Mar 15th, 2023 - Heart failure with preserved ejection fraction (HFpEF), defined as HF with an EF of 50% or higher at diagnosis, affects approximately 3 million people in the US and up to 32 million people worldwide. Patients with HFpEF are hospitalized approximately 1.4 times per year and have an annual mortality rate of approximately 15%. Risk factors for HFpEF include older age, hypertension, diabetes, dysli...

Mar 11th, 2023 - This study aimed to investigate the safety and efficacy of vericiguat in patients with heart failure (HF). We conducted a comprehensive literature review of the PubMed, Embase, and Cochrane Library databases up to 14 December 2022 for studies comparing vericiguat with placebo in patients with HF. Clinical data were extracted and cardiovascular deaths, adverse effects, and HF-related hospitaliza...

Mar 8th, 2023 - Effects of YKL-40 on one-year clinical outcomes including poor clinical outcome, all-cause mortality, and stroke recurrence among acute ischemic stroke (AIS) patients remained elusive. The purpose of this study was to explore the association between serum YKL-40 at admission and one-year clinical outcomes in AIS patients. In this prospective cohort study, a total of 1002 participants out of 136...

Mar 8th, 2023 - Neonatal sepsis is a leading cause of neonatal mortality. New interventions are needed to decrease neonatal sepsis and mortality in regions with highest burden. To evaluate the efficacy of intrapartum azithromycin to reduce neonatal sepsis or mortality, as well as neonatal and maternal infections. This double-blind, placebo-controlled, randomized clinical trial enrolled and followed up birthing...

Mar 2nd, 2023 - Syria after the earthquakes: what researchers can do to help.|2023||mortality,epidemiology,

Mar 2nd, 2023 - Characteristics and mortality of central nervous system TB in the Netherlands: a 15-year comparison with other forms of TB.|2023|Akkerman OW,van Het Hof S,de Vries G,van Crevel R,|epidemiology,epidemiology,mortality,

Mar 2nd, 2023 - The coronavirus disease 2019 (COVID-19) pandemic continues to evolve. Globally, COVID-19 continues to strain even the most resilient healthcare systems, with Omicron being the latest variant. We made a thorough search for literature describing the effects of the COVID-19 in a high human immunodeficiency virus (HIV)/tuberculosis (TB) burden district-level hospital setting. We found scanty litera...

Mar 2nd, 2023 - The aim of this study is to explore the role of IL6 in predicting outcome in critically ill COVID-19 patients. Design Prospective observational cohort study. Setting 20-bed respiratory medical intensive care unit of Abderrahmen Mami Teaching Hospital between September and December 2020. We included all critically ill patients diagnosed with COVID-19 managed in ICU. IL6 was measured during the f...

Mar 1st, 2023 - One MRI for 4.7 million people: the battle to treat Syria's earthquake survivors.|2023|Naddaf M,|mortality,instrumentation,statistics & numerical data,mortality,statistics & numerical data,epidemiology,

Mar 1st, 2023 - Characterising cause of death among people treated for drug-susceptible TB in India.|2023|Cox SR,Padmapriyadarsini C,Mave V,Seth B,Thiruvengadam K,|epidemiology,mortality,

Mar 1st, 2023 - The aim of the study was to investigate the gene polymorphisms of angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin type 1 receptor (AT1R) in association with coronavirus disease 2019 (COVID-19) mortality rates worldwide. The prevalence of ACE I/D, AGT M235T, and AT1R A1166C alleles' frequencies in different populations was assessed. Data on COVID-19-related cases and ...

Feb 26th, 2023 - To assess temporal changes to the risk of death in COVID-19 cases caused by the Omicron variant, we calculated age-standardized case fatality rates (CFR) in patients aged ≥40 years over nine diagnostic periods (3 January to 28 August 2022) in ten Japanese prefectures (14.8 million residents). Among 552,581 study subjects, we found that there were 1836 fatalities during the isolation period (up ...

Feb 26th, 2023 - Black women in the US have significantly higher breast cancer mortality than White women. Within biomarker-defined tumor subtypes, disparate outcomes seem to be limited to women with hormone receptor positive and HER2 negative (HR+/HER2-) breast cancer, a subtype usually associated with favorable prognosis. In this review, we present data from an array of studies that demonstrate significantly ...

Feb 23rd, 2023 - Mpox: Clinicians identify severe form with high mortality in advanced HIV patients.|2023|Mahase E,|complications,mortality,

Feb 17th, 2023 - Black heart transplant recipients have a higher mortality rate than white recipients 6-12 months after transplant. Whether there are racial disparities in post-transplant stroke incidence and all-cause mortality following post-transplant stroke among cardiac transplant recipients is unknown. Using a nationwide transplant registry, we assessed the association between race and incident post-trans...

Feb 16th, 2023 - Limited level 1 evidence is available on the omission of radiotherapy after breast-conserving surgery in older women with hormone receptor-positive early breast cancer receiving adjuvant endocrine therapy. We performed a phase 3 randomized trial of the omission of irradiation; the trial population included women 65 years of age or older who had hormone receptor-positive, node-negative, T1 or T2...

Feb 16th, 2023 - Overcoming Resistance - Omission of Radiotherapy for Low-Risk Breast Cancer.|2023|Ho AY,Bellon JR,|mortality,pathology,radiotherapy,surgery,

Feb 16th, 2023 - Most COVID-19 Deaths Worldwide Were Among Older People.|2023|Harris E,|mortality,

Feb 15th, 2023 - Acute respiratory distress syndrome (ARDS) patients with different lung morphology have distinct pulmonary mechanical dysfunction and outcomes. Whether lung morphology impacts the association between ventilatory variables and mortality remains unclear. Moreover, the impact of a novel combined ventilator variable [(4×DP) + RR] on morality in ARDS patients needs external validation. We obtained d...

Feb 15th, 2023 - Reducing HSV-2 Morbidity and Mortality: Routine Serologic Screening Still Not the Best Answer.|2023|Pearlman MD,|diagnosis,mortality,diagnosis,mortality,