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About 2,091,310 results

Relationship between circulating miRNA-21, atrial fibrosis, and atrial fibrillation in ...
https://doi.org/10.21037/apm-21-3518
Annals of Palliative Medicine; Chen H, Zhang F et. al.

Jan 13th, 2022 - Atrial fibrosis is a landmark of cardiac remodeling to perpetuate atrial fibrillation (AF), and recent studies have indicated that microRNAs (miRNAs) are essential regulators of multiple cardiovascular disease processes. Herein, we aimed to investigate the relationship between circulating microRNA-21 (miR-21), atrial fibrosis, and AF in patients with atrial enlargement. A total of 60 persistent...

Epithelial Basement Membrane Regeneration After PRK-Induced Epithelial-Stromal Injury i...
https://doi.org/10.3928/1081597X-20211007-02
Journal of Refractive Surgery (Thorofare, N.J. : 1995); de Oliveira RC, Sampaio LP et. al.

Jan 13th, 2022 - To study epithelial basement membrane (EBM) regeneration in non-fibrotic and fibrotic corneas after photorefractive keratectomy (PRK). Rabbits (120 total) had either epithelial scrape alone, -4.50 diopters (D) PRK, -9.00 D PRK, or no surgery. Immunohistochemistry was performed on cryofixed corneas at time points from unwounded to 8 weeks (four corneas at each time point in each group). Multiple...

Hsa_circ_0020850 promotes the malignant behaviors of lung adenocarcinoma by regulating ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750879
World Journal of Surgical Oncology; Li X, Su S et. al.

Jan 12th, 2022 - Circular RNAs (circRNAs) are a novel type of endogenous RNAs and play vital roles in lung adenocarcinoma. However, the function and underlying mechanism of circ_0020850 in lung adenocarcinoma remain unknown. The levels of circ_0020850, microRNA-326 (miR-326), and Beclin1 (BECN1) were analyzed by real-time quantitative polymerase chain reaction and western blot analyses. The migration and invasi...

The role of vascular invasion and lymphatic invasion in predicting recurrent thoracic o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744266
World Journal of Surgical Oncology; Ma Y, Yao X et. al.

Jan 12th, 2022 - Numerous studies have addressed lymphovascular invasion (LVI) in patients with thoracic oesophageal squamous cell carcinoma (ESCC); however, little is known about the individual roles of lymphatic invasion (LI) and vascular invasion (VI). We aimed to analyse the prognostic significance of LI and VI in patients with thoracic ESCC from a single centre. This retrospective study included 396 patien...

Longitudinal In Vivo Changes in Radial Peripapillary Capillaries and Optic Nerve Head S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742514
Investigative Ophthalmology & Visual Science; Musial G, Adhikari S et. al.

Jan 8th, 2022 - There is conflicting evidence regarding whether a loss of radial peripapillary capillaries (RPCs) precedes neuronal loss in glaucoma. We examined the time course of in vivo changes in RPCs, optic nerve head (ONH) structure, and retinal nerve fiber layer thickness (RNFLT) in experimental glaucoma (EG). Spectral domain optical coherence tomography images were acquired before and approximately eve...

Obesity as a mortality risk factor in the medical ward: a case control study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733434
BMC Endocrine Disorders; Soffer S, Zimlichman E et. al.

Jan 8th, 2022 - Research regarding the association between severe obesity and in-hospital mortality is inconsistent. We evaluated the impact of body mass index (BMI) levels on mortality in the medical wards. The analysis was performed separately before and during the COVID-19 pandemic. We retrospectively retrieved data of adult patients admitted to the medical wards at the Mount Sinai Health System in New York...

Data from small cell neuroendocrine carcinoma of the cervix: FIGO 2018 staging is more ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753085
The Journal of International Medical Research; Zhang Y, Ding J et. al.

