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About 19,068 results

Acetogenin-induced fibrotic heart disease from avocado (Persea americana, Lauraceae) po...
https://doi.org/10.1016/j.toxicon.2022.09.007
Toxicon : Official Journal of the International Society O... Freitas MS, Pereira AHB et. al.

Sep 20th, 2022 - Poisoning by avocado (Persea americana) has been confirmed in sheep, goats, dogs, rabbits and ostriches. The clinical signs and lesions are attributed to the acetogenin, persin. Little is known regarding the epidemiology, clinical signs, lesions and therapy caused by acetogenin-induced heart damage. During the two-year study, we investigated a horse farm with six horses that often fed themselve...

Black Individuals Are Hardest Hit by Drug Overdose Death Increases.
https://doi.org/10.1001/jama.2022.13702
JAMA Kuehn BM

Aug 24th, 2022 - Black Individuals Are Hardest Hit by Drug Overdose Death Increases.|2022|Kuehn BM,|poisoning,statistics & numerical data,epidemiology,ethnology,mortality,epidemiology,ethnology,mortality,

Metabolic Competency of Larval Zebrafish in Drug-Induced Liver Injury: A Case Study of ...
https://doi.org/10.1093/toxsci/kfac082
Toxicological Sciences : an Official Journal of the Socie... Chen Y, Song W et. al.

Aug 10th, 2022 - Larval zebrafish is emerging as a new model organism for studying drug-induced liver injury (DILI) with superiorities in visual assessment, genetic engineering as well as high throughput. Metabolic bioactivation to form reactive intermediates is a common event that triggers DILI. This study first addressed the correlation between acetaminophen metabolism and hepatotoxicity in zebrafish larvae (...

Young Children Increasingly Ingest Melatonin, With Serious Outcomes.
https://doi.org/10.1001/jama.2022.11156
JAMA Kuehn BM

Jul 13th, 2022 - Young Children Increasingly Ingest Melatonin, With Serious Outcomes.|2022|Kuehn BM,|poisoning,

Gabapentin Increasingly Implicated in Overdose Deaths.
https://doi.org/10.1001/jama.2022.10100
JAMA Kuehn BM

Jun 29th, 2022 - Gabapentin Increasingly Implicated in Overdose Deaths.|2022|Kuehn BM,|poisoning,mortality,poisoning,

MicroRNA-200b-3p as a biomarker for diagnosis and survival prognosis of multiple organ ...
https://doi.org/10.1177/09603271221094008
Human & Experimental Toxicology; Ding M, Zhang Y et. al.

Apr 21st, 2022 - Acute paraquat poisoning-induced multiple organ dysfunction syndrome (MODS) leads to the high mortality. This study aimed to investigate the clinical significance of microRNA-200b-3p (miR-200b-3p), an upstream inhibitor of high-mobility group box 1 (HMGB1), in acute paraquat poisoning patients for the prediction of MODS and survival. This study enrolled 80 patients with MODS induced by paraquat...

Liver transcriptome analyses of acute poisoning and recovery of male ICR mice exposed t...
https://doi.org/10.1007/s00204-022-03278-2
Archives of Toxicology; Wu Z, Li H et. al.

Apr 7th, 2022 - Approximately 70-90% of mushroom poisoning deaths are caused by α-amanitin-induced liver injury resulting from RNA polymerase II (RNAP II) inhibition. Liver regeneration ability may contribute greatly to individual survival after α-amanitin poisoning. However, it is unclear what cellular pathways are activated to stimulate regeneration. We conducted dose-effect and time-effect studies in mice t...

Severe Vitamin K-dependent Coagulopathy from Rodenticide-contaminated Synthetic Cannabi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328164
The Western Journal of Emergency Medicine; Wright E, Hafner JW et. al.

Mar 31st, 2022 - Synthetic cannabinoids are a rapidly expanding subset of designer drugs widely available in the United States since 2008. In Illinois during the spring of 2018, over 160 documented cases of bleeding and prolonged coagulopathy occurred secondary to contaminated synthetic cannabinoids. We conducted a retrospective cohort study consisting of 38 patients to describe the initial emergency department...

Prolonged coma due to amitriptyline overdose and genetic polymorphism: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925239
Journal of Medical Case Reports; van de Wint T, de Vries Schultink AHM et. al.

Mar 18th, 2022 - Reduced consciousness has a wide variety of possible causes, not infrequently being toxic in nature. An intoxication might be obvious, but in this paper an unexpected case with a tricyclic antidepressant is presented. A 76-year-old caucasian female was found unconscious. Primary diagnostic evaluation, including a negative drugs of abuse test, did not give direction to any clear cause. Yet an in...

Human chlorine gas exposition and its management - an umbrella review on human data.
https://doi.org/10.1080/10408444.2022.2035317
Critical Reviews in Toxicology; Nambiema A, Coyo G et. al.

