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About 102,003 results

Histidine acid phosphatase domain-containing protein from Haemonchus contortus is a sti...
https://doi.org/10.1186/s13071-022-05411-7
Parasites & Vectors; Wen Z, Zhang Z et. al.

Aug 7th, 2022 - Histidine acid phosphatase (HAP), a member of the histidine phosphatase superfamily, is widely found in parasites and is also a potential vaccine antigen or drug target. However, the biological function of HAP in Haemonchus contortus is still unclear. We cloned the HAP gene from H. contortus (Hc-HAP) and expressed the purified recombinant Hc-HAP (rHc-HAP) protein. The transcription of the Hc-HA...

Prevalence of Plasmodium spp. in Anopheles mosquitoes in Thailand: a systematic review ...
https://doi.org/10.1186/s13071-022-05397-2
Parasites & Vectors; Sukkanon C, Masangkay FR et. al.

Aug 7th, 2022 - The entomological inoculation rate (EIR) is one of the key indices used to evaluate malaria transmission and vector control interventions. One of the components of the EIR is the sporozoite rate in Anopheles vectors. A systematic review and meta-analysis was performed to identify the prevalence of Plasmodium spp. in field-collected Anopheles species across Thailand. This systematic review was r...

Soil-transmitted helminthes and Schistosoma mansoni infections among primary school chi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356502
BMC Pediatrics; Feleke DG, Ali A et. al.

Aug 6th, 2022 - Schistosomiasis and soil-transmitted helminthiasis (STHs) are the major public health problem in the world especially in school age children. Therefore, this study aimed to determine the burden of soil transmitted helminths and Schistosoma mansoni among Ambesame primary school children, North-West Ethiopia. A cross sectional study was carried out at Ambasame primary school children from March t...

Maturation and substrate processing topography of the Plasmodium falciparum invasion/eg...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352755
Nature Communications; Mukherjee S, Nguyen S et. al.

Aug 5th, 2022 - The malaria parasite Plasmodium invades a host erythrocyte, multiplies within a parasitophorous vacuole (PV) and then ruptures the PV and erythrocyte membranes in a process known as egress. Both egress and invasion are controlled by effector proteins discharged from specialized secretory organelles. The aspartic protease plasmepsin X (PM X) regulates activity for many of these effectors, but it...

Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria.
https://doi.org/10.1056/NEJMoa2203067
The New England Journal of Medicine; Wu RL, Idris AH et. al.

Aug 4th, 2022 - New approaches for the prevention and elimination of malaria, a leading cause of illness and death among infants and young children globally, are needed. We conducted a phase 1 clinical trial to assess the safety and pharmacokinetics of L9LS, a next-generation antimalarial monoclonal antibody, and its protective efficacy against controlled human malaria infection in healthy adults who had never...

First report of haemosporidia and associated risk factors in red junglefowl (Gallus gal...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344640
Parasites & Vectors; Li Z, Ren XX et. al.

Aug 2nd, 2022 - Avian haemosporidia infect both domestic and wild birds, causing anemia, acute tissue degeneration, and depopulation in wild birds. Poultry and wild birds have been reported as common reservoirs of haemosporidia, but limited information is available for red junglefowl (Gallus gallus) in China. The present study investigated the prevalence and molecular characterization of haemosporidia in red j...

Neospora caninum infection induced mitochondrial dysfunction in caprine endometrial epi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344697
Parasites & Vectors; Tao DL, Zhao SS et. al.

Aug 2nd, 2022 - Infection of Neospora caninum, an important obligate intracellular protozoan parasite, causes reproductive dysfunctions (e.g. abortions) in ruminants (e.g. cattle, sheep and goats), leading to serious economic losses of livestock worldwide, but the pathogenic mechanisms of N. caninum are poorly understood. Mitochondrial dysfunction has been reported to be closely associated with pathogenesis of...

A landscape of gene regulation in the parasitic amoebozoa Entamoeba spp.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342746
PloS One; Galán-Vásquez E, Gómez-García MDC et. al.

Aug 2nd, 2022 - Entamoeba are amoeboid extracellular parasites that represent an important group of organisms for which the regulatory networks must be examined to better understand how genes and functional processes are interrelated. In this work, we inferred the gene regulatory networks (GRNs) in four Entamoeba species, E. histolytica, E. dispar, E. nuttalli, and E. invadens, and the GRN topological properti...

Clinical performance testing of the automated haematology analyzer XN-31 prototype usin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338637
Malaria Journal; Komaki-Yasuda K, Kutsuna S et. al.

Jul 31st, 2022 - The automated haematology analyzer XN-31 prototype (XN-31p) is a new flow cytometry-based device developed to measure the number and the ratio of malaria-infected red blood cells (MI-RBC) with a complete blood count (CBC). The XN-31p can provide results in about one minute and also can simultaneously provide information on the malaria parasite (Plasmodium) species. In this study, clinical testi...

Spatiotemporal dynamics of malaria in Banmauk Township, Sagaing region of Northern Myan...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331130
BMC Infectious Diseases; Aung PL, Soe MT et. al.

Jul 29th, 2022 - While national malaria incidence has been declining in Myanmar, some subregions within the nation continue to have high burdens of malaria morbidity and mortality. This study assessed the malaria situation in one of these regions, Banmauk Township, located near the Myanmar-India border. Our goal was to provide a detailed description of the malaria epidemiology in this township and to provide so...

Evidence underscoring immunological and clinical pathological changes associated with S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335973
BMC Infectious Diseases; Næsborg-Nielsen C, Wilkinson V et. al.

