Proceedings of the National Academy of Sciences of the Un... Snyder M, Alburez-Gutierrez D et. al.
Jun 24th, 2022 - Excess mortality associated with the COVID-19 pandemic has led many to experience the loss of family members, with significant negative outcomes. We quantify the extent to which these population-wide rates of kin loss represent a departure from levels expected in the absence of COVID-19 excess mortality and consider which demographic groups are most likely to be affected. Results for biological...
JAMA Edmonson MB, Zhao Q et. al.
Jun 22nd, 2022 - The rate of postoperative death in children undergoing tonsillectomy is uncertain. Mortality rates are not separately available for children at increased risk of complications, including young children (aged <3 y) and those with sleep-disordered breathing or complex chronic conditions. To estimate postoperative mortality following tonsillectomy in US children, both overall and in relation to re...
JAMA Larkin HD
Jun 22nd, 2022 - Cancer Deaths May Double by 2030 in Sub-Saharan Africa.|2022|Larkin HD,|epidemiology,epidemiology,mortality,
The New England Journal of Medicine; Jatoi I, Sung H et. al.
Jun 18th, 2022 - The Emergence of the Racial Disparity in U.S. Breast-Cancer Mortality.|2022|Jatoi I,Sung H,Jemal A,|mortality,epidemiology,
JAMA Kuehn BM
Jun 15th, 2022 - Rising US Firearm Deaths During Pandemic Linked to Poverty.|2022|Kuehn BM,|statistics & numerical data,statistics & numerical data,trends,statistics & numerical data,statistics & numerical data,statistics & numerical data,epidemiology,epidemiology,mortality,
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Cardiovascular Diabetology; Shen Y, Chen L et. al.
Jun 11th, 2022 - The association between osteocalcin and mortality has been scantly studied. We aimed to investigate the association between osteocalcin along with its trajectories and mortality based on long-term longitudinal data. We performed a retrospective cohort study of 9413 type 2 diabetic patients with at least three measurements of total serum osteocalcin within 3 years since their first inpatient dia...
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Critical Care (London, England); Wang G, Jiang C et. al.
Jun 9th, 2022 - The purpose of this study was to clarify the prognostic value of Pentraxin-3 (PTX3) on the mortality of patients with sepsis. Publications published up to January 2021 were retrieved from PubMed, EMBASE, and the Cochrane library. Data from eligible cohort and case-control studies were extracted for the meta-analysis. Multivariate regression analysis was used to evaluate the correlation of the o...
The New England Journal of Medicine; Priemer DS, Iacono D et. al.
Jun 9th, 2022 - Persistent neuropsychiatric sequelae may develop in military personnel who are exposed to combat; such sequelae have been attributed in some cases to chronic traumatic encephalopathy (CTE). Only limited data regarding CTE in the brains of military service members are available. We performed neuropathological examinations for the presence of CTE in 225 consecutive brains from a brain bank dedica...
The Lancet. HIV; Trickey A, Zhang L et. al.
Jun 7th, 2022 - Over the past decade, antiretroviral therapy (ART) regimens that include integrase strand inhibitors (INSTIs) have become the most commonly used for people with HIV starting ART. Although trials and observational studies have compared virological failure on INSTI-based with other regimens, few data are available on mortality in people with HIV treated with INSTIs in routine care. Therefore, we ...
JAMA Meersch M, Weiss R et. al.
Jun 7th, 2022 - Intraoperative handovers of anesthesia care are common. Handovers might improve care by reducing physician fatigue, but there is also an inherent risk of losing critical information. Large observational analyses report associations between handover of anesthesia care and adverse events, including higher mortality. To determine the effect of handovers of anesthesia care on postoperative morbidit...
JAMA Gutiérrez OM, Sang Y et. al.
