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About 110,980 results

COVID is here to stay: countries must decide how to adapt.
https://doi.org/10.1038/d41586-022-00057-y
Nature

Jan 12th, 2022 - COVID is here to stay: countries must decide how to adapt.|2022||drug therapy,epidemiology,prevention & control,economics,supply & distribution,analogs & derivatives,therapeutic use,statistics & numerical data,therapeutic use,therapeutic use,therapeutic use,therapeutic use,therapeutic use,epidemiology,virology,therapeutic use,genetics,immunology,isolation & purification,pathogenicity,epidemiology,

Emotions and emotion up-regulation during the COVID-19 pandemic in Germany.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741032
PloS One; Schelhorn I, Schlüter S et. al.

Jan 8th, 2022 - In stressful situations such as the COVID-19-pandemic, unpleasant emotions are expected to increase while pleasant emotions will likely decrease. Little is known about the role cognitive appraisals, information management, and upregulating pleasant emotions can play to support emotion regulation in a pandemic. In an online survey (N = 1682), we investigated predictors of changes in pleasant and...

Baseline clinical features of COVID-19 patients, delay of hospital admission and clinic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741026
PloS One; Dananché C, Elias C et. al.

Jan 8th, 2022 - Delay between symptom onset and access to care is essential to prevent clinical worsening for different infectious diseases. For COVID-19, this delay might be associated with the clinical prognosis, but also with the different characteristics of patients. The objective was to describe characteristics and symptoms of community-acquired (CA) COVID-19 patients at hospital admission according to th...

The mediation of perceived risk's impact on destination image and travel intention: An ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741017
PloS One; Jiang X, Qin J et. al.

Jan 8th, 2022 - Perceived risk clearly impacts travel behavior, including destination selection and satisfaction, but it is unclear how or why its effect is only significant in certain cases. This is because existing studies have undervalued the mediating factors of risk aversion, government initiatives, and media influence as well as the multiple forms or dimensions of risk that can mask its direct effect. Th...

COVID-19 outbreaks in nursing homes: A strong link with the coronavirus spread in the s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741027
PloS One; Rabilloud M, Riche B et. al.

Jan 8th, 2022 - Worldwide, COVID-19 outbreaks in nursing homes have often been sudden and massive. The study investigated the role SARS-CoV-2 virus spread in nearby population plays in introducing the disease in nursing homes. This was carried out through modelling the occurrences of first cases in each of 943 nursing homes of Auvergne-Rhône-Alpes French Region over the first epidemic wave (March-July, 2020). ...

Improved log-Gaussian approximation for over-dispersed Poisson regression: Application ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741021
PloS One; Murakami D, Matsui T

Jan 8th, 2022 - In the era of open data, Poisson and other count regression models are increasingly important. Still, conventional Poisson regression has remaining issues in terms of identifiability and computational efficiency. Especially, due to an identification problem, Poisson regression can be unstable for small samples with many zeros. Provided this, we develop a closed-form inference for an over-disper...

Mental health status of informal waste workers during the COVID-19 pandemic in Bangladesh.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741044
PloS One; Haque MR, Khan MMA et. al.

Jan 8th, 2022 - The deadliest coronavirus disease 2019 (COVID-19) is taking thousands of lives worldwide and presents an extraordinary challenge to mental resilience. This study assesses mental health status during the COVID-19 pandemic and its associated factors among informal waste workers in Bangladesh. A cross-sectional survey was conducted in June 2020 among 176 informal waste workers selected from nine m...

Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740962
PloS One; Traets MJM, Nijhuis RHT et. al.

Jan 8th, 2022 - Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can manifest with varying disease severity and mortality. Genetic predisposition influences the clinical course of infectious diseases. We investigated whether genetic polymorphisms in candidate genes ACE2, TIRAP, and factor X are associated with clinical outcomes in COVID-19. We con...

The Australian living guidelines for the clinical care of people with COVID-19: What wo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741039
PloS One; Turner T, Elliott J et. al.

Jan 8th, 2022 - The Australian National COVID-19 Clinical Evidence Taskforce is producing living, evidence-based, national guidelines for treatment of people with COVID-19 which are updated each week. To continually improve the process and outputs of the Taskforce, and inform future living guideline development, we undertook a concurrent process evaluation examining Taskforce activities and experience of team ...

Factors associated with excess all-cause mortality in the first wave of the COVID-19 pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735664
PLoS Medicine; Strongman H, Carreira H et. al.

Jan 7th, 2022 - Excess mortality captures the total effect of the Coronavirus Disease 2019 (COVID-19) pandemic on mortality and is not affected by misspecification of cause of death. We aimed to describe how health and demographic factors were associated with excess mortality during, compared to before, the pandemic. We analysed a time series dataset including 9,635,613 adults (≥40 years old) registered at Uni...

The social specificities of hostility toward vaccination against Covid-19 in France.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735622
PloS One; Bajos N, Spire A et. al.

