×
About 1,185,435 results

Inhibition of DEK Enhances Doxorubicin-Induced Apoptosis and Cell Cycle Arrest in T-Cel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236779
Disease Markers; Tian X, Zhu Z et. al.

Jul 1st, 2022 - T-cell acute lymphoblastic leukemia (T-ALL) is a serious hematological tumor derived from early T-cell progenitors, which is extremely resistant to chemotherapy. Classically, doxorubicin (DOX) is an effective first-line drug for the treatment of T-ALL; however, DOX resistance limits its clinical effect. The DEK proto-oncogene (DEK) has been involved in neoplasms but remains unexplored in T-ALL....

Age Differences in Naloxone Reversibility of Electroacupuncture on the Jaw Opening Refl...
https://doi.org/10.51507/j.jams.2021.14.4.167
Journal of Acupuncture and Meridian Studies; Yamashita H, Zeredo JLL et. al.

Jul 1st, 2022 - Electroacupuncture is one of the most popular physical treatments for clinical pain, but the potential influence of a patient's age on the effectiveness of electroacupuncture treatment has not been clearly established. Objectives: The present study aimed to detect a potential difference in electroacupuncture- induced analgesia between juvenile and adult rats. In this study, we investigated the ...

Hepatoprotective Effect of Mitochondria-Targeted Antioxidant Mito-TEMPO against Lipopol...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236847
Mediators of Inflammation; Wang PF, Xie K et. al.

Jul 1st, 2022 - The liver is vulnerable to sepsis, and sepsis-induced liver injury is closely associated with poor survival of sepsis patients. Studies have found that the overproduction of reactive oxygen species (ROS) is the major cause of oxidative stress, which is the main pathogenic factor for the progression of septic liver injury. The mitochondria are a major source of ROS. Mito-TEMPO is a mitochondria-...

Perisciatic Nerve Dexmedetomidine Alleviates Spinal Oxidative Stress and Improves Perip...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236761
Disease Markers; Mu Y, Mei Y et. al.

Jul 1st, 2022 - Neuropathic pain (NPP) is a debilitating clinical condition that presently has few effective treatments. NPP is caused by uncontrolled central oxidative stress and inflammation. Preliminary studies indicate that dexmedetomidine (DEX), an agonist of the alpha-2 adrenergic receptor, is beneficial for treating NPP. In this paper, the effects of administering DEX around injured nerves in a chronic ...

Photocatalytic Cu2WS4 Nanocrystals for Efficient Bacterial Killing and Biofilm Disruption.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234186
International Journal of Nanomedicine; Dong H, Yang K et. al.

Jul 1st, 2022 - Bacterial biofilm-related wound infections threaten human health due to the lack of efficient treatments. Therefore, developing a novel strategy for wound infection care is urgently needed. Cube-shaped Cu2WS4 nanocrystals (CWSNs) were successfully prepared via a microwave-assisted method. CWSNs, as photocatalysts, were first studied by using fluorescence spectroscopy for their ability to genera...

Adrenergic Control of Primo Tissue Size in Rats.
https://doi.org/10.51507/j.jams.2022.15.1.25
Journal of Acupuncture and Meridian Studies; Shen Y, Kim YJ et. al.

Jul 1st, 2022 - Hyperplastic morphological changes associated with erythropoiesis have been reported in the primo vascular system (PVS) tissue on the surface of abdominal organs in rats with heart failure (HF) or hemolytic anemia (HA). Objectives: Since adrenergic activity is commonly activated in both HF and HA, we investigated whether adrenergic signaling mediates the abovementioned morphological changes. We...

Participation of Potential Transient Receptors in the Antinociceptive Effect of Pharmac...
https://doi.org/10.51507/j.jams.2022.15.2.105
Journal of Acupuncture and Meridian Studies; Argôlo IPR, Parisi JR et. al.

Jul 1st, 2022 - Despite the widespread clinical use of acupuncture in painful situations, the use of this treatment should be further clarified. Nociception is mediated by the activation of nociceptors, such as transient receptor potentials (TRPs). The family of TRPs includes TRPV1, TRPM8, and TRPA1, which can be stimulated by substances such as capsaicin, menthol, and methyl salicylate, respectively. This stu...

Perioperative Analgesic Efficacy of Yamamoto New Scalp Acupuncture for Canine Mastectom...
https://doi.org/10.51507/j.jams.2022.15.2.121
Journal of Acupuncture and Meridian Studies; Bacarin CC, Nicácio GM et. al.

Jul 1st, 2022 - Yamamoto New Scalp Acupuncture (YNSA) is a therapy based on the stimulation of points on the scalp and applied to treat different states of pain. To investigate the analgesic efficacy of YNSA for dogs undergoing radical unilateral mastectomy with ovariohysterectomy. Twenty-four dogs were randomly distributed into two treatments (n = 12, per group): bilateral stimulation of basic B, D, and E poi...

Comparison of the Effects of Electroacupuncture and Melatonin on Nerve Regeneration in ...
https://doi.org/10.51507/j.jams.2021.14.5.176
Journal of Acupuncture and Meridian Studies; Özkan Y, Turgut M et. al.

