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About 1,270,813 results

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
https://doi.org/10.1002/art.41752
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising c...

Finerenone and Heart Failure Outcomes by Kidney Function/Albuminuria in Chronic Kidney ...
https://doi.org/10.1016/j.jchf.2022.07.013
JACC. Heart Failure; Filippatos G, Anker SD et. al.

Nov 4th, 2022 - In patients with type 2 diabetes (T2D), risks of cardiovascular mortality and heart failure (HF) increase with decreasing kidney function (estimated glomerular filtration rate [eGFR]) and increasing albuminuria (urine albumin-to-creatinine ratio [UACR]). Finerenone, a selective, nonsteroidal mineralocorticoid receptor antagonist, improved cardiorenal outcomes in patients with chronic kidney dis...

Inflammation fuels bone marrow exhaustion caused by Samd9l mutation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621124
The Journal of Clinical Investigation; Jung M

Nov 2nd, 2022 - Sterile α motif domain-containing 9 (SAMD9) and SAMD9-like (SAMD9L) syndromes are inherited bone marrow failure syndromes known for their frequent development of myelodysplastic syndrome with monosomy 7. In this issue of the JCI, Abdelhamed, Thomas, et al. report a mouse model with a hematopoietic cell-specific heterozygous Samd9l mutation knockin. This mouse model resembles human disease in ma...

Post-operative electrical muscle stimulation attenuates loss of muscle mass and functio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9621149
Age and Ageing; Hardy EJ, Hatt J et. al.

Nov 1st, 2022 - Significant losses of muscle mass and function occur after major abdominal surgery. Neuromuscular electrical stimulation (NMES) has been shown to reduce muscle atrophy in some patient groups, but evidence in post-operative patients is limited. This study assesses the efficacy of NMES for attenuating muscle atrophy and functional declines following major abdominal surgery in older adults. Fiftee...

Establishment of Clinical Construct of Intrinsic Capacity in Older Adults and Its Predi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594878
Clinical Interventions in Aging; Waris M, Upadhyay AD et. al.

Oct 29th, 2022 - The World Health Organization has conceptualised the health and healthcare of older adults around the concept of healthy ageing. Healthy ageing is defined as "the process of developing and maintaining the functional ability that enables well-being in older age". This functional ability is the sum of two key factors: intrinsic capacity and interacting environment. This concept of intrinsic capac...

Effectiveness of Physical Exercise on Alzheimer's disease. A Systematic Review.
https://doi.org/10.14283/jpad.2022.57
The Journal of Prevention of Alzheimer's Disease; Cámara-Calmaestra R, Martínez-Amat A et. al.

Oct 26th, 2022 - A systematic review of randomized controlled trials was conducted to determine the effect of physical exercise on physical-functional capacity, cognitive performance, neuropsychiatric symptoms, and quality of life in a population of older people with Alzheimer´s disease. Pubmed, Scopus, PEDro, Web of Science, CINAHL, Cochrane Library, grey literature and a reverse search from inception to April...

Atrial Fibrillation as a Disorder of Heart-Brain Communication.
https://doi.org/10.1016/j.jacep.2022.07.021
JACC. Clinical Electrophysiology; Khalsa SS, Verdonk C

Oct 21st, 2022 - Atrial Fibrillation as a Disorder of Heart-Brain Communication.|2022|Khalsa SS,Verdonk C,|physiopathology,physiology,physiology,

Influence of baseline arterial stiffness on effects of intensive compared with standard...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583479
BMC Medicine; Song Q, Ling Q et. al.

Oct 20th, 2022 - The benefits and risks of intensive versus standard systolic blood pressure (SBP) treatment in older patients with arterial stiffness (AS) remains unclear. This study aims to investigate the interaction between the baseline AS and SBP treatments on cardiovascular outcomes. In this post hoc analysis of the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial,...

Hepatic T1-Time Predicts Cardiovascular Risk in All-Comers Referred for Cardiovascular ...
https://doi.org/10.1161/CIRCIMAGING.122.014716
Circulation. Cardiovascular Imaging; Mascherbauer K, Donà C et. al.

Oct 19th, 2022 - Liver damage is frequently observed in patients with cardiovascular disease but infrequently quantified. We hypothesized that in patients with cardiovascular disease undergoing cardiac magnetic resonance, liver T1-times indicate liver damage and are associated with cardiovascular outcome. We measured hepatic T1-times, displayed on standard cardiac T1-maps, in an all-comer cardiac magnetic reson...

Insight into postural control in unilateral sensorineural hearing loss and vestibular h...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576045
PloS One; Lubetzky AV, Kelly JL et. al.

Oct 18th, 2022 - This pilot study aimed to identify postural strategies in response to sensory perturbations (visual, auditory, somatosensory) in adults with and without sensory loss. We tested people with unilateral peripheral vestibular hypofunction (N = 12, mean age 62 range 23-78), or with Unilateral Sensorineural Hearing Loss (USNHL, N = 9, 48, 22-82), or healthy controls (N = 21, 52, 28-80). Postural sway...

Implications of Neural Plasticity in Retinal Prosthesis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586139
Investigative Ophthalmology & Visual Science; Caravaca-Rodriguez D, Gaytan SP et. al.