Jan 7th, 2022 - Equal Access to the COVID-19 vaccine for all remains a major public health issue. The current study compared the prevalence of vaccination reluctance in general and COVID-19 vaccine hesitancy and social and health factors associated with intentions to receive the vaccine. A random socio-epidemiological population-based survey was conducted in France in November 2020, in which 85,855 adults part...

Omicron's feeble attack on the lungs could make it less dangerous.
https://doi.org/10.1038/d41586-022-00007-8
Nature Kozlov M

Jan 7th, 2022 - Omicron's feeble attack on the lungs could make it less dangerous.|2022|Kozlov M,|immunology,mortality,transmission,virology,immunology,statistics & numerical data,pathology,physiopathology,virology,virology,virology,genetics,immunology,isolation & purification,pathogenicity,metabolism,epidemiology,epidemiology,

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SA...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690919
Theranostics Huang KA, Zhou D et. al.

Jan 7th, 2022 - Background: Administration of potent anti-receptor-binding domain (RBD) monoclonal antibodies has been shown to curtail viral shedding and reduce hospitalization in patients with SARS-CoV-2 infection. However, the structure-function analysis of potent human anti-RBD monoclonal antibodies and its links to the formulation of antibody cocktails remains largely elusive. Methods: Previously, we isol...

Pandemic-related declines in hospitalization for non-COVID-19-related illness in the Un...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735608
PloS One; Nguyen JL, Benigno M et. al.

Jan 7th, 2022 - The COVID-19 pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has substantially impacted healthcare utilization worldwide. The objective of this retrospective analysis of a large hospital discharge database was to compare all-cause and cause-specific hospitalizations during the first six months of the pandemic in the United States with the same months ...

The impact of COVID-19 on fertility behaviour and intentions in a middle income country.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735619
PloS One; Emery T, Koops JC

Jan 7th, 2022 - The COVID Pandemic may affect fertility behaviour and intentions in many ways. Restrictions on service provision reduce access to family planning services and increase fertility in the short term. By contrast, the economic uncertainty brought about by the pandemic and its impact on mental health and well-being may reduce fertility. These various pathways have been explored in the context of hig...

Audio Interview: Covid-19 - The Outlook in Europe.
https://doi.org/10.1056/NEJMe2200149
The New England Journal of Medicine; Rubin EJ, Baden LR et. al.

Jan 6th, 2022 - Audio Interview: Covid-19 - The Outlook in Europe.|2022|Rubin EJ,Baden LR,Drosten C,Morrissey S,|epidemiology,prevention & control,transmission,methods,prevention & control,epidemiology,epidemiology,methods,genetics,pathogenicity,physiology,

Clinicopathological Analysis of Non-B Non-C Hepatocellular Carcinoma Focusing on Cellul...
https://doi.org/10.21873/anticanres.15503
Anticancer Research; Mizuochi S, Akiba J et. al.

Jan 1st, 2022 - Non-B non-C hepatocellular carcinomas (NBNC-HCCs) are larger than hepatitis virus-related HCCs. We conducted a clinicopathological study of patients who underwent curative NBNC-HCC resection, including proliferative activity assessments, such as nuclear grade and Ki-67 labelling index (LI). Histopathological findings of 197 patients were examined, including 56 NBNC-HCCs, 45 hepatitis B virus (H...

Helicobacter pylori Targets in AGS Human Gastric Adenocarcinoma: In Situ Proteomic Prof...
https://doi.org/10.21873/anticanres.15511
Anticancer Research; Yang JS, Kang CY et. al.

Jan 1st, 2022 - Helicobacter pylori, a gram-negative bacterium, causes chronic stomach diseases in humans. Heat shock proteins (HSPs) are involved in cell integrity, cell growth, and gastric mucosa colonization by H. pylori. This study aimed to investigate HSP expression levels in H. pylori-infected gastric adenocarcinoma AGS cells. We determined protein expression levels using iTRAQ proteomics analysis. We an...

Olaparib-induced Apoptosis Through EBNA1-ATR-p38 MAPK Signaling Pathway in Epstein-Barr...
https://doi.org/10.21873/anticanres.15513
Anticancer Research; Moon SH, Park NS et. al.

Jan 1st, 2022 - Epstein-Barr virus (EBV)-associated gastric cancer has been identified as a cancer subtype with definitive clinical and molecular characteristics. Although olaparib, a poly ADP ribose polymerase (PARP) inhibitor, is considered a potential effective agent for gastric cancer, the effect and underlying mechanism of olaparib on gastric cancer depending on EBV infection is not fully understood. EBV-...

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune...
https://doi.org/10.1073/pnas.2116853118
Proceedings of the National Academy of Sciences of the Un... Leon J, Michelson DA et. al.

Jan 1st, 2022 - Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) provokes a potentially fatal pneumonia with multiorgan failure, and high systemic inflammation. To gain mechanistic insight and ferret out the root of this immune dysregulation, we modeled, by in vitro coculture, the interactions between infected epithelial cells and immunocytes. A strong response was induced in monocytes...