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About 1,593,182 results

Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer (J...
https://doi.org/10.1016/S0140-6736(17)30565-2
Lancet (London, England); Hida T, Nokihara H et. al.

May 15th, 2017 - Alectinib, a potent, highly selective, CNS-active inhibitor of anaplastic lymphoma kinase (ALK), showed promising efficacy and tolerability in the single-arm phase 1/2 AF-001JP trial in Japanese patients with ALK-positive non-small-cell lung cancer. Given those promising results, we did a phase 3 trial to directly compare the efficacy and safety of alectinib and crizotinib. J-ALEX was a randomi...

Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis.
https://doi.org/10.1056/NEJMoa1800149
The New England Journal of Medicine; Chitnis T, Arnold DL et. al.

Sep 12th, 2018 - Treatment of patients younger than 18 years of age with multiple sclerosis has not been adequately examined in randomized trials. We compared fingolimod with interferon beta-1a in this population. In this phase 3 trial, we randomly assigned patients 10 to 17 years of age with relapsing multiple sclerosis in a 1:1 ratio to receive oral fingolimod at a dose of 0.5 mg per day (0.25 mg per day for ...

Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally ad...
https://doi.org/10.1016/S1470-2045(17)30111-0
The Lancet. Oncology; Thuss-Patience PC, Shah MA et. al.

Mar 27th, 2017 - Although trastuzumab plus chemotherapy is the standard of care for first-line treatment of HER2-positive advanced gastric cancer, there is no established therapy in the second-line setting. In GATSBY, we examined the efficacy and tolerability of trastuzumab emtansine in patients previously treated for HER2-positive advanced gastric cancer (unresectable, locally advanced, or metastatic gastric c...

Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC.
https://doi.org/10.1056/NEJMoa1716948
The New England Journal of Medicine; Socinski MA, Jotte RM et. al.

Jun 4th, 2018 - The cancer-cell-killing property of atezolizumab may be enhanced by the blockade of vascular endothelial growth factor-mediated immunosuppression with bevacizumab. This open-label, phase 3 study evaluated atezolizumab plus bevacizumab plus chemotherapy in patients with metastatic nonsquamous non-small-cell lung cancer (NSCLC) who had not previously received chemotherapy. We randomly assigned pa...

Primary angiitis of the central nervous system: description of the first fifty-two adul...
https://doi.org/10.1002/art.38340
Arthritis & Rheumatology (Hoboken, N.J.); de Boysson H, Zuber M et. al.

May 1st, 2014 - To describe characteristics and outcomes of a multicenter cohort of patients diagnosed as having primary angiitis of the central nervous system (PACNS). In 2010, we initiated a cohort study of adults diagnosed as having PACNS ≤15 years ago and with followup of >6 months (unless they died earlier of biopsy-proven PACNS). Its first analysis was planned at 2 years. Multidisciplinary investigators ...

Vaccinated children and adolescents with pertussis infections experience reduced illnes...
https://doi.org/10.1093/cid/ciu156
Clinical Infectious Diseases : an Official Publication Of... Barlow RS, Reynolds LE et. al.

Mar 18th, 2014 - Bordetella pertussis causes severe respiratory illness among infants and adolescents. High proportions of breakthrough infection have been observed. To understand the effect of vaccination in the era of acellular pertussis vaccines (DTaP and Tdap), we assessed if vaccination status is associated with disease severity and duration. The Multnomah County Health Department conducts enhanced pertuss...

Melanoma patients with an unknown primary tumor site have a better outcome than those w...
https://doi.org/10.1245/s10434-014-3679-5
Annals of Surgical Oncology; van der Ploeg AP, Haydu LE et. al.

May 7th, 2014 - Several reports in the literature suggest a difference in outcome between melanoma patients with macroscopic (clinically palpable) nodal disease from an unknown primary (MUP) and a known primary (MKP). The purpose of this study was to compare the outcomes for MUP and MKP patients after therapeutic lymph node dissection (TLND) for macroscopic nodal disease. From a large, prospective, single-inst...

Ultrasonography of the colon in pediatric ulcerative colitis: a prospective, blind, com...
https://doi.org/10.1016/j.jpeds.2014.02.055
The Journal of Pediatrics; Civitelli F, Di Nardo G et. al.

Apr 14th, 2014 - To evaluate the usefulness of colonic ultrasonography (US) in assessing the extent and activity of disease in pediatric ulcerative colitis (UC) and to compare US findings with clinical and endoscopic features. Consecutive pediatric patients (n = 60) with a diagnosis of UC and suspected disease flare-up were prospectively enrolled; of these, 50 patients were eligible for the study. All underwent...

A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119497
The American Journal of Psychiatry; Phillips ML, Swartz HA

Mar 14th, 2014 - In this critical review, the authors appraise neuroimaging findings in bipolar disorder in emotion-processing, emotion-regulation, and reward-processing neural circuitry in order to synthesize the current knowledge of the neural underpinnings of bipolar disorder and provide a neuroimaging research road map for future studies. The authors examined findings from all major studies in bipolar disor...

A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104022
The Lancet. Neurology; Sabater L, Gaig C et. al.

