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About 562,603 results

Estimates from 31 countries show the significant impact of COVID-19 excess mortality on...
https://doi.org/10.1073/pnas.2202686119
Proceedings of the National Academy of Sciences of the Un... Snyder M, Alburez-Gutierrez D et. al.

Jun 24th, 2022 - Excess mortality associated with the COVID-19 pandemic has led many to experience the loss of family members, with significant negative outcomes. We quantify the extent to which these population-wide rates of kin loss represent a departure from levels expected in the absence of COVID-19 excess mortality and consider which demographic groups are most likely to be affected. Results for biological...

Association of Patient Characteristics With Postoperative Mortality in Children Undergo...
https://doi.org/10.1001/jama.2022.8679
JAMA Edmonson MB, Zhao Q et. al.

Jun 22nd, 2022 - The rate of postoperative death in children undergoing tonsillectomy is uncertain. Mortality rates are not separately available for children at increased risk of complications, including young children (aged <3 y) and those with sleep-disordered breathing or complex chronic conditions. To estimate postoperative mortality following tonsillectomy in US children, both overall and in relation to re...

Cancer Deaths May Double by 2030 in Sub-Saharan Africa.
https://doi.org/10.1001/jama.2022.10019
JAMA Larkin HD

Jun 22nd, 2022 - Cancer Deaths May Double by 2030 in Sub-Saharan Africa.|2022|Larkin HD,|epidemiology,epidemiology,mortality,

The Emergence of the Racial Disparity in U.S. Breast-Cancer Mortality.
https://doi.org/10.1056/NEJMp2200244
The New England Journal of Medicine; Jatoi I, Sung H et. al.

Jun 18th, 2022 - The Emergence of the Racial Disparity in U.S. Breast-Cancer Mortality.|2022|Jatoi I,Sung H,Jemal A,|mortality,epidemiology,

Rising US Firearm Deaths During Pandemic Linked to Poverty.
https://doi.org/10.1001/jama.2022.9111
JAMA Kuehn BM

Jun 15th, 2022 - Rising US Firearm Deaths During Pandemic Linked to Poverty.|2022|Kuehn BM,|statistics & numerical data,statistics & numerical data,trends,statistics & numerical data,statistics & numerical data,statistics & numerical data,epidemiology,epidemiology,mortality,

Low total osteocalcin levels are associated with all-cause and cardiovascular mortality...
https://doi.org/10.1186/s12933-022-01539-z 10.1007/s11154-019-09517-9 10.1016/j.abb.2014.05.022 10.1530/EJE-09-0585 10.1210/jc.2012-2906 10.1111/cen.12793 10.1186/s12933-018-0786-9 10.2337/dc21-2113 10.1007/s12020-016-0926-5 10.1038/aps.2015.81 10.1097/gme.0b013e318271b1da 10.1111/j.1365-2265.2011.04065.x 10.1111/1440-1681.12853 10.1038/s41401-018-0080-0 10.1186/1475-2840-13-74 10.7326/0003-4819-150-9-200905050-00006 10.2337/dc20-1862 10.1136/bmjopen-2017-020683 10.1016/j.bcp.2017.02.001 10.1515/cclm-2015-0953 10.1371/journal.pone.0173799 10.1007/s00198-011-1586-1 10.1038/s41419-018-1257-7 10.1016/j.molmet.2015.01.005 10.1016/j.cell.2007.05.047 10.1016/j.jhep.2016.02.023 10.1016/j.metabol.2013.03.005 10.1038/s41467-021-25673-6 10.1002/jbmr.4041 10.1371/journal.pone.0116479 10.1152/ajpendo.00445.2015 10.1007/s40620-019-00595-1 10.1093/gerona/gly163 10.1210/jc.2008-0270 10.1210/jc.2008-1455
Cardiovascular Diabetology; Shen Y, Chen L et. al.

Jun 11th, 2022 - The association between osteocalcin and mortality has been scantly studied. We aimed to investigate the association between osteocalcin along with its trajectories and mortality based on long-term longitudinal data. We performed a retrospective cohort study of 9413 type 2 diabetic patients with at least three measurements of total serum osteocalcin within 3 years since their first inpatient dia...

