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About 1,134,198 results

Early and Very Early GRIM19 and MCL1 Expression Are Correlated to Late Acquired Prednis...
https://doi.org/10.1007/978-3-030-78787-5_20 10.1016/j.leukres.2009.04.018 10.1055/s-2001-16848 10.1001/jamaoncol.2019.5582 10.31557/apjcp.2019.20.9.2619 10.1002/ajh.25619 10.1007/s12185-019-02703-0 10.1007/s12185-019-02678-y 10.1182/blood.V70.3.860.860 10.1182/blood-2006-11-056366 10.1158/1078-0432.CCR-04-2097 10.1186/s10020-019-0106-1 10.2174/2589977512666200220122650 10.22034/apjcp.2018.19.8.2319 10.1038/cddis.2017.344 10.1016/S1567-5769(02)00081-4 10.2174/1389450003349056 10.1016/j.mce.2012.01.003 10.1177/1010428317694308 10.1371/journal.pone.0072326 10.1016/j.leukres.2015.04.012 10.1002/1097-0142(196611)19:11<1725::aid-cncr2820191142>3.0.co;2-t 10.1002/humu.20533 10.1097/00008571-200011000-00006 10.1093/nar/gki475 10.1093/nar/gkt439 10.1093/nar/gkx356 10.1002/cyto.990080101 10.1002/cyto.990080617 10.1007/s00432-004-0659-3 10.1074/jbc.M411767200 10.3324/haematol.10543 10.1038/s41419-018-0625-7 10.1038/s41375-018-0201-2 10.3390/cancers11111779 10.1016/j.bbrc.2020.02.165 10.3324/haematol.2013.093823 10.1016/j.ejca.2014.03.011 10.1016/S0960-0760(00)00161-8
Advances in Experimental Medicine and Biology; G L, Adamaki M et. al.

Jan 14th, 2022 - Glucocorticoids (GCs) are still first-line drugs for the treatment of childhood acute lymphoblastic leukemia (ALL). Prednisolone is a corticosteroid and one of the most important agents in the treatment of ALL. We report here a study of Prednisolone treatment using as a model a leukemia cell line with subsequent investigation of resistance-related gene expression. Gene silencing has been used i...

Synthesis and Biological Evaluation of Substituted Thiophene Derivatives.
https://doi.org/10.1007/978-3-030-78787-5_23 10.1007/s00044-011-9862-3 10.1016/S0223-5234(96)80005-5 10.1016/j.bmc.2010.05.034 10.1016/j.bmcl.2011.10.056 10.1016/j.ejmech.2011.11.004 10.2298/JSC0607713C
Advances in Experimental Medicine and Biology; Palupanuri N, Konda S et. al.

Jan 14th, 2022 - A novel series of pyrazolines were synthesized by cycloaddition of various chalcones (prepared by a Claisen-Schmidt condensation of 3-acetyl-2,5-dimethyl thiophene and various aromatic aldehydes) with the phenyl hydrazines in the presence of pyridine and subjected to molecular property prediction by Molinspiration, MolSoft, and Osiris software. The structures of new compounds were established b...

Designing and Screening of New Schiff Bases of Isatins for Antibacterial Activity by In...
https://doi.org/10.1007/978-3-030-78787-5_30 10.1002/prac.18410220148 10.1002/prac.18420250155 10.1074/jbc.275.1.135 10.4314/tjpr.v17i11.18 10.3389/fchem.2017.00107 10.5937/savteh1502049T
Advances in Experimental Medicine and Biology; Swathi K, Meghana B et. al.

Jan 14th, 2022 - Isatin or tribulin is an indole derivative; the compound was first obtained by Erdmann [1] and Laurent [2] and Erdmann in 1841 as a product from the oxidation of indigo dye by nitric acid and chromic acids. The compound is found in many plants, such as Isatis tinctoria, Calanthe discolor, and Couroupita guianensis. Schiff bases of isatin are investigated for their pharmaceutical properties. Isa...