Oct 18th, 2022 - Retinal degenerative diseases such as retinitis pigmentosa cause a progressive loss of photoreceptors that eventually prevents the affected person from perceiving visual sensations. The absence of a visual input produces a neural rewiring cascade that propagates along the visual system. This remodeling occurs first within the retina. Then, subsequent neuroplastic changes take place at higher vi...

Short-term Evaluation of Visual Quality, Amplitude of Accommodation, and Stereoacuity B...
https://doi.org/10.3928/1081597X-20220919-02
Journal of Refractive Surgery (Thorofare, N.J. : 1995); Long Y, Li X et. al.

Oct 11th, 2022 - To compare the visual quality, accommodation, and stereoacuity between patients with a myopia magnitude of -3.00 to -8.50 diopters (D) who underwent ICLV4c (STAAR Surgical) implantation and small incision lenticule extraction (SMILE). The visual quality parameters, amplitude of accommodation (AMP), and stereoacuity were compared between and within the ICLV4c and SMILE groups (40 eyes/group) wit...

Mediating role of cognitive status on performance in the two-minute step test and its n...
https://doi.org/10.1111/ggi.14489
Geriatrics & Gerontology International; Ibrahim A, Singh DKA et. al.

Oct 9th, 2022 - The two-minute step test (2MST) has been used to estimate cardiorespiratory fitness and optimum scores are needed for performing activities of daily living with ease among older persons. However, there is limited information on the mediating role of cognitive impairment on 2MST performance and the 2MST normative data. Hence, we aim to identify the mediating role of cognitive status on performan...

Post-viral fatigue in COVID-19: A review of symptom assessment methods, mental, cogniti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528075
Neuroscience and Biobehavioral Reviews; Campos MC, Nery T et. al.

Oct 7th, 2022 - Coronavirus 2 is responsible for Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), and the main sequela is persistent fatigue. Post-viral fatigue is common and affects patients with mild, asymptomatic coronavirus disease-2019 (COVID-19). However, the exact mechanisms involved in developing post-COVID-19 fatigue remain unclear. Furthermore, physical and cognitive impairments in these...

Escape from breast tumor dormancy: The convergence of obesity and menopause.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9564105
Proceedings of the National Academy of Sciences of the Un... Roy R, Yang J et. al.

Oct 4th, 2022 - Obesity is associated with an increased risk of, and a poor prognosis for, postmenopausal (PM) breast cancer (BC). Our goal was to determine whether diet-induced obesity (DIO) promotes 1) shorter tumor latency, 2) an escape from tumor dormancy, and 3) an acceleration of tumor growth and to elucidate the underlying mechanism(s). We have developed in vitro assays and PM breast tumor models comple...

Prevención y manejo de la colestasis asociada a la nutrición parenteral y la enfermedad...
https://doi.org/10.1159/000526555
World Review of Nutrition and Dietetics; Frazer LC, Gura KM et. al.

Sep 30th, 2022 - Prevención y manejo de la colestasis asociada a la nutrición parenteral y la enfermedad hepática asociada a la insuficiencia intestinal en los lactantes críticamente enfermos.|2022|Frazer LC,Gura KM,Bines JE,Puder M,Martin CR,|physiopathology,

Impaired hemodynamic response to exercise in patients with peripheral artery disease: e...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602942
American Journal of Physiology. Regulatory, Integrative A... Craig JC, Hart CR et. al.

Sep 27th, 2022 - An exaggerated mean arterial blood pressure (MAP) response to exercise in patients with peripheral artery disease (PAD), likely driven by inflammation and oxidative stress and, perhaps, required to achieve an adequate blood flow response, is well described. However, the blood flow response to exercise in patients with PAD actually remains equivocal. Therefore, eight patients with PAD and eight ...

Muscle contractile exercise through a belt electrode device prevents myofiber atrophy, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506634
PloS One; Honda Y, Takahashi A et. al.

Sep 24th, 2022 - Immobilization of skeletal muscles causes muscle atrophy, muscle contracture, and muscle pain, the mechanisms of which are related to macrophage accumulation. However, muscle contractile exercise through a belt electrode device may mitigate macrophage accumulation. We hypothesized that such exercise would be effective in preventing myofiber atrophy, muscle contracture, and muscular pain. This s...

Sexual function and fertility of adult males with anorectal malformations or Hirschspru...
https://doi.org/10.1007/s00383-022-05216-w
Pediatric Surgery International; Reppucci ML, Wehrli LA et. al.

Sep 24th, 2022 - The long-term impact of anorectal malformations (ARM) and Hirschsprung disease (HD) on sexual function is well recognized but understudied. This study evaluated self-reported sexual and fertility outcomes in adult males with ARM and HD. This was an IRB approved, prospective study of males in the Adult Colorectal Research Registry who completed surveys between October 2019 and March 2022. Electr...

Oncogenic β-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522414
Proceedings of the National Academy of Sciences of the Un... Liu F, Gai X et. al.

Sep 20th, 2022 - CTNNB1, encoding β-catenin protein, is the most frequently altered proto-oncogene in hepatic neoplasms. In this study, we studied the significance and pathological mechanism of CTNNB1 gain-of-function mutations in hepatocarcinogenesis. Activated β-catenin not only triggered hepatic tumorigenesis but also exacerbated Tp53 deletion or hepatitis B virus infection-mediated liver cancer development ...