Jul 1st, 2022 - Development of methods to accelerate nerve regeneration in peripheral nerve damage is important. Electroacupuncture is a new therapeutic method that combines traditional acupuncture with modern electrotherapy. Melatonin has been shown to reduce nerve damage. Objectives: In this study, we aimed to determine and compare the therapeutic effects of electroacupuncture and melatonin on rat sciatic ne...

Enteral lorazepam is a promising weaning strategy for midazolam-responsive febrile infe...
https://doi.org/10.1684/epd.2022.1438
Epileptic Disorders : International Epilepsy Journal With... Jain V, Konanki R et. al.

Jul 1st, 2022 - Prolonged and repetitive cycles of pharmacological coma, with midazolam or other general anaesthetics, is often the mainstay for seizure control in febrile infection-related epilepsy syndrome (FIRES). Here we present our experience of enteral lorazepam as an effective weaning substitute in midazolam-dependent patients. This was a retrospective study based on a review of medical records of all F...

Natural Killer Cell Expansion and Cytotoxicity Differ Depending on the Culture Medium U...
https://doi.org/10.3343/alm.2022.42.6.638
Annals of Laboratory Medicine; Koh SK, Park J et. al.

Jun 30th, 2022 - Adoptive cell therapy using umbilical cord blood (UCB)-derived allogeneic natural killer (NK) cells has shown encouraging results. However, because of the insufficient availability of NK cells and limited UCB volume, more effective culture methods are required. NK cell expansion and functionality are largely affected by the culture medium. While human serum is a major affecting component in cul...

Fabrication of bio-engineered chitosan nanoformulations to inhibition of bacterial infe...
https://doi.org/10.1080/10717544.2022.2081381
Drug Delivery; Wan X, Liu L et. al.

Jun 30th, 2022 - Overdosage of antibiotics used to prevent bacterial infections in the human and animal gastrointestinal tract would result in disturbing of intestinal barrier, significant misbalancing effects of intestinal microflora and persuading bacterial resistance. The main objective of the present investigation is to design and develop novel combinations of organic curcumin (Cur) and antimicrobial peptid...

Anticandidal activity of green synthesised silver nanoparticles and extract loaded chit...
https://doi.org/10.1080/21691401.2022.2088546
Artificial Cells, Nanomedicine, and Biotechnology; Dzoyem JP, Tchuenguem RT et. al.

Jun 30th, 2022 - This study aimed to synthesize the silver nanoparticles (SNPs) and loaded chitosan nanoparticles (LCNPs) using Euphorbia prostata based on their anticandidal activity. Antioxidant capacity and the total phenolic and total flavonoid content of plant samples and synthesized nanoparticles (NPs) were also evaluated. SNPs and LCNPs were prepared, respectively using chemical reduction of silver salt ...

The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeut...
https://doi.org/10.1042/CS20220212
Clinical Science (London, England : 1979); Barrera-Chimal J, Gerarduzzi C et. al.

Jun 30th, 2022 - Despite strong preclinical data supporting the use of mineralocorticoid receptor antagonists (MRAs) to provide cardiorenal protection in rodent models of diabetes, the clinical evidence of their utility in treating chronic kidney disease (CKD) has been limited. Two major clinical trials (FIDELIO-DKD and FIGARO-DKD) including more than 13,000 patients with albuminuric CKD and Type 2 diabetes ran...

Detection of netrin-1 as a novel biomarker for diagnosis and chemotherapeutic monitorin...
https://doi.org/10.1177/03000605221105364
The Journal of International Medical Research; Zhao Y, Song J et. al.

Jun 30th, 2022 - Lung cancer has high morbidity and mortality. We aimed to determine the value of netrin-1 for the diagnosis and chemotherapeutic monitoring of lung cancer. Thirty pairs of lung cancer tissues and serum were collected. Netrin-1 expression was detected by immunohistochemistry and enzyme-linked immunosorbent assay. Netrin-1 expression was downregulated in A549 cells using small interfering RNA, an...

Phenylboronic ester-modified polymeric nanoparticles for promoting TRP2 peptide antigen...
https://doi.org/10.1080/10717544.2022.2086941
Drug Delivery; Wang Q, Dong Z et. al.

Jun 30th, 2022 - The tremendous development of peptide-based cancer vaccine has attracted incremental interest as a powerful approach in cancer management, prevention and treatment. As successful as tumor vaccine has been, major challenges associated with achieving efficient immune response against cancer are (1) drainage to and retention in lymph nodes; (2) uptake by dendritic cells (DCs); (3) activation of DC...

Immunosafety evaluation in Juvenile Göttingen Minipigs.
https://doi.org/10.1080/1547691X.2022.2088904
Journal of Immunotoxicology; Allais L, Perbet A et. al.

Jun 30th, 2022 - Although an extrapolation from the clinical experience in adults can often be considered to support the pediatric use for most pharmaceutical compounds, differences in safety profiles between adult and pediatric patients can be observed. The developing immune system may be affected due to exaggerated pharmacological or non-expected effects of a new drug. Toxicology studies in juvenile animals c...