Pentraxin-3 as a predictive marker of mortality in sepsis: an updated systematic review...
https://doi.org/10.1186/s13054-022-04032-x 10.1001/jama.2016.0287 10.1016/j.mcna.2020.02.011 10.1097/SHK.0000000000001253 10.3389/fimmu.2021.678156 10.1038/s41598-020-73558-3 10.3390/ijms20215376 10.1684/ecn.2009.0185 10.1371/journal.pone.0243849 10.3389/fimmu.2018.03048 10.1016/j.jinf.2020.01.010 10.18632/oncotarget.23701 10.1097/MD.0000000000020495 10.1097/SHK.0000000000001543 10.5152/tao.2019.4058 10.4103/0253-7184.69003 10.3389/fimmu.2019.00794 10.1007/s10875-007-9126-7 10.1093/eurjhf/hfs092 10.1002/ijc.29822 10.1002/jmv.20397 10.1097/MPH.0b013e318180bc1d 10.1371/journal.pone.0073119 10.1016/j.jmii.2015.12.006 10.1186/s13054-016-1210-z 10.1371/journal.pone.0017653 10.1016/j.amjms.2017.01.003 10.3349/ymj.2017.58.2.370 10.1016/j.hrtlng.2012.11.005 10.1007/s00134-010-1752-5 10.1097/00003246-200107000-00017 10.1371/journal.pone.0053661 10.1016/j.jinf.2009.04.004 10.1016/j.jinf.2017.10.016 10.4065/75.12.1284 10.1136/bmjebm-2018-110891
Critical Care (London, England); Wang G, Jiang C et. al.

Jun 9th, 2022 - The purpose of this study was to clarify the prognostic value of Pentraxin-3 (PTX3) on the mortality of patients with sepsis. Publications published up to January 2021 were retrieved from PubMed, EMBASE, and the Cochrane library. Data from eligible cohort and case-control studies were extracted for the meta-analysis. Multivariate regression analysis was used to evaluate the correlation of the o...

Chronic Traumatic Encephalopathy in the Brains of Military Personnel.
https://doi.org/10.1056/NEJMoa2203199
The New England Journal of Medicine; Priemer DS, Iacono D et. al.

Jun 9th, 2022 - Persistent neuropsychiatric sequelae may develop in military personnel who are exposed to combat; such sequelae have been attributed in some cases to chronic traumatic encephalopathy (CTE). Only limited data regarding CTE in the brains of military service members are available. We performed neuropathological examinations for the presence of CTE in 225 consecutive brains from a brain bank dedica...

Associations of modern initial antiretroviral drug regimens with all-cause mortality in...
https://doi.org/10.1016/S2352-3018(22)00046-7
The Lancet. HIV; Trickey A, Zhang L et. al.

Jun 7th, 2022 - Over the past decade, antiretroviral therapy (ART) regimens that include integrase strand inhibitors (INSTIs) have become the most commonly used for people with HIV starting ART. Although trials and observational studies have compared virological failure on INSTI-based with other regimens, few data are available on mortality in people with HIV treated with INSTIs in routine care. Therefore, we ...

Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Pos...
https://doi.org/10.1001/jama.2022.9451
JAMA Meersch M, Weiss R et. al.

Jun 7th, 2022 - Intraoperative handovers of anesthesia care are common. Handovers might improve care by reducing physician fatigue, but there is also an inherent risk of losing critical information. Large observational analyses report associations between handover of anesthesia care and adverse events, including higher mortality. To determine the effect of handovers of anesthesia care on postoperative morbidit...

Association of Estimated GFR Calculated Using Race-Free Equations With Kidney Failure a...
https://doi.org/10.1001/jama.2022.8801
JAMA Gutiérrez OM, Sang Y et. al.

Jun 7th, 2022 - At a given estimated glomerular filtration rate (eGFR), individuals who are Black have higher rates of mortality and kidney failure with replacement therapy (KFRT) compared with those who are non-Black. Whether the recently adopted eGFR equations without race preserve racial differences in risk of mortality and KFRT at a given eGFR is unknown. To assess whether eGFR equations with and without r...

Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer.
https://doi.org/10.1056/NEJMoa2200075
The New England Journal of Medicine; Tie J, Cohen JD et. al.

Jun 4th, 2022 - The role of adjuvant chemotherapy in stage II colon cancer continues to be debated. The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor recurrence-free survival, whereas its absence predicts a low risk of recurrence. The benefit of adjuvant chemotherapy for ctDNA-positive patients is not well understood. We conducted a trial to assess whether a ctDNA-guided approach c...

Association of Bariatric Surgery With Cancer Risk and Mortality in Adults With Obesity.
https://doi.org/10.1001/jama.2022.9009
JAMA Aminian A, Wilson R et. al.

Jun 4th, 2022 - Obesity increases the incidence and mortality from some types of cancer, but it remains uncertain whether intentional weight loss can decrease this risk. To investigate whether bariatric surgery is associated with lower cancer risk and mortality in patients with obesity. In the SPLENDID (Surgical Procedures and Long-term Effectiveness in Neoplastic Disease Incidence and Death) matched cohort st...

COVID death tolls: scientists acknowledge errors in WHO estimates.
https://doi.org/10.1038/d41586-022-01526-0 10.1016/S0140-6736(21)02796-3
Nature Van Noorden R

Jun 2nd, 2022 - COVID death tolls: scientists acknowledge errors in WHO estimates.|2022|Van Noorden R,|mortality,

Autopsy study of fatal invasive pulmonary aspergillosis: Often undiagnosed premortem.
https://doi.org/10.1016/j.rmed.2022.106882
Respiratory Medicine; Mudrakola HV, Tandon YK et. al.

