Annals of Clinical and Laboratory Science; Rohr D, Ali M
Aug 29th, 2021 - In this study, we evaluated the analytical interference of glycolic acid on several lactate assays that use lactate oxidase and dehydrogenase. Herein, we tested the effect of different concentrations of glycolic acid (0.01-46mM) on the lactate assay by using central lab and point of care (POCT) analyzers: Radiometer ABL 800, Beckman AU480, Roche Cobas c502, and Abbott i-STAT. Glycolic acid conc...
MMWR. Morbidity and Mortality Weekly Report; Liu S, O'Donnell J et. al.
Aug 27th, 2021 - Nonfatal and fatal drug overdoses increased overall from 2019 to 2020 (1).* Illicit benzodiazepines (e.g., etizolam, flualprazolam, and flubromazolam)† were increasingly detected among postmortem and clinical samples in 2020, often with opioids,§ and might have contributed to overall increases in drug overdoses. Availability of recent multistate trend data on nonfatal benzodiazepine-involved ov...
Forensic Science International; Hickey TBM, MacNeil JA et. al.
Jul 24th, 2021 - Unintentional exposure to nitrite- or nitrate-containing toxic salts is a recognized cause of acquired methemoglobinemia (MetHb). This systemic alteration of the blood can be fatal if not recognized and treated promptly. The intentional ingestion of sodium nitrite (NaNO2) or sodium nitrate (NaNO3), causing MetHb, is an uncommon and recently identified method of suicide, with the first reported ...
Forensic Science International; Ottaviano V, Tavone AM et. al.
Jul 18th, 2021 - Toxicology investigation on human's buried dead bodies is a rare and challenging task in the forensic field. As requested by the Judicial Authority, this work aimed to verify testimonial evidence that emerged during a criminal investigation involving multiple murder cases. The statements indicated an improper medical administration of one or more alleged drugs (propofol, morphine, diazepam, and...
Experimental and Clinical Psychopharmacology; Dolan SB, Johnson MW et. al.
Jul 16th, 2021 - As fatal overdoses from synthetic opioids continue to rise, we need to understand decision-making processes underlying heroin and synthetic opioid use. This study evaluated the influence of sample impurity and fatal overdose risk on hypothetical heroin use. Individuals who currently use heroin (n = 69) were recruited online. Participants completed two probability-discounting tasks evaluating th...
Medicine Jun-Hua S, Jin-Song Z et. al.
Jul 8th, 2021 - To studied epidemiological characteristics of 493 cases of acute poisoning in Nantong city, Jiangsu province.Based on the analysis platform of poisoning treatment, adopted single center and prospective investigation method, analyzed data of acute poisoning patients from May 2015 to December 2018 in the second affiliated hospital of Nantong University.Among 493 patients with acute poisoning, men...
The Cochrane Database of Systematic Reviews; Li LR, Chaudhary B et. al.
Jul 1st, 2021 - This an update of a Cochrane Review. Paraquat is a widely used herbicide, but is also a lethal poison. In some low- and middle-income countries (LMICs) paraquat is commonly available and inexpensive, making poisoning prevention difficult. Most of the people poisoned by paraquat have taken it as a means of self-poisoning. Standard treatment for paraquat poisoning prevents further absorption and ...
The Nurse Practitioner; Richardson KJ, Schwinck JL et. al.
Jun 18th, 2021 - Organophosphate poisoning.|2021|Richardson KJ,Schwinck JL,Robinson MV,|adverse effects,nursing,poisoning,
Clinical Pediatrics; Takia L, Awasthi P et. al.
Jun 11th, 2021 - Pregabalin Toxicity Induced Encephalopathy Reverted With Hemodialysis: A Case Report.|2021|Takia L,Awasthi P,Ezhumalai G,Agrawal N,Jayashree M,|poisoning,chemically induced,therapy,poisoning,methods,
Forensic Science International; Taus F, Pigaiani N et. al.
Jun 8th, 2021 - In recent years, a significant increase of reports about suicidal cases due to intentional sodium nitrite intake has been described. In the forensic pathology context, the strategy to approach intoxication cases by sodium nitrite, without any preliminary information or hint, is not straightforward. Indeed, in a number of cases the lack of crime scene data and/or specific pathological signs make...
Forensic Science International; Mehamha H, Doudka N et. al.
