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About 1,208,465 results

Remimazolam: An Updated Review of a New Sedative and Anaesthetic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675580
Drug Design, Development and Therapy; Hu Q, Liu X et. al.

Nov 23rd, 2022 - Remimazolam (CNS7056) is a novel benzodiazepine for intravenous sedation; it has an ultra-short duration of action and was recently approved for use in procedural sedation and general anaesthesia. It acts on γ-aminobutyric acid type A receptors and is rapidly converted into an inactive metabolite by tissue esterase enzymes. Remimazolam has been successfully used in endoscopic inspection or surg...

ED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentia...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675334
Drug Design, Development and Therapy; Rong X, Kou Y et. al.

Nov 23rd, 2022 - Long-term glucocorticoid- usage can lead to glucocorticoid-induced osteoporosis (GIOP). The study focused on the preventative effects of a novel active vitamin D3 analog, eldecalcitol (ED-71), against GIOP and explored the underlying molecular mechanisms. Intraperitoneal injection of methylprednisolone (MPED) or dexamethasone (DEX) induced the GIOP model within C57BL/6 mice in vivo. Simultaneou...

Prolonged inhibition of bladder function is evoked by low-amplitude electrical stimulat...
https://doi.org/10.14814/phy2.15517
Physiological Reports; Moazzam Z, Yoo PB

Nov 23rd, 2022 - To better understand the effects of saphenous nerve (SN) stimulation on bladder function, we investigated the duration of electrical stimulation as a key variable in eliciting urodynamic changes. SN stimulation is a novel approach to electrically modulating bladder function. In previous animal studies, bladder-inhibitory responses were evoked by low-amplitude (25 μA) stimulus pulses applied in ...

Selective Polyetheretherketone Implants Combined with Graphene Cause Definitive Cell Ad...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675333
International Journal of Nanomedicine; Su Z, Zhang J et. al.

Nov 23rd, 2022 - Polyetheretherketone (PEEK) has good biosafety and chemical stability for bone repair. However, PEEK is biologically inert and cannot promote bone apposition. This study investigated whether graphene-modified PEEK (G-PEEK) could improve cell adhesion and osteogenic differentiation. G-PEEK was prepared by melted blending and was characterized. In vitro, the biocompatibility of G-PPEK and the abi...

Photodynamic Therapy and Antibacterial Activities of a Novel Synthesized Quaternary Zn-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675416
International Journal of Nanomedicine; Tsolekile N, Parani S et. al.

Nov 23rd, 2022 - Photodynamic therapy (PDT) is a non-invasive treatment modality that destroys abnormally growing cells or microorganisms. Porphyrins are used as photosensitizers in PDT; however, their clinical application has been limited by their poor water solubility, resulting in aggregation and low quantum yields of reactive oxygen species (ROS). To overcome these limitations and improve PDT efficacy, we h...

Preparation, Characterization, and Staphylococcus aureus Biofilm Elimination Effect of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675332
International Journal of Nanomedicine; Zhang Z, Chen J et. al.

Nov 23rd, 2022 - Infections caused by Staphylococcus aureus (S. aureus) colonization in medical implants are resistant to antibiotics due to the formation of bacterial biofilm internal. Baicalein (BA) has been confirmed as an inhibitor of bacterial biofilm with less pronounced effects owing to its poor solubility and absorption. Studies have found that β-cyclodextrin-grafted chitosan (CD-CS) can improve drug ef...

Evaluation of the toxic effects of thimerosal and/or aluminum hydroxide in SH-SY5Y cell...
https://doi.org/10.1177/09603271221136206
Human & Experimental Toxicology; Öztürk ME, Yirün A et. al.

Nov 22nd, 2022 - In this study, we aimed to evaluate possible toxic effects of thimerosal, aluminum and combination of thimerosal and aluminum in SH-SY5Y cells. Inhibitory concentrations were determined by MTT assay; reactive oxygen species (ROS) were determined by a fluorometric kit and antioxidant/oxidant parameters were measured by spectrophotometric kits. Nuclear factor erythroid 2-associated factor 2 (Nrf2...

