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About 355,310 results

Clinical standards for drug-susceptible pulmonary TB.
https://doi.org/10.5588/ijtld.22.0228
The International Journal of Tuberculosis and Lung Diseas... Akkerman OW, Duarte R et. al.

Jul 1st, 2022 - BACKGROUND: The aim of these clinical standards is to provide guidance on 'best practice´ for diagnosis, treatment and management of drug-susceptible pulmonary TB (PTB).METHODS: A panel of 54 global experts in the field of TB care, public health, microbiology, and pharmacology were identified; 46 participated in a Delphi process. A 5-point Likert scale was used to score draft standards. The fin...

Photocatalytic Cu2WS4 Nanocrystals for Efficient Bacterial Killing and Biofilm Disruption.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234186
International Journal of Nanomedicine; Dong H, Yang K et. al.

Jul 1st, 2022 - Bacterial biofilm-related wound infections threaten human health due to the lack of efficient treatments. Therefore, developing a novel strategy for wound infection care is urgently needed. Cube-shaped Cu2WS4 nanocrystals (CWSNs) were successfully prepared via a microwave-assisted method. CWSNs, as photocatalysts, were first studied by using fluorescence spectroscopy for their ability to genera...

Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apopto...
https://doi.org/10.1371/journal.ppat.1010628
PLoS Pathogens; Palrasu M, Zaika E et. al.

Jun 30th, 2022 - Helicobacter pylori (H. pylori) is a common gastric pathogen that infects approximately half of the world's population. Infection with H. pylori can lead to diverse pathological conditions, including chronic gastritis, peptic ulcer disease, and cancer. The latter is the most severe consequence of H. pylori infection. According to epidemiological studies, gastric infection with H. pylori is the ...

Risk factor-based analysis of community-acquired pneumonia, healthcare-associated pneum...
https://doi.org/10.1371/journal.pone.0270261
PloS One; Hyun H, Song JY et. al.

Jun 30th, 2022 - Healthcare-associated pneumonia (HCAP) lies in the intersection of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP). Although HCAP is excluded from the revised HAP guideline, reassessment for HCAP is needed considering its heterogeneous characteristics. The microbiological distribution, antibiotic resistance, and clinical outcomes in CAP, HCAP, and HAP were studied retro...

Characterization of some fungal pathogens causing anthracnose disease on yam in Cross R...
https://doi.org/10.1371/journal.pone.0270601
PloS One; Okon NI, Markson AA et. al.

Jun 30th, 2022 - Yam anthracnose is one of the most serious fungal diseases affecting white and water yam production. Screening of available landraces for new sources of durable resistance to the pathogen is a continuous process. In the present study, the pathogens causing anthracnose in Dioscorea alata and Dioscorea rotundata farms in Cross River State yam belt region were characterized. Diseased yam leaves wi...

TPGS-based and S-thanatin functionalized nanorods for overcoming drug resistance in Kle...
https://doi.org/10.1038/s41467-022-31500-3 10.1038/s41564-019-0503-9 10.1093/femsre/fuz014 10.1002/med.21591 10.2217/fmb.14.66 10.1093/femsre/fuy043 10.1038/s41579-019-0315-1 10.1111/joim.13007 10.1093/femsre/fux013 10.1016/j.cmi.2019.04.013 10.1080/22221751.2020.1768805 10.1038/s41579-019-0288-0 10.1002/adma.201904106 10.1016/j.ajps.2019.03.002 10.1039/C7CS00748E 10.1093/femsre/fux003 10.1039/C8NR07146B 10.1016/j.ijantimicag.2016.04.017 10.7150/thno.22711 10.7150/thno.33452 10.1039/C9BM00343F 10.1038/s41589-020-00694-2 10.1038/s41598-017-18102-6 10.1002/phar.2209 10.3389/fphar.2015.00249 10.1016/j.cis.2020.102157 10.1021/acsami.8b12784 10.1046/j.1432-1327.1998.2560404.x 10.1016/j.ijantimicag.2009.11.009 10.1038/s41598-016-0028-x 10.1128/AAC.01198-06 10.1038/s41467-019-11503-3 10.1164/rccm.201708-1733OC 10.1021/acsnano.8b04433 10.4161/viru.3.1.18382 10.1128/CMR.00059-12 10.1021/acs.molpharmaceut.8b00861 10.1016/j.toxlet.2018.11.002 10.1001/jama.2020.6348 10.2967/jnumed.117.195420 10.1183/16000617.0051-2016 10.1093/jac/dky164 10.3389/fmicb.2021.678165 10.1039/C9BM01544B 10.1016/j.jconrel.2020.04.047 10.1021/acs.nanolett.8b04020
Nature Communications; Wang X, Xu X et. al.

