×
About 1,898,063 results

Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426591
Molecular Medicine (Cambridge, Mass.); Duarte RRR, Copertino DC et. al.

Sep 11th, 2021 - Vaccination programs have been launched worldwide to halt the spread of COVID-19. However, the identification of existing, safe compounds with combined treatment and prophylactic properties would be beneficial to individuals who are waiting to be vaccinated, particularly in less economically developed countries, where vaccine availability may be initially limited. We used a data-driven approach...

The use of head helmets to deliver noninvasive ventilatory support: a comprehensive rev...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424168
Critical Care (London, England); Coppadoro A, Zago E et. al.

Sep 10th, 2021 - A helmet, comprising a transparent hood and a soft collar, surrounding the patient's head can be used to deliver noninvasive ventilatory support, both as continuous positive airway pressure and noninvasive positive pressure ventilation (NPPV), the latter providing active support for inspiration. In this review, we summarize the technical aspects relevant to this device, particularly how to prev...

Latent Epstein-Barr virus infection status and prognosis in patients with newly diagnos...
https://doi.org/10.1080/16078454.2021.1971864
Hematology (Amsterdam, Netherlands); Wang C, Zou SP et. al.

Sep 9th, 2021 - This study aimed to investigate the latent Epstein-Barr virus (EBV) infection status of patients with newly diagnosed Hodgkin lymphoma (HL) and to discuss the relationship between tumor cell EBV status and the prognosis of HL patients. A total of 134 previously untreated HL patients were analyzed in the study. Epstein-Barr virus encoded RNAs (EBERs) in situ hybridization was performed to detect...

The association between physical activity, sedentary time and health-related quality of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419900
Health and Quality of Life Outcomes; Yan R, Che B et. al.

Sep 8th, 2021 - Although physical activity (PA) and sedentary time in cancer survivors (CSs) were associated with health-related quality of life (HRQOL), it was not clear whether their associations were similar among CSs with different number of comorbid chronic diseases (CCDs). This study aimed to investigate the associations between PA, sedentary time and HRQOL in CSs with different number of CCDs. A cross-s...

C-terminal domain phosphatase-like 1 (CPL1) is involved in floral transition in Arabido...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418720
BMC Genomics; Yuan C, Xu J et. al.

Sep 7th, 2021 - RNA polymerase II plays critical roles in transcription in eukaryotic organisms. C-terminal Domain Phosphatase-like 1 (CPL1) regulates the phosphorylation state of the C-terminal domain of RNA polymerase II subunit B1, which is critical in determining RNA polymerase II activity. CPL1 plays an important role in miRNA biogenesis, plant growth and stress responses. Although cpl1 mutant showes dela...

β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome ...
https://doi.org/10.1038/s41467-021-25596-2 10.1038/nrg.2016.112 10.1096/fj.201700753R 10.1038/nrm.2017.101 10.1371/journal.pgen.1007846 10.1074/mcp.M111.015099 10.1038/ng.3734 10.1016/j.pbi.2019.03.008 10.1101/gad.326488.119 10.1074/jbc.RA118.006620 10.1128/MCB.25.24.11047-11058.2005 10.1038/nature11243 10.1038/nature04733 10.3390/epigenomes3030017 10.1007/s00441-014-2011-9 10.1074/jbc.M309198200 10.1016/j.cell.2011.11.054 10.1074/jbc.M605370200 10.1128/MCB.06222-11 10.1073/pnas.1722219115 10.1002/stem.2304 10.1002/jcb.25148 10.1016/j.conb.2017.12.008 10.1016/j.celrep.2018.11.035 10.1101/gr.131508.111 10.1016/j.ccell.2018.11.014 10.1038/s41586-019-1115-5 10.1016/j.molcel.2004.05.026 10.1016/j.cell.2005.03.013 10.1126/science.1076469 10.1126/science.1181369 10.1038/s41423-019-0269-2 10.1016/j.isci.2018.04.021 10.1038/nature11082 10.1101/gr.201624.115 10.1038/nature23881 10.1016/j.tig.2015.11.001 10.1038/nature22822 10.1038/nature22989 10.1016/j.molcel.2017.12.011 10.1016/j.molcel.2014.05.029 10.1038/ncomms10291 10.1016/j.devcel.2013.08.016 10.1101/gad.17288211 10.1016/j.cell.2017.02.007 10.1126/sciadv.aay6515 10.1002/advs.202002261 10.1186/s13059-014-0550-8 10.1186/1471-2164-15-583 10.1093/bioinformatics/btp616 10.1016/j.molcel.2010.05.004 10.1093/nar/gky504 10.1038/s41467-017-02088-w 10.1093/bioinformatics/btq033 10.1093/bioinformatics/btp698 10.1093/nar/gkw257 10.1186/gb-2008-9-9-r137 10.1038/s41467-019-09234-6
Nature Communications; Mahmood SR, Xie X et. al.

