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About 962,970 results

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.
https://doi.org/10.1056/NEJMoa1803760
The New England Journal of Medicine; Fenske W, Refardt J et. al.

Aug 1st, 2018 - The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. From 2013 to 2017, we recruited 156...

Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney...
https://doi.org/10.1053/j.gastro.2017.05.046
Gastroenterology Klatte DCF, Gasparini A et. al.

Jun 6th, 2017 - Proton pump inhibitors (PPI) have been associated with acute kidney injury and recent studies suggest that they may be associated with the risk of chronic kidney disease (CKD). We performed a retrospective analysis using the Stockholm creatinine measurements database, which contains information on diagnoses, dispensation claims, and laboratory test results for all citizens in the Stockholm regi...

Time to Epinephrine Administration and Survival From Nonshockable Out-of-Hospital Cardi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940513
Circulation Hansen M, Schmicker RH et. al.

Mar 7th, 2018 - Previous studies have demonstrated that earlier epinephrine administration is associated with improved survival from out-of-hospital cardiac arrest (OHCA) with shockable initial rhythms. However, the effect of epinephrine timing on patients with nonshockable initial rhythms is unclear. The objective of this study was to measure the association between time to epinephrine administration and surv...

Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome...
https://doi.org/10.1001/jama.2019.4149
JAMA Nordberg P, Taccone FS et. al.

May 7th, 2019 - Therapeutic hypothermia may increase survival with good neurologic outcome after cardiac arrest. Trans-nasal evaporative cooling is a method used to induce cooling, primarily of the brain, during cardiopulmonary resuscitation (ie, intra-arrest). To determine whether prehospital trans-nasal evaporative intra-arrest cooling improves survival with good neurologic outcome compared with cooling init...

Effect of Natriuretic Peptide-Guided Therapy on Hospitalization or Cardiovascular Morta...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605776
JAMA Felker GM, Anstrom KJ et. al.

Aug 22nd, 2017 - The natriuretic peptides are biochemical markers of heart failure (HF) severity and predictors of adverse outcomes. Smaller studies have evaluated adjusting HF therapy based on natriuretic peptide levels ("guided therapy") with inconsistent results. To determine whether an amino-terminal pro-B-type natriuretic peptide (NT-proBNP)-guided treatment strategy improves clinical outcomes vs usual car...

Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217655
JAMA Castro M, King TS et. al.

May 19th, 2014 - In asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes. It is not known if supplementing inhaled corticosteroids with oral vitamin D3 improves outcomes in patients with asthma and vitamin D insufficiency. To evaluate if vitamin D supplementation would improve the clinical efficacy of inhaled corticosteroids in patients with symptomatic asthma and lower vitamin...

2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: exe...
https://doi.org/10.1161/CIR.0000000000000040
Circulation January CT, Wann LS et. al.

Mar 31st, 2014 - 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society.|2014|January CT,Wann LS,Alpert JS,Calkins H,Cigarroa JE,|standards,physiopathology,therapy,standards,standards,

A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119497
The American Journal of Psychiatry; Phillips ML, Swartz HA

Mar 14th, 2014 - In this critical review, the authors appraise neuroimaging findings in bipolar disorder in emotion-processing, emotion-regulation, and reward-processing neural circuitry in order to synthesize the current knowledge of the neural underpinnings of bipolar disorder and provide a neuroimaging research road map for future studies. The authors examined findings from all major studies in bipolar disor...

The neuropsychiatry of tinnitus: a circuit-based approach to the causes and treatments ...
https://doi.org/10.1136/jnnp-2013-307339
Journal of Neurology, Neurosurgery, and Psychiatry; Minen MT, Camprodon J et. al.

Apr 19th, 2014 - Patients presenting with tinnitus commonly have neuropsychiatric symptoms with which physicians need to be familiar. We provide an overview of tinnitus, including its types and pathophysiology. We discuss how recent methods such as transcranial magnetic stimulation, positron emission tomography, MRI, magnetoencephalography and quantitative EEG improve our understanding of the pathophysiology of...

Simvastatin for the prevention of exacerbations in moderate-to-severe COPD.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375247
The New England Journal of Medicine; Criner GJ, Connett JE et. al.

May 19th, 2014 - Retrospective studies have shown that statins decrease the rate and severity of exacerbations, the rate of hospitalization, and mortality in chronic obstructive pulmonary disease (COPD). We prospectively studied the efficacy of simvastatin in preventing exacerbations in a large, multicenter, randomized trial. We designed the Prospective Randomized Placebo-Controlled Trial of Simvastatin in the ...

Randomised clinical trial: The beneficial effects of VSL#3 in obese children with non-a...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046270
Alimentary Pharmacology & Therapeutics; Alisi A, Bedogni G et. al.

