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About 2,813,785 results

Multi-intervention integrated deworming strategy for sustained control of soil-transmit...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434715
Infectious Diseases of Poverty; Mao FZ, Chen YY et. al.

Sep 12th, 2021 - Soil-transmitted helminths (STH) infections still present a global health problem. Mass drug administration (MDA) is a widely applied strategy to reduce morbidity and mortality caused by STH. Yet, this approach has some shortcomings. In this study, we analyzed the impact of a multi-intervention integrated deworming approach including MDA, health education (HE), and environmental sanitation impr...

Using Wastewater Surveillance Data to Support the COVID-19 Response - United States, 20...
https://doi.org/10.15585/mmwr.mm7036a2
MMWR. Morbidity and Mortality Weekly Report; Kirby AE, Walters MS et. al.

Sep 10th, 2021 - Wastewater surveillance, the measurement of pathogen levels in wastewater, is used to evaluate community-level infection trends, augment traditional surveillance that leverages clinical tests and services (e.g., case reporting), and monitor public health interventions (1). Approximately 40% of persons infected with SARS-CoV-2, the virus that causes COVID-19, shed virus RNA in their stool (2); t...

Machine-learning-based COVID-19 mortality prediction model and identification of patien...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424411
Critical Care (London, England); Banoei MM, Dinparastisaleh R et. al.

Sep 10th, 2021 - The coronavirus disease 2019 (COVID-19) pandemic caused by the SARS-Cov2 virus has become the greatest health and controversial issue for worldwide nations. It is associated with different clinical manifestations and a high mortality rate. Predicting mortality and identifying outcome predictors are crucial for COVID patients who are critically ill. Multivariate and machine learning methods may ...

The use of head helmets to deliver noninvasive ventilatory support: a comprehensive rev...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424168
Critical Care (London, England); Coppadoro A, Zago E et. al.

Sep 10th, 2021 - A helmet, comprising a transparent hood and a soft collar, surrounding the patient's head can be used to deliver noninvasive ventilatory support, both as continuous positive airway pressure and noninvasive positive pressure ventilation (NPPV), the latter providing active support for inspiration. In this review, we summarize the technical aspects relevant to this device, particularly how to prev...

Learning to live with COVID-19 in Australia: time for a new approach.
https://doi.org/10.17061/phrp3132110
Public Health Research & Practice; Bennett CM

Sep 9th, 2021 - The emergence of the Delta variant of SARS-CoV-2 has made Australia's 'COVID-zero' strategy unviable. As signalled by the Australian Government's National plan to transition Australia's national COVID-19 response, we need to plan a pathway forward for life beyond lockdown. However, this plan must be guided by long overdue discussions on our tolerance for serious illness, and hospital and intens...

Acceptability and satisfaction towards self-collection for chlamydia and gonorrhoea tes...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425782
Journal of the International AIDS Society; Hiransuthikul A, Janamnuaysook R et. al.

Sep 9th, 2021 - Provider-collected swabs are an unappealing procedure for many transgender women and may have led to suboptimal rates of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) testing. Self-collection for CT/NG testing is recommended for men who have sex with men. However, the information on acceptability and clinical performance to support a recommendation for transgender women is lacking. ...

Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and i...
https://doi.org/10.1073/pnas.2106845118
Proceedings of the National Academy of Sciences of the Un... Dalvie NC, Rodriguez-Aponte SA et. al.

Sep 9th, 2021 - Global containment of COVID-19 still requires accessible and affordable vaccines for low- and middle-income countries (LMICs). Recently approved vaccines provide needed interventions, albeit at prices that may limit their global access. Subunit vaccines based on recombinant proteins are suited for large-volume microbial manufacturing to yield billions of doses annually, minimizing their manufac...

Bondi and beyond. Lessons from three waves of COVID-19 from 2020.
https://doi.org/10.17061/phrp3132112
Public Health Research & Practice; Capon A, Sheppeard V et. al.

Sep 9th, 2021 - To describe local operational aspects of the coronavirus disease 2019 (COVID-19) response during the first three waves of outbreaks in New South Wales (NSW), Australia, which began in January, July and December 2020. Type of program or service: Public health outbreak response. Narrative with epidemiological linking and genomic testing. Epidemiological linking and genomic testing found that duri...