Jul 29th, 2022 - Sarcoptes scabiei is one of the most impactful mammalian parasites. There has been much research on immunological and clinical pathological changes associated with S. scabiei parasitism across a range of host species. This rich body of literature is complex, and we seek to bring that complexity together in this study. We first (1) synthesise narrative reviews of immunopathological relationships...

Low Prevalence of Deletions of the pfhrp2 and pfhrp3 Genes in Plasmodium falciparum Par...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209925
The American Journal of Tropical Medicine and Hygiene; McCaffery JN, Huber CS et. al.

Jul 28th, 2022 - Sierra Leone relies heavily on histidine-rich protein 2-based diagnostics for malaria because of the high transmission of Plasmodium falciparum. During the 2015 recombinant vesicular stomatitis virus (VSV)-Zaire Ebola virus envelope glycoprotein (GP) vaccine trial, 77 participants with asymptomatic Plasmodium infection were enrolled, with all but four having P. falciparum malaria. Of the 73 par...

Insights into Plasmodium vivax Asymptomatic Malaria Infections and Direct Skin-Feeding ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294676
The American Journal of Tropical Medicine and Hygiene; Moreno M, Torres K et. al.

Jul 28th, 2022 - Understanding the reservoir and infectivity of Plasmodium gametocytes to vector mosquitoes is crucial to align strategies aimed at malaria transmission elimination. Yet, experimental information is scarce regarding the infectivity of Plasmodium vivax for mosquitoes in diverse epidemiological settings where the proportion of asymptomatically infected individuals varies at a microgeographic scale...

RECRUITMENT AND SEASONAL OCCURRENCE OF PARASITES IN JUVENILE INVASIVE ROUND GOBIES (NEO...
https://doi.org/10.1645/22-35
The Journal of Parasitology; Marcogliese DJ

Jul 28th, 2022 - The round goby (Neogobius melanostomus) is an invasive species that has become one of the most abundant fish in the St. Lawrence River, Quebec, Canada over the past 15 yr. Since its introduction, the round goby has acquired a number of native parasites, yet little is known about the dynamics of parasite recruitment. To examine this question, young-of-the-year and juvenile round gobies were coll...

DNA recovery from used malaria RDT to detect Plasmodium species and to assess Plasmodiu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327223
Malaria Journal; Andrianaranjaka VHI, Ravaoarisoa E et. al.

Jul 27th, 2022 - Rapid diagnostic tests (RDT) are widely used for malaria diagnosis in Madagascar, where Plasmodium falciparum is the predominant species. Molecular diagnosis is essential for malaria surveillance, but requires additional blood samples for DNA extraction. Used RDTs is an attractive alternative that can be used as a source of DNA. Plasmodium falciparum genetic diversity and multiplicity of infect...

EVALUATION OF THE INHIBITORY EFFECTS OF SIX NATURAL PRODUCT EXTRACTS AGAINST BABESIA GI...
https://doi.org/10.1645/21-108
The Journal of Parasitology; Zhai X, Li L et. al.

Jul 26th, 2022 - New antibabesial drugs are required to fight resistant parasites, and plant-derived natural products are a robust source. Six kinds of natural product extracts derived from herbal medicines that are traditionally used for the treatment of malaria were selected to test the antibabesial effect on Babesia gibsoni in vitro and in vivo. Parasitized blood was collected from dogs infected with B. gibs...

DESCRIPTIVE EPIDEMIOLOGY OF THE MAIN INTERNAL PARASITES ON ALTERNATIVE PIG FARMS IN FRA...
https://doi.org/10.1645/21-126
The Journal of Parasitology; Delsart M, Fablet C et. al.

Jul 26th, 2022 - Alternative pig farms, which do not raise animals in closed buildings with slatted and/or concrete floors, have critical points that need particular attention. Internal parasitism is one, as the farming conditions in such structures are more favorable to the development and survival of parasites. The objectives of this study, carried out on 70 alternative farms in continental France, were to (i...

MORPHOMETRY OF FIRST-STAGE LARVAE OF ORTHOSTRONGYLUS MACROTIS (NEMATODA: PROTOSTRONGYLI...
https://doi.org/10.1645/22-20
The Journal of Parasitology; Verocai GG, Kafle P et. al.

Jul 26th, 2022 - Orthostrongylus macrotis (Dikmans, 1931) is a protostrongylid lungworm in wild ungulates from western North America, including mule and Columbia black-tailed deer, pronghorn, and rarely moose and elk. The lack of morphological data for certain developmental stages of O. macrotis and the unresolved taxonomic status of the genus indicate a more detailed morphological characterization of the speci...

The microscopic five of the big five: Managing zoonotic diseases within and beyond Afri...
https://doi.org/10.1016/bs.apar.2022.05.001
Advances in Parasitology; Tober AV, Govender D et. al.

Jul 26th, 2022 - African protected areas strive to conserve the continent's great biodiversity with a targeted focus on the flagship 'Big Five' megafauna. Though often not considered, this biodiversity protection also extends to the lesser-known microbes and parasites that are maintained in these diverse ecosystems, often in a silent and endemically stable state. Climate and anthropogenic change, and associated...

Anthelmintic Baiting of Foxes against Echinococcus multilocularis in Small Public Area,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328911
Emerging Infectious Diseases; Uraguchi K, Irie T et. al.

Jul 26th, 2022 - We distributed anthelmintic baits on a university campus in Japan inhabited by foxes infected with Echinococcus multilocularis to design an effective baiting protocol for small public areas. High-density baiting can reduce the risk for human exposure to the parasite to near zero. However, monthly baiting is recommended to maintain this effect.