Human Bone Marrow Cell Extracts Mitigate Radiation Injury to Salivary Gland.
https://doi.org/10.1177/00220345221112332
Journal of Dental Research; Su X, Liu Y et. al.

Nov 22nd, 2022 - Mitigation of irradiation injury to salivary glands was previously reported using a cell-free extract from mouse bone marrow. However, to bring this potential therapy a step closer to clinical application, a human bone marrow cell extract (BMCE) needs to be tested. Here, we report that irradiation-induced injury of salivary glands in immunocompetent mice treated with human BMCE secreted 50% mor...

Antimicrobial resistance in shigellosis: A surveillance study among urban and rural chi...
https://doi.org/10.1371/journal.pone.0277574
PloS One; Nuzhat S, Das R et. al.

Nov 22nd, 2022 - Antimicrobial resistance against shigellosis is increasingly alarming. However, evidence-based knowledge gaps regarding the changing trends of shigellosis in Bangladesh exist due to the scarcity of longitudinal data on antimicrobial resistance. Our study evaluated the last 20 years antimicrobial resistance patterns against shigellosis among under-5 children in the urban and rural sites of Bangl...

48-Week effectiveness and tolerability of dolutegravir (DTG) + lamivudine (3TC) in anti...
https://doi.org/10.1371/journal.pone.0277606
PloS One; Cabello-Ubeda A, de Quirós JCLB et. al.

Nov 22nd, 2022 - The main international guidelines indicate DTG/3TC therapy as one of the preferred regimens for people living with HIV (PLWH), due to its observed efficacy in randomized clinical trials. However, information in real-life cohorts is relatively scarce for first-line use. A retrospective multicenter study of adult PLWH starting DTG+3TC as a first-line regimen before January 31st, 2020. Virological...

Evaluation of compressed sodium chloride on the inactivation of SARS-CoV-2 and surrogates.
https://doi.org/10.1371/journal.pone.0277881
PloS One; Bhavanam S, Lee B et. al.

Nov 22nd, 2022 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the global COVID-19 pandemic. Limited studies have been performed on various types of disinfectants utilized to control the spread of this highly contagious virus. This study aimed to investigate the inactivation of SARS-CoV-2 using compressed sodium chloride (CSC) surface. A real-time reverse transcriptase quantitative PCR (RT...

Temperature moderates impact of formulated moxidectin on seed germination of three temp...
https://doi.org/10.1371/journal.pone.0277865
PloS One; Eichberg C, Hartman AM et. al.

Nov 22nd, 2022 - Formulations of macrocyclic lactone anthelmintics such as moxidectin are regularly administered to sheep to combat parasites. A disadvantage of these pharmaceuticals are their side effects on non-target organisms when entering the environment. Little is known about anthelmintic effects on plant reproduction and whether the effects depend on environmental factors. For ecological and methodologic...

Maternal sevoflurane exposure affects neural stem cell differentiation in offspring rat...
https://doi.org/10.1016/j.neuro.2022.10.014
Neurotoxicology Zhang Y, Kuai S et. al.

Nov 22nd, 2022 - Studies have shown that sevoflurane, a halogenated inhalational anesthetic, interferes with neurogenesis in the developing rodent brain. However, the mechanisms by which sevoflurane affects neural stem cells (NSCs) differentiation require further elucidation. Pregnant rats (gestational day 14) were anesthetized with 3.5% sevoflurane for 2 h, with or without ML385 pretreatment. ML385 is a specif...

Optimization on the dose and time of nicaraven administration for mitigating the side e...
https://doi.org/10.1177/17534666221137277
Therapeutic Advances in Respiratory Disease; Xu Y, Abdelghany L et. al.