May 29th, 2022 - Invasive aspergillosis (IA) is a serious complication in immunocompromised and critically ill patients but is difficult to diagnose. We sought to examine how often cases go undiagnosed and to understand the presenting clinical and radiologic features associated with fatal IA. We reviewed cases of fatal IA confirmed at autopsy (N = 67) between 1999 and 2019 at a tertiary academic hospital. At au...

Conditional estimates for uterine serous cancer: Tools for survivorship counseling and ...
https://doi.org/10.1016/j.ygyno.2022.05.013
Gynecologic Oncology; Nolin AC, Tian C et. al.

May 28th, 2022 - Develop conditional survival and risk-assessment estimates for uterine serous carcinoma (USC) overall and stratified by stage as tools for annual survivorship counseling and care planning. Patients in the National Cancer Data Base diagnosed between 2004 and 2014 with stage I-IV USC were eligible. Individuals missing stage or survival data or with multiple malignancies were excluded. Five-year c...

Relationship between risk, cumulative burden of exacerbations and mortality in patients...
https://doi.org/10.1186/s12874-022-01616-7 10.5588/ijtld.19.0397 10.1016/S0140-6736(18)32279-7 10.1183/13993003.02191-2016 10.1183/09031936.04.00014304 10.1097/MCP.0000000000000454 10.1183/09031936.03.00078002 10.1053/rmed.2002.1334 10.1183/13993003.01391-2014 10.2147/COPD.S276819 10.2147/COPD.S163795 10.1183/16000617.00010114 10.1136/bmjopen-2014-006171 10.1056/NEJMoa0909883 10.2147/COPD.S253812 10.1513/AnnalsATS.201710-815OC 10.1016/j.ejim.2019.12.014 10.1186/1471-2466-13-54 10.1164/rccm.201710-2029OC 10.1177/0962280208092301 10.1056/NEJMoa1916046 10.1002/sim.1680 10.18637/jss.v038.i08 10.1191/0962280202SM276ra 10.1080/00224065.1969.11980344 10.1016/S0140-6736(16)30069-1 10.1056/NEJMoa0805800 10.1056/NEJMoa063070 10.1007/978-1-4757-3294-8 10.1002/sim.2712 10.18637/jss.v070.i08 10.1164/rccm.202006-2618OC 10.1177/0272989X16639900 10.7326/M15-0288
BMC Medical Research Methodology; Rhodes K, Jenkins M et. al.

May 26th, 2022 - The major drivers of cost-effectiveness for chronic obstructive pulmonary disease (COPD) therapies are the occurrence of exacerbations and deaths. Exacerbations, including acute and long-term events, can cause worsening of COPD and lead to an increased risk of further exacerbations, and ultimately may elevate the risk of death. In contrast to this, health economic models are based on COPD sever...

Effect of Metformin vs Placebo on Invasive Disease-Free Survival in Patients With Breas...
https://doi.org/10.1001/jama.2022.6147
JAMA Goodwin PJ, Chen BE et. al.

May 25th, 2022 - Metformin, a biguanide commonly used to treat type 2 diabetes, has been associated with potential beneficial effects across breast cancer subtypes in observational and preclinical studies. To determine whether the administration of adjuvant metformin (vs placebo) to patients with breast cancer without diabetes improves outcomes. MA.32, a phase 3 randomized, placebo-controlled, double-blind tria...

Trends in lifetime risk and years of potential life lost from diabetes in the United St...
https://doi.org/10.1371/journal.pone.0268805
PloS One; Koyama AK, Cheng YJ et. al.

May 25th, 2022 - Both incidence and mortality of diagnosed diabetes have decreased over the past decade. However, the impact of these changes on key metrics of diabetes burden-lifetime risk (LR), years of potential life lost (YPLL), and years spent with diabetes-is unknown. We used data from 653,811 adults aged ≥18 years from the National Health Interview Survey, a cross-sectional sample of the civilian non-ins...

Cancer-specific mortality in patients with non-metastatic renal cell carcinoma who have...
https://doi.org/10.1053/j.seminoncol.2022.04.002
Seminars in Oncology; Flammia RS, Hoeh B et. al.

May 25th, 2022 - Data in patients with malignant melanoma, who have been previously treated with pembrolizumab as adjuvant therapy, show a reduction in pembrolizumab efficacy upon rechallenge. We examined this scenario in patients with non-metastatic renal cell carcinoma (RCC) eligible for adjuvant pembrolizumab after nephrectomy. We hypothesized that a proportion of such patients will either require re-treatme...