Apr 7th, 2014 - Autoimmunity might be associated with or implicated in sleep and neurodegenerative disorders. We aimed to describe the features of a novel neurological syndrome associated with prominent sleep dysfunction and antibodies to a neuronal antigen. In this observational study, we used clinical and video polysomnography to identify a novel sleep disorder in three patients referred to the Sleep Unit of...

The optimal number of biopsy fragments to establish a morphologic diagnosis of eosinoph...
https://doi.org/10.1038/ajg.2013.463
The American Journal of Gastroenterology; Nielsen JA, Lager DJ et. al.

Jan 21st, 2014 - Eosinophilic esophagitis (EoE) is characterized clinically by dysphagia, chest pain, and food impaction, and morphologically by increased numbers of intraepithelial eosinophils and marked basal hyperplasia of the squamous mucosa. The consensus criteria for a diagnosis of EoE include the presence of ≥15 eosinophils/HPF in biopsies from both proximal and distal esophagus in the absence of other c...

Effect of PET before liver resection on surgical management for colorectal adenocarcino...
https://doi.org/10.1001/jama.2014.3740
JAMA Moulton CA, Gu CS et. al.

May 15th, 2014 - Patients with colorectal cancer with liver metastases undergo hepatic resection with curative intent. Positron emission tomography combined with computed tomography (PET-CT) could help avoid noncurative surgery by identifying patients with occult metastases. To determine the effect of preoperative PET-CT vs no PET-CT (control) on the surgical management of patients with resectable metastases an...

Clinical review: Central hypothyroidism: pathogenic, diagnostic, and therapeutic challe...
https://doi.org/10.1210/jc.2012-1616
The Journal of Clinical Endocrinology and Metabolism; Persani L

Aug 1st, 2012 - Central hypothyroidism (CH) is a particular hypothyroid condition due to an insufficient stimulation by TSH of an otherwise normal thyroid gland. This condition raises several challenges for clinicians; therefore, a review of the most relevant findings on CH epidemiology, pathogenesis, and clinical management has been performed. The relevant papers were selected by a PubMed search using appropr...

Screening pelvic examination in adult women: a clinical practice guideline from the Ame...
https://doi.org/10.7326/M14-0701
Annals of Internal Medicine; Qaseem A, Humphrey LL et. al.

Jun 30th, 2014 - The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on the utility of screening pelvic examination for the detection of pathology in asymptomatic, nonpregnant, adult women. This guideline is based on a systematic review of the published literature in the English language from 1946 through January 2014 identified using ME...

Efficacy of dietary interventions for inducing histologic remission in patients with eo...
https://doi.org/10.1053/j.gastro.2014.02.006
Gastroenterology Arias A, González-Cervera J et. al.

Feb 18th, 2014 - Various dietary interventions have been used to treat patients with eosinophilic esophagitis (EoE), yielding varied results. This systematic review assesses the efficacy of different dietary therapies in inducing disease remission. We performed a systematic search of the MEDLINE, EMBASE, and SCOPUS databases for studies investigating the efficacy of dietary interventions (reducing infiltration ...

Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast...
https://doi.org/10.1016/S1470-2045(14)70160-3
The Lancet. Oncology; von Minckwitz G, Schneeweiss A et. al.

May 5th, 2014 - Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, trastuzumab, and a platinum salt for HER2-positive breast cancer. We therefore aimed to assess the efficacy of the addition of carboplatin to neoadjuvant therapy for triple-negative and HER2-positive breast cancer. Patients wi...

Local recurrence after endoscopic mucosal resection of nonpedunculated colorectal lesio...
https://doi.org/10.1055/s-0034-1364970
Endoscopy Belderbos TD, Leenders M et. al.

Mar 28th, 2014 - Local recurrence has been observed after endoscopic mucosal resection (EMR) of nonpedunculated colorectal lesions. The indications for follow-up colonoscopy and the optimal time interval are currently unclear. The aims of this systematic review were to assess the frequency of local recurrence after EMR, to identify risk factors for recurrence, and to provide follow-up recommendations. A literat...

Accelerated methotrexate, vinblastine, doxorubicin, and cisplatin is safe, effective, a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050203
Journal of Clinical Oncology : Official Journal of the Am... Plimack ER, Hoffman-Censits JH et. al.

May 13th, 2014 - Neoadjuvant cisplatin-based chemotherapy is standard of care for muscle-invasive bladder cancer (MIBC); however, it is infrequently adopted in practice because of concerns regarding toxicity and delay to cystectomy. We hypothesized that three cycles of neoadjuvant accelerated methotrexate, vinblastine, doxorubicin, and cisplatin (AMVAC) would be safe, shorten the time to surgery, and yield simi...

Recurrence and mortality following severe cutaneous adverse reactions.
https://doi.org/10.1001/jama.2014.839
JAMA Finkelstein Y, Macdonald EM et. al.

Jun 3rd, 2014 - Recurrence and mortality following severe cutaneous adverse reactions.|2014|Finkelstein Y,Macdonald EM,Li P,Hutson JR,Juurlink DN,|statistics & numerical data,epidemiology,mortality,pathology,

Actionable diagnosis of neuroleptospirosis by next-generation sequencing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134948
The New England Journal of Medicine; Wilson MR, Naccache SN et. al.

Jun 4th, 2014 - A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 se...