About 107,595 results

Binding and entering: COVID finds a new home.
PLoS Pathogens; Vu MN, Menachery VD

Aug 31st, 2021 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility similar to common cold coronaviruses (CoVs). In this review, we briefly discuss the features of the receptor-binding domain (RBD) and protease cle...

Serum Albumin to Creatinine Ratio as Predictor for 30-Day All-Cause Mortality in Patien...
Annals of Clinical and Laboratory Science; Nseir W, Njidat J et. al.

Aug 29th, 2021 - Clostridium difficile-associated diarrhea (CDAD) is a significant cause of mortality and morbidity in hospitalized patients. Several scores have developed in order to assess the severity of CDAD. To determine the role of the serum albumin to creatinine ratio (sACR) in predicting the 30-day all-cause mortality of patients with CDAD in comparison with other known severity scores of CDAD. A retros...

Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SRE...
Proceedings of the National Academy of Sciences of the Un... Zhang S, Wang J et. al.

Aug 29th, 2021 - COVID-19, caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has presented a serious risk to global public health. The viral main protease Mpro (also called 3Clpro) encoded by NSP5 is an enzyme essential for viral replication. However, very few host proteins have been experimentally validated as targets of 3Clpro. Here, through bioinformatics analysis of 300 interferon stimulatory g...

Novel effects of acute COVID-19 on cardiac mechanical function: Two case studies.
Physiological Reports; Singh J, Bhagaloo L et. al.

Aug 28th, 2021 - The spread of the novel coronavirus 2019 (COVID-19) has caused a global pandemic. The disease has spread rapidly, and research shows that COVID-19 can induce long-lasting cardiac damage. COVID-19 can result in elevated cardiac biomarkers indicative of acute cardiac injury, and research utilizing echocardiography has shown that there is mechanical dysfunction in these patients as well, especiall...

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PA...
Cardiovascular Diabetology; Pretorius E, Vlok M et. al.

Aug 25th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the cause of coronavirus disease 2019 (COVID-19), is characterized by acute clinical pathologies, including various coagulopathies that may be accompanied by hypercoagulation and platelet hyperactivation. Recently, a new COVID-19 phenotype has been noted in patients after they have ostensibly recovered from acute CO...

The mutation that helps Delta spread like wildfire.
Nature Callaway E

Aug 22nd, 2021 - The mutation that helps Delta spread like wildfire.|2021|Callaway E,|epidemiology,transmission,virology,metabolism,genetics,growth & development,isolation & purification,pathogenicity,chemistry,genetics,metabolism,

SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma.
Proceedings of the National Academy of Sciences of the Un... Andreano E, Piccini G et. al.

Aug 22nd, 2021 - To investigate the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the immune population, we coincupi bated the authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The plasma fully neutralized the virus for seven passages, but, after 45 d, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthroug...

SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CA...
Nature Communications; Steens JA, Zhu Y et. al.

Aug 21st, 2021 - Characteristic properties of type III CRISPR-Cas systems include recognition of target RNA and the subsequent induction of a multifaceted immune response. This involves sequence-specific cleavage of the target RNA and production of cyclic oligoadenylate (cOA) molecules. Here we report that an exposed seed region at the 3' end of the crRNA is essential for target RNA binding and cleavage, wherea...

Incentives can spur COVID-19 vaccination uptake.
Proceedings of the National Academy of Sciences of the Un... Klüver H, Hartmann F et. al.

Aug 21st, 2021 - Recent evidence suggests that vaccination hesitancy is too high in many countries to sustainably contain COVID-19. Using a factorial survey experiment administered to 20,500 online respondents in Germany, we assess the effectiveness of three strategies to increase vaccine uptake, namely, providing freedoms, financial remuneration, and vaccination at local doctors. Our results suggest that all t...

Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candid...
Proceedings of the National Academy of Sciences of the Un... Mirabelli C, Wotring JW et. al.

Aug 21st, 2021 - The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the associated disease COVID-19, requires therapeutic interventions that can be rapidly identified and translated to clinical care. Traditional drug discovery methods have a >90% failure rate and can take 10 to 15 y from target identification to clinical use. In contrast, drug repurposing can significantl...

The risk of indoor sports and culture events for the transmission of COVID-19.
Nature Communications; Moritz S, Gottschick C et. al.

