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About 2,209,643 results

Identification of Malassezia globosa as a Gastric Fungus Associated with PD-L1 Expressi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669766
Journal of Immunology Research; Zhang Z, Qiu Y et. al.

Nov 22nd, 2022 - Microbiotas affected the prognosis of cancer patients by regulating programmed death ligand-1 (PD-L1) expression. However, the relationship between gastric fungi and PD-L1 expression is still unclear in gastric cancer (GC). We aimed at exploring the association of gastric fungi with PD-L1 expression and overall survival in GC. A total of 61 GC patients were divided into the two groups based on ...

Oxidative Phosphorylation-Related Signature Participates in Cancer Development, and PTP...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673183
Journal of Immunology Research; Huang L, Xie Y et. al.

Nov 22nd, 2022 - Clear cell renal cell carcinoma (ccRCC) was a common cancer type diagnosed with frequent metastases, harboring an unfavorable therapeutic response, and results in a poor prognosis. More promising therapeutic targets are urgently required for treating ccRCC. This study was conducted to explore the role of oxidative phosphorylation in ccRCC development and reveal its clinical potential. We first ...

Prognostic analysis of patients with combined hepatocellular-cholangiocarcinoma after r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669829
World Journal of Gastroenterology; Zhang G, Chen BW et. al.

Nov 22nd, 2022 - Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a form of rare primary liver cancer that combines intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma. To investigate overall survival (OS) and recurrence-free survival (RFS) after radical resection in patients with cHCC-CCA, and the clinicopathological factors affecting prognosis in two center hospitals of China. We review...

Esophageal lichen planus: Current knowledge, challenges and future perspectives.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669830
World Journal of Gastroenterology; Decker A, Schauer F et. al.

Nov 22nd, 2022 - Lichen planus (LP) is a frequent, chronic inflammatory disease involving the skin, mucous membranes and/or skin appendages. Esophageal involvement in lichen planus (ELP) is a clinically important albeit underdiagnosed inflammatory condition. This narrative review aims to give an overview of the current knowledge on ELP, its prevalence, pathogenesis, clinical manifestation, diagnostic criteria, ...

Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepat...
https://doi.org/10.1080/15384047.2022.2149039
Cancer Biology & Therapy; Yuan W, Zhao H et. al.

Nov 22nd, 2022 - Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Ephrin A4 (EFNA4) acts as an oncogene in multiple cancers but is little known in HCC. It is revealed that EFNA4 is highly expressed in patients with HCC and influences the proliferation of HCC cells; however, detailed regulatory mechanism of EFNA4 in HCC needs to be unveiled. Here, we discovered that EFNA4 was highly expres...

Collagenous gastritis in a young Chinese woman: A case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669833
World Journal of Gastroenterology; Zheng QH, Hu J et. al.

Nov 22nd, 2022 - Collagenous gastritis (CG) is a rare condition whose pathogenesis may be related to immune abnormalities. We report a case of CG from China. A 24-year-old woman presented with recurrent abdominal distension and discomfort for 3 mo. Upper gastrointestinal endoscopy found diffuse nodular elevation-depression changes in the mucosa of the entire gastric corpus. Endoscopic ultrasound showed predomin...

Thrombospondin 2 is a Functional Predictive and Prognostic Biomarker for Triple-Negativ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673122
Pathology Oncology Research : POR; Lin Y, Lin E et. al.

Nov 22nd, 2022 - Background: Triple-negative breast cancer (TNBC) is characterized by a more aggressive biological behavior and unfavorable outcome. Circulating and histological expression of THBS2 has been demonstrated to be a novel diagnostic and prognostic biomarker in patients with various types of tumors. However, few studies have evaluated the predictive and prognostic value of THBS2 in TNBC specifically....

Anterior Gradient 2 is a Significant Prognostic Biomarker in Bone Metastasis of Breast ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668893
Pathology Oncology Research : POR; Li JJ, Wang S et. al.

Nov 22nd, 2022 - Background: The study aimed to detect DEGs associated with BRCA bone metastasis, filter prognosis biomarkers, and explore possible pathways. Methods: GSE175692 dataset was used to detect DEGs between BRCA bone metastatic cases and non-bone metastatic cases, followed by the construction of a PPI network among DEGs. The main module among the PPI network was then determined and pathway analysis on...

Outcomes After Liver Transplantation With Incidental Cholangiocarcinoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667791
Transplant International : Official Journal of the Europe... Safdar NZ, Hakeem AR et. al.

Nov 22nd, 2022 - Cholangiocarcinoma (CCA) is currently a contraindication to liver transplantation (LT) in the United Kingdom (UK). Incidental CCA occurs rarely in some patients undergoing LT. We report on retrospective outcomes of patients with incidental CCA from six UK LT centres. Cases were identified from pathology records. Data regarding tumour characteristics and post-transplant survival were collected. ...

Conjunctival Merkel cell carcinoma: case report and review of the literature.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635759
Digital Journal of Ophthalmology : DJO; Tran MN, Ratnayake G et. al.

Nov 22nd, 2022 - Merkel cell carcinoma (MCC) of the conjunctiva is rare. We report the case of a 73-year-old man who presented with unilateral foreign body sensation and blurred vision. A rapidly enlarging conjunctival lesion was identified and excised. The histopathological diagnosis was poorly differentiated squamous cell carcinoma, later reclassified as neuroendocrine / Merkel cell carcinoma following excisi...

Overexpression of Pleckstrin Homology Domain-Containing Family A Member 4 Is Correlated...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9674417
Disease Markers; Huang B, Pan W et. al.

