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About 2,172,365 results

Inhibition of DEK Enhances Doxorubicin-Induced Apoptosis and Cell Cycle Arrest in T-Cel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236779
Disease Markers; Tian X, Zhu Z et. al.

Jul 1st, 2022 - T-cell acute lymphoblastic leukemia (T-ALL) is a serious hematological tumor derived from early T-cell progenitors, which is extremely resistant to chemotherapy. Classically, doxorubicin (DOX) is an effective first-line drug for the treatment of T-ALL; however, DOX resistance limits its clinical effect. The DEK proto-oncogene (DEK) has been involved in neoplasms but remains unexplored in T-ALL....

G Protein-Coupled Receptor Kinase 4 Is a Novel Prognostic Factor in Hepatocellular Carc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236775
Disease Markers; Luo Y, Wang Z et. al.

Jul 1st, 2022 - We previously reported that G protein-coupled receptor kinase (GRK) 4 halts cell cycle progression and induces cellular senescence in HEK293 cells. The present study was aimed at assessing the prognostic value of GRK4 in hepatocellular carcinoma (HCC). GRK4 expression was detected by immunohistochemistry in paired tumoral and peritumoral tissues of 325 HCC patients. One hundred and twenty-six p...

The prognostic value of the advanced lung cancer inflammation index (ALI) for patients ...
https://doi.org/10.1177/03000605221109382
The Journal of International Medical Research; Qi C, Zhou Y et. al.

Jul 1st, 2022 - The advanced lung cancer inflammation index (ALI) can predict the survival of patients with lung cancer and other malignancies. However, the prognostic significance of ALI in neuroblastoma has not been reported. This study aimed to evaluate the correlation between ALI and neuroblastoma patient prognosis. We retrospectively analyzed the data of 72 neuroblastoma patients treated between January 2...

Application of Auriculotherapy for Post-Burn Scar Syndrome in Young Adults with Major B...
https://doi.org/10.51507/j.jams.2021.14.4.127
Journal of Acupuncture and Meridian Studies; Chen CC, Chen SP et. al.

Jul 1st, 2022 - A burn scar is a type of hypertrophic scar that can cause significant clinical symptoms, discomfort, and post-burn scar (PBS) syndrome in up to 77% of patients with burn injuries. Medication and rehabilitation are rarely effective at managing patient discomfort, and both laser and surgical interventions are postponed until the scar stabilizes and discomfort is tolerable. Objectives: The present...

Predictors of respiratory failure after thoracic surgery: a retrospective cohort study ...
https://doi.org/10.1177/03000605221094531
The Journal of International Medical Research; Pezzuto A, Trabalza Marinucci B et. al.

Jul 1st, 2022 - Only approximately 15% of patients with lung cancer are suitable for surgery and clinical postoperative outcomes vary. The aim of this study was to investigate variables associated with post-surgery respiratory failure in this patient cohort. Patients who underwent surgery for lung cancer were retrospectively studied for respiratory function. All patients had undergone lung resection by a mini-...

Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipog...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234046
Journal of Immunology Research; Zhu L, Zhou KX et. al.

Jul 1st, 2022 - Hepatocellular carcinoma (HCC) is the most common type of primary liver malignancy with poor prognosis worldwide. Emerging evidences demonstrated critical roles of lipid de novo synthesis in HCC progression, yet its regulatory mechanisms are not fully understood. Herein, we found that tuftelin 1 (TUFT1), an acidic phosphorylated glycoprotein with secretory capacity, was significantly upregulate...

circACTG1 Promotes Hepatocellular Carcinoma Progression by Regulating miR-940/RIF1 Axis...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234050
Journal of Immunology Research; Wu C, Tian S et. al.

Jul 1st, 2022 - Hepatocellular carcinoma (HCC) is recognized as the fourth in incidence and the third in mortality worldwide. The onset of HCC is insidious and often asymptomatic at the early stage. HCC is more prone to metastasis, recurrence, and drug resistance than other solid tumors owing to its feature of high heterogeneity. Therefore, what particularly important is to search for effective molecular marke...

Downregulation of DNMT3A Attenuates the Warburg Effect, Proliferation, and Invasion via...
https://doi.org/10.1177/15330338221110668
Technology in Cancer Research & Treatment; Lu J, Zhen S et. al.

Jul 1st, 2022 - Background: Ovarian cancer is a highly malignant gynecological cancer. Aerobic glycolysis is one of the features of cancer cell metabolism. Studying the molecular modulation of the Warburg effect in ovarian cancer is significantly valuable for understanding the progression mechanism of ovarian cancer. Materials and Methods: The expression level and prognostic significance of DNMT3A were analyze...

G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Mali...
https://doi.org/10.1177/15330338221105733
Technology in Cancer Research & Treatment; Cheng Y, Heng X et. al.

Jul 1st, 2022 - Background: G-protein coupled receptor 34 (GPR34) is involved in cell motility, differentiation, and mitosis. GPR34 was reported to be highly expressed and play an oncogenic role in several solid tumors. Here, we investigated the mechanisms underlying how GPR34 promotes glioma progression. Methods: Bioinformatic analysis was performed on RNA-seq and clinical data from the gene expression omnibu...