Aug 21st, 2021 - Nearly all mass gathering events worldwide were banned at the beginning of the COVID-19 pandemic, as they were suspected of presenting a considerable risk for the transmission of SARS-CoV-2. We investigated the risk of transmitting SARS-CoV-2 by droplets and aerosols during an experimental indoor mass gathering event under three different hygiene practices, and used the data in a simulation stu...

Hypervirulent Klebsiella pneumoniae.
The New England Journal of Medicine; Zou Q, Li Y

Aug 21st, 2021 - Hypervirulent Klebsiella pneumoniae.|2021|Zou Q,Li Y,|diagnostic imaging,microbiology,complications,diagnostic imaging,complications,diagnostic imaging,microbiology,isolation & purification,pathogenicity,diagnostic imaging,microbiology,microbiology,

The Epidemiology of Drug Abuse.
Journal of Clinical Pharmacology; Ignaszewski MJ

Aug 17th, 2021 - Many Americans use alcohol and recreational drugs. Some will develop substance use disorders that affect a person's brain and behavior, leading to continued use despite problems caused. We review the epidemiology of addiction in the United States, including changes in use patterns over time, highlighting rates in adolescents and young adults, as well as adults. An overview of the health and soc...

Clinical study of invasive pulmonary aspergillosis following influenza A H1N1.
Medicine Liu Y, Xie ZZ et. al.

Aug 17th, 2021 - This study to analyze the clinical characteristics of patients with invasive pulmonary aspergillosis (IPA) following influenza A (H1N1) infection.We retrospectively analyzed 10 cases with IPA following H1N1 infection. The clinical manifestations, laboratory examination results, chest computed tomography, and treatments were analyzed.Clinical manifestations: all 10 cases had typical flu-like sym...

Identification of sensitive indicators in immune response for leprosy affected patients...
Medicine Zheng Y, Xing HY et. al.

Aug 17th, 2021 - Cured leprosy patients have special physical conditions, which could pose challenges for safety and immunogenicity after immunization. We performed an observational clinical study aimed to identify the safety and immunogenicity of influenza vaccine in cured leprosy patients. A total of 65 participants from a leprosarium were recruited into leprosy cured group or control group, and received a 0....

Identification of COVID-19 prognostic markers and therapeutic targets through meta-anal...
EBioMedicine Biji A, Khatun O et. al.

Aug 16th, 2021 - While our battle with the COVID-19 pandemic continues, a multitude of Omics data have been generated from patient samples in various studies. Translation of these data into clinical interventions against COVID-19 remains to be accomplished. Exploring host response to COVID-19 in the upper respiratory tract can unveil prognostic markers and therapeutic targets. We conducted a meta-analysis of pu...

Evolutionary trajectory of SARS-CoV-2 and emerging variants.
Virology Journal; Singh J, Pandit P et. al.

Aug 15th, 2021 - The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 variants has generated renewed interest in virus evolution and cross-species transmission. While all known human coronaviruses (HCoVs) are speculated to have originated in animals, very little is known about their evolutionary hi...

How do vaccinated people spread Delta? What the science says.
https://doi.org/10.1038/d41586-021-02187-1 10.15585/mmwr.mm7031e2
Nature Subbaraman N

Aug 14th, 2021 - How do vaccinated people spread Delta? What the science says.|2021|Subbaraman N,|immunology,transmission,virology,immunology,immunology,transmission,virology,virology,immunology,pathogenicity,statistics & numerical data,

Right-sided endocarditis caused by polyclonal Staphylococcus aureus infection.
European Journal of Medical Research; Kolben Y, Ishay Y et. al.

Aug 13th, 2021 - We present a case of bacterial endocarditis with both methicillin-sensitive and methicillin-resistant Staphylococcus aureus, which based on typing, originated from two distinct clones. Such a case may be misinterpreted by microbiology lab automation to be a monoclonal multi-drug resistant Staphylococcus aureus, while simple microbiology techniques will instantly reveal distinct clonality.

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisyste...
Nature Communications; Beckmann ND, Comella PH et. al.

Aug 13th, 2021 - Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and pathology of multiple organs in individuals under 21 years of age in the weeks following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although an autoimmune pathogenesis has been proposed, the genes, pathways and cell types causal to this new disease remain unknown. Here we per...