Jun 7th, 2021 - France is the country with the highest prevalence of cannabis use in Europe, despite the fact that cannabis has not been legalized. This prevalence is still increasing along with THC content in cannabis products. In the meantime, unintentional cannabis poisoning by ingestion in toddlers is constantly rising. The aim of this study was to document children's cannabis poisoning biologically and cl...
Forensic Science International; Gicquel T, Richeval C et. al.
May 29th, 2021 - Continuous development and rapid turnover of drug market of new psychoactive substances (NPS) make it difficult to obtain up-to-date analytical methods for efficient detection of intoxication cases with new substances: no analytical data and no previously published concentration values in biological samples are indeed available. In this context, we aim to report the first fatal case involving t...
Forensic Science International; Jarsiah P, Roehrich J et. al.
May 22nd, 2021 - GHB related acids (3,4-dihydroxy butyric acid, 2,4-dihydroxy butyric acid and glycolic acid) are produced through oxidative GHB metabolism. These analytes could be potential biomarkers to ensure the diagnosis of a GHB intoxication and even prolong the detection window. Within this study, forensic routine cases were measured to consider the potential of additional gas chromatographic mass spectr...
Forensic Science International; Kriikku P, Ojanperä I
May 18th, 2021 - Post-mortem findings of gabapentinoids have often been connected to drug abuse and especially opioid use. We aimed to investigate whether gabapentinoids have been implicated in the cause of death without the presence of opioids. In a three-year study period from 2016 to 2018, a total of 907 Finnish post-mortem cases positive for pregabalin or gabapentin were found. In nearly half of the pregaba...
Forensic Science International; Carelli C, Freni F et. al.
May 18th, 2021 - We report a case in which a tapentadol acute intoxication was suspected as the cause of death of a 39-year-old man: approximately two days after death, cardiac and femoral blood, as well as urine, bile, gastric content and chest hair, were collected during the autopsy. Tapentadol was detected before and after hydrolysis in femoral (530 ng/mL unconjugated and 1570 ng/mL conjugated) and cardiac (...
Undersea & Hyperbaric Medicine : Journal of the Undersea ... Price WD, Price SM et. al.
May 12th, 2021 - Hydrogen sulfide (H2S) is a toxic gas produced via breakdown of organic matter. Hydrogen sulfide exposure can cause symptoms ranging in severity from mild effects (dizziness, headache, nausea) to severe lactic acidosis, respiratory failure, pulmonary edema, cardiac arrhythmias and death. Treatment modalities include oral countermeasures and 100% FiO2 with supportive therapy. However, case studi...
Undersea & Hyperbaric Medicine : Journal of the Undersea ... Pak S, Valencia D et. al.
May 12th, 2021 - A 52-year-old male accidentally ingested approximately 100 mL of 35% hydrogen peroxide (H2O2), resulting in the sudden onset of gastrointestinal and neurologic symptoms. Non-contrast abdominal CT revealed extensive portal venous gas and gastric pneumatosis. The patient was treated with hyperbaric oxygen therapy which resulted in complete resolution of symptoms. The case highlights the therapeut...
Undersea & Hyperbaric Medicine : Journal of the Undersea ... Lee JS, Cha YS
May 12th, 2021 - Hydrogen peroxide (H2O2) ingestion can cause vascular gas embolism (GE). Hyperbaric oxygen therapy (HBO2) is known to improve neurological abnormalities in patients with arterial gas embolism (AGE). Previously, HBO2 based on the U.S. Navy Table 6 diving protocol has been adopted for treating AGE and preventing the progression of portal venous GE, caused by H2O2 ingestion, to AGE. However, the i...
Current Opinion in Psychiatry; Ciccarone D
May 10th, 2021 - This review provides an update on recently published literature on the rise of illicit fentanyls, risks for overdose, combinations with other substances, e.g. stimulants, consequences, and treatment. Overdose due to illicit synthetic opioids (e.g. fentanyl and fentanyl analogs) continues to rise in the US both preceding and during the COVID-19 pandemic. Fentanyl-related overdose is rising in ne...
PLoS Neglected Tropical Diseases; Larson AJ, Paz-Soldán VA et. al.
May 7th, 2021 - The current body of research on insecticide use in Peru deals primarily with application of insecticides offered through Ministry of Health-led campaigns against vector-borne disease. However, there is a gap in the literature regarding the individual use, choice and perceptions of insecticides which may influence uptake of public health-based vector control initiatives and contribute to the tho...