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About 113,125 results

Heart disease after COVID: what the data say.
https://doi.org/10.1038/d41586-022-02074-3
Nature Sidik SM

Aug 3rd, 2022 - Heart disease after COVID: what the data say.|2022|Sidik SM,|complications,epidemiology,epidemiology,etiology,pathogenicity,

Association between Pathogenic Variants of Diarrheagenic Escherichia coli and Growth in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294710
The American Journal of Tropical Medicine and Hygiene; Das R, Palit P et. al.

Jul 28th, 2022 - There is a lack of information highlighting associations between different pathogenic variants of diarrheagenic Escherichia coli and childhood growth. Pathogenic variants of E. coli from stool samples, collected from 22,567 children enrolled in the Global Enteric Multicenter Study from December 2007 to March 2011, were detected by real-time polymerase chain reaction. We estimated the associatio...

How long is COVID infectious? What scientists know so far.
https://doi.org/10.1038/d41586-022-02026-x
Nature Adam D

Jul 27th, 2022 - How long is COVID infectious? What scientists know so far.|2022|Adam D,|transmission,virology,transmission,virology,growth & development,pathogenicity,

Gga-miR-30c-5p Suppresses Avian Reovirus (ARV) Replication by Inhibition of ARV-Induced...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327706
Journal of Virology; Zhou L, Haiyilati A et. al.

Jul 23rd, 2022 - Avian reovirus (ARV) causes viral arthritis, chronic respiratory diseases, retarded growth, and malabsorption syndrome. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression posttranscriptionally by silencing or degrading their targets, thus playing important roles in the host response to pathogenic infection. However, the role of miRNAs in host response to ARV infection is ...

Deletion of the H108R Gene Reduces Virulence of the Pandemic Eurasia Strain of African ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327699
Journal of Virology; Vuono E, Ramirez-Medina E et. al.

Jul 22nd, 2022 - African swine fever virus (ASFV) is the etiological agent of African swine fever (ASF), a devastating disease affecting domestic and wild swine and currently causing a global pandemic, severely affecting swine production. Here, we demonstrate that the deletion of the previously uncharacterized ASFV gene, H108R from the highly virulent ASFV-Georgia2007 (ASFV-G) genome strain, reduces virulence i...

Evaluation of the Deletion of MGF110-5L-6L on Swine Virulence from the Pandemic Strain ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327674
Journal of Virology; Ramirez-Medina E, Vuono E et. al.

Jul 22nd, 2022 - African swine fever virus (ASFV) is responsible for an ongoing pandemic that is affecting central Europe, Asia, and recently the Dominican Republic, the first report of the disease in the Western Hemisphere in over 40 years. ASFV is a large, complex virus with a double-stranded DNA (dsDNA) genome that carries more than 150 genes, most of which have not been studied. Here, we assessed the role o...

Human Cytomegalovirus Manipulates Syntaxin 6 for Successful Trafficking and Subsequent ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327712
Journal of Virology; Mosher BS, Fulkerson HL et. al.

Jul 22nd, 2022 - Human cytomegalovirus (HCMV) exhibits a complex host-pathogen interaction with peripheral blood monocytes. We have identified a unique, cell-type specific retrograde-like intracellular trafficking pattern that HCMV utilizes to gain access to the monocyte nucleus and for productive infection. We show that infection of primary human monocytes, epithelial cells, and fibroblasts leads to an increas...

Controlling Herpes Simplex Virus-Induced Immunoinflammatory Lesions Using Metabolic The...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327707
Journal of Virology; Berber E, Rouse BT

Jul 22nd, 2022 - Herpes simplex virus (HSV) infection of the eye can result in a blinding immunoinflammatory lesion in the cornea called herpetic stromal keratitis (HSK). This lesion is orchestrated by T cells and can be reduced in magnitude by anti-inflammatory drugs and procedures that change the balance of cellular participants in lesions. This report evaluates the effect of drugs that cause metabolic reprog...

Abrupt decreases in infectivity of SARS-CoV-2 in aerosols.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304013
Proceedings of the National Academy of Sciences of the Un... Löndahl J, Alsved M

Jul 21st, 2022 - Abrupt decreases in infectivity of SARS-CoV-2 in aerosols.|2022|Löndahl J,Alsved M,|transmission,virology,growth & development,isolation & purification,pathogenicity,

Pervasive transcription enhances the accessibility of H-NS-silenced promoters and gener...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335307
Proceedings of the National Academy of Sciences of the Un... Figueroa-Bossi N, Sánchez-Romero MA et. al.

Jul 21st, 2022 - In Escherichia coli and Salmonella, many genes silenced by the nucleoid structuring protein H-NS are activated upon inhibiting Rho-dependent transcription termination. This response is poorly understood and difficult to reconcile with the view that H-NS acts mainly by blocking transcription initiation. Here we have analyzed the basis for the up-regulation of H-NS-silenced Salmonella pathogenici...