Jun 30th, 2022 - Tigecycline is regarded as the last line of defense to combat multidrug-resistant Klebsiella pneumoniae. However, increasing utilization has led to rising drug resistance and treatment failure. Here, we design a D-alpha tocopheryl polyethylene glycol succinate-modified and S-thanatin peptide-functionalized nanorods based on calcium phosphate nanoparticles for tigecycline delivery and pneumonia ...

Probiotics and dairy products in dentistry: A bibliometric and critical review of rando...
https://doi.org/10.1016/j.foodres.2022.111228
Food Research International (Ottawa, Ont.); Farias da Cruz M, Baraúna Magno M et. al.

Jun 29th, 2022 - The oral environment is an essential part of the human microbiome. The consumption of probiotic products may improve the oral microbiota and reduce the risk of diseases. This paper presents a bibliometric and critical review of randomized clinical trials (RCTs) that used probiotics to analyze oral parameters in humans. RCTs carried out with no age, gender, and ethnicity restrictions and publish...

Conjugative transfer of mcr-1-bearing plasmid from Salmonella to Escherichia coli in vi...
https://doi.org/10.1016/j.foodres.2022.111263
Food Research International (Ottawa, Ont.); Li W, Bai X et. al.

Jun 29th, 2022 - Since mcr-1 was first discovered in 2015, this gene has shown excellent transmission ability and evolutionary characteristics worldwide, leading to major public health and food safety concerns. In this study, chicken meat was used as a food vehicle for the conjugation of mcr-1-bearing Salmonella at different storage temperatures (4 °C, 25 °C, and 37 °C) to simulate mcr-1 transmission during foo...

Fate of Escherichia coli artificially inoculated in Tenebrio molitor L. larvae rearing ...
https://doi.org/10.1016/j.foodres.2022.111269
Food Research International (Ottawa, Ont.); Cesaro C, Mannozzi C et. al.

Jun 29th, 2022 - The edible insect food chain represents a relatively novel food-producing system; hence, associated biological risks still need to be exhaustively evaluated. In the present study, the dynamics of Escherichia coli during the whole living period of Tenebrio molitor larvae (from eggs to pupae) were studied. To this end, a rearing substrate consisting of organic wheat middlings was spiked with E. c...

Sugary kefir grains as the inoculum for developing a low sodium isotonic beverage.
https://doi.org/10.1016/j.foodres.2022.111257
Food Research International (Ottawa, Ont.); Lima Parente Fernandes M, Cristina de Souza A et. al.

Jun 29th, 2022 - The objective of this study was to apply for the first time sugary kefir to produce a new isotonic with low sodium. Additionally, the microbial community profile of grains and fermented kefir was evaluated through metataxonomics. The kefir grains were inoculated into filtered water containing 40 g L-1 sugar at 25 °C for 48 h. Grains and beverage samples were collected at 0, 24, and 48 h for DNA...

Goat milk fermented with combined lactic acid bacterium alter microbial community struc...
https://doi.org/10.1016/j.foodres.2022.111352
Food Research International (Ottawa, Ont.); Ma H, Yu Z et. al.

Jun 29th, 2022 - The present study investigated effects of the fermented goat milk (FGM) produced with a combination of Streptococcus salivarius subsp. thermophilus and Lactobacillus delbrueckii subsp. bulgaricus (SL) and with another one of SL as well as Bifidobacterium animalis subsp. lactis (SLB) on the internal environment in the large intestine of mice. Both the richness and the diversity of microbiota was...

The intestinal colonization of Lactiplantibacillus plantarum AR113 is influenced by its...
https://doi.org/10.1016/j.foodres.2022.111382
Food Research International (Ottawa, Ont.); Qin W, Xia Y et. al.

Jun 29th, 2022 - Lactiplantibacillus plantarum is an important member of the probiotic family and colonization of the host intestinal is essential for its continued probiotic function. The mechanism of L. plantarum intestinal colonization has not been elucidated until now, an important reason being that the colonization process is influenced by a number of factors. In this study, to confirm the influences of ad...

