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About 1,251,578 results

Obesity as a mortality risk factor in the medical ward: a case control study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733434
BMC Endocrine Disorders; Soffer S, Zimlichman E et. al.

Jan 8th, 2022 - Research regarding the association between severe obesity and in-hospital mortality is inconsistent. We evaluated the impact of body mass index (BMI) levels on mortality in the medical wards. The analysis was performed separately before and during the COVID-19 pandemic. We retrospectively retrieved data of adult patients admitted to the medical wards at the Mount Sinai Health System in New York...

Visual Field Characteristics in East Asian Patients With Occult Macular Dystrophy (Miya...
https://doi.org/10.1167/iovs.63.1.12
Investigative Ophthalmology & Visual Science; Ahn SJ, Yang L et. al.

Jan 8th, 2022 - The purpose of this study was to investigate the perimetric features and their associations with structural and functional features in patients with RP1L1-associated occult macular dystrophy (OMD; i.e. Miyake disease). In this international, multicenter, retrospective cohort study, 76 eyes of 38 patients from an East Asian cohort of patients with RP1L1-associated OMD were recruited. Visual fiel...

Longitudinal In Vivo Changes in Radial Peripapillary Capillaries and Optic Nerve Head S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742514
Investigative Ophthalmology & Visual Science; Musial G, Adhikari S et. al.

Jan 8th, 2022 - There is conflicting evidence regarding whether a loss of radial peripapillary capillaries (RPCs) precedes neuronal loss in glaucoma. We examined the time course of in vivo changes in RPCs, optic nerve head (ONH) structure, and retinal nerve fiber layer thickness (RNFLT) in experimental glaucoma (EG). Spectral domain optical coherence tomography images were acquired before and approximately eve...

Pathogenic Mechanism of Dry Eye-Induced Chronic Ocular Pain and a Mechanism-Based Thera...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742529
Investigative Ophthalmology & Visual Science; Tei Y, Mikami Y et. al.

Jan 7th, 2022 - Dry eye-induced chronic ocular pain is also called ocular neuropathic pain. However, details of the pathogenic mechanism remain unknown. The purpose of this study was to elucidate the pathogenic mechanism of dry eye-induced chronic pain in the anterior eye area and develop a pathophysiology-based therapeutic strategy. We used a rat dry eye model with lacrimal gland excision (LGE) to elucidate t...

Contrast Sensitivity and Stereoacuity in Successfully Treated Refractive Amblyopia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742522
Investigative Ophthalmology & Visual Science; Jia Y, Ye Q et. al.

Jan 7th, 2022 - To assess whether monocular contrast sensitivity and stereoacuity impairments remain when visual acuity is fully recovered in children with refractive amblyopia. A retrospective review of 487 patients diagnosed with refractive amblyopia whose visual acuity improved to 0.08 logMAR or better in both eyes following optical treatment was conducted. Measurements of monocular contrast sensitivity and...

Respiratory effects of lung recruitment maneuvers depend on the recruitment-to-inflatio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727044
Critical Care (London, England); Zerbib Y, Lambour A et. al.

Jan 6th, 2022 - In the context of acute respiratory distress syndrome (ARDS), the response to lung recruitment maneuvers (LRMs) varies considerably from one patient to another and so is difficult to predict. The aim of the study was to determine whether or not the recruitment-to-inflation (R/I) ratio could differentiate between patients according to the change in lung mechanics during the LRM. We evaluated the...

A 12-hospital prospective evaluation of a clinical decision support prognostic algorith...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730444
PloS One; Lupei MI, Li D et. al.

Jan 6th, 2022 - To prospectively evaluate a logistic regression-based machine learning (ML) prognostic algorithm implemented in real-time as a clinical decision support (CDS) system for symptomatic persons under investigation (PUI) for Coronavirus disease 2019 (COVID-19) in the emergency department (ED). We developed in a 12-hospital system a model using training and validation followed by a real-time assessme...

Visual classification of three computed tomography lung patterns to predict prognosis o...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721943
BMC Pulmonary Medicine; Yamada D, Ohde S et. al.

Jan 5th, 2022 - Quantitative evaluation of radiographic images has been developed and suggested for the diagnosis of coronavirus disease 2019 (COVID-19). However, there are limited opportunities to use these image-based diagnostic indices in clinical practice. Our aim in this study was to evaluate the utility of a novel visually-based classification of pulmonary findings from computed tomography (CT) images of...

Sildenafil for treating patients with COVID-19 and perfusion mismatch: a pilot randomiz...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721481
Critical Care (London, England); Santamarina MG, Beddings I et. al.

Jan 5th, 2022 - SARS-CoV-2 seems to affect the regulation of pulmonary perfusion. Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation-perfusion mismatch that can be characterized using subtraction computed tomography angiography (sCTA). This study aims to evaluate the efficacy of oral sildenafil in treating COVID-19 inpatients showing perfusion abnormalities in sCTA. Triple-blinded,...

Blur Representation in the Amblyopic Visual System Using Natural and Synthetic Images.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742520
Investigative Ophthalmology & Visual Science; Abbas Farishta R, Yang CL et. al.

