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About 102,753 results

Malaria among under-five children in rural communities of Al-Mahweet governorate, Yemen.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675118
Malaria Journal; Al-Quhaiti MAA, Abdul-Ghani R et. al.

Nov 20th, 2022 - Malaria burden among under-five children living in endemic areas of Yemen is largely unknown due to the lack of community-based studies. Therefore, this study determined the prevalence and risk factors associated with falciparum malaria among under-five children in rural communities of Al-Mahweet governorate, Yemen. This community-based, cross-sectional study recruited 400 under-five children f...

Significance of nested PCR testing for the detection of low-density malaria infection a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669540
Malaria Journal; Singh A, Singh MP et. al.

Nov 19th, 2022 - Low-density malaria infections (LDMI) are defined as infections that are missed by the rapid diagnostic test (RDT) and/or microscopy which can lead to continued transmission and poses a challenge in malaria elimination efforts. This study was conducted to investigate the prevalence of LDMI in febrile cases using species-specific nested Polymerase Chain Reaction (PCR) tests in the Malaria Elimin...

Ring stage classification of Babesia microti and Plasmodium falciparum using optical di...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673388
Parasites & Vectors; Mazigo E, Jun H et. al.

Nov 19th, 2022 - Babesia is an intraerythrocytic parasite often misdiagnosed as a malaria parasite, leading to inappropriate treatment of the disease especially in co-endemic areas. In recent years, optical diffraction tomography (ODT) has shown great potential in the field of pathogen detection by quantification of three-dimensional (3D) imaging tomograms. The 3D imaging of biological cells is crucial to inves...

Impact of pulmonary African trypanosomes on the immunology and function of the lung.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674601
Nature Communications; Mabille D, Dirkx L et. al.

Nov 19th, 2022 - Approximately 20% of sleeping sickness patients exhibit respiratory complications, however, with a largely unknown role of the parasite. Here we show that tsetse fly-transmitted Trypanosoma brucei parasites rapidly and permanently colonize the lungs and occupy the extravascular spaces surrounding the blood vessels of the alveoli and bronchi. They are present as nests of multiplying parasites ex...

Modulation of the porcine intestinal microbiota in the course of Ascaris suum infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673396
Parasites & Vectors; Springer A, Wagner L et. al.

Nov 19th, 2022 - The porcine roundworm Ascaris suum impairs feed conversion and weight gain, but its effects on intestinal microbiota remain largely unexplored. Modulation of the intestinal microbiota was assessed in pigs that were infected once with 10,000 A. suum eggs and pigs that received a trickle infection (1000 eggs/day over 10 days), compared with a non-infected control group. Six pigs each were sacrifi...

Malaria vector bionomics in Taita-Taveta County, coastal Kenya.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670438
Parasites & Vectors; Karisa J, Ominde K et. al.

Nov 18th, 2022 - Estimation of the composition and densities of mosquito species populations is crucial for monitoring the epidemiology of mosquito-borne diseases and provide information on local vectors to public health officials and policy-makers. The aim of this study was to evaluate malaria vector bionomics in ecologically distinct sites in Taita-Taveta County, Kenya. Adult mosquitoes were collected using b...

Dissecting the mechanisms of pathogenesis in cerebral malaria.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671333
PLoS Pathogens; Ramachandran A, Sharma A

Nov 18th, 2022 - Cerebral malaria (CM) is one of the leading causes of death due to malaria. It is characterised by coma, presence of asexual parasites in blood smear, and absence of any other reason that can cause encephalopathy. The fatality rate for CM is high, and those who survive CM often experience long-term sequelae, including cognitive and motor dysfunctions. It is unclear how parasites sequestered in ...

Diagnosis of Acute Chagas Disease in a Belizean Child with Evidence of a Multiclonal Tr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9709023
The American Journal of Tropical Medicine and Hygiene; Murray KO, Saldaña MA et. al.

Nov 18th, 2022 - In January 2020, we instituted acute febrile illness surveillance in 11 hospitals and clinics across Belize. Within 3 months, we diagnosed an acute case of Chagas disease by polymerase chain reaction in a 7-year-old child in the northern part of the country. Phylogenetic analyses of the parasite from the acute blood specimen revealed a multiclonal Trypanosoma cruzi infection, including parasite...

Evaluation of an ultrasensitive HRP2-based rapid diagnostic test for detection of asymp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667565
Malaria Journal; Turnbull LB, Ayodo G et. al.

Nov 17th, 2022 - Accurate detection of asymptomatic malaria parasitaemia in children living in high transmission areas is important for malaria control and reduction programmes that employ screen-and-treat surveillance strategies. Relative to microscopy and conventional rapid diagnostic tests (RDTs), ultrasensitive RDTs (us-RDTs) have demonstrated reduced limits of detection with increased sensitivity to detect...

Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668162
PLoS Pathogens; Raghavan SSR, Dagil R et. al.

Nov 17th, 2022 - Malaria during pregnancy is a major global health problem caused by infection with Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected erythrocytes in the placenta. Here, erythrocytes infected by late blood-stage parasites adhere to placental chondroitin sulphate A (CS) via VAR2CSA-type P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion proteins. ...