Personalized profiles for disease risk must capture all facets of health.
https://doi.org/10.1038/d41586-021-02401-0 10.1038/s41576-018-0018-x 10.1093/hmg/ddz187 10.1038/s41698-021-00176-1 10.1038/s41588-018-0183-z 10.1016/j.ajhg.2018.11.002 10.1038/s41588-019-0379-x 10.1038/s41467-020-17374-3 10.1038/s41467-020-19966-5 10.7554/eLife.48376
Nature McCarthy M, Birney E

Sep 8th, 2021 - Personalized profiles for disease risk must capture all facets of health.|2021|McCarthy M,Birney E,|trends,methods,trends,methods,

Efficacy and safety of direct-acting oral anticoagulants compared to vitamin K antagoni...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417638
Cardiovascular Diabetology; Rivera-Caravaca JM, Harrison SL et. al.

Sep 6th, 2021 - It remains uncertain if prior use of oral anticoagulants (OACs) in COVID-19 outpatients with multimorbidity impacts prognosis, especially if cardiometabolic diseases are present. Clinical outcomes 30-days after COVID-19 diagnosis were compared between outpatients with cardiometabolic disease receiving vitamin K antagonist (VKA) or direct-acting OAC (DOAC) therapy at time of COVID-19 diagnosis. ...

Could Clinician Sensitivity to Cultural and Historical Considerations Help Reduce COVID...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395970
Southern Medical Journal; Kountz D, Rodriguez F et. al.

Sep 5th, 2021 - Could Clinician Sensitivity to Cultural and Historical Considerations Help Reduce COVID-19 Deaths among Blacks?|2021|Kountz D,Rodriguez F,Vital V,Vora S,Gough R,|statistics & numerical data,ethnology,mortality,methods,statistics & numerical data,ethnology,epidemiology,

Analysis of the Effects of COVID-19 Mask Mandates on Hospital Resource Consumption and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395971
Southern Medical Journal; Schauer SG, Naylor JF et. al.

Sep 5th, 2021 - Coronavirus disease 2019 (COVID-19) threatens vulnerable patient populations, resulting in immense pressures at the local, regional, national, and international levels to contain the virus. Laboratory-based studies demonstrate that masks may offer benefit in reducing the spread of droplet-based illnesses, but few data are available to assess mask effects via executive order on a population basi...

Early Impacts of the COVID-19 Pandemic on Telehealth Patterns in Primary Care, Mental H...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395963
Southern Medical Journal; Adepoju OE, Chae M et. al.

Sep 5th, 2021 - Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, many US clinics have shifted some or all of their practice from in-person to virtual visits. In this study, we assessed the use of telehealth among primary care and specialty clinics, by targeting healthcare administrators via multiple channels. Using an online survey, we assessed the use of, barriers to, and reimbursement for...

Prevalence of abnormal cardiovascular magnetic resonance findings in recovered patients...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414035
Journal of Cardiovascular Magnetic Resonance : Official J... Kim JY, Han K et. al.

Sep 5th, 2021 - The prevalence of abnormal cardiovascular magnetic resonance (CMR) findings in recovered coronavirus disease 2019 (COVID-19) patients is unclear. This study aimed to investigate the prevalence of abnormal CMR findings in recovered COVID-19 patients. A systematic literature search was performed to identify studies that report the prevalence of abnormal CMR findings in recovered COVID-19 patients...

Feminine Appeals on Cigarette Packs Sold in 14 Countries.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406490
International Journal of Public Health; Czaplicki L, Welding K et. al.

Sep 4th, 2021 - Objective: Limited research has examined feminine marketing appeals on cigarette packs in low-and middle-income countries (LMICs). We reviewed a systematically collected sample of cigarette packs sold across 14 LMICs in 2013 (Wave 1) and 2015-2017 (Wave 2). Methods: Packs in Wave 1 (n = 3,240) and Wave 2 (n = 2,336) were coded for feminine imagery and descriptors (flowers, fashion, women/girls,...