Jan 5th, 2022 - Amblyopia is diagnosed as a reduced acuity in an otherwise healthy eye, which indicates that the deficit is not happening in the eye, but in the brain. One suspected mechanism explaining these deficits is an elevated amount of intrinsic blur in the amblyopic visual system compared to healthy observers. This "internally produced blur" can be estimated by the "equivalent intrinsic blur method", w...

Current Status of Metastatic Cardiophrenic Lymph Nodes (CPLNs) in Patients With Ovarian...
https://doi.org/10.21873/anticanres.15452
Anticancer Research; Acs M, Piso P et. al.

Jan 1st, 2022 - One of the most common sites of extra-abdominal disease spread of advanced stage ovarian cancer is the cardiophrenic lymph node (CPLN) region. The role and impact of extra-abdominal cytoreduction is not obvious in patients with cardiophrenic lymph node metastases. We examined the relevant and currently available literature to determine the prognostic value and management of enlarged CPLNs in ov...

Moderate Intensity Endurance and Resistance Exercise Attenuates Cachexia in Tumor-beari...
https://doi.org/10.21873/anticanres.15498
Anticancer Research; Wood NR, Garritson J et. al.

Jan 1st, 2022 - Cancer cachexia encompasses several deleterious physiological alterations associated with functional impairments, poor quality of life, and increased mortality. The aim of this study was to examine the effects of chronic moderate intensity exercise training on markers of cachexia. Balb/c mice were randomly assigned to sedentary (SED) or exercise (EX) groups and EX mice were further randomly ass...

Functionality Assessment of Patients With Cleft Hands.
https://doi.org/10.1097/SCS.0000000000008022
The Journal of Craniofacial Surgery; Rosa MFF, do Monte TM et. al.

Dec 31st, 2021 - Ectrodactyly, commonly referred to as cleft hand, is a rare pathology characterized by a deficiency and/or complete absence of the central ray in each hand. In order to customize treatment and improve the patient's quality of life, a more detailed functional evaluation is required. Although several studies evaluate functionality in different types of cleft hands, there are only a few studies th...

Decreased Choroidal Blood Perfusion Induces Myopia in Guinea Pigs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740532
Investigative Ophthalmology & Visual Science; Zhou X, Zhang S et. al.

Dec 31st, 2021 - The development of myopia in guinea pigs can be inhibited by attenuating scleral hypoxia by increasing choroidal blood perfusion (ChBP). In this study, we reduced ChBP through surgical and pharmacological methods to determine the effect on myopia development. We also determined whether ChBP was reduced by quinpirole, a drug that enhances form-deprivation myopia (FDM). ChBP was reduced in the ri...

Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726722
Gut Microbes; Sencio V, Machelart A et. al.

Dec 30th, 2021 - Mounting evidence suggests that the gut-to-lung axis is critical during respiratory viral infections. We herein hypothesized that disruption of gut homeostasis during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may associate with early disease outcomes. To address this question, we took advantage of the Syrian hamster model. Our data confirmed that this model recapitu...

Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727307
Investigative Ophthalmology & Visual Science; You QS, Camino A et. al.

Dec 30th, 2021 - The purpose of this study was to assess the associations between baseline choriocapillaris (CC) flow deficits and geographic atrophy (GA) progression. In this prospective cohort study, patients with GA underwent 3 × 3-mm macular spectral-domain optical coherence tomographic angiography (OCTA) at baseline and follow-up visits. Annual GA enlargement rate was defined as change of square root of GA...

Quantification of stroke volume in a simulated healthy volunteer model of traumatic hae...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699736
PloS One; Hutchings SD, Watchorn J et. al.

Dec 24th, 2021 - Haemorrhage is a leading cause of death following traumatic injury and the early detection of hypovolaemia is critical to effective management. However, accurate assessment of circulating blood volume is challenging when using traditional vital signs such as blood pressure. We conducted a study to compare the stroke volume (SV) recorded using two devices, trans-thoracic electrical bioimpedance ...

The diagnostic accuracy and prognostic value of OCT for the evaluation of the visual fu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699950
PloS One; Nuijts MA, Imhof SM et. al.

Dec 24th, 2021 - To systematically review the evidence on the diagnostic accuracy and prognostic value of retinal optical coherence tomography (OCT) to detect visual acuity (VA) or visual field (VF) loss in children with a brain tumour. PubMed, Embase and Cochrane Library databases were searched from inception to February 2021. We included studies evaluating retinal OCT and standard visual function parameters (...

Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreati...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699632
PloS One; Weegh N, Zentrich E et. al.

Dec 24th, 2021 - Laboratory animals frequently undergo routine experimental procedures such as handling, restraining and injections. However, as a known source of stress, these procedures potentially impact study outcome and data quality. In the present study, we, therefore, performed an evidence-based severity assessment of experimental procedures used in a pancreatic cancer model including surgical tumour ind...

Recent trends of refractive surgery rate and detailed analysis of subjects with refract...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699644
PloS One; Lee Y, Kim JS et. al.

Dec 24th, 2021 - The present study was conducted to investigate recent trends of refractive surgery rates and analyze subjects undergoing refractive surgery using large-scale population studies over the past 8 years. We used the dataset of the Korean National Health and Nutrition Examination Surveys, a nationwide population-based cross-sectional study which were performed from 2008 to 2015. Of the 21,415 partic...