Mar 12th, 2022 - Even though exposure to chlorine gas has been quite frequent in the past few decades, no specific antidotes exist. This umbrella review aimed to investigate possible recommendations for treatment after a chlorine gas exposure. A published systematic review protocol that adapted the existing Navigation Guide methodology was used for including studies without comparator. Using PubMed, Web of Scie...

Treatment of acute hypernatremia caused by sodium overload in adults: A systematic review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878611
Medicine Goshima T, Terasawa T et. al.

Feb 26th, 2022 - Rapid-onset, acute hypernatremia caused by sodium overload is a rare, life-threatening condition. Although experts recommend rapid correction of sodium concentration [Na] based on pathophysiological theories, only a few reports have documented the specific details of sodium correction methods. The objective of this study was to systematically review the reported treatment regimens, achieved [Na...

Methylmercury as a molecular imposter.
https://doi.org/10.1038/s41557-021-00885-x
Nature Chemistry; Schartup AT

Feb 2nd, 2022 - Methylmercury as a molecular imposter.|2022|Schartup AT,|chemistry,poisoning,

Management of intentional overdose of low-molecular-weight heparin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900780
CMAJ : Canadian Medical Association Journal = Journal De ... Lu C, Crowther MA et. al.

Feb 2nd, 2022 - Management of intentional overdose of low-molecular-weight heparin.|2022|Lu C,Crowther MA,Mithoowani S,|etiology,therapy,poisoning,poisoning,complications,drug therapy,etiology,administration & dosage,pharmacology,administration & dosage,pharmacology,

Notes from the Field: Increased Incidence of Fentanyl-Related Deaths Involving Para-flu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9351528
MMWR. Morbidity and Mortality Weekly Report; Trecki J, Gerona RR et. al.

Jan 28th, 2022 - Notes from the Field: Increased Incidence of Fentanyl-Related Deaths Involving Para-fluorofentanyl or Metonitazene - Knox County, Tennessee, November 2020-August 2021.|2022|Trecki J,Gerona RR,Ellison R,Thomas C,Mileusnic-Polchan D,|poisoning,poisoning,mortality,poisoning,

Case 298: Skeletal Fluorosis Secondary to Huffing.
https://doi.org/10.1148/radiol.203739
Radiology Mayer MJ, Gliedt JA et. al.

Jan 25th, 2022 - History A 37-year-old man from the United States presented with a 1-year history of neck pain and stiffness that had been unsuccessfully treated with manipulative therapy by a chiropractor at another institution. Past medical history was remarkable only for marijuana and air duster abuse. He denied use of any prescription medications. Physical examination was notable for markedly reduced range ...

Oxidative stress and biochemical indicators in blood of patients addicted to alcohol tr...
https://doi.org/10.1177/09603271211061502
Human & Experimental Toxicology; Sommerfeld-Klatta K, Łukasik-Głębocka M et. al.

Jan 14th, 2022 - Ethylene glycol (EG), in addition to its neurotoxic and nephrotoxic effects, evokes oxidative stress. The aim of this study was to assess the influence of the ethylene glycol on the biochemical indicators and oxidoreductive balance of patients treated for acute poisoning. The total study group consisted of 56 persons including 26 alcoholics who took EG as a substitute for ethyl alcohol in the c...

First report of a confirmed case of Montivipera latifii (Latifi's viper) envenoming and...
https://doi.org/10.1016/j.toxicon.2021.12.020
Toxicon : Official Journal of the International Society O... Hassanian-Moghaddam H, Monzavi SM et. al.

Jan 8th, 2022 - Latifi's viper (Montivipera latifii), also known as Lar Valley or Damavandi viper, is endemic to Iran. It has rarely been recorded, as it occurs in a highly-protected national park. In this first clinical report of a confirmed bite by this species, a teenage girl was bitten on the chin, causing rapidly-progressive swelling of the face and oropharyngeal mucosa. At a local hospital, a misleading ...

Methanol-induced optic neuropathy: a still-present problem.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8731680
Archives of Toxicology; Liberski S, Kaluzny BJ et. al.

Jan 7th, 2022 - Methanol-induced optic neuropathy (Me-ION) is a serious condition that may result in long-term or irreversible visual impairment or even blindness secondary to damage and loss of function of the optic nerve and retina. Me-ION shows a tendency to occur as mass poisonings around the world with a clear predilection for poor societies in developing countries. The main mechanism underlying the molec...

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837711
Archives of Toxicology; Akakpo JY, Ramachandran A et. al.

Jan 4th, 2022 - Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 years after its introduction. The standard oral or intravenous dosing regimen of NAC is highly effective for patients with moderate overdoses who present within 8 h of APAP ingestion. However, for late-presenting patients or after...

Notes from the Field: Coagulopathy Associated with Brodifacoum Poisoning — Florida, December 2021
https://www.cdc.gov/mmwr/volumes/71/wr/mm7140a5.htm?s_cid=mm7140a5_w

Jan 1st, 2022 - This report describes instances of coagulopathy associated with synthetic cannabinoid use in Florida.