Nov 22nd, 2022 - Radiation-induced lung injury (RILI) is one of the serious complications of radiotherapy. We have recently demonstrated that nicaraven can effectively mitigate RILI in healthy mice. Here, we further tried to optimize the dose and time of nicaraven administration for alleviating the side effects of radiotherapy in tumor-bearing mice. A subcutaneous tumor model was established in the back of the ...

Optimization of process parameters for fabrication of electrospun nanofibers containing...
https://doi.org/10.1080/10717544.2022.2144963
Drug Delivery; Monirul Islam M, Hemmanahalli Ramesh V et. al.

Nov 22nd, 2022 - Diabetes mellitus is one of the most concerning conditions, and its chronic consequences are almost always accompanied by infection, oxidative stress, and inflammation. Reducing excessive reactive oxygen species and the wound's inflammatory response is a necessary treatment during the acute inflammatory phase of diabetic wound healing. Malva sylvestris extract (MS) containing nanofibers contain...

San-Zhong-Kui-Jian-Tang Exerts Antitumor Effects Associated With Decreased Cell Prolife...
https://doi.org/10.1177/15347354221134921
Integrative Cancer Therapies; Hsu PY, Chen JL et. al.

Nov 22nd, 2022 - Oral squamous cell carcinoma (OSCC) is an aggressive cancer whose 5-year survival rate remains poor. San-Zhong-Kui-Jian-Tang (SZKJT), a Chinese herbal formula, has long been used in clinical practice as adjuvant therapy in cancers. However, its therapeutic effects and molecular mechanisms in OSCC remain unclear. We investigated the potential therapeutic effects and molecular mechanism of SZKJT ...

Dose Adjustment of Poly (ADP‑Ribose) Polymerase Inhibitors in Patients with Hepatic or ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673935
Drug Design, Development and Therapy; Zhao D, Long X et. al.

Nov 22nd, 2022 - Poly (ADP-ribose) polymerase (PARP) inhibitors are small-molecule inhibitors of PARP enzymes (including PARP1, PARP2, and PARP3) that exhibit activity against tumor cells with defects in DNA repair. In recent years, five PARP inhibitors, olaparib, niraparib, rucaparib, talazoparib and veliparib, have been developed for the treatment of solid tumors, particularly in patients with breast-related ...

Novel Curcumin Derivative-Decorated Ultralong-Circulating Paclitaxel Nanoparticles: A N...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673813
International Journal of Nanomedicine; Wei Y, Zeng M et. al.

Nov 22nd, 2022 - Paclitaxel (PTX) has been widely utilized for the treatment of breast cancer. However, drawbacks, such as poor aqueous solubility, rapid blood clearance and severe toxicity, greatly reduce its efficacy and safety. Herein, a novel self-developed curcumin derivative (CUD) was chosen as the carrier to develop a long-acting PTX nano-delivery system (PTX-Sln@CUD) in order to improve its pharmacokine...

Macrophage-Targeted Berberine-Loaded β-Glucan Nanoparticles Enhance the Treatment of Ul...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673505
International Journal of Nanomedicine; Xu Y, Huang J et. al.

Nov 22nd, 2022 - This study focuses on constructing of an anti-inflammatory drug delivery system by encapsulation of berberine in the β-glucan nanoparticles and evaluates its effect on treating ulcerative colitis. β-Glucan and the anti-inflammatory drug berberine (BER) are self-assembled into nanoparticles to construct a drug delivery system (GLC/BER). The interaction between the drug and the carrier was charac...

Biosynthesis MgO and ZnO nanoparticles using chitosan extracted from Pimelia Payraudi L...
https://doi.org/10.1007/s11274-022-03464-5
World Journal of Microbiology & Biotechnology; Amor IB, Hemmami H et. al.

Nov 22nd, 2022 - Chitosan (CS) is one of the most abundant biopolymers in nature with superior properties such as biocompatibility, biodegradability, lack of toxicity, antimicrobial activity, acceleration of wound healing, and stimulation of the immune system. In this study, chitosan was extracted from the exoskeletons of beetles (Pimelia payraudi latreille) and then used for the biosynthesis of highly pure MgO...