Synthesis, Anti-inflammatory Activity, and In Silico Studies of Some New 3-({P-Dimethyl...
https://doi.org/10.1007/978-3-030-78787-5_43 10.1002/prac.18410240101 10.1002/prac.18420250155 10.1002/anie.198811133 10.1192/bjp.109.462.687 10.1016/S0014-827X(99)00075-0 10.1016/S0968-0896(02)00439-X 10.1016/j.antiviral.2006.02.010 10.1002/ardp.201100055 10.1016/j.ejmech.2009.12.035 10.1080/14756366.2017.1279155 10.5530/ijper.52.1.13 10.1016/j.bmcl.2004.05.025 10.5897/AJPP2014.4261 10.1016/j.ejmech.2008.02.034 10.17344/acsi.2017.3575 10.1021/jm051256o 10.1155/2015/826489 10.1016/j.molstruc.2017.09.092
Advances in Experimental Medicine and Biology; Swathi K, Chaitanya M et. al.

Jan 14th, 2022 - Ten novel isatin Schiff base analogs have been designed using a combination of isatin, hydrazine hydrate, and para-dimethylaminobenzaldehyde. Molecular docking studies have been performed to study the binding interactions of the designed compounds with COX-2 protein as a target (PDB code: 3LN1). The ten novel 3-({p-dimethylamino}benzylidenehydrazinylidene)-1,3-dihydro-2H-indole-2-one derivative...

Resveratrol as a Skincare Ingredient: Current Evidence and the Future Potential.
https://www.ncbi.nlm.nih.gov/pubmed/35022111
Skinmed Zachary CM, Wang JV et. al.

Jan 14th, 2022 - Resveratrol is a compound found abundantly in grapes' skin and red wine. It has recently become an increasingly popular ingredient of cosmeceuticals due to its reported anti-aging properties and inhibiting effects on melanogenesis. When compared to synthetic chemicals, natural ingredients, such as resveratrol, are often less expensive to produce and more widely available, which make them an att...

Design, Characterization, and Docking Studies of Some Novel Isatin Derivatives for Anti...
https://doi.org/10.1007/978-3-030-78787-5_44 10.1002/prac.18410220148 10.1002/prac.18420250155 10.1002/anie.198801131 10.3390/M437 10.1248/cpb.46.886 10.1016/S0040-4020(01)89832-X 10.1016/S0304-4165(89)80048-0 10.1016/0378-4347(91)80585-Z 10.1016/S0040-4020(01)96609-8 10.1039/c39770000535 10.1016/0040-4020(80)80221-3 10.1055/s-2006-959766 10.3329/bjp.v13i1.33625
Advances in Experimental Medicine and Biology; Swathi K, Sowjanya K et. al.

Jan 14th, 2022 - Isatin (indoline-2,3-dione) derivatives are derived from plant origin indole derivatives by the Sandmeyer method and characterized by IR, NMR, and mass spectrometric method. Molinspiration is used to calculate the molecular properties of all the synthesized compounds and to generate bioactivity scores (GPCR ligand, ion channel inhibitor, kinase inhibitor, nuclear receptor ligand, protease inhib...

A modified decision tree approach to improve the prediction and mutation discovery for ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753810
BMC Genomics; Deelder W, Napier G et. al.

Jan 13th, 2022 - Drug resistant Mycobacterium tuberculosis is complicating the effective treatment and control of tuberculosis disease (TB). With the adoption of whole genome sequencing as a diagnostic tool, machine learning approaches are being employed to predict M. tuberculosis resistance and identify underlying genetic mutations. However, machine learning approaches can overfit and fail to identify causal m...

The combination of sucrose dilaurate and sucrose laurate suppresses HMGB1: an enhancer ...
https://doi.org/10.1111/jdv.17846
Journal of the European Academy of Dermatology and Venere... Wang J, Jarrold B et. al.

Jan 12th, 2022 - Hyperpigmented spots are common issues in all ethnicities, involving multiple intrinsic and extrinsic factors such as UVB exposure, hormone balance, inflammatory status and ageing. To determine (i) melanocyte dendricity in multiple facial spot types, (ii) impact of High Mobility Group Box 1 (HMGB1), and the combination of sucrose dilaurate and sucrose laurate (SDL) on melanogenesis and melanocy...

Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Eff...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727453
International Journal of Nanomedicine; Wu L, Li Q et. al.

Jan 11th, 2022 - Cell membrane-camouflaged nanoparticles (NPs) are drawing increasing attention because their surfaces acquire some characteristics of the cell membranes, making them a unique class of biomimetic materials for diverse applications. Modification of cell membrane or combination of different types of membranes can enhance their functionality. We prepared platelet and tumor cell membrane camouflaged...

Neuroprotective Efficiency of Prodigiosins Conjugated with Selenium Nanoparticles in Ra...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722537
International Journal of Nanomedicine; Albrakati A, Alsharif KF et. al.

Jan 11th, 2022 - Depression is a mood disorder accompanied by intensive molecular and neurochemical alterations. Currently, available antidepressant therapies are not fully effective and are often accompanied by several adverse impacts. Accordingly, the ultimate goal of this investigation was to clarify the possible antidepressant effects of prodigiosins (PDGs) loaded with selenium nanoparticles (PDGs-SeNPs) in...

Proliferation of Fibroblast Cells in Periradicular Tissue Following Intentional Replant...
https://www.ncbi.nlm.nih.gov/pubmed/35000942
The Journal of Contemporary Dental Practice; Untara RTE, Widjijono et. al.

Jan 11th, 2022 - This study aimed to investigate the fibroblast cells proliferation in periradicular tissue using mineral trioxide aggregate (MTA) and self-adhesive resin cement as the adhesive material for vertical root fracture fragments following intentional replantation. This study used 27 male New Zealand rabbits aged 8-12 weeks. The mandibular incisor of each rabbit was extracted, and to simulate vertical...

Carriage of distinct blaKPC-2 and blaOXA-48 plasmids in a single ST11 hypervirulent Kle...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742346
BMC Genomics; Yang Y, Yang Y et. al.

Jan 9th, 2022 - Carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP) causes serious infections with significant morbidity and mortality. However, the epidemiology and transmission mechanisms of CR-hvKP and the corresponding carbapenem-resistant plasmids require further investigation. Herein, we have characterized an ST11 K. pneumoniae strain EBSI041 from the blood sample encoding both hypervirulence and ...

Burden of illness in carbapenem-resistant Acinetobacter baumannii infections in US hosp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740340
BMC Infectious Diseases; Pogue JM, Zhou Y et. al.

Jan 8th, 2022 - Carbapenem-resistant (CR) Acinetobacter baumannii is a concerning pathogen in the USA and worldwide. To assess the comparative burden of CR vs carbapenem-susceptible (CS) A. baumannii, this retrospective cohort study analyzed data from adult patients in 250 US hospitals from the Premier HealthCare Database (2014-2019). The outcomes analyzed included hospital length of stay (LOS), intensive care...

Polymeric Nanocarriers for Effective Synergistic Action of Sorafenib Tosylate and Gold-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711844
International Journal of Nanomedicine; Sukkar F, Shafaa M et. al.

Jan 8th, 2022 - One of the key parameters towards effective and synergistic combinatorial anticancer therapeutic models is the nanocarrier. Nearly all previous studies have been limited to one nanocarrier for one drug. However, a comparative study on two polymeric nanocarriers for the same drug against the same cancer cell and under the same conditions helps to rationalize the properties of each polymeric nano...

Biodegradable Materials with Disulfide-Bridged-Framework Confine Photosensitizers for E...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714971
International Journal of Nanomedicine; Li D, Chen F et. al.

Jan 8th, 2022 - Photodynamic therapy (PDT) with spatiotemporal controlled and noninvasive advantages has obtained growing attention in cancer treatment. Nevertheless, PDT still suffers from self-aggregation-induced photosensitizer quenching and reactive oxygen species (ROS) scavenging in cancer cells with abundant glutathione (GSH) pools, leading to insufficient performance. In this study, we develop a versati...

Selenium and protozoan parasitic infections: selenocompounds and selenoproteins potential.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8735723
Parasitology Research; Rashidi S, Fernández-Rubio C et. al.