Jun 7th, 2022 - At a given estimated glomerular filtration rate (eGFR), individuals who are Black have higher rates of mortality and kidney failure with replacement therapy (KFRT) compared with those who are non-Black. Whether the recently adopted eGFR equations without race preserve racial differences in risk of mortality and KFRT at a given eGFR is unknown. To assess whether eGFR equations with and without r...
The New England Journal of Medicine; Tie J, Cohen JD et. al.
Jun 4th, 2022 - The role of adjuvant chemotherapy in stage II colon cancer continues to be debated. The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor recurrence-free survival, whereas its absence predicts a low risk of recurrence. The benefit of adjuvant chemotherapy for ctDNA-positive patients is not well understood. We conducted a trial to assess whether a ctDNA-guided approach c...
JAMA Aminian A, Wilson R et. al.
Jun 4th, 2022 - Obesity increases the incidence and mortality from some types of cancer, but it remains uncertain whether intentional weight loss can decrease this risk. To investigate whether bariatric surgery is associated with lower cancer risk and mortality in patients with obesity. In the SPLENDID (Surgical Procedures and Long-term Effectiveness in Neoplastic Disease Incidence and Death) matched cohort st...
Nature Van Noorden R
Jun 2nd, 2022 - COVID death tolls: scientists acknowledge errors in WHO estimates.|2022|Van Noorden R,|mortality,
Respiratory Medicine; Mudrakola HV, Tandon YK et. al.
May 29th, 2022 - Invasive aspergillosis (IA) is a serious complication in immunocompromised and critically ill patients but is difficult to diagnose. We sought to examine how often cases go undiagnosed and to understand the presenting clinical and radiologic features associated with fatal IA. We reviewed cases of fatal IA confirmed at autopsy (N = 67) between 1999 and 2019 at a tertiary academic hospital. At au...
Gynecologic Oncology; Nolin AC, Tian C et. al.
May 28th, 2022 - Develop conditional survival and risk-assessment estimates for uterine serous carcinoma (USC) overall and stratified by stage as tools for annual survivorship counseling and care planning. Patients in the National Cancer Data Base diagnosed between 2004 and 2014 with stage I-IV USC were eligible. Individuals missing stage or survival data or with multiple malignancies were excluded. Five-year c...
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BMC Medical Research Methodology; Rhodes K, Jenkins M et. al.
May 26th, 2022 - The major drivers of cost-effectiveness for chronic obstructive pulmonary disease (COPD) therapies are the occurrence of exacerbations and deaths. Exacerbations, including acute and long-term events, can cause worsening of COPD and lead to an increased risk of further exacerbations, and ultimately may elevate the risk of death. In contrast to this, health economic models are based on COPD sever...
JAMA Goodwin PJ, Chen BE et. al.
May 25th, 2022 - Metformin, a biguanide commonly used to treat type 2 diabetes, has been associated with potential beneficial effects across breast cancer subtypes in observational and preclinical studies. To determine whether the administration of adjuvant metformin (vs placebo) to patients with breast cancer without diabetes improves outcomes. MA.32, a phase 3 randomized, placebo-controlled, double-blind tria...
PloS One; Koyama AK, Cheng YJ et. al.
May 25th, 2022 - Both incidence and mortality of diagnosed diabetes have decreased over the past decade. However, the impact of these changes on key metrics of diabetes burden-lifetime risk (LR), years of potential life lost (YPLL), and years spent with diabetes-is unknown. We used data from 653,811 adults aged ≥18 years from the National Health Interview Survey, a cross-sectional sample of the civilian non-ins...
Seminars in Oncology; Flammia RS, Hoeh B et. al.
May 25th, 2022 - Data in patients with malignant melanoma, who have been previously treated with pembrolizumab as adjuvant therapy, show a reduction in pembrolizumab efficacy upon rechallenge. We examined this scenario in patients with non-metastatic renal cell carcinoma (RCC) eligible for adjuvant pembrolizumab after nephrectomy. We hypothesized that a proportion of such patients will either require re-treatme...