Jan 7th, 2022 - To compare the prognostic value of International Federation of Gynecology and Obstetrics (FIGO) 2009 and 2018 staging systems in surgical patients with small cell neuroendocrine carcinoma of the cervix (SCNEC). We re-staged 64 surgical IB-IIA (FIGO 2009) SCNEC patients according to the FIGO 2018 system and refined stage IIIC of FIGO 2018 based on tumor local invasion. The prognostic factors wer...

Skeletal muscle wasting during neoadjuvant therapy as a prognosticator in patients with...
https://doi.org/10.1016/j.ijsu.2021.106206
International Journal of Surgery (London, England); Wang P, Wang S et. al.

Jan 7th, 2022 - Considerable controversies exist regarding the severity of skeletal muscle wasting (SMW) during neoadjuvant therapy (NAT) and its impact on therapeutic outcomes in patients with esophageal or esophagogastric junction cancer (EC/EGJC). This systematic review and meta-analysis aimed to resolve these issues. Particularly, the prognostic value of SMW during NAT was compared to pre-NAT and pre-surge...

Spontaneous Intracerebral Hemorrhage (ICH) associated with pregnancy and SARS-CoV-2 inf...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8731675
BMC Pregnancy and Childbirth; Dini P, Aminimoghaddam S et. al.

Jan 7th, 2022 - Coronavirus Disease 2019 (COVID-19) is predominately known as a respiratory disease associated with pneumonia, acute respiratory distress syndrome and multiorgan failure. However, extra-pulmonary complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are increasingly being recognized. In this regard, some studies implied the hemostatic and vascular involvements in patient...

Pathogenic Mechanism of Dry Eye-Induced Chronic Ocular Pain and a Mechanism-Based Thera...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742529
Investigative Ophthalmology & Visual Science; Tei Y, Mikami Y et. al.

Jan 7th, 2022 - Dry eye-induced chronic ocular pain is also called ocular neuropathic pain. However, details of the pathogenic mechanism remain unknown. The purpose of this study was to elucidate the pathogenic mechanism of dry eye-induced chronic pain in the anterior eye area and develop a pathophysiology-based therapeutic strategy. We used a rat dry eye model with lacrimal gland excision (LGE) to elucidate t...

Soluble PD-L1 Concentration Is Proportional to the Expression of PD-L1 in Tissue and Is...
https://doi.org/10.1159/000518740
Oncology Shiraishi T, Toyozumi T et. al.

Jan 7th, 2022 - We determined the soluble programmed cell death-1 ligand-1 (sPD-L1) concentration in patients with esophageal squamous cell carcinoma (ESCC), and confirmed the PD-L1 expression in resected specimens. Blood samples were collected from 73 patients with histologically proven ESCC. The serum levels of sPD-L1 were measured using an enzyme-linked immunosorbent assay. The correlations between the sPD-...

Clotting events among hospitalized patients infected with COVID-19 in a large multisite...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730413
PloS One; Nemetski SM, Ip A et. al.

Jan 6th, 2022 - COVID-19 infection has been hypothesized to precipitate venous and arterial clotting events more frequently than other illnesses. We demonstrate this increased risk of blood clots by comparing rates of venous and arterial clotting events in 4400 hospitalized COVID-19 patients in a large multisite clinical network in the United States examined from April through June of 2020, to patients hospita...

A Population-Based Analysis of Diabetes-Related Care Measures, Foot Complications, and ...
https://doi.org/10.1001/jamanetworkopen.2021.42354
JAMA Network Open; de Mestral C, Gomez D et. al.

Jan 6th, 2022 - Deferred diabetic foot screening and delays in timely care of acute foot complications during the COVID-19 pandemic may have contributed to an increase in limb loss. To evaluate the association of the COVID-19 pandemic with diabetes-related care measures, foot complications, and amputation. This population-based cohort study included all adult residents of Ontario, Canada, with diabetes and com...

