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About 1,103,175 results

Dapsone Prevents Allodynia and Hyperalgesia and Decreased Oxidative Stress After Spinal...
https://doi.org/10.1097/BRS.0000000000004015
Spine Mata-Bermudez A, Diaz-Ruiz A et. al.

Sep 14th, 2021 - Prospective longitudinal experimental study. We evaluate the effect of dapsone on tactile allodynia and mechanical hyperalgesia and to determine its anti-oxidant effect in a spinal cord injury (SC) model in rats. Neuropathic pain (NP) as result of traumatic spinal cord injury is a deleterious medical condition with temporal or permanent time-course. Painful stimuli trigger a cascade of events t...

Biomechanical Response After Corneal Cross-linking With Riboflavin Dissolved in Dextran...
https://doi.org/10.3928/1081597X-20210610-04
Journal of Refractive Surgery (Thorofare, N.J. : 1995); Fischinger I, Seiler TG et. al.

Sep 11th, 2021 - To evaluate corneal stiffening in porcine eyes induced by corneal cross-linking (CXL) using riboflavin dissolved in either aqueous dextran or hydroxypropyl methylcellulose (HPMC) solution. Fifty-one porcine corneas were divided into three groups of 17 each. After deepithelialization, the first (Dresden) group was treated for 30 minutes with 0.1% riboflavin (riboflavin-5-monophosphate in 0.9% Na...

Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426591
Molecular Medicine (Cambridge, Mass.); Duarte RRR, Copertino DC et. al.

Sep 11th, 2021 - Vaccination programs have been launched worldwide to halt the spread of COVID-19. However, the identification of existing, safe compounds with combined treatment and prophylactic properties would be beneficial to individuals who are waiting to be vaccinated, particularly in less economically developed countries, where vaccine availability may be initially limited. We used a data-driven approach...

Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384739
World Journal of Gastroenterology; Chen JH, Sun Y et. al.

Sep 10th, 2021 - Chronic stress during pregnancy may increase visceral hyperalgesia of offspring in a sex-dependent way. Combining adult stress in offspring will increase this sensitivity. Based on the evidence implicating estrogen in exacerbating visceral hypersensitivity in female rodents in preclinical models, we predicted that chronic prenatal stress (CPS) + chronic adult stress (CAS) will maximize visceral...

Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424978
Journal of Translational Medicine; Fang K, Zhan Y et. al.

Sep 10th, 2021 - Antiangiogenic therapy has increasingly become an important strategy for the treatment of colorectal cancer. Recent studies have shown that the tumour microenvironment (TME) promotes tumour angiogenesis. Bufalin is an active antitumour compound whose efficacy has been indicated by previous studies. However, there are very few studies on the antiangiogenic effects of bufalin. Herein, human umbil...

In vitro efficacy of Artemisia extracts against SARS-CoV-2.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424155
Virology Journal; Nie C, Trimpert J et. al.

Sep 10th, 2021 - Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Teas and drinks containing extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent SARS-CoV-2 infection and fight COVID-19. T...

Machine Learning augmented docking studies of aminothioureas at the SARS-CoV-2-ACE2 int...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428716
PloS One; Rola M, Krassowski J et. al.

Sep 10th, 2021 - The current pandemic outbreak clearly indicated the urgent need for tools allowing fast predictions of bioactivity of a large number of compounds, either available or at least synthesizable. In the computational chemistry toolbox, several such tools are available, with the main ones being docking and structure-activity relationship modeling either by classical linear QSAR or Machine Learning te...

Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial home...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424887
Microbiome Wu Z, Huang S et. al.

Sep 9th, 2021 - Alteration of the gut microbiota may contribute to the development of inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG), a major bioactive constituent of green tea, is known to be beneficial in IBD alleviation. However, it is unclear whether the gut microbiota exerts an effect when EGCG attenuates IBD. We first explored the effect of oral or rectal EGCG delivery on the DSS-ind...

Antimicrobial susceptibility patterns of respiratory Gram-negative bacterial isolates f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422836
Annals of Clinical Microbiology and Antimicrobials; Gysin M, Acevedo CT et. al.

Sep 9th, 2021 - Bacterial superinfections associated with COVID-19 are common in ventilated ICU patients and impact morbidity and lethality. However, the contribution of antimicrobial resistance to the manifestation of bacterial infections in these patients has yet to be elucidated. We collected 70 Gram-negative bacterial strains, isolated from the lower respiratory tract of ventilated COVID-19 patients in Zur...

Transient receptor potential ankyrin 1 mediates cisplatin-induced apoptosis in renal tu...
https://doi.org/10.21037/apm-21-1867
Annals of Palliative Medicine; Meng X, Zhang Y et. al.

Sep 8th, 2021 - Cisplatin has been a vital drug used for tumor treatment because of its excellent effect on numerous malignant solid cancers. Nonetheless, its nephrotoxicity is non-negligible in clinical practice. This study aims to provide a new understanding of the molecular mechanism of transient receptor potential ankyrin 1 (TRPA1) in cisplatin-induced renal apoptosis. We evaluated the effect on apoptosis,...

Clinical efficacy of regional citrate anticoagulation in continuous renal replacement t...
https://doi.org/10.21037/apm-21-1693
Annals of Palliative Medicine; Chang H, Gong Y et. al.

Sep 8th, 2021 - A systematic review and meta-analysis were conducted to explore the clinical efficacy and coagulation function of regional citrate anticoagulation (RCA) in continuous renal replacement therapy (CRRT) in critically ill patients, to provide an effective treatment options for CRRT in severe patients. The English databases Embase, Medline, PubMed, Ovid, Springer, and Web of Science were searched to...

