic role of galectin-3 in melanoma progression: Unraveling the enigma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895887
Advances in Cancer Research; Mohammed NBB, Antonopoulos A et. al.

Feb 2nd, 2023 - Melanoma is a highly aggressive skin cancer with poor outcomes associated with distant metastasis. Intrinsic properties of melanoma cells alongside the crosstalk between melanoma cells and surrounding microenvironment determine the tumor behavior. Galectin-3 (Gal-3), a ß-galactoside-binding lectin, has emerged as a major effector in cancer progression, including melanoma behavior. Data from mel...

Role of O-GlcNAcylation on cancer stem cells: Connecting nutrient sensing to cell plast...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895886
Advances in Cancer Research; Le Minh G, Reginato MJ

Feb 2nd, 2023 - Tumor growth and metastasis can be promoted by a small sub-population of cancer cells, termed cancer stem-like cells (CSCs). While CSCs possess capability in self-renewing and differentiating, the hierarchy of CSCs during tumor growth is highly plastic. This plasticity in CSCs fate and function can be regulated by signals from the tumor microenvironment. One emerging pathway in CSCs that connec...

Advanced Compounding: Compounding with Microneedle Arrays, Part 3: Microneedle Array De...
https://www.ncbi.nlm.nih.gov/pubmed/36720061
International Journal of Pharmaceutical Compounding; Allen LV

Feb 1st, 2023 - Microneedle arrays, or microneedle array patches (terms are often used interchangeably), are promising devices for the transdermal delivery of drugs and vaccines. Unique microneedle arrays can be prepared from various materials and can be either solid or hollow. Upon insertion, they rapidly take up skin interstitial fluid to form continuous, open conduits from the attached patch-type drug reser...

Comparative transcription profiling of mRNA and lncRNA in pulmonary arterial hypertensi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887911
BMC Pulmonary Medicine; Hou C, Xie L et. al.

Feb 1st, 2023 - To investigate mRNA and long non-coding RNA (lncRNA) expression profiles in monocrotaline (MCT)- mice. Lung tissues (Control-Vehicle, MCT-Vehicle, and MCT-C75) were examined by high-throughput sequencing (HTS). Aberrantly expressed mRNAs and lncRNAs were analyzed by bioinformatics. Cell proliferation and cell cycle analysis were performed to detect the potential protective effects of C75, an in...