Sep 4th, 2021 - β-actin is a crucial component of several chromatin remodeling complexes that control chromatin structure and accessibility. The mammalian Brahma-associated factor (BAF) is one such complex that plays essential roles in development and differentiation by regulating the chromatin state of critical genes and opposing the repressive activity of polycomb repressive complexes (PRCs). While previous ...

Neural evidence for lexical parafoveal processing.
https://doi.org/10.1038/s41467-021-25571-x 10.1126/science.504987 10.1016/0010-0285(85)90013-1 10.3758/BF03203972 10.2307/747752 10.1016/S1364-6613(00)01619-3 10.3758/s13414-011-0219-2 10.1017/S0140525X03000104 10.1037/0033-295X.105.1.125 10.1111/j.1469-8986.2011.01169.x 10.1016/j.tics.2008.12.002 10.1016/j.cogsys.2005.07.002 10.3758/PBR.16.1.1 10.1080/13506285.2013.873508 10.1037/a0030910 10.1016/S0042-6989(01)00301-7 10.1037/0033-295X.112.4.777 10.1037/rev0000119 10.1037/0096-1523.34.1.205 10.1037/xge0000494 10.1037/xlm0000128 10.1037/a0027735 10.1037/a0034997 10.1037/0096-1523.33.5.1250 10.1016/j.neuroimage.2019.03.056 10.1523/JNEUROSCI.3134-20.2021 10.1111/psyp.12765 10.1038/366153a0 10.1016/j.visres.2004.07.037 10.1037/0096-3445.135.1.12 10.1016/j.jml.2017.04.001 10.3389/fnhum.2013.00361 10.1111/cogs.12246 10.1016/j.cogpsych.2012.03.001 10.1016/j.neuroimage.2005.11.048 10.1097/00001756-199807130-00009 10.1097/00001756-200102120-00007 10.1016/j.tics.2019.04.006 10.1126/science.841308 10.1016/j.tics.2011.04.003 10.1016/j.tics.2013.11.005 10.1093/cercor/bhs365 10.1016/0010-0285(75)90005-5 10.1016/j.neuroimage.2012.04.006 10.1080/17470210902816461 10.3758/BF03212147 10.1080/09541440340000150 10.1037/a0023885 10.1016/j.tics.2003.09.010 10.1027/0269-8803.19.3.204 10.1016/j.neuropsychologia.2012.04.011 10.1016/j.neuroimage.2007.07.035 10.3758/PBR.16.3.561 10.1037/a0033670 10.1371/journal.pone.0173720 10.1037/a0029710 10.1016/j.tics.2009.12.003 10.1002/ana.410400206 10.1016/S0893-6080(00)00071-X 10.1016/j.jneumeth.2007.02.011 10.1073/pnas.98.2.694 10.1088/0031-9155/48/22/002 10.3758/BF03206399
Nature Communications; Pan Y, Frisson S et. al.

Sep 4th, 2021 - In spite of the reduced visual acuity, parafoveal information plays an important role in natural reading. However, competing models on reading disagree on whether words are previewed parafoveally at the lexical level. We find neural evidence for lexical parafoveal processing by combining a rapid invisible frequency tagging (RIFT) approach with magnetoencephalography (MEG) and eye-tracking. In a...

