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About 157,723 results

Prognostic significance of volume-based 18F-FDG PET/CT parameters and correlation with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415941
Medicine Wang D, Li Y et. al.

Sep 4th, 2021 - The aim of this study was to retrospectively analyze 18F-FDG positron emission tomography/computed tomography (18F-FDG PET/CT) metabolic variables, programmed death-ligand 1 (PD-L1) and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) tumor expression, and other factors as predictors of disease-free survival (DFS) in patients with lung adenocarcinoma (LUAD) (stage IA-...

Small-molecule polymerase inhibitor protects non-human primates from measles and reduce...
https://doi.org/10.1038/s41467-021-25497-4 10.1038/nature10639 10.1017/S0950268817002564 10.15585/mmwr.mm6945a6 10.1007/s00430-016-0451-4 10.1016/j.vaccine.2017.10.065 10.1126/science.368.6487.116 10.1126/science.7063839 10.1016/j.coviro.2020.02.007 10.1128/AAC.00289-07 10.1126/scitranslmed.3008517 10.1016/j.cmi.2017.06.030 10.1128/AAC.00503-09 10.1074/jbc.REV119.009961 10.1016/j.coviro.2020.03.001 10.1086/314993 10.1001/jama.2016.1353 10.1517/17460441.2014.867324 10.1021/jm201699w 10.1016/j.jviromet.2005.10.006
Nature Communications; Wittwer K, Anderson DE et. al.

Sep 4th, 2021 - Measles virus (MeV) is a highly contagious pathogen that enters the human host via the respiratory route. Besides acute pathologies including fever, cough and the characteristic measles rash, the infection of lymphocytes leads to substantial immunosuppression that can exacerbate the outcome of infections with additional pathogens. Despite the availability of effective vaccine prophylaxis, measl...

Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, base...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415986
Medicine Yang S, Fu Q et. al.

Sep 4th, 2021 - In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat allergic rhinitis (AR) for centuries. However, the mechanisms underlying its effects or its molecular targets in AR treatment are yet to be elucidated. Therefore, the active compounds of YPFP and their targets were collected and identified from the Traditional Chinese Medicine Systems Pharmacology database....

The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411519
World Journal of Surgical Oncology; Zuo M, Yao L et. al.

Sep 3rd, 2021 - This study aimed to investigate the correlation between miRNA-216b expression in patients with non-small cell lung cancer (NSCLC) and 18F-fluorodeoxyglucose (FDG) uptake by PET/CT and to explore the clinical application value of 18F-FDG PET/CT in miRNA-216b based on therapy for NSCLC. Eighty patients with NSCLC and 40 healthy subjects were enrolled in our study. The SUVmax of the lesion area by...

Safety and efficacy of tolebrutinib, an oral brain-penetrant BTK inhibitor, in relapsin...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434816
The Lancet. Neurology; Reich DS, Arnold DL et. al.

Aug 22nd, 2021 - Tolebrutinib is an oral, CNS-penetrant, irreversible inhibitor of Bruton's tyrosine kinase, an enzyme expressed in B lymphocytes and myeloid cells including microglia, which are major drivers of inflammation in multiple sclerosis. We aimed to determine the dose-response relationship between tolebrutinib and the reduction in new active brain MRI lesions in patients with relapsing multiple sclero...

Knowledge, attitudes, and practices related to augmented renal clearance among pediatri...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360415
Medicine Zhou R, Fang Y et. al.

Aug 17th, 2021 - Our purpose was to assess pediatricians' knowledge of augmented renal clearance (ARC).We conducted cross-sectional analyses of 500 pediatricians from 16 tertiary hospitals in Anhui Province, China. Pediatricians provided demographic information and were asked questions about their knowledge of ARC, including risk factors, evaluation tools, and the impact on patient prognosis, with a focus on th...

Network pharmacology study on the mechanism of the Chinese medicine Radix Isatidis (Ban...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360416
Medicine Yu B, Lin F et. al.

Aug 17th, 2021 - Radix Isatidis (Banlangen) is a well-known traditional Chinese medicine for the treatment of different diseases and prevention of many body disorders. Besides, it also plays a pivotal role in novel coronavirus pneumonia, coronavirus disease 2019 (COVID-19). However, few researchers know its active ingredients and mechanism of action for COVID-19. To find whether Banlangen has a pharmacological ...

Decrease in dysbaric osteonecrosis severity as a result of 45-minute oxygen pre-breathe.
https://www.ncbi.nlm.nih.gov/pubmed/34390632
Undersea & Hyperbaric Medicine : Journal of the Undersea ... Lamers J, MacLaughlin K et. al.

Aug 15th, 2021 - Sudden decompression can result in bubble formation as the result of nitrogen gas (N2) dissolved in tissue during disabled submarine escape (DISSUB). This may cause dysbaric osteonecrosis (DON), a condition in long bones where bubbles in fatty marrow result in ischemia and necrosis. Previous research has shown that oxygen (O2) pre-breathe of two hours resulted in a reduction of DON; however, ef...

Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production fro...
https://doi.org/10.4049/jimmunol.2100127
Journal of Immunology (Baltimore, Md. : 1950); Kountz TS, Jairaman A et. al.

Aug 15th, 2021 - The airway epithelial cells (AECs) lining the conducting passageways of the lung secrete a variety of immunomodulatory factors. Among these, PGE2 limits lung inflammation and promotes bronchodilation. By contrast, IL-6 drives intense airway inflammation, remodeling, and fibrosis. The signaling that differentiates the production of these opposing mediators is not understood. In this study, we fi...

Real-World Use of Dalbavancin in the Era of Empowerment of Outpatient Antimicrobial Tre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349200
Drug Design, Development and Therapy; Gatti M, Andreoni M et. al.