Effectiveness of a Video-Based Intervention on Reducing Perceptions of Fear, Loneliness...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407346
International Journal of Public Health; Valeri L, Amsalem D et. al.

Sep 4th, 2021 - Objectives: During the first peak of the COVID-19 outbreak in the United States, we investigated the impact of digital interventions to reduce COVID-19 related fear, loneliness, and public stigma. Methods: We recruited and randomly assigned 988 United States residents to: 1) no intervention 2) informational sheet to learn about COVID-19, 3) (2) AND video encouraging digital social activity, 4) ...

Metoprolol in Critically Ill Patients With COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404624
Journal of the American College of Cardiology; Clemente-Moragón A, Martínez-Milla J et. al.

Sep 4th, 2021 - Severe coronavirus disease-2019 (COVID-19) can progress to an acute respiratory distress syndrome (ARDS), which involves alveolar infiltration by activated neutrophils. The beta-blocker metoprolol has been shown to ameliorate exacerbated inflammation in the myocardial infarction setting. The purpose of this study was to evaluate the effects of metoprolol on alveolar inflammation and on respirat...

Does Panoramic X-ray Induce Cytogenetic Damage to Oral Cells? A Systematic Review With ...
https://doi.org/10.21873/anticanres.15224
Anticancer Research; DE Souza DV, Suarez Alpire ME et. al.

Sep 4th, 2021 - The aim of this review was to evaluate the scientific literature regarding the cytogenetic damage in oral exfoliated cells of adult patients submitted to panoramic X-ray. An extensive search of the literature was conducted on PubMed, Scopus and Web of Science databases for all studies published until April 2021 using combinations of the following keywords: "panoramic X-ray," "DNA damage," "gene...

HGF-mediated Up-regulation of PHLDA2 Is Associated With Apoptosis in Gastric Cancer.
https://doi.org/10.21873/anticanres.15242
Anticancer Research; Koh SA, Lee KH

Sep 4th, 2021 - Expression of pleckstrin homology-like domain family A member 2 (PHLDA2) has been reported to be suppressed or activated in several cases of malignant tumors. However, its apoptotic regulatory mechanism and role in gastric cancer are not understood. This study examined the role of PHLDA2 in apoptosis in gastric cancer. We used cell culture, western blotting, semiquantitative reverse transcripti...

Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy.
https://doi.org/10.1038/s41467-021-25561-z 10.1038/nrc2067 10.1038/nrd4333 10.1038/natrevmats.2016.75 10.1016/j.addr.2009.02.005 10.1089/ars.2013.5302 10.1021/acsnano.7b05215 10.1038/s41467-017-01050-0 10.1002/adfm.201800145 10.1021/acsnano.7b06852 10.1002/anie.201701181 10.1021/acsnano.5b06175 10.1002/advs.201801733 10.1038/s41467-018-08234-2 10.1016/j.isci.2019.03.008 10.1002/anie.201915118 10.1038/nature21375 10.1016/j.cmet.2014.01.002 10.1038/nature24057 10.1038/s41587-019-0377-7 10.1126/science.aad4017 10.1002/adfm.200901493 10.1002/adma.201103521 10.1016/j.biomaterials.2019.05.009 10.1021/acsnano.9b07789 10.1021/acs.nanolett.9b03340 10.1016/j.biomaterials.2019.119498 10.1016/j.biomaterials.2020.119911 10.1107/S0909049513003671 10.1021/acs.langmuir.6b01483 10.1038/s41598-017-08988-7 10.1126/science.aaf1559 10.1016/j.biomaterials.2018.02.041 10.1002/anie.200461119 10.1021/ja0380852 10.1002/adma.201704490 10.1002/adma.201504782
Nature Communications; Qin X, Wu C et. al.

Sep 4th, 2021 - Peroxisome, a special cytoplasmic organelle, possesses one or more kinds of oxidases for hydrogen peroxide (H2O2) production and catalase for H2O2 degradation, which serves as an intracellular H2O2 regulator to degrade toxic peroxides to water. Inspired by this biochemical pathway, we demonstrate the reactive oxygen species (ROS) induced tumor therapy by integrating lactate oxidase (LOx) and ca...