Electrode pooling can boost the yield of extracellular recordings with switchable silic...
https://doi.org/10.1038/s41467-021-25443-4 10.1038/nature24636 10.1021/acs.nanolett.6b02673 10.1016/j.neuron.2019.08.011 10.1109/JRPROC.1949.232969 10.1109/TBCAS.2010.2041350 10.1109/JSSC.2003.819174 10.3390/s17102388 10.1039/C5TB00108K 10.1039/C5LC00133A 10.1109/TBCAS.2016.2646901 10.1097/00004647-200110000-00001 10.1109/JMEMS.2012.2206564 10.1109/PROC.1968.6458 10.1152/jn.2000.84.1.401 10.1523/JNEUROSCI.0656-12.2012 10.1088/0954-898X_9_4_001 10.7554/eLife.55167 10.1109/MSP.2008.4408439 10.1109/JSSC.2005.858479 10.1109/TBCAS.2014.2359180 10.1109/JMEMS.2011.2167661 10.1109/JSSC.2017.2686580 10.3390/jlpea9030026 10.1016/j.jneumeth.2016.02.022
Nature Communications; Lee KH, Ni YL et. al.

Sep 4th, 2021 - State-of-the-art silicon probes for electrical recording from neurons have thousands of recording sites. However, due to volume limitations there are typically many fewer wires carrying signals off the probe, which restricts the number of channels that can be recorded simultaneously. To overcome this fundamental constraint, we propose a method called electrode pooling that uses a single wire to...

Identification of the similarly expressed genes in patients with polycystic ovary syndr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415929
Medicine Dong R, Gao S et. al.

Sep 4th, 2021 - Polycystic ovary syndrome (PCOS) is a common female infertility, which may be caused by excessive androgen, but its mechanism remains unknown. Transsexuals are women who take androgen drugs for a long time, and gradually have male signs. Their ovaries may have received high concentrations of androgen, which leads to the failure of ovarian reproductive function. Therefore, we searched the releva...

Physical exercise keeps the brain connected by increasing white matter integrity in hea...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415959
Medicine Bashir S, Al-Sultan F et. al.

Sep 4th, 2021 - Physical exercise leads to structural changes in the brain. However, it is unclear whether the initiation or continuous practice of physical exercise causes this effect and whether brain connectivity benefits from exercise. We examined the effect of 6 months of exercise on the brain in participants who exercise regularly (n = 25) and in matched healthy controls (n = 20). Diffusion tensor imagin...

Prolidase expression in knee osteoarthritis and healthy controls: Observational study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415933
Medicine Silva-Luna K, Ventura-Ríos L et. al.

Sep 4th, 2021 - Prolidase enzyme activity is important for collagen resynthesis. In late stages of osteoarthritis (OA) its activity is decreased.To evaluate prolidase expression in knees of patients undergoing total arthroplasty for OA, and compare with young people undergoing knee arthroscopy due to traumatic injuries.In this cross-sectional study we included 20 patients with OA grade IV who underwent total k...

To evaluate the microcirculation of retinochoroid capillary between acute and chronic c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415977
Medicine Lu H, Wang Z et. al.

Sep 4th, 2021 - To investigate the difference in chorioretinal microcirculation between acute central serous chorioretinopathy (aCSC) and chronic central serous chorioretinopathy (cCSC) using optical coherence tomography angiography.In total, 65 patients previously diagnosed with central serous chorioretinopathy (33 aCSC and 32 cCSC) were included in our cross-sectional study. All patients underwent complete o...

Cardiopulmonary function findings of pediatric patients with patent ductus arteriosus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415991
Medicine Huang HY, Wang SP et. al.

Sep 4th, 2021 - Transcatheter occlusion and surgical ligation are the treatments of choice for most patent ductus arteriosus (PDA) in children. Fifty-five children who had PDA completed a pulmonary function test and a symptom-limited treadmill exercise test from 2016 to 2018 at 1 medical center in southern Taiwan. The study group was divided into surgical ligation and catheterization groups, which were compare...

The effects of additional electrical stimulation combined with repetitive transcranial ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416012
Medicine Kang JH, Kim MW et. al.

Sep 4th, 2021 - To evaluate the therapeutic effects of additional electrical stimulation (ES) combined with low frequency (LF)-repetitive transcranial magnetic stimulation (rTMS) and motor imagery (MI) training on upper extremity (UE) motor function following stroke. The participants with subacute stroke in the experimental group (n = 8) received LF rTMS + MI + active ES interventions, and those in control gro...

The ability to kneel before and after total knee arthroplasty : the role of the pattern...
https://doi.org/10.1302/0301-620X.103B9.BJJ-2020-2129.R2
The Bone & Joint Journal; Scott CEH, Holland G et. al.