Aug 12th, 2021 - Dalbavancin is a novel, long-acting lipoglycopeptide characterized by a long elimination half-life coupled with excellent in vitro activity against multidrug-resistant Gram-positives. Although it is currently approved only for the treatment of acute bacterial skin and skin structure infections, an ever-growing amount of evidence supports the efficacy of dalbavancin as a long-term therapy in ost...

A Monoclonal Antibody for Malaria Prevention.
https://doi.org/10.1056/NEJMoa2034031
The New England Journal of Medicine; Gaudinski MR, Berkowitz NM et. al.

Aug 12th, 2021 - Additional interventions are needed to reduce the morbidity and mortality caused by malaria. We conducted a two-part, phase 1 clinical trial to assess the safety and pharmacokinetics of CIS43LS, an antimalarial monoclonal antibody with an extended half-life, and its efficacy against infection with Plasmodium falciparum. Part A of the trial assessed the safety, initial side-effect profile, and p...

Pharmacokinetic and pharmacodynamic evaluation of the new prolonged-release leuprorelin...
https://doi.org/10.1080/17425255.2021.1948534
Expert Opinion on Drug Metabolism & Toxicology; Zhou H, Xie J et. al.

Aug 11th, 2021 - To compare the pharmacokinetics, pharmacodynamics and safety of the new prolonged-release leuprorelin acetate microspheres for injection (3.75 mg) with the reference product Enantone® (3.75 mg). 48 healthy male volunteers were enrolled and randomly received a single 3.75 mg dose of the test drug or Enantone®. There were no significant differences in Cmax, AUC0-t and AUC0-48 between the test gro...

Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervou...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333062
Nature Communications; Bolaender A, Zatorska D et. al.

Aug 5th, 2021 - Diseases are a manifestation of how thousands of proteins interact. In several diseases, such as cancer and Alzheimer's disease, proteome-wide disturbances in protein-protein interactions are caused by alterations to chaperome scaffolds termed epichaperomes. Epichaperome-directed chemical probes may be useful for detecting and reversing defective chaperomes. Here we provide structural, biochemi...

Subcellular localization of biomolecules and drug distribution by high-definition ion b...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324837
Nature Communications; Rovira-Clavé X, Jiang S et. al.

Aug 1st, 2021 - Simultaneous visualization of the relationship between multiple biomolecules and their ligands or small molecules at the nanometer scale in cells will enable greater understanding of how biological processes operate. We present here high-definition multiplex ion beam imaging (HD-MIBI), a secondary ion mass spectrometry approach capable of high-parameter imaging in 3D of targeted biological enti...

Rituximab biosimilars for B-cell lymphomas: a decade of real-world experience from India.
https://doi.org/10.1016/S2352-3026(21)00212-X
The Lancet. Haematology; Nair R, Radhakrishnan VS et. al.

Jul 31st, 2021 - Rituximab biosimilars for B-cell lymphomas: a decade of real-world experience from India.|2021|Nair R,Radhakrishnan VS,Mallath MK,|adverse effects,pharmacokinetics,therapeutic use,adverse effects,pharmacokinetics,therapeutic use,epidemiology,drug therapy,epidemiology,adverse effects,pharmacokinetics,therapeutic use,

Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmaco...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315226
International Journal of Nanomedicine; Chen R, Wang T et. al.

Jul 31st, 2021 - Antiviral drugs (AvDs) are the primary resource in the global battle against viruses, including the recent fight against corona virus disease 2019 (COVID-19). Most AvDs require multiple medications, and their use frequently leads to drug resistance, since they have poor oral bioavailability and low efficacy due to their low solubility/low permeability. Characterizing the in vivo metabolism and ...

A Novel Therapeutic Peptide Blocks SARS-CoV-2 Spike Protein Binding with Host Cell ACE2...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319882
Drugs in R&D; Rajpoot S, Ohishi T et. al.

Jul 30th, 2021 - Coronavirus disease 2019 is a novel disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus. It was first detected in December 2019 and has since been declared a pandemic causing millions of deaths worldwide. Therefore, there is an urgent need to develop effective therapeutics against coronavirus disease 2019. A critical step in the crosstalk between the virus and...

Pharmacokinetics of Remdesivir and GS-441524 during PIRRT and Seraph 100 Therapy.
https://doi.org/10.2215/CJN.17601120
Clinical Journal of the American Society of Nephrology : ... Schmidt JJ, Bode-Böger SM et. al.

Jul 25th, 2021 - Pharmacokinetics of Remdesivir and GS-441524 during PIRRT and Seraph 100 Therapy.|2021|Schmidt JJ,Bode-Böger SM,Martens-Lobenhoffer J,Hoeper MM,Kielstein JT,|analogs & derivatives,pharmacokinetics,analogs & derivatives,pharmacokinetics,analogs & derivatives,pharmacokinetics,drug therapy,

Structural and mechanistic basis for translation inhibition by macrolide and ketolide a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298421
Nature Communications; Beckert B, Leroy EC et. al.

Jul 24th, 2021 - Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these antibiotics are known to interrupt translation at specific sequence motifs, with ketolides predominantly stalling at Arg/Lys-X-Arg/Lys motifs and macrolides displaying a broader specificity, a structural basis for ...

Inhalable nanocatchers for SARS-CoV-2 inhibition.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307760
Proceedings of the National Academy of Sciences of the Un... Zhang H, Zhu W et. al.

Jul 23rd, 2021 - The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2), presents an urgent health crisis. More recently, an increasing number of mutated strains of SARS-CoV-2 have been identified globally. Such mutations, especially those on the spike glycoprotein to render its higher binding affinity to human angiotensin-conver...