Jan 8th, 2022 - The current drug treatments against protozoan parasitic diseases including Chagas, malaria, leishmaniasis, and toxoplasmosis represent good examples of drug resistance mechanisms and have shown diverse side effects. Therefore, the identification of novel therapeutic strategies and drug compounds against such life-threatening diseases is urgent. According to the successful usage of selenium (Se)...

Amoebicidal Activity of Poly-Epsilon-Lysine Functionalized Hydrogels.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742527
Investigative Ophthalmology & Visual Science; Kennedy SM, Deshpande P et. al.

Jan 8th, 2022 - To determine the amoebicidal activity of functionalized poly-epsilon-lysine hydrogels (pɛK+) against Acanthamoeba castellanii. A. castellanii trophozoites and cysts were grown in the presence of pɛK solution (0-2.17 mM), pɛK or pɛK+ hydrogels, or commercial hydrogel contact lens (CL) for 24 hours or 7 days in PBS or Peptone-Yeast-Glucose (PYG) media (nutrient-deplete or nutrient-replete culture...

Transcriptional analysis of Bemisia tabaci MEAM1 cryptic species under the selection pr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728913
BMC Genomics; Zhou CS, Lv HH et. al.

Jan 6th, 2022 - Neonicotinoids are widely applied in the control of the destructive agricultural pest Bemisia tabaci, and resistance against these chemicals has become a common, severe problem in the control of whiteflies. To investigate the molecular mechanism underlying resistance against nenonicotinoids in whiteflies, RNA-seq technology was applied, and the variation in the transcriptomic profiles of suscep...

Social isolation induces neuroinflammation and microglia overactivation, while dihydrom...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724741
Journal of Neuroinflammation; Al Omran AJ, Shao AS et. al.

Jan 6th, 2022 - Anxiety disorders are the most prevalent mental illnesses in the U.S. and are estimated to consume one-third of the country's mental health treatment cost. Although anxiolytic therapies are available, many patients still exhibit treatment resistance, relapse, or substantial side effects. Further, due to the COVID-19 pandemic and stay-at-home order, social isolation, fear of the pandemic, and un...

Evaluation of the Effects of Nanomicellar Curcumin, Berberine, and Their Combination wi...
https://doi.org/10.1007/978-3-030-73234-9_3 10.6004/jnccn.2003.0016 10.1172/JCI45014 10.1016/S0140-6736(05)66544-0 10.1016/j.phrs.2009.01.017 10.2174/1871520616666160826150659 10.2174/1568009616666151207105851 10.1039/C5RA14925H 10.1097/CAD.0b013e328330d95b 10.1016/S0140-6736(16)32454-0 10.1038/415530a 10.1002/jcb.23350 10.1038/srep12465 10.1158/1078-0432.CCR-14-0816 10.1200/JCO.2005.05.064 10.1111/j.1349-7006.2012.02359.x 10.1016/j.tem.2012.11.002 10.1016/S1471-4914(01)02243-2 10.32598/IJT.12.4.546.1 10.1080/01635581.2015.1085581 10.1007/s10616-012-9452-3 10.7150/ijms.9982 10.14800/ccm.710 10.1007/s11010-013-1723-6 10.1016/j.biomaterials.2003.12.025 10.1186/1471-2407-11-149 10.1186/1471-2407-13-418 10.18632/oncotarget.16761 10.1038/s41598-018-25672-6 10.12659/MSM.902711 10.1016/j.cbi.2009.06.012 10.1038/sj.onc.1204586 10.1371/journal.pone.0074928 10.1038/cddis.2013.26 10.3390/molecules18010701 10.1016/S0959-437X(05)80334-X 10.1046/j.1523-1755.1999.00704.x 10.1038/nrclinonc.2016.26
Advances in Experimental Medicine and Biology; Ziasarabi P, Sahebkar A et. al.

Jan 5th, 2022 - Breast cancer is one of the main challenging areas in cancer treatment. Natural compounds such as curcumin and berberine have been approved with anticancer effects and are more favorable to people. Here, we investigated the potential synergistic anticancer effects of these two compounds in combination with the standard cancer drug 5-FU on the growth of MCF-7 breast cancer cells. This study test...