Sep 2nd, 2021 - The aims of this study were to investigate the ability to kneel after total knee arthroplasty (TKA) without patellar resurfacing, and its effect on patient-reported outcome measures (PROMs). Secondary aims included identifying which kneeling positions were most important to patients, and the influence of radiological parameters on the ability to kneel before and after TKA. This prospective long...

Changes in the distribution of fitness effects and adaptive mutational spectra followin...
https://doi.org/10.1038/s41467-021-25440-7 10.1126/science.aan1425 10.1098/rstb.2018.0237 10.1016/j.cell.2016.08.002 10.1371/journal.pgen.1008365 10.1038/s41564-019-0552-0 10.1098/rstb.2019.0102 10.1073/pnas.1616132114 10.1111/mec.12312 10.1093/molbev/msv033 10.1098/rspb.2012.2146 10.1038/nrg3483 10.1111/j.1095-8312.2006.00629.x 10.1186/s12862-015-0424-z 10.1371/journal.pgen.1007958 10.1371/journal.pgen.1007284 10.1126/science.1212986 10.1126/science.aar4416 10.1016/j.cub.2018.01.009 10.1038/s41559-019-0993-0 10.1371/journal.pbio.1002591 10.1093/molbev/msz144 10.1093/molbev/msq024 10.1038/s41559-016-0061 10.1111/evo.12958 10.1534/genetics.110.123083 10.1098/rspb.2000.1030 10.1186/s12862-016-0662-8 10.1126/science.1250939 10.1126/science.1203799 10.1126/science.1203801 10.1371/journal.pgen.1002056 10.1016/j.ygeno.2014.10.011 10.1038/nature18959 10.1038/ng.280 10.1038/nature24287 10.1038/nrg3937 10.1038/nature12344 10.1038/s41559-018-0758-1 10.1038/s41586-019-1749-3 10.1111/evo.12868 10.1038/nature14279 10.1016/j.cub.2018.01.062 10.1371/journal.pgen.1007396 10.1093/molbev/msx185 10.1371/journal.pgen.1005635 10.1371/journal.pgen.1004041 10.1371/journal.pgen.0020145 10.1038/s41467-019-11540-y 10.1093/molbev/mss019 10.1371/journal.pbio.2001872 10.1128/MMBR.70.1.253-282.2006 10.1263/jbb.104.245 10.1016/j.mad.2019.02.003 10.1021/acs.jproteome.8b00012 10.1002/1873-3468.13463 10.1089/omi.2010.0069 10.1002/(SICI)1097-0061(199812)14:16<1511::AID-YEA356>3.0.CO;2-S 10.1007/s004380050017 10.1073/pnas.1909987116 10.1111/1567-1364.12157 10.1111/1574-6976.12065 10.1016/S0021-9258(19)77815-6 10.1371/journal.pbio.3000757 10.1146/annurev.genet.40.110405.090613 10.1073/pnas.1921881117 10.1126/science.aag0822 10.1073/pnas.1410631112 10.1002/yea.320080703 10.1534/g3.116.034207 10.1093/bioinformatics/btx655 10.1038/ncomms13270 10.1371/journal.pone.0128036 10.14806/ej.17.1.200 10.1093/bioinformatics/btp324 10.4161/fly.19695
Nature Communications; Aggeli D, Li Y et. al.

Sep 2nd, 2021 - Historical contingency and diminishing returns epistasis have been typically studied for relatively divergent genotypes and/or over long evolutionary timescales. Here, we use Saccharomyces cerevisiae to study the extent of diminishing returns and the changes in the adaptive mutational spectra following a single first adaptive mutational step. We further evolve three clones that arose under iden...

