About 1,269,455 results

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Tas2R activation relaxes airway smooth muscle by release of Gαt targeting on AChR signa...
Proceedings of the National Academy of Sciences of the Un... Zhou YW, Sun J et. al.

Jun 24th, 2022 - Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory diseases. Bitter receptor-mediated bronchodilation is a potential therapy for asthma, but the mechanism underlying the agonistic relaxation of airway smooth muscle (ASM) is not well defined. By exploring the ASM relaxation mechanism of bitter substances, we observed that pretreatment with the bitter substances n...

The science behind COVID's assault on smell.
https://doi.org/10.1038/d41586-022-01627-w 10.1016/j.cell.2022.01.024 10.1021/acschemneuro.0c00210 10.1126/sciadv.abc5801 10.1183/13993003.01948-2020 10.1016/j.cell.2021.10.027 10.1126/scitranslmed.abf8396 10.1038/s41588-021-00986-w 10.1021/acschemneuro.1c00542 10.1126/scitranslmed.abq3059
Nature Dolgin E

Jun 23rd, 2022 - The science behind COVID's assault on smell.|2022|Dolgin E,|physiopathology,virology,pathogenicity,

Activation of STIM1/Orai1‑mediated SOCE in sepsis‑induced myocardial depression.
Molecular Medicine Reports; Ye J, Li M et. al.

Jun 18th, 2022 - Unbalanced Ca2+ homeostasis serves an essential role in the occurrence and development of septic myocardial injury. However, the mechanism of Ca2+ homeostasis in septic myocardial depression is poorly understood due to the complexity of Ca2+ transporters in excitable cells. It was therefore hypothesized that cardiac dysfunction, myocardial injury and cardiac apoptosis in septic myocardial depre...

A syntax-lexicon trade-off in language production.
Proceedings of the National Academy of Sciences of the Un... Rezaii N, Mahowald K et. al.

Jun 17th, 2022 - Spoken language production involves selecting and assembling words and syntactic structures to convey one's message. Here we probe this process by analyzing natural language productions of individuals with primary progressive aphasia (PPA) and healthy individuals. Based on prior neuropsychological observations, we hypothesize that patients who have difficulty producing complex syntax might choo...

Temporal relations between peripheral and central arousals in good and poor sleepers.
Proceedings of the National Academy of Sciences of the Un... Ribeiro A, Gabriel R et. al.

Jun 14th, 2022 - Good sleepers and patients with insomnia symptoms (poor sleepers) were tracked with two measures of arousal; conventional polysomnography (PSG) for electroencephalogram (EEG) assessed cortical arousals, and a peripheral arterial tonometry device was used for the detection of peripheral nervous system (PNS) arousals associated with vasoconstrictions. The relationship between central (cortical) a...

Control of tertiary lymphoid tissue revealed.
American Journal of Transplantation : Official Journal Of... Cravedi P, Li XC

Jun 9th, 2022 - Control of tertiary lymphoid tissue revealed.|2022|Cravedi P,Li XC,|prevention & control,physiopathology,

Uses of GFR and Albuminuria Level in Acute and Chronic Kidney Disease.
The New England Journal of Medicine; Levey AS, Grams ME et. al.

Jun 2nd, 2022 - Uses of GFR and Albuminuria Level in Acute and Chronic Kidney Disease.|2022|Levey AS,Grams ME,Inker LA,|etiology,complications,physiopathology,urine,complications,physiopathology,urine,

Treatment with the soluble guanylate cyclase activator BAY 60-2770 normalizes bladder f...
European Journal of Pharmacology; Aydogdu O, Perez F et. al.

Jun 2nd, 2022 - Chronic pelvic pain syndrome (CPPS) is a common and bothersome condition for which no pharmacological treatment options with acceptable efficacy exist. The aim of this study was to investigate the effects of the soluble guanylate cyclase (sGC) activator BAY 60-2770 and the COX-2 inhibitor celecoxib on bladder function in a rat model of CPPS. Forty-eight male Sprague-Dawley rats were intraprosta...

Multiscale neural signatures of major depressive, anxiety, and stress-related disorders.
Proceedings of the National Academy of Sciences of the Un... Zhukovsky P, Wainberg M et. al.

Jun 2nd, 2022 - SignificanceMajor depressive, anxiety, and stress-related disorders are highly comorbid and may affect similar neurocircuitry and cognitive processes. However, the neurocircuitry underlying shared dimensions of cognitive impairment is unclear and holds the promise of reimagining psychiatric nosology. Here we leverage population imaging data (n = 27,132) to show that while major depressive and a...

Causes of Shoulder Dysfunction in Diabetic Patients: A Review of Literature.
International Journal of Environmental Research and Publi... Struyf F, Mertens MG et. al.