Distribution pattern of carbapenemases and solitary contribution to resistance in clini...
https://doi.org/10.21037/apm-21-1805
Annals of Palliative Medicine; Zhang Y, Ding F et. al.

Sep 8th, 2021 - This study aimed to investigate the distribution pattern of carbapenemases and evaluate their solitary contribution to carbapenem resistance. One hundred and twelve isolates of Acinetobacter baumannii (A. baumannii) isolated from the intensive care unit (ICU) of a southern China tertiary hospital were identified, and antimicrobial susceptibility tests (ASTs) of these strains were determined. Co...

Treatment of pulmonary infection of extensively drug-resistant Acinetobacter baumannii ...
https://doi.org/10.21037/apm-21-2112
Annals of Palliative Medicine; Xue X, Zhou T et. al.

Sep 8th, 2021 - Extensively drug-resistant Acinetobacter baumannii (XDRAB) pulmonary infection is a serious respiratory system infection. Patients are often very sick and even need to be admitted to the ICU for treatment. In this case report, we presented our treatment experience of one XDRAB pulmonary infection patient. A 71-year-old male patient was admitted to our hospital complaining of "fatigue accompanie...

Influences of cold atmospheric plasma on apoptosis related molecules in osteoblast-like...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414668
Head & Face Medicine; Eggers B, Marciniak J et. al.

Sep 5th, 2021 - Cold atmospheric plasma (CAP) has recently been identified as a novel therapeutic strategy for supporting processes of wound healing. Since CAP is additionally known to kill malignant cells, our study intends to determine the influence of CAP on crucial molecules involved in the molecular mechanism of apoptosis in osteoblast-like cells. Human osteoblast-like cells were CAP-treated for 30 and 60...

In vivo evaluation of the virucidal efficacy of chlorhexidine and povidone-iodine mouth...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080510
The Journal of Evidence-based Dental Practice; Elzein R, Abdel-Sater F et. al.

Sep 5th, 2021 - The oral cavity is potentially high-risk transmitter of COVID-19. Antimicrobial mouthrinses are used in many clinical preprocedural situations for decreasing the risk of cross-contamination in the dental setting. It is important to investigate the efficacy of mouthwash solutions against salivary SARS-CoV-2 in order to reduce the exposure of the dental team during dental procedures. The aim of t...

The Mechanisms of the Growth Inhibitory Effects of Paclitaxel on Gefitinib-resistant No...
https://doi.org/10.21873/cgp.20288
Cancer Genomics & Proteomics; Mohiuddin M, Kasahara K

Sep 5th, 2021 - Coronavirus disease 2019 (COVID-19) poses a great challenge for the treatment of cancer patients. It presents as a severe respiratory infection in aged individuals, including some lung cancer patients. COVID-19 may be linked to the progression of aggressive lung cancer. In addition, the side effects of chemotherapy, such as chemotherapy resistance and the acceleration of cellular senescence, ca...

EFFECT OF LOCALLY DELIVERED BISPHOSPHONATES ON ALVEOLAR BONE: A SYSTEMATIC REVIEW AND M...
https://doi.org/10.1016/j.jebdp.2021.101580
The Journal of Evidence-based Dental Practice; Kc K, Bhattarai BP et. al.

Sep 5th, 2021 - To assess the effect of locally applied bisphosphonate drugs on alveolar bone defects caused by periodontitis and marginal bone level after placement of dental implants. Three electronic databases (PubMed/MEDLINE, Web of Science, and Scopus) were searched from January 2010 until May 2020 for randomized controlled clinical trials reporting the effect of locally delivered bisphosphonates on alveo...

Tumor Vascular Microenvironment of Colorectal Hepatic Metastasis and Chemotherapy Respo...
https://doi.org/10.21873/anticanres.15261
Anticancer Research; Okamoto H, Shiba S et. al.

Sep 4th, 2021 - The tumor vascular microenvironment has an important role in tumor progression and metastasis. The objective of this study was to assess the significance of metastatic hepatic tumor vascular microenvironment in relation to the response to systemic fluorouracil-based chemotherapy [folinic acid/fluorouracil/oxaliplatin (FOLFOX) or folinic acid/fluorouracil/irinotecan (FOLFIRI)]. A total of 48 con...

Down-regulated MicroRNAs in Gastric Carcinoma May Be Targets for Therapeutic Interventi...
https://doi.org/10.21873/anticanres.15223
Anticancer Research; Weidle UH, Birzele F et. al.

Sep 4th, 2021 - Gastric cancer is one of the leading types of cancer with an annual death toll of 700,000 worldwide. Despite the fact that several agents are approved for its treatment, high percentage of recurrence and intractability of metastatic disease remain a major problem. The identification of new targets and modalities for treatment are therefore of high priority. We have searched the literature for m...

Telmisartan Facilitates the Anticancer Effects of CARP-1 Functional Mimetic and Sorafen...
https://doi.org/10.21873/anticanres.15226
Anticancer Research; Surapaneni SK, Nottingham E et. al.

Sep 4th, 2021 - Tyrosine kinase inhibitors (TKIs) are used for the treatment of both wild type and mutant non-small cell lung cancer (NSCLC); however, acquired resistance is a major clinical challenge. Herein, we aimed to investigate the effects of telmisartan (Tel), CFM 4.16 and sorafenib combination in rociletinib resistant NSCLC tumors. 3D spheroid cultures and western blotting were used for evaluating cyto...