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About 1,492,576 results

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.
https://doi.org/10.1056/NEJMoa1803760
The New England Journal of Medicine; Fenske W, Refardt J et. al.

Aug 1st, 2018 - The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. From 2013 to 2017, we recruited 156...

Assessing Optimal Blood Pressure in Patients With Asymptomatic Aortic Valve Stenosis: T...
https://doi.org/10.1161/CIRCULATIONAHA.115.021213
Circulation Nielsen OW, Sajadieh A et. al.

Aug 3rd, 2016 - Evidence for treating hypertension in patients with asymptomatic aortic valve stenosis is scarce. We used data from the SEAS trial (Simvastatin Ezetimibe in Aortic Stenosis) to assess what blood pressure (BP) would be optimal. A total of 1767 patients with asymptomatic aortic stenosis and no manifest atherosclerotic disease were analyzed. Outcomes were all-cause mortality, cardiovascular death,...

A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119497
The American Journal of Psychiatry; Phillips ML, Swartz HA

Mar 14th, 2014 - In this critical review, the authors appraise neuroimaging findings in bipolar disorder in emotion-processing, emotion-regulation, and reward-processing neural circuitry in order to synthesize the current knowledge of the neural underpinnings of bipolar disorder and provide a neuroimaging research road map for future studies. The authors examined findings from all major studies in bipolar disor...

Subclinical thyroid disease.
https://doi.org/10.1016/S0140-6736(11)60276-6
Lancet (London, England); Cooper DS, Biondi B

Jan 25th, 2012 - Subclinical thyroid diseases--subclinical hyperthyroidism and subclinical hypothyroidism--are common clinical entities that encompass mild degrees of thyroid dysfunction. The clinical significance of mild thyroid overactivity and underactivity is uncertain, which has led to controversy over the appropriateness of diagnostic testing and possible treatment. In this Seminar, we discuss the definit...

Clinical review: Central hypothyroidism: pathogenic, diagnostic, and therapeutic challe...
https://doi.org/10.1210/jc.2012-1616
The Journal of Clinical Endocrinology and Metabolism; Persani L

Aug 1st, 2012 - Central hypothyroidism (CH) is a particular hypothyroid condition due to an insufficient stimulation by TSH of an otherwise normal thyroid gland. This condition raises several challenges for clinicians; therefore, a review of the most relevant findings on CH epidemiology, pathogenesis, and clinical management has been performed. The relevant papers were selected by a PubMed search using appropr...

Testosterone dose-response relationships in hysterectomized women with or without oopho...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701202
Menopause (New York, N.Y.); Huang G, Basaria S et. al.

Nov 27th, 2013 - This study aims to determine the dose-dependent effects of testosterone on sexual function, body composition, muscle performance, and physical function in hysterectomized women with or without oophorectomy. Seventy-one postmenopausal women who previously underwent hysterectomy with or without oophorectomy and had total testosterone levels less than 31 ng/dL or free testosterone levels less than...

Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159743
Neuron Tang G, Gudsnuk K et. al.

Aug 26th, 2014 - Developmental alterations of excitatory synapses are implicated in autism spectrum disorders (ASDs). Here, we report increased dendritic spine density with reduced developmental spine pruning in layer V pyramidal neurons in postmortem ASD temporal lobe. These spine deficits correlate with hyperactivated mTOR and impaired autophagy. In Tsc2 ± ASD mice where mTOR is constitutively overactive, we ...

Causes of pulmonary hypertension in the elderly.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077408
Chest Pugh ME, Sivarajan L et. al.

Jan 31st, 2014 - Pulmonary hypertension (PH) is common in elderly patients, but a detailed analysis of the causes of PH in the elderly has not been performed. We hypothesized that pulmonary arterial hypertension (PAH) is rare in elderly patients and sought to describe the characteristics of these patients at a large referral center. Clinical and hemodynamic data were collected on consecutive patients ≥ 65 years...

Metformin for the treatment of the polycystic ovary syndrome.
https://doi.org/10.1056/NEJMct0707092
The New England Journal of Medicine; Nestler JE

Jan 3rd, 2008 - Metformin for the treatment of the polycystic ovary syndrome.|2008|Nestler JE,|blood,adverse effects,therapeutic use,physiology,adverse effects,therapeutic use,complications,complications,drug therapy,physiopathology,blood,

Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women:...
https://doi.org/10.7326/M14-0353
Annals of Internal Medicine; Harman SM, Black DM et. al.

Jul 29th, 2014 - Whether menopausal hormone therapy (MHT) protects against cardiovascular disease (CVD) remains unclear. To assess atherosclerosis progression and CVD risk factors after MHT initiated in early menopause. Randomized, controlled trial. (ClinicalTrials.gov: NCT00154180). Nine U.S. academic centers. Healthy menopausal women aged 42 to 58 years between 6 and 36 months from last menses without prior C...

Midodrine for orthostatic hypotension and recurrent reflex syncope: A systematic review.
https://doi.org/10.1212/WNL.0000000000000815
Neurology Izcovich A, González Malla C et. al.