Adaptive laboratory evolution and independent component analysis disentangle complex va...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335240
Proceedings of the National Academy of Sciences of the Un... Fait A, Seif Y et. al.

Jul 21st, 2022 - Human infections with methicillin-resistant Staphylococcus aureus (MRSA) are commonly treated with vancomycin, and strains with decreased susceptibility, designated as vancomycin-intermediate S. aureus (VISA), are associated with treatment failure. Here, we profiled the phenotypic, mutational, and transcriptional landscape of 10 VISA strains adapted by laboratory evolution from one common MRSA ...

Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351483
Proceedings of the National Academy of Sciences of the Un... Syed AM, Ciling A et. al.

Jul 21st, 2022 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant contains extensive sequence changes relative to the earlier-arising B.1, B.1.1, and Delta SARS-CoV-2 variants that have unknown effects on viral infectivity and response to existing vaccines. Using SARS-CoV-2 virus-like particles (VLPs), we examined mutations in all four structural proteins and found that Omicron a...

Transcriptome analysis and characterization of genes associated to leaf tannin content ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284691
BMC Genomics; Li S, Cui Y et. al.

Jul 15th, 2022 - Chinese chestnut is an economically important tree species whose yield and quality are seriously affected by red spider attack. Tannins is one of the most important class secondary metabolites in plants, and is closely associated with plant defense mechanisms against insect and herbivory. In our previous studies, it was revealed that several low-tannin foxtail millet varieties growing under the...

Clinical risk factors for admission with Pseudomonas and multidrug-resistant Pseudomona...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284849
Antimicrobial Resistance and Infection Control; Idigo AJ, Wells JM et. al.

Jul 15th, 2022 - Microbial etiology for community-acquired pneumonia (CAP) is evolving with pathogens known for high CAP mortality e.g., Pseudomonas species. Chronic obstructive pulmonary disease (COPD) patients are at risk for hospitalization for CAP. Understanding regional patterns and risk factors for multidrug-resistant (MDR) Pseudomonas acquisition has implications for antimicrobial stewardship. To evaluat...

Within-host evolution of a gut pathobiont facilitates liver translocation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308686
Nature Yang Y, Nguyen M et. al.

Jul 14th, 2022 - Gut commensal bacteria with the ability to translocate across the intestinal barrier can drive the development of diverse immune-mediated diseases1-4. However, the key factors that dictate bacterial translocation remain unclear. Recent studies have revealed that gut microbiota strains can adapt and evolve throughout the lifetime of the host5-9, raising the possibility that changes in individual...

A genetically linked pair of NLR immune receptors shows contrasting patterns of evolution.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271155
Proceedings of the National Academy of Sciences of the Un... Shimizu M, Hirabuchi A et. al.

Jul 1st, 2022 - Throughout their evolution, plant nucleotide-binding leucine-rich-repeat receptors (NLRs) have acquired widely divergent unconventional integrated domains that enhance their ability to detect pathogen effectors. However, the functional dynamics that drive the evolution of NLRs with integrated domains (NLR-IDs) remain poorly understood. Here, we reconstructed the evolutionary history of an NLR l...

The dynamics of SARS-CoV-2 infectivity with changes in aerosol microenvironment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271203
Proceedings of the National Academy of Sciences of the Un... Oswin HP, Haddrell AE et. al.

Jun 29th, 2022 - Understanding the factors that influence the airborne survival of viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in aerosols is important for identifying routes of transmission and the value of various mitigation strategies for preventing transmission. We present measurements of the stability of SARS-CoV-2 in aerosol droplets (∼5 to 10 µm equilibrated radius) over ...

The science behind COVID's assault on smell.
https://doi.org/10.1038/d41586-022-01627-w
Nature Dolgin E

Jun 23rd, 2022 - The science behind COVID's assault on smell.|2022|Dolgin E,|physiopathology,virology,pathogenicity,

Field-Reassortment of Bluetongue Virus Illustrates Plasticity of Virus Associated Pheno...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9278112
Journal of Virology; Sanders C, Veronesi E et. al.

Jun 22nd, 2022 - Segmented RNA viruses are a taxonomically diverse group that can infect plant, wildlife, livestock and human hosts. A shared feature of these viruses is the ability to exchange genome segments during coinfection of a host by a process termed "reassortment." Reassortment enables rapid evolutionary change, but where transmission involves a biological arthropod vector, this change is constrained b...

The source of the Black Death in fourteenth-century central Eurasia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217749
Nature Spyrou MA, Musralina L et. al.

Jun 16th, 2022 - The origin of the medieval Black Death pandemic (AD 1346-1353) has been a topic of continuous investigation because of the pandemic's extensive demographic impact and long-lasting consequences1,2. Until now, the most debated archaeological evidence potentially associated with the pandemic's initiation derives from cemeteries located near Lake Issyk-Kul of modern-day Kyrgyzstan1,3-9. These sites...