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About 551,808 results

Studies Suggest COVID-19 Vaccine Boosters Save Lives.
https://doi.org/10.1001/jama.2021.23455
JAMA Abbasi J

Jan 12th, 2022 - Studies Suggest COVID-19 Vaccine Boosters Save Lives.|2022|Abbasi J,|mortality,prevention & control,

Obesity as a mortality risk factor in the medical ward: a case control study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733434
BMC Endocrine Disorders; Soffer S, Zimlichman E et. al.

Jan 8th, 2022 - Research regarding the association between severe obesity and in-hospital mortality is inconsistent. We evaluated the impact of body mass index (BMI) levels on mortality in the medical wards. The analysis was performed separately before and during the COVID-19 pandemic. We retrospectively retrieved data of adult patients admitted to the medical wards at the Mount Sinai Health System in New York...

Factors associated with excess all-cause mortality in the first wave of the COVID-19 pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735664
PLoS Medicine; Strongman H, Carreira H et. al.

Jan 7th, 2022 - Excess mortality captures the total effect of the Coronavirus Disease 2019 (COVID-19) pandemic on mortality and is not affected by misspecification of cause of death. We aimed to describe how health and demographic factors were associated with excess mortality during, compared to before, the pandemic. We analysed a time series dataset including 9,635,613 adults (≥40 years old) registered at Uni...

Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is...
https://doi.org/10.1159/000518740
Oncology Shiraishi T, Toyozumi T et. al.

Jan 7th, 2022 - We determined the soluble programmed cell death-1 ligand-1 (sPD-L1) concentration in patients with esophageal squamous cell carcinoma (ESCC), and confirmed the PD-L1 expression in resected specimens. Blood samples were collected from 73 patients with histologically proven ESCC. The serum levels of sPD-L1 were measured using an enzyme-linked immunosorbent assay. The correlations between the sPD-...

Diagnostic and prognostic value of presepsin and procalcitonin in non-infectious organ ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725484
BMC Infectious Diseases; Lee S, Song J et. al.

Jan 6th, 2022 - We investigated the diagnostic and prognostic value of presepsin among patients with organ failure, including sepsis, in accordance with the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). This prospective observational study included 420 patients divided into three groups: non-infectious organ failure (n = 142), sepsis (n = 141), and septic shock (n = 137). Op...

Clotting events among hospitalized patients infected with COVID-19 in a large multisite...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730413
PloS One; Nemetski SM, Ip A et. al.

Jan 6th, 2022 - COVID-19 infection has been hypothesized to precipitate venous and arterial clotting events more frequently than other illnesses. We demonstrate this increased risk of blood clots by comparing rates of venous and arterial clotting events in 4400 hospitalized COVID-19 patients in a large multisite clinical network in the United States examined from April through June of 2020, to patients hospita...

The Role of Surgery in the Treatment of Metachronous Liver Metastasis from Gastric Canc...
https://doi.org/10.21873/anticanres.15453
Anticancer Research; Aurello P, Minervini A et. al.

Jan 1st, 2022 - Few data are available regarding metachronous liver metastases from gastric cancer. We aimed to identify data regarding the survival of these patients, considering the chosen treatment, with particular attention to the role of surgery. A systematic review was carried out from 2000 to 2020. We chose articles reporting data from patients with metachronous liver metastases after curative gastrecto...

Conversion Surgery for Hepatocellular Carcinoma Following Molecular Therapy.
https://doi.org/10.21873/anticanres.15454
Anticancer Research; Yamamura K, Beppu T et. al.

Jan 1st, 2022 - Novel molecular therapies using targeted drugs and immune checkpoint inhibitors for advanced hepatocellular carcinoma have been evolving. Sorafenib and lenvatinib have been commonly used as first-line therapy, followed by recent atezolizumab plus bevacizumab. The median survival time has gradually improved to over 1.5 years. The complete radiological response does not always mean a complete pat...

The Benefit of Postoperative Radiotherapy and Extending Neck Dissection in pT1-2 Oral S...
https://doi.org/10.21873/anticanres.15462
Anticancer Research; Alsharif U, Steller D et. al.

Jan 1st, 2022 - We compared postoperative radiotherapy (PORT) to surgery only (SO), and supraomohyoidal neck dissection (SOHND) to modified radical neck dissection (MRND) in patients with pT1-T2 squamous cell carcinomas of the oral cavity (OSCC) and a single cervical lymph node metastasis (pN1) in terms of overall survival (OS), oral cancer specific survival (OCSS), and regional recurrence-free survival (RRFS)...

Prognostic Impact of Upfront Surgery for Locally Advanced Upper Rectal Adenocarcinoma.
https://doi.org/10.21873/anticanres.15469
Anticancer Research; Muller O, Sindayigaya R et. al.

Jan 1st, 2022 - Impact of neoadjuvant chemoradiotherapy (CRT) in locally advanced upper rectal adenocarcinoma (LAURC) is debated. The aim of this study was to compare outcomes between LAURC and locally advanced sigmoid and recto-sigmoid junction cancer (LASC). This retrospective study included 149 consecutive patients [42 CRT/LAURC, 16 upfront surgery (US/LAURC) and 91 LASC]. Partial mesorectum excision (PME) ...