Effects of kefir lactic acid bacteria-derived postbiotic components on high fat diet-in...
https://doi.org/10.1016/j.foodres.2022.111445
Food Research International (Ottawa, Ont.); Seo KH, Gyu Lee H et. al.

Jun 29th, 2022 - Cellular components, surface layer protein (SLP) and exopolysaccharides (EPS) of postbiotic lactic bacteria (PLAB) can rehabilitate high-fat diet-induced dysbiosis and obese characteristic gut microbiome. However, it is not clear whether and how PLAB components affect gut microbiota and specifically adipocyte gene expression. Furthermore, SLP and EPS of PLAB in combination with polyphenolics of...

Microbial diversity, morpho-textural characterization, and volatilome profile of the Po...
https://doi.org/10.1016/j.foodres.2022.111481
Food Research International (Ottawa, Ont.); Cardinali F, Foligni R et. al.

Jun 29th, 2022 - The aim of the present study was to characterize the bacterial and fungal communities naturally occurring in Queijo da Beira Baixa PDO cheese samples produced in Castelo Branco district (Beira Baixa Region, Portugal) through viable counts and metataxonomic analyses. Physico-chemical and morpho-textural analyses were also carried out, together with the analysis of volatile organic compounds (VOC...

New insights of bacterial communities in fermented vegetables from shotgun metagenomics...
https://doi.org/10.1016/j.foodres.2022.111190
Food Research International (Ottawa, Ont.); Yasir M, Al-Zahrani IA et. al.

Jun 29th, 2022 - Consumption of fermented foods has grown worldwide due to the purported health benefits. It is thus critical to understand fermented foods microbiome that mainly influences the quality and safety of these foods. This study identified bacterial communities, including functional profiles of probiotics and antimicrobial resistance genes (ARGs), in pickled vegetables commonly consumed in the Middle...

Impact of water activity on the radial growth of fungi in a dairy environment.
https://doi.org/10.1016/j.foodres.2022.111247
Food Research International (Ottawa, Ont.); Valle M, Nguyen Van Long N et. al.

Jun 29th, 2022 - Filamentous fungi are used in the dairy industry as adjunct cultures in fermented products, but can also lead to food spoilage, waste and economic losses. The control of filamentous fungi with abiotic factors contributes to longer food shelf life and prevention of fungal spoilage. One of the main abiotic factors for controlling fungal growth in foods is water activity (aw). This study aimed to ...

Transcriptomics reveals the anti-obesity mechanism of Lactobacillus plantarum fermented...
https://doi.org/10.1016/j.foodres.2022.111285
Food Research International (Ottawa, Ont.); Gu Y, Bai J et. al.

Jun 29th, 2022 - Fermentation by lactic acid bacteria can improve the nutritional value and biological function of cereal. Our previous studies have confirmed that Lactobacillus plantarum fermented barley extract (LFBE) can alleviate obesity caused by high-fat diet (HFD) in rats, while the precise mechanism remains unclear. Herein, we explored the effect of LFBE on the adipose tissue in obese rats and its mecha...

Thermal death kinetics of Salmonella Enteritidis PT30 in peanut butter as influenced by...
https://doi.org/10.1016/j.foodres.2022.111288
Food Research International (Ottawa, Ont.); Yang R, Wei L et. al.

Jun 29th, 2022 - It has been a challenge in developing effective thermal pasteurization processes for foods with high-fat and low-moisture contents like peanut butter, due to a general lack of reliable data on thermal resistance of pathogens in those food matrices. Recent studies on low-moisture foods like wheat flour and almond flour suggest that temperature and water activity (at the process temperatures) are...

Tryptophan-rich diet ameliorates chronic unpredictable mild stress induced depression- ...
https://doi.org/10.1016/j.foodres.2022.111289
Food Research International (Ottawa, Ont.); Wang D, Wu J et. al.

Jun 29th, 2022 - Tryptophan, an essential amino acid, has been reported that it has the potential to regulate depression-like behavior. Meanwhile, Chronic stress-induced depression also has a close relationship with gut microbiota structure and composition. In the current research, we demonstrated that a tryptophan-rich diet (0.6% tryptophan w/w) significantly attenuated depression- and anxiety-like behaviors i...