The Acute Toxicities and Efficacy of Concurrent Chemotherapy With Docetaxel Plus Cispla...
https://doi.org/10.1177/15330338221109974
Technology in Cancer Research & Treatment; Luo Y, Cai B et. al.

Jul 1st, 2022 - Objective: The objective of this trial is to evaluate and compare the acute toxicity in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) treated with docetaxel plus cisplatin, or docetaxel, or cisplatin concurrently with helical tomotherapy during concurrent chemoradiotherapy (CCRT). Methods: In a prospective, single-center, open-label, randomized phase II study, after 2 ...

Comparison of Clinical Characteristics and Genetic Aberrations of Plasma Cell Disorders...
https://doi.org/10.1177/15330338221111228
Technology in Cancer Research & Treatment; Jirabanditsakul C, Dakeng S et. al.

Jul 1st, 2022 - Multiple myeloma is an incurable malignancy of plasma cells resulting from impaired terminal B cell development. Almost all patients with multiple myeloma eventually have a relapse. Many studies have demonstrated the importance of the various genomic mutations that characterize multiple myeloma as a complex heterogeneous disease. In recent years, next-generation sequencing has been used to iden...

Lymphocytic myocarditis presenting as acute myocardial infarction: a case report and re...
https://doi.org/10.1177/03000605221108933
The Journal of International Medical Research; Huang Z, Feng G et. al.

Jul 1st, 2022 - We report a case that presented as acute myocardial infarction (AMI) caused by lymphocytic myocarditis (LM), and explore the relationship between AMI and LM. We also performed a literature search to identify publications that previously reported LM-associated myocardial infarction. Coronary angiography of our patient revealed normal coronary arteries. However, a perfusion-metabolism mismatch in...

Tumor Volume Reduction Rate to Induction Chemotherapy is a Prognostic Factor for Locall...
https://doi.org/10.1177/15330338221107714
Technology in Cancer Research & Treatment; Lin TC, Huang CH et. al.

Jul 1st, 2022 - Introduction: Aim of this retrospective cohort study is to evaluate the prognostic value of tumor volume reduction rate status post-induction chemotherapy in locally advanced head and neck squamous cell carcinoma. Methods: Patients newly diagnosed from year 2007 to 2016 at a single center were included in this retrospective study. All patients had received induction Taxotere, Platinum, Fluorour...

Somatomotor or somatosensory facial manifestations in patients with temporobasal epilep...
https://doi.org/10.1684/epd.2022.1413
Epileptic Disorders : International Epilepsy Journal With... Taussig D, David O et. al.

Jul 1st, 2022 - The semiology of temporo-basal epilepsy has rarely been analysed in the literature. In this paper, we report three patients with proven basal temporal epilepsy with somatomotor or somatosensory facial ictal semiology, highly suggestive of insulo-opercular onset. The three patients had a temporobasal lesion and their drugresistant epilepsy was cured with resection of the lesion (follow-up durati...

Clinical evaluation of hydration index using a corneometer in metastatic melanoma patie...
https://doi.org/10.1684/ejd.2022.4198
European Journal of Dermatology : EJD; Amabile S, Tonella L et. al.

Jun 30th, 2022 - Clinical evaluation of hydration index using a corneometer in metastatic melanoma patients treated with BRAF/MEK inhibitors: a prospective study.|2022|Amabile S,Tonella L,Rubatto M,Argenziano G,Babino G,|drug therapy,pathology,therapeutic use,genetics,

Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma.
https://doi.org/10.1056/NEJMoa2202028
The New England Journal of Medicine; Gállego Pérez-Larraya J, Garcia-Moure M et. al.

Jun 30th, 2022 - Pediatric patients with diffuse intrinsic pontine glioma (DIPG) have a poor prognosis, with a median survival of less than 1 year. Oncolytic viral therapy has been evaluated in patients with pediatric gliomas elsewhere in the brain, but data regarding oncolytic viral therapy in patients with DIPG are lacking. We conducted a single-center, dose-escalation study of DNX-2401, an oncolytic adenovir...

Clinicopathological characteristics and risk factors in elderly patients with biopsy-pr...
https://doi.org/10.1080/0886022X.2022.2087527
Renal Failure; Tan J, Luo X et. al.

Jun 30th, 2022 - Immunoglobulin A nephropathy (IgAN) has been well studied among young people, but few data on clinicopathological characteristics, treatment response and outcomes for elderly IgAN patients are available. A cohort study of elderly IgAN patients was performed. The combined endpoints of renal outcome were a 50% decline in eGFR compared with the time of renal biopsy, end-stage kidney disease and/or...