Fatality risk and issues of inequity among vulnerable road users in South Africa.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719710
PloS One; Sukhai A, Govender R et. al.

Jan 1st, 2022 - Contextual effects from the physical and social environment contribute to inequitable protection for a large proportion of road users, especially in low- and middle-income countries like South Africa where distorted urban planning and socio-spatial disparities from the apartheid era prevail. This paper examines the differentiated risk of road traffic crashes and injuries to vulnerable road user...

Combined mRNAs and clinical factors model on predicting prognosis in patients with trip...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716048
PloS One; Hu Y, Zou D

Dec 30th, 2021 - Triple-negative breast cancer (TNBC) is aggressive cancer usually diagnosed in young women with no effective prognosis prediction model to use. The present study was performed to develop a useful prognostic model for predicting overall survival (OS) for TNBC patients. The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) databases were used a...

Incidence and Outcomes Associated With Clostridioides difficile Infection in Solid Orga...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717111
JAMA Network Open; Hosseini-Moghaddam SM, Luo B et. al.

Dec 30th, 2021 - Little is known about the incidence and outcomes of Clostridioides difficile infection (CDI) in solid organ transplant (SOT) recipients. To estimate the CDI incidence and outcomes in SOT recipients. A population-based cohort study was conducted using administrative health care data for all Ontario, Canada, residents who received organ allografts from April 1, 2003, to December 31, 2017; March 3...

Effect of Colchicine vs Usual Care Alone on Intubation and 28-Day Mortality in Patients...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717104
JAMA Network Open; Diaz R, Orlandini A et. al.

Dec 30th, 2021 - Hospitalized patients with COVID-19 pneumonia have high rates of morbidity and mortality. To assess the efficacy of colchicine in hospitalized patients with COVID-19 pneumonia. The Estudios Clínicos Latino América (ECLA) Population Health Research Institute (PHRI) COLCOVID trial was a multicenter, open-label, randomized clinical trial performed from April 17, 2020, to March 28, 2021, in adults ...

Clinical and radiological characteristics of acute pulmonary embolus in relation to 28-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714121
PloS One; Norton L, Cooper G et. al.

Dec 29th, 2021 - Patients with acute pulmonary embolism (PE) exhibit a wide spectrum of clinical and laboratory features when presenting to hospital and pathophysiologic mechanisms differentiating low-risk and high-risk PE are poorly understood. To investigate the prognostic value of clinical, laboratory and radiological information that is available within routine tests undertaken for patients with acute PE. E...

Colchicine use in patients with COVID-19: A systematic review and meta-analysis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714120
PloS One; Chiu L, Lo CH et. al.

Dec 29th, 2021 - Colchicine may inhibit inflammasome signaling and reduce proinflammatory cytokines, a purported mechanism of COVID-19 pneumonia. The aim of this systematic review and meta-analysis is to report on the state of the current literature on the use of colchicine in COVID-19 and to investigate the reported clinical outcomes in COVID-19 patients by colchicine usage. The literature was searched from Ja...

On the relation between COVID-19, mobility, and the stock market.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714095
PloS One; van Ruitenbeek RE, Slik JS et. al.

Dec 29th, 2021 - The Covid-19 pandemic has brought forth a major landscape shock in the mobility sector. Due to its recentness, researchers have just started studying and understanding the implications of this crisis on mobility. We contribute by combining mobility data from various sources to bring a novel angle to understanding mobility patterns during Covid-19. The goal is to expose relations between mobilit...

Effect of pentoxifylline on colon cancer patients treated with chemotherapy (Part I).
https://doi.org/10.3233/TUB-211533
Tumour Biology : the Journal of the International Society... Meirovitz A, Baider L et. al.

Dec 28th, 2021 - Cancer progression is associated with significant systemic clinical manifestations including cachexia induced weight loss and anorexia. Pentoxifylline (PTX) is a drug that has been shown to have multiple beneficial effects in cancer patients through its anti-inflammatory properties. To evaluate PTX effects on colon cancer patients treated with chemotherapy. Forty metastatic colon cancer patient...

Updates in sepsis management.
https://doi.org/10.1016/S1473-3099(21)00773-8
The Lancet. Infectious Diseases; Mushtaq A, Kazi F

Dec 27th, 2021 - Updates in sepsis management.|2021|Mushtaq A,Kazi F,|adverse effects,therapeutic use,drug therapy,mortality,prevention & control,drug therapy,mortality,prevention & control,

COVID-19 vaccine mandates in Europe.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694743
The Lancet. Infectious Diseases; Burki T

Dec 27th, 2021 - COVID-19 vaccine mandates in Europe.|2021|Burki T,|epidemiology,immunology,mortality,prevention & control,administration & dosage,immunology,epidemiology,legislation & jurisprudence,statistics & numerical data,statistics & numerical data,