A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes.
https://doi.org/10.1038/s41467-022-31351-y 10.1128/CMR.00032-13 10.1016/j.idc.2018.10.010 10.4103/0972-9062.310863 10.3201/eid2205.151824 10.1086/592254 10.1128/IAI.00109-12 10.1016/j.ajpath.2018.09.005 10.7554/eLife.67029 10.1371/journal.pntd.0007054 10.2217/fmb-2019-0266 10.1016/j.mib.2016.11.007 10.1073/pnas.1520699113 10.1002/j.1460-2075.1992.tb05253.x 10.1046/j.1462-5822.1999.00019.x 10.1128/IAI.73.3.1432-1440.2005 10.1046/j.1365-2958.1999.01627.x 10.1111/j.1462-5822.2006.00780.x 10.1084/jem.186.7.1159 10.1084/jem.167.4.1459 10.1016/j.micinf.2007.05.005 10.1111/j.1462-5822.2009.01338.x 10.1111/j.1365-2958.1993.tb01211.x 10.1128/JB.185.21.6295-6307.2003 10.1128/iai.63.11.4531-4534.1995 10.1128/iai.63.11.4231-4237.1995 10.1128/JB.00155-10 10.1086/379080 10.1128/IAI.00395-09 10.1128/IAI.73.10.6668-6673.2005 10.1128/iai.57.1.36-40.1989 10.1128/iai.38.1.109-113.1982 10.1128/iai.40.2.840-842.1983 10.4269/ajtmh.2001.65.936 10.1128/iai.60.7.2733-2740.1992 10.1371/journal.ppat.1003399 10.1038/nrmicro3160 10.1016/j.molcel.2009.04.026 10.1016/j.cub.2004.04.033 10.4161/auto.7.3.14487 10.1074/jbc.M111.223610 10.1074/jbc.M702824200 10.4049/jimmunol.0900441 10.1038/ni.1800 10.4161/auto.6.2.11118 10.1093/emboj/19.21.5720 10.1016/j.biocel.2004.05.009 10.1128/IAI.00110-15 10.1038/emboj.2013.234 10.1186/s12929-021-00713-x 10.1111/j.1462-5822.2009.01415.x 10.1093/glycob/cwy017 10.1016/j.chom.2009.07.005 10.1038/nature10744 10.1073/pnas.1615771114 10.3389/fcimb.2017.00112 10.1083/jcb.201304188 10.1371/journal.pone.0197012 10.1038/s41564-020-0673-5 10.1128/iai.63.1.366-374.1995 10.1073/pnas.0601838103 10.1016/j.cub.2013.11.025 10.1016/0092-8674(82)90087-3 10.1128/IAI.00614-08 10.1016/j.cell.2016.09.023 10.1128/IAI.00100-10 10.1128/MMBR.00082-15 10.1016/j.toxicon.2003.11.013 10.1128/IAI.72.9.5204-5215.2004 10.1111/j.1365-2958.2004.04194.x 10.1074/jbc.M411465200 10.1371/journal.ppat.1004760 10.1074/jbc.M115.671974 10.3390/cells9092042 10.1073/pnas.0508477102 10.1038/nature21032 10.1038/s41564-019-0583-6 10.1128/IAI.67.11.6104-6108.1999 10.1128/mBio.00820-20 10.1128/mBio.00899-17 10.1126/sciadv.abg2517 10.1152/physrev.00036.2009 10.1073/pnas.1705032114 10.1016/j.ceb.2018.08.003 10.1016/j.ceb.2019.03.011 10.1016/j.chom.2012.03.001 10.1091/mbc.E19-04-0197 10.1038/nature13168 10.1038/nri3859 10.1128/IAI.00095-21 10.1172/JCI1578 10.1128/AEM.01727-07 10.1093/nar/gkq971 10.1186/1472-6807-8-42 10.1111/j.1462-5822.2004.00402.x 10.1128/jcm.25.1.167-171.1987
Nature Communications; Borgo GM, Burke TP et. al.

Jun 28th, 2022 - Rickettsia species of the spotted fever group are arthropod-borne obligate intracellular bacteria that can cause mild to severe human disease. These bacteria invade host cells, replicate in the cell cytosol, and spread from cell to cell. To access the host cytosol and avoid immune detection, they escape membrane-bound vacuoles by expressing factors that disrupt host membranes. Here, we show tha...