Thelazia lacrymalis in horses from Romania: epidemiology, morphology and phylogenetic a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664606
Parasites & Vectors; Cotuțiu VD, Ionică AM et. al.

Nov 16th, 2022 - Equine thelaziosis is a neglected vector-borne parasitic disease in modern veterinary medicine, lacking recent reports. It is transmitted by Musca autumnalis, and potentially other Muscidae species, by ingesting the lachrymal secretions of its equine host. The distribution of both Thelazia lacrymalis and its intermediate hosts remains largely unknown throughout Europe, with most studies dating ...

Evaluating noninvasive methods for estimating cestode prevalence in a wild carnivore po...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665365
PloS One; Brandell EE, Jackson MK et. al.

Nov 16th, 2022 - Helminth infections are cryptic and can be difficult to study in wildlife species. Helminth research in wildlife hosts has historically required invasive animal handling and necropsy, while results from noninvasive parasite research, like scat analysis, may not be possible at the helminth species or individual host levels. To increase the utility of noninvasive sampling, individual hosts can be...

A prospective cohort study of Plasmodium falciparum malaria in three sites of Western K...
https://doi.org/10.1186/s13071-022-05503-4
Parasites & Vectors; Ondeto BM, Wang X et. al.

Nov 11th, 2022 - Malaria in western Kenya is currently characterized by sustained high Plasmodial transmission and infection resurgence, despite positive responses in some areas following intensified malaria control interventions since 2006. This study aimed to evaluate long-term changes in malaria transmission profiles and to assess patterns of asymptomatic malaria infections in school children aged 5-15 years...

Identification and expression profile of odorant-binding proteins in the parasitic wasp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645227
Parasite (Paris, France); Zhang H, Wang JY et. al.

Nov 10th, 2022 - Microplitis pallidipes Szépligeti (Hymenoptera: Braconidae) is an important parasitic wasp of second and third-instar noctuid larvae such as the insect pests Spodoptera exigua, Spodoptera litura, and Spodoptera frugiperda. As in other insects, M. pallidipes has a chemosensory recognition system that is critical to foraging, mating, oviposition, and other behaviors. Odorant-binding proteins (OBP...

A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage.
https://doi.org/10.1038/s41586-022-05406-5
Nature Afriat A, Zuzarte-Luís V et. al.

Nov 10th, 2022 - Malaria infection involves an obligatory, yet clinically silent liver stage1,2. Hepatocytes operate in repeating units termed lobules, exhibiting heterogeneous gene expression patterns along the lobule axis3, but the effects of hepatocyte zonation on parasite development at the molecular level remain unknown. Here we combine single-cell RNA sequencing4 and singl...

Transcriptomic analysis supports a role for the nervous system in regulating growth and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639813
PLoS Neglected Tropical Diseases; Robb E, McCammick EM et. al.

Nov 8th, 2022 - Fasciola spp. liver flukes have significant impacts in veterinary and human medicine. The absence of a vaccine and increasing anthelmintic resistance threaten sustainable control and underscore the need for novel flukicides. Functional genomic approaches underpinned by in vitro culture of juvenile Fasciola hepatica facilitate control target validation in the most pathogenic life stage. Comparat...

Prevalence of malaria and its risk factors in Lake Tana and surrounding areas, northwes...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636828
Malaria Journal; Adugna F, Wale M et. al.

Nov 6th, 2022 - In Ethiopia, malaria is a major concern to the health, and socio-economic development of the country because of its occurrence at the peak agricultural activities. Factors such as environmental, human host, parasite, and vector determine malaria transmission. Therefore, the present study was conducted to determine the prevalence and associated factors of malaria among febrile patients who visit...

Association between water, sanitation, and hygiene access and the prevalence of soil-tr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636783
Parasites & Vectors; Phillips AE, Ower AK et. al.

Nov 6th, 2022 - The Geshiyaro project is a 5-year intervention to assess the impact of community- and school-based water, sanitation, and hygiene (WaSH) interventions on reducing infection with soil-transmitted helminths (STH) and schistosome parasites in combination with deworming in Wolayita zone, Ethiopia. A population-based, cross-sectional census and parasitological mapping activity was conducted between ...

The microbial community associated with Parascaris spp. infecting juvenile horses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636743
Parasites & Vectors; Cain JL, Norris JK et. al.

Nov 6th, 2022 - Parasitic nematodes, including large roundworms colloquially known as ascarids, affect the health and well-being of livestock animals worldwide. The equine ascarids, Parascaris spp., are important parasites of juvenile horses and the first ascarids to develop widespread anthelmintic resistance. The microbiota has been shown to be an important factor in the fitness of many organisms, including p...

The presence of Plasmodium malariae and Plasmodium knowlesi in near malaria elimination...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636705
Malaria Journal; Nainggolan IRA, Syafutri RD et. al.

Nov 6th, 2022 - Indonesia is progressing towards malaria elimination. To achieve this goal, intervention measures must be addressed to cover all Plasmodium species. Comprehensive control measures and surveillance programmes must be intensified. This study aims to determine the prevalence of microscopic and submicroscopic malaria in Langkat district, North Sumatera Province, Indonesia. A cross-sectional survey ...