Apr 17th, 2014 - Gut microbiota modifiers may have beneficial effects of non-alcoholic fatty liver disease (NAFLD) but randomised controlled trials (RCT) are lacking in children. To perform a double-blind RCT of VSL#3 vs. placebo in obese children with biopsy-proven NAFLD. Of 48 randomised children, 44 (22 VSL#3 and 22 placebo) completed the study. The main outcome was the change in fatty liver severity at 4 mo...

CPAP, weight loss, or both for obstructive sleep apnea.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138510
The New England Journal of Medicine; Chirinos JA, Gurubhagavatula I et. al.

Jun 11th, 2014 - Obesity and obstructive sleep apnea tend to coexist and are associated with inflammation, insulin resistance, dyslipidemia, and high blood pressure, but their causal relation to these abnormalities is unclear. We randomly assigned 181 patients with obesity, moderate-to-severe obstructive sleep apnea, and serum levels of C-reactive protein (CRP) greater than 1.0 mg per liter to receive treatment...

Incidence of clinically important biphasic reactions in emergency department patients w...
https://doi.org/10.1016/j.annemergmed.2013.10.017
Annals of Emergency Medicine; Grunau BE, Li J et. al.

Nov 18th, 2013 - Allergic reactions are common presentations to the emergency department (ED). An unknown proportion of patients will develop biphasic reactions, and patients are often monitored for prolonged periods to manage potential reactions. We seek to determine the incidence of clinically important biphasic reactions. Consecutive adult patients presenting to 2 urban EDs with allergic reactions during a 5...

Subclinical thyroid disease.
https://doi.org/10.1016/S0140-6736(11)60276-6
Lancet (London, England); Cooper DS, Biondi B

Jan 25th, 2012 - Subclinical thyroid diseases--subclinical hyperthyroidism and subclinical hypothyroidism--are common clinical entities that encompass mild degrees of thyroid dysfunction. The clinical significance of mild thyroid overactivity and underactivity is uncertain, which has led to controversy over the appropriateness of diagnostic testing and possible treatment. In this Seminar, we discuss the definit...

CPAP versus oxygen in obstructive sleep apnea.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172401
The New England Journal of Medicine; Gottlieb DJ, Punjabi NM et. al.

Jun 11th, 2014 - Obstructive sleep apnea is associated with hypertension, inflammation, and increased cardiovascular risk. Continuous positive airway pressure (CPAP) reduces blood pressure, but adherence is often suboptimal, and the benefit beyond management of conventional risk factors is uncertain. Since intermittent hypoxemia may underlie cardiovascular sequelae of sleep apnea, we evaluated the effects of no...

Relationships among stressful life events and physiological markers, treatment adherenc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145025
The Journal of Pediatrics; Walders-Abramson N, Venditti EM et. al.

Jun 20th, 2014 - To examine the relationships between stressful life events and physiological measures, adherence to prescribed oral medication regimens, depressive symptoms, and impaired quality of life (QoL) in adolescents with recent-onset type 2 diabetes (T2D). Data were collected from 497 ethnically diverse participants (66% female) in the final year of the Treatment Options for Type 2 Diabetes in Adolesce...

Type 1 diabetes through the life span: a position statement of the American Diabetes As...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865481
Diabetes Care; Chiang JL, Kirkman MS et. al.

Jun 17th, 2014 - Type 1 diabetes through the life span: a position statement of the American Diabetes Association.|2014|Chiang JL,Kirkman MS,Laffel LM,Peters AL, ,|complications,physiopathology,therapy,

Vitamin C supplementation for pregnant smoking women and pulmonary function in their ne...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296045
JAMA McEvoy CT, Schilling D et. al.

May 19th, 2014 - Maternal smoking during pregnancy adversely affects offspring lung development, with lifelong decreases in pulmonary function and increased asthma risk. In a primate model, vitamin C blocked some of the in-utero effects of nicotine on lung development and offspring pulmonary function. To determine if newborns of pregnant smokers randomized to receive daily vitamin C would have improved results ...

Nonselective β blockers increase risk for hepatorenal syndrome and death in patients wi...
https://doi.org/10.1053/j.gastro.2014.03.005
Gastroenterology Mandorfer M, Bota S et. al.

Mar 18th, 2014 - Nonselective β blockers (NSBBs) reduce portal pressure and the risk for variceal hemorrhage in patients with cirrhosis. However, development of spontaneous bacterial peritonitis (SBP) in these patients could preclude treatment with NSBBs because of their effects on the circulatory reserve. We investigated the effects of NSBBs in patients with cirrhosis and ascites with and without SBP. We perfo...

Long-term mortality risk in individuals with atrial or ventricular premature complexes ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334655
The American Journal of Cardiology; Qureshi W, Shah AJ et. al.

May 13th, 2014 - Premature ectopic beats are frequently detected on routine 12-lead screening electrocardiograms (ECGs). However, their prognostic importance in subjects without known cardiovascular disease (CVD) is not well established. We evaluated prognostic value of atrial premature complexes (APCs) and ventricular premature complexes (VPCs) detected by a single 12-lead electrocardiography. A prospective co...