Incidence of COVID-19 reinfection among Midwestern healthcare employees.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726474
PloS One; Rivelli A, Fitzpatrick V et. al.

Jan 5th, 2022 - Given the overwhelming worldwide rate of infection and the disappointing pace of vaccination, addressing reinfection is critical. Understanding reinfection, including longevity after natural infection, will allow us to better know the prospect of herd immunity, which hinges on the assumption that natural infection generates sufficient, protective immunity. The primary objective of this observat...

Axonal Protection by Netarsudil, a ROCK Inhibitor, Is Linked to an AMPK-Autophagy Pathw...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742515
Investigative Ophthalmology & Visual Science; Kitaoka Y, Sase K et. al.

Jan 5th, 2022 - Netarsudil, a Rho kinase inhibitor with norepinephrine transport inhibitory effect, lowers intraocular pressure, however, its effect on axon damage remains to be elucidated. The aim of the current study was to investigate the effect of netarsudil on TNF-induced axon loss and to examine whether it affects phosphorylated-AMP-activated kinase (p-AMPK) and autophagy in the optic nerve. Intravitreal...

Morphology of the Trabecular Meshwork and Schlemm's Canal in Posner-Schlossman Syndrome.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742513
Investigative Ophthalmology & Visual Science; Yan X, Li M et. al.

Jan 4th, 2022 - The purpose of this study was to investigate trabecular meshwork (TM) and Schlemm's canal (SC) morphology in Posner-Schlossman syndrome (PSS). Forty-five patients with PSS were recruited. TM thickness and length as well as SC area and diameter of both affected and fellow eyes were assessed using swept-source optical coherence tomography. TM thickness (108.24 ± 28.29 µm vs. 89.36 ± 25.82 µm, P =...

COVID-19: systemic pathology and its implications for therapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692150
International Journal of Biological Sciences; Shen Q, Li J et. al.

Jan 4th, 2022 - Responding to the coronavirus disease 2019 (COVID-19) pandemic has been an unexpected and unprecedented global challenge for humanity in this century. During this crisis, specialists from the laboratories and frontline clinical personnel have made great efforts to prevent and treat COVID-19 by revealing the molecular biological characteristics and epidemic characteristics of the severe acute re...

Tissue Characterization in Cardiology: Moving Beyond Function.
https://doi.org/10.1007/978-3-030-78771-4_11
Advances in Experimental Medicine and Biology; Markousis-Mavrogenis G, Bacopoulou F et. al.

Jan 2nd, 2022 - Cardiovascular Magnetic Resonance (CMR) offers accurate and highly reproducible tissue characterization, beyond cardiac function. Late gadolinium enhancement (LGE), although represents a noninvasive biopsy for fibrosis quantification, it is unable to detect diffuse myocardial disease. Native T1 mapping and extracellular volume fraction (ECV) are able to provide important information about proce...

European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology...
https://doi.org/10.1016/S1470-2045(21)00539-8
The Lancet. Oncology; Meattini I, Becherini C et. al.

Jan 2nd, 2022 - High-quality randomised clinical trials testing moderately fractionated breast radiotherapy have clearly shown that local control and survival is at least as effective as with 2 Gy daily fractions with similar or reduced normal tissue toxicity. Fewer treatment visits are welcomed by patients and their families, and reduced fractions produce substantial savings for health-care systems. Implement...

Diagnostic and Prognostic Impact of Crypt Branching in Patients With Ulcerative Colitis...
https://doi.org/10.21873/anticanres.15468
Anticancer Research; Lang-Schwarz C, Rubio CA et. al.

Jan 1st, 2022 - This study aimed to validate the inter-rater agreement of the assessment of crypt branching (also called crypt fission) in patients with ulcerative colitis (UC) and to elucidate its potential diagnostic and prognostic impact. A total of 100 biopsies from patients with UC were analyzed. Two cohorts of 50 patients each served as controls [infectious controls/controls with low grade intraepithelia...