A nomogram based on A-to-I RNA editing predicting overall survival of patients with lun...
https://doi.org/10.1186/s12885-022-09773-0 10.3322/caac.21660 10.21037/jtd.2020.03.11 10.1007/s00432-021-03619-1 10.1186/s12967-021-02800-x 10.7150/thno.56202 10.21037/tlcr-20-822 10.7717/peerj.10749 10.3389/fcell.2021.657667 10.1002/cam4.1349 10.21037/jtd.2020.03.31 10.1111/jcmm.15393 10.3892/ijmm.2020.4590 10.18632/aging.102189 10.1101/gr.164749.113 10.1016/j.ccell.2018.03.026 10.1016/j.ccell.2015.08.013 10.1038/ncomms10715 10.1172/jci.insight.99976 10.1172/JCI123396 10.1186/s12943-021-01333-7 10.1126/sciadv.aba5136 10.1016/j.jhep.2020.07.021 10.1038/s41388-020-1248-x 10.2174/1568009621666210127092828 10.1002/(SICI)1097-0258(19970228)16:4<385::AID-SIM380>3.0.CO;2-3 10.1093/eurheartj/ehu207 10.1136/bmj.i6 10.1093/nar/gkaa970 10.1158/1078-0432.CCR-04-0713 10.1038/nrm.2015.4 10.1101/gr.242636.118 10.1101/gr.256933.119 10.1158/0008-5472.CAN-06-4784 10.1002/ijc.1265 10.1021/jacs.9b06068 10.1002/stem.2411 10.1080/15548627.2016.1254864 10.1371/journal.pone.0050672 10.1002/jcp.29188 10.12659/MSM.908966 10.1007/978-1-0716-0787-9_14 10.18632/aging.102544 10.3389/fimmu.2021.752643 10.3389/fgene.2020.00185 10.1111/1759-7714.14195 10.1186/s12885-021-08207-7
BMC Cancer; Liu L, Liu J et. al.

Jun 30th, 2022 - Adenosine-to-inosine RNA editing (ATIRE) is characterized as non-mutational epigenetic reprogramming hallmark of cancer, while little is known about its predictive role in cancer survival. To explore survival-related ATIRE events in lung squamous cell carcinoma (LUSC), ATIRE profile, gene expression data, and corresponding clinical information of LUSC patients were downloaded from the TCGA data...

The clinical and prognostic factors for biliary neuroendocrine neoplasm: a study based ...
https://doi.org/10.1186/s12893-022-01689-7 10.1002/cncr.11105 10.1002/ijc.23529 10.1016/j.hoc.2015.08.006 10.1001/jamaoncol.2019.4568 10.1016/j.neo.2017.09.002 10.1007/s40618-021-01715-0 10.1111/his.13975 10.1002/(SICI)1097-0142(19970215)79:4<813::AID-CNCR19>3.0.CO;2-2 10.1016/j.anndiagpath.2009.08.002 10.1097/MCG.0b013e3181d7a6d4 10.1007/s12253-014-9808-4 10.1097/MD.0000000000011487 10.1016/j.clgc.2016.10.007 10.1016/j.lungcan.2018.11.010 10.1097/COC.0000000000000305 10.3748/wjg.v21.i1.269 10.1016/j.ecl.2018.04.006 10.1158/2159-8290.CD-17-0245 10.1001/jamanetworkopen.2021.14180 10.1001/jama.2018.11815 10.1016/j.path.2018.02.005 10.1007/s40618-021-01528-1 10.1177/17562848211036453 10.1001/jamanetworkopen.2021.24750 10.1007/s10620-018-5103-7 10.3748/wjg.v21.i43.12211 10.1007/s00423-016-1491-3
BMC Surgery; Zheng BH, Zhang C et. al.

Jun 30th, 2022 - In this study, we aimed at elucidating the postoperative survival and prognostic factors in patients with biliary neuroendocrine neoplasm (NEN). Cases of biliary system NEN and adenocarcinoma from 1975 to 2016 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. A propensity score matching (PSM) method was used to adjust baseline differences in clinicopathologica...

Diagnosis and management of hypoglossal nerve-derived schwannoma in the floor of mouth:...
https://doi.org/10.1186/s12903-022-02302-2 10.1016/S0196-0709(03)00064-4 10.1016/S1079-2104(03)00462-1 10.1016/j.jcms.2010.10.004 10.4103/0970-9290.70790 10.1258/0022215001905058 10.1007/s12070-015-0925-5 10.1111/j.1834-7819.1998.tb00179.x 10.1016/j.anl.2007.01.006 10.1177/000348940111001106 10.4103/0971-3026.184418 10.1016/j.otohns.2003.12.011 10.4103/jcrt.JCRT_1125_16 10.2174/1874210601812010012 10.1016/j.jocn.2018.11.037 10.2214/AJR.17.18102 10.1016/j.wneu.2017.11.069 10.1016/j.anndiagpath.2010.12.003 10.1177/014556131008900707 10.1259/dmfr/93898716 10.1212/WNL.16.7.709 10.3171/jns.1962.19.3.0248 10.4103/0973-1482.25856 10.1093/neuros/nyx076
BMC Oral Health; Zhong J, Zhou Z et. al.

Jun 30th, 2022 - Schwannomas or neurilemmomas are well-encapsulated, benign, solitary, and slow-growing tumors that originate from Schwann cells of the nerve sheath. Extracranial schwannoma is reported to have a relatively high incidence in the tongue while an extremely low incidence in the floor of mouth. In the current study, we presented the first case series of hypoglossal nerve-derived schwannoma in the fl...