Development and validation of a larval bioassay and selection protocol for insecticide ...
https://doi.org/10.1371/journal.pone.0270747
PloS One; Gress BE, Zalom FG

Jun 30th, 2022 - The rapid invasion of Drosophila suzukii (Matsumura) throughout Europe and the Americas has led to an increased reliance on calendar-based broad-spectrum insecticide programs among berry and cherry growers. Relatively few active ingredients (AIs) are currently available for effective D. suzukii management, and studies from multiple growing regions indicate that susceptibility to at least some o...

Acetazolamide modulates intracranial pressure directly by its action on the cerebrospin...
https://doi.org/10.1186/s12987-022-00348-6 10.1016/j.ccc.2006.06.003 10.2174/156802607780636690 10.1002/0470015535 10.1016/S0140-6736(57)92384-X 10.3171/jns.1978.49.2.0256 10.3390/life11070718 10.1097/WNO.0000000000000513 10.1016/0361-9230(85)90158-3 10.1016/j.neulet.2017.02.032 10.1177/0333102418776455 10.3171/jns.1966.25.4.0430 10.1136/adc.84.1.68 10.1152/jappl.1972.32.5.612 10.1152/ajplegacy.1972.223.3.503 10.1113/jphysiol.1970.sp009159 10.1152/ajplegacy.1963.205.3.617 10.1016/0006-8993(81)91071-4 10.1113/jphysiol.1965.sp007780 10.3181/00379727-87-21386 10.1139/y82-059 10.1016/j.jneumeth.2014.12.015 10.1038/s41583-021-00454-8 10.1152/jn.1960.23.5.485 10.1016/j.expneurol.2015.02.032 10.1152/physrev.00004.2013 10.1152/ajpcell.00240.2003 10.1073/pnas.87.14.5278 10.1152/ajpcell.00313.2005 10.1016/j.bbrc.2008.06.053 10.1073/pnas.0705487105 10.1074/jbc.M111.249961 10.1186/1471-213X-6-22 10.1073/pnas.98.4.1918 10.1016/0304-3940(93)90011-9 10.1177/30.4.6801110 10.1016/S0002-9440(10)64038-2 10.1152/ajplegacy.1963.205.4.693 10.1001/archopht.1979.01020010132006 10.5664/jcsm.6968 10.3171/jns.1974.41.3.0350 10.1152/jappl.1998.84.2.683 10.2170/jjphysiol.36.523 10.1097/ACO.0000000000000764 10.1093/bja/aeg150 10.1111/j.1476-5381.2010.00872.x 10.1152/ajpcell.1994.267.6.C1616 10.1093/bioinformatics/bts635 10.1186/s12859-019-3247-x 10.1186/s40478-020-00903-y 10.1523/JNEUROSCI.3081-14.2015 10.1093/bioinformatics/btu170 10.1152/japplphysiol.00165.2015 10.1056/NEJM195405132501902 10.1016/j.ab.2006.01.003 10.1371/journal.pone.0045976 10.1002/glia.23851 10.1590/1980-57642018dn13-020001 10.1007/s12975-018-0663-6 10.1007/s12975-011-0106-0 10.1136/jnnp-2019-320442 10.1113/jphysiol.2011.206052 10.1152/jappl.1987.63.5.2134
Fluids and Barriers of the CNS; Barbuskaite D, Oernbo EK et. al.

Jun 30th, 2022 - Elevated intracranial pressure (ICP) is observed in many neurological pathologies, e.g. hydrocephalus and stroke. This condition is routinely relieved with neurosurgical approaches, since effective and targeted pharmacological tools are still lacking. The carbonic anhydrase inhibitor, acetazolamide (AZE), may be employed to treat elevated ICP. However, its effectiveness is questioned, its locat...

Epidemiological and virological surveillance of influenza viruses in China during 2020-...
https://doi.org/10.1186/s40249-022-01002-x 10.1016/S0140-6736(17)33293-2 10.2105/AJPH.2012.301137 10.1080/21645515.2015.1111494 10.1006/viro.2002.1719 10.1073/pnas.1916585116 10.2807/1560-7917.ES.2018.23.13.18-00146 10.1093/infdis/jiy723 10.1093/cid/ciu664 10.1038/s41467-021-21157-9 10.1111/irv.12866 10.1128/JCM.03265-13 10.1093/molbev/mst010 10.1371/journal.pone.0009490 10.1080/22221751.2019.1648183 10.46234/ccdcw2020.228 10.46234/ccdcw2021.224 10.1007/s007050050399 10.1099/0022-1317-82-9-2169 10.1016/j.antiviral.2022.105281 10.1128/AAC.02628-13
Infectious Diseases of Poverty; Huang WJ, Cheng YH et. al.

Jun 30th, 2022 - During the coronavirus disease 2019 (COVID-19) pandemic, seasonal influenza activity declined globally and remained below previous seasonal levels, but intensified in China since 2021. Preventive measures to COVID-19 accompanied by different epidemic characteristics of influenza in different regions of the world. To better respond to influenza outbreaks under the COVID-19 pandemic, we analyzed ...