May 29th, 2022 - Understanding the underlying mechanisms behind shoulder dysfunctions in patients with diabetes mellitus. Systematic qualitative literature review. Patients with shoulder dysfunctions and diagnosed with impaired glucose tolerance or diabetes mellitus. Published scientific literature containing evidence about the mechanisms of shoulder dysfunctions in the diabetic population. Articles were select...

Pathophysiology of bilateral hyperaldosteronism.
Current Opinion in Endocrinology, Diabetes, and Obesity; Nanba K, Rainey WE

May 28th, 2022 - Renin-independent aldosterone production from one or both affected adrenal(s), a condition known as primary aldosteronism (PA), is a common cause of secondary hypertension. In this review, we aimed to summarize recent findings regarding pathophysiology of bilateral forms of PA, including sporadic bilateral hyperaldosteronism (BHA) and rare familial hyperaldosteronism. The presence of subcapsula...

Development and Evaluation of Pediatric Versions of the Vanderbilt Fatigue Scale for Ch...
Journal of Speech, Language, and Hearing Research : JSLHR; Hornsby BWY, Camarata S et. al.

May 28th, 2022 - Growing evidence suggests that fatigue associated with listening difficulties is particularly problematic for children with hearing loss (CHL). However, sensitive, reliable, and valid measures of listening-related fatigue do not exist. To address this gap, this article describes the development, psychometric evaluation, and preliminary validation of a suite of scales designed to assess listenin...

Progressive Worsening of Neurological Manifestations in HIV-Associated Opportunistic Ce...
The American Journal of Case Reports; Hanif F, Satiti S et. al.

May 26th, 2022 - BACKGROUND The iceberg phenomenon (in which the most of a problem is invisible) of people living with HIV/AIDS, particularly those with unknown HIV status, has been epidemiologically challenging. Central nervous system (CNS) opportunistic infections in patients with HIV/AIDS are one of the leading causes of morbidity and mortality in people living with HIV/AIDS. There are currently limited data...

Neuropathic pain caused by miswiring and abnormal end organ targeting.
Nature Gangadharan V, Zheng H et. al.

May 26th, 2022 - Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as well as a loss of sensation in the areas in which injured and non-injured nerves come together1-3. The mechanisms that disambiguate these mixed and paradoxical symptoms are unknown. Here we longitudinally and non-invasively imaged genetically labelled populations of fibres that sense noxious stimuli (n...

Kidney Denervation Results in Lasting Blood Pressure Control.
JAMA Slomski A

May 25th, 2022 - Kidney Denervation Results in Lasting Blood Pressure Control.|2022|Slomski A,|physiology,methods,methods,diagnosis,physiopathology,surgery,therapy,innervation,physiopathology,

Identification and validation of aging-related genes in COPD based on bioinformatics an...
Aging Zhong S, Yang L et. al.

May 25th, 2022 - Chronic obstructive pulmonary disease (COPD) is a serious chronic respiratory disorder. One of the major risk factors for COPD progression is aging. Therefore, we investigated aging-related genes in COPD using bioinformatic analyses. Firstly, the Aging Atlas database containing 500 aging-related genes and the Gene Expression Omnibus database (GSE38974) were utilized to screen candidates. A tota...

Head rotation improves airway obstruction, especially in patients with less severe obst...
PloS One; Tan SN, Kim JM et. al.

May 25th, 2022 - Head rotation is thought to have an effect on obstructive sleep apnea (OSA) severity. However, keeping the head rotated fully during sleep is difficult to maintain, and the effect of head rotation is not the same in all OSA patients. Thus, this study aimed to identify whether less head rotation has an effect on airway patency and determine the responder characteristics to the head rotation mane...

Ocular and Hemodynamic Factors Contributing to the Central Visual Function in Glaucoma ...
Investigative Ophthalmology & Visual Science; Hong KE, Kim SA et. al.

May 24th, 2022 - The purpose of this study was to investigate the ocular and hemodynamic factors contributing to the central visual function in glaucoma patients with myopia. This study was a prospective observational study, which included 236 eyes of 140 patients with normal-tension glaucoma (NTG), which includes 114 eyes with mild myopia (axial length ≥24 and <26 mm) and 122 eyes with moderate-to-severe myopi...

Species- and strain-level assessment using rrn long-amplicons suggests donor's influenc...
Gut Microbes; Benítez-Páez A, Hartstra AV et. al.

May 24th, 2022 - Fecal microbiota transplantation (FMT) is currently used for treating Clostridium difficile infection and explored for other clinical applications in experimental trials. However, the effectiveness of this therapy could vary, and partly depend on the donor's bacterial species engraftment, whose evaluation is challenging because there are no cost-effective strategies for accurately tracking the ...