A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces po...
https://doi.org/10.1038/s41467-021-25506-6 10.1038/nrc3239 10.1111/cts.12391 10.1038/mt.2016.134 10.1158/0008-5472.CAN-14-3017 10.1073/pnas.0308054101 10.1093/jnci/djy033 10.1038/s41573-019-0029-0 10.1038/nrc3770 10.1038/mt.2011.217 10.1172/JCI122287 10.1016/j.omtm.2020.01.001 10.1073/pnas.1904022116 10.1038/s41416-019-0574-7 10.2147/OV.S154494 10.1128/JVI.03276-13 10.1038/mto.2016.21 10.1038/mt.2010.98 10.1016/j.ebiom.2018.04.020 10.1038/mt.2009.318 10.1080/2162402X.2018.1445459 10.1038/nature14001 10.1038/nri.2017.140 10.3389/fimmu.2018.00610 10.1158/2326-6066.CIR-17-0102 10.1080/2162402X.2018.1512329 10.1002/ijc.32325 10.1038/mt.2009.194 10.1080/2162402X.2019.1629259 10.1016/j.it.2017.11.006 10.1038/nbt.4327 10.1016/j.cell.2017.08.027 10.1080/2162402X.2017.1393598 10.1016/j.ccell.2017.04.003 10.1158/1078-0432.CCR-19-1868 10.1016/j.ccell.2019.05.004 10.1146/annurev.immunol.15.1.749 10.3389/fimmu.2019.00219 10.1080/2162402X.2019.1673125 10.1038/s41591-018-0198-0 10.1016/j.immuni.2016.06.001 10.1016/j.vaccine.2003.07.003 10.1093/nar/gkv468
Nature Communications; Das K, Belnoue E et. al.

Sep 2nd, 2021 - Functional tumor-specific cytotoxic T cells elicited by therapeutic cancer vaccination in combination with oncolytic viruses offer opportunities to address resistance to checkpoint blockade therapy. Two cancer vaccines, the self-adjuvanting protein vaccine KISIMA, and the recombinant oncolytic vesicular stomatitis virus pseudotyped with LCMV-GP expressing tumor-associated antigens, termed VSV-G...

B-SOiD, an open-source unsupervised algorithm for identification and fast prediction of...
https://doi.org/10.1038/s41467-021-25420-x 10.1016/j.bbr.2012.04.045 10.1523/JNEUROSCI.23-06-02459.2003 10.1016/S0168-1699(02)00019-4 10.1038/nmeth.2281 10.1016/j.jneumeth.2017.05.026 10.1098/rsif.2014.0672 10.1073/pnas.1607601113 10.1088/1478-3975/14/1/015002 10.1016/j.cell.2017.06.032 10.1371/journal.pcbi.1000028 10.1126/science.1250298 10.1016/j.neuron.2015.11.031 10.1523/JNEUROSCI.0264-07.2007 10.1037/a0026955 10.1016/j.neuron.2019.01.038 10.1038/s41592-018-0234-5 10.1038/nbt.4314 10.1371/journal.pgen.1008432 10.1126/science.aaz9468 10.1016/0166-4328(87)90242-7 10.1016/j.cell.2018.04.019 10.1007/BF01074656 10.1016/0166-2236(89)90074-X 10.1523/JNEUROSCI.23-27-09078.2003 10.1002/mds.27321 10.1097/j.pain.0000000000001843 10.1038/nature17639 10.1016/S0896-6273(01)00575-X 10.1016/j.cell.2013.04.017 10.1016/j.immuni.2016.04.014 10.1007/s00371-019-01673-y
Nature Communications; Hsu AI, Yttri EA

Sep 2nd, 2021 - Studying naturalistic animal behavior remains a difficult objective. Recent machine learning advances have enabled limb localization; however, extracting behaviors requires ascertaining the spatiotemporal patterns of these positions. To provide a link from poses to actions and their kinematics, we developed B-SOiD - an open-source, unsupervised algorithm that identifies behavior without user bi...

Do the Renal Function Parameters of Serum and Salivary Urea and Creatinine Alter in Smo...
https://www.ncbi.nlm.nih.gov/pubmed/34463293
The Journal of Contemporary Dental Practice; Basavarajappa S, Shahira

Sep 1st, 2021 - To evaluate and correlate the salivary urea and creatinine levels to the serum levels in smokeless tobacco (SLT) chewers. The present study included 60 subjects, 30 SLT chewers, and 30 controls aged between 20 years and 60 years. Serum and salivary urea and creatinine levels were estimated using Berthelot-urease method enzymatic colorimetric method and modified Jaffe's method, respectively. The...

Optimization and validation of RT-LAMP assay for diagnosis of SARS-CoV2 including the g...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404189
Virology Journal; Jamwal VL, Kumar N et. al.

Sep 1st, 2021 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 pandemic, has infected more than 179 million people worldwide. Testing of infected individuals is crucial for identification and isolation, thereby preventing further spread of the disease. Presently, Taqman™ Reverse Transcription Real Time PCR is considered gold standard, and is the most common techni...