Nov 22nd, 2022 - The global incidence of brain tumors, the most common of which is lower grade glioma (LGG), remains high. Pleckstrin homology domain-containing family A member 4 (PLEKHA4) has been reported to be related to tumor invasion and growth. However, its role and correlation with immunity in LGG remain elusive. We evaluated the expression pattern, prognostic value, biological functions, and immune effe...

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xeno...
https://doi.org/10.3791/64589
Journal of Visualized Experiments : JoVE; Chang J, Sun X et. al.

Nov 22nd, 2022 - As the most common male malignancy, prostate cancer (PC) ranks second in mortality, primarily due to a 65%-75% bone metastasis rate. Therefore, it is essential to understand the process and related mechanisms of prostate cancer bone metastasis for developing new therapeutics. For this, an animal model of bone metastasis is an essential tool. Here, we report detailed procedures to generate a bon...

Clinicopathological characteristics and outcome predictors of anti-glomerular basement ...
https://doi.org/10.1080/0886022X.2022.2147673
Renal Failure; Ge Y, Liu K et. al.

Nov 22nd, 2022 - To explore the clinicopathological features of anti-glomerular basement membrane (anti-GBM) glomerulonephritis (anti-GBM-GN) and the prognostic values of clinical and laboratory indicators at diagnosis on renal and patient survival. A total of 76 patients (34 males and 42 females) with anti-GBM-GN who were hospitalized in the First Affiliated Hospital of Nanjing Medical University between Janua...

Testosterone Therapy for Dropped Head Syndrome: A Case Report.
https://doi.org/10.1097/CND.0000000000000372
Journal of Clinical Neuromuscular Disease; Felong TJ, Balos LL et. al.

Nov 22nd, 2022 - Dropped head syndrome (DHS) is an impairment of neck extension resulting in a chin-on-chest deformity. DHS is rarely seen but a major hindrance to daily function in affected patients. DHS has been associated with movement disorders, neuromuscular disorders, and electrolyte and endocrine abnormalities. DHS has also been seen in survivors of Hodgkin lymphoma (HL) years after irradiation. HL survi...

The impact of breast milk feeding on early brain development in preterm infants in Chin...
https://doi.org/10.1371/journal.pone.0272125
PloS One; Zhang Y, Deng Q et. al.

Nov 22nd, 2022 - The prevailing consensus from large epidemiological studies is that breastfeeding is associated with improved IQ and cognitive functioning in later childhood and adolescence. Current research is exploring the association between breastfeeding and early brain development in preterm infants. To explore the differences in brain gray matter between breastmilk-fed and formula-fed preterm infants usi...

Tumor microenvironment-associated lactate metabolism regulates the prognosis and precis...
https://doi.org/10.1186/s40001-022-00895-6
European Journal of Medical Research; Qiu S, Wang Y et. al.

Nov 22nd, 2022 - Despite the wide clinical application of checkpoint inhibitor immunotherapy in lung adenocarcinoma, its limited benefit to patients remains puzzling to researchers. One of the mechanisms of immunotherapy resistance may be the dysregulation of lactate metabolism in the immunosuppressive tumor microenvironment (TME), which can inhibit dendritic cell maturation and prevent T-cell invasion into tum...

Evaluation of tumor-infiltrating lymphocytes (TILs) in molecular subtypes of an Indian ...
https://doi.org/10.1186/s13000-022-01271-y
Diagnostic Pathology; Vaid PM, Puntambekar AK et. al.

Nov 22nd, 2022 - Evaluation of tumor-infiltrating lymphocytes (TILs) distribution in an Indian cohort of breast cancer patients for its prognostic significance. A retrospective cohort of breast cancer patients from a single onco-surgeon's breast cancer clinic with a uniform treatment strategy was evaluated for TILs. Tumor sections were H&E stained and scored for the spatial distribution and percent stromal TILs...

Microglia and metastases to the central nervous system: victim, ravager, or something e...
https://doi.org/10.1186/s13046-022-02535-7
Journal of Experimental & Clinical Cancer Research : CR; Caffarel MM, Braza MS

Nov 22nd, 2022 - Central nervous system (CNS) metastases are a major cause of death in patients with cancer. Tumor cells must survive during their migration and dissemination in various sites and niches. The brain is considered an immunological sanctuary site, and thus the safest place for metastasis establishment. The risk of brain metastases is highest in patients with melanoma, lung, or breast cancers. In th...

Impact of opioid analgesics on the efficacy of immune checkpoint inhibitors in a lung c...
https://doi.org/10.1186/s12890-022-02210-9
BMC Pulmonary Medicine; Yu X, Zhao L et. al.

Nov 22nd, 2022 - A retrospective clinical study was conducted to compare the prognosis between the opioid analgesic (OA) treated and OA-untreated groups and to evaluate the effect of opioid analgesics on the efficacy of immune checkpoint inhibitors (ICIs) in the treatment of advanced lung cancer patients. In addition, a subgroup analysis of the clinical characteristics of the enrolled patients was performed to ...

Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis.
https://doi.org/10.1186/s40478-022-01472-y
Acta Neuropathologica Communications; Westfall JJ, Schwind WN et. al.

Nov 22nd, 2022 - Rasmussen encephalitis (RE) is a rare childhood neurological disease characterized by progressive unilateral loss of function, hemispheric atrophy and drug-resistant epilepsy. Affected brain tissue shows signs of infiltrating cytotoxic T-cells, microglial activation, and neuronal death, implicating an inflammatory disease process. Recent studies have identified molecular correlates of inflammat...