Aug 25th, 2014 - Symptomatic orthostatic hypotension (SOH) and recurrent reflex syncope (RRS) can be disabling. Midodrine has been proposed in the management of patients with these conditions but its impact on patient important outcomes remains uncertain. We performed a systematic review to evaluate the efficacy and safety of midodrine in patients with SOH and RRS. We searched multiple electronic databases with...

Low bone mineral density in patients with well-suppressed HIV infection: association wi...
https://doi.org/10.1093/infdis/jiu499
The Journal of Infectious Diseases; Kooij KW, Wit FW et. al.

Sep 2nd, 2014 - Human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) may both contribute to the higher prevalence of osteoporosis and osteopenia in HIV-infected individuals. Using dual-energy X-ray absorptiometry, we compared lumbar spine, total hip, and femoral neck bone mineral density (BMD) in 581 HIV-positive (94.7% receiving cART) and 520 HIV-negative participants of the AGEhIV...

School start times for adolescents.
https://doi.org/10.1542/peds.2014-1697
Pediatrics , et. al.

Aug 26th, 2014 - The American Academy of Pediatrics recognizes insufficient sleep in adolescents as an important public health issue that significantly affects the health and safety, as well as the academic success, of our nation's middle and high school students. Although a number of factors, including biological changes in sleep associated with puberty, lifestyle choices, and academic demands, negatively affe...

2019 Canadian guideline for physical activity throughout pregnancy.
https://doi.org/10.1136/bjsports-2018-100056
British Journal of Sports Medicine; Mottola MF, Davenport MH et. al.

Oct 19th, 2018 - The objective is to provide guidance for pregnant women and obstetric care and exercise professionals on prenatal physical activity. The outcomes evaluated were maternal, fetal or neonatal morbidity, or fetal mortality during and following pregnancy. Literature was retrieved through searches of MEDLINE, EMBASE, PsycINFO, Cochrane Database of Systematic Reviews, Cochrane Central Register of Cont...

Impaired bone and muscle development in young people treated with antiepileptic drugs.
https://doi.org/10.1111/epi.13893
Epilepsia Simm PJ, Seah S et. al.

Sep 7th, 2017 - Antiepileptic drugs (AEDs) are associated with reduced bone density, balance impairment, and increased fracture risk in adults. However, pediatric data are limited. Therefore, we aimed to examine bone, muscle, and balance outcomes in young patients taking AEDs. We undertook a case-control study utilizing an AED exposure-discordant matched-pair approach. Subjects were aged 5-18 years with at lea...

Hepatitis B reactivation in patients with previous hepatitis B virus exposure undergoin...
https://doi.org/10.1200/JCO.2014.56.7081
Journal of Clinical Oncology : Official Journal of the Am... Seto WK, Chan TS et. al.

Oct 7th, 2014 - Patterns of hepatitis B virus (HBV) reactivation in hepatitis B surface antigen (HBsAg) -negative, antihepatitis B core antigen antibody (anti-HBc) -positive patients with lymphoma receiving rituximab-containing chemotherapy have not been well described. HBsAg-negative, anti-HBc-positive Chinese patients with undetectable serum HBV DNA (< 10 IU/mL), diagnosed with hematologic malignancies and r...

Longitudinal recovery patterns of penile length and the underexplored benefit of long-t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941788
BMC Urology; Kwon YS, Farber N et. al.

May 9th, 2018 - Penile length (PL) shortening is an underreported phenomenon following radical prostatectomy (RP) and risk factors are not fully explored. We aimed to describe longitudinal patterns of PL recovery and evaluate factors predicting complete return to baseline PL. PL measurement was performed during a preoperative and postoperative follow-up visits at 7 days and 3, 6, 9, and 12 months. Patients who...

The effectiveness of cricoid pressure for occluding the esophageal entrance in anesthet...
https://doi.org/10.1213/ANE.0000000000000068
Anesthesia and Analgesia; Zeidan AM, Salem MR et. al.

Feb 21st, 2014 - In the last 2 decades, the effectiveness of cricoid pressure (CP) in occluding the esophageal entrance has been questioned. Recent magnetic resonance imaging studies yielded conflicting conclusions. We used real-time visual and mechanical means to assess the patency of the esophageal entrance with and without CP in anesthetized and paralyzed adult patients. One hundred seven, nonobese ASA physi...

Effect of gravity on volume of placental transfusion: a multicentre, randomised, non-in...
https://doi.org/10.1016/S0140-6736(14)60197-5
Lancet (London, England); Vain NE, Satragno DS et. al.

Apr 21st, 2014 - Delayed cord clamping allows for the passage of blood from the placenta to the baby and reduces the risk of iron deficiency in infancy. To hold the infant for more than 1 min at the level of the vagina (as is presently recommended), on the assumption that gravity affects the volume of placental transfusion, is cumbersome, might result in low compliance, and interferes with immediate contact of ...

Bleeding patterns during the menopausal transition in the multi-ethnic Study of Women's...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199918
BJOG : an International Journal of Obstetrics and Gynaeco... Paramsothy P, Harlow SD et. al.

Apr 16th, 2014 - Previous studies describing menses duration and heaviness of flow during the menopausal transition (MT) have been short in duration and limited to white women. We estimated the frequency of and risk factors for prolonged bleeding, spotting and heavy bleeding during the MT in an ethnically diverse population. Prospective community-based cohort study. southeastern Michigan, northern California an...