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About 18,865 results

Trends in and Characteristics of Drug Overdose Deaths Involving Illicitly Manufactured ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675656
MMWR. Morbidity and Mortality Weekly Report; O'Donnell J, Tanz LJ et. al.

Dec 17th, 2021 - During May 2020-April 2021, the estimated number of drug overdose deaths in the United States exceeded 100,000 over a 12-month period for the first time, with 64.0% of deaths involving synthetic opioids other than methadone (mainly illicitly manufactured fentanyls [IMFs], which include both fentanyl and illicit fentanyl analogs).* Introduced primarily as adulterants in or replacements for white...

Emergency Medical Services and Syndromic Surveillance: A Comparison With Traditional Su...
https://doi.org/10.1177/00333549211018673
Public Health Reports (Washington, D.C. : 1974); Rock PJ, Quesinberry D et. al.

Nov 3rd, 2021 - Traditional public health surveillance of nonfatal opioid overdose relies on emergency department (ED) billing data, which can be delayed substantially. We compared the timeliness of 2 new data sources for rapid drug overdose surveillance-emergency medical services (EMS) and syndromic surveillance-with ED billing data. We used data on nonfatal opioid overdoses in Kentucky captured in EMS, syndr...

Intestinal perforation associated with chlorine dioxide ingestion: an adult chronic con...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522852
Clinical Journal of Gastroenterology; Arellano-Gutiérrez G, Aldana-Zaragoza EH et. al.

Oct 20th, 2021 - COVID-19 pandemic is one of the most devastating worldwide crises in recent years. During this pandemic, people have been exposed to products that have not been proven to be safe and effective against COVID-19. We present an adult chronic consumer of chlorine dioxide, in which a fatal outcome is described. This case demonstrates that for people searching products to protect themselves from COVI...

Epidemiological investigations identified an outbreak of Shiga toxin-producing Escheric...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365849
Epidemiology and Infection; Butt S, Allison L et. al.

Oct 13th, 2021 - In October 2019, public health surveillance systems in Scotland identified an increase in the number of reported infections of Shiga toxin-producing Escherichia coli (STEC) O26:H11 involving bloody diarrhoea. Ultimately, across the United Kingdom (UK) 32 cases of STEC O26:H11 stx1a were identified, with the median age of 27 years and 64% were male; six cases were hospitalised. Among food exposu...

Trends in Ketamine Use, Exposures, and Seizures in the United States up to 2019.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630483
American Journal of Public Health; Palamar JJ, Rutherford C et. al.

Oct 8th, 2021 - Objectives. To determine whether there have been shifts in nonmedical ketamine use, poisonings ("exposures"), and seizures. Methods. We used generalized additive models to detect trends in past-year use (2006-2019), exposures (1991-2019), and seizures (2000-2019) involving ketamine in the United States. Results. There was a quarterly increase in self-reported past-year nonmedical ketamine use i...

Advice on assistance and protection provided by the Scientific Advisory Board of the Or...
https://doi.org/10.1016/j.tox.2021.152967
Toxicology Timperley CM, Forman JE et. al.

Oct 8th, 2021 - Blister agents damage the skin, eyes, mucous membranes and subcutaneous tissues. Other toxic effects may occur after absorption. The response of the Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) to a request from the OPCW Director-General in 2013 on the status of medical countermeasures and treatments to blister agents is updated through the ...

Pediatric Fatalities Associated With Over-the-Counter Cough and Cold Medications.
https://doi.org/10.1542/peds.2020-049536
Pediatrics Halmo LS, Wang GS et. al.

Oct 6th, 2021 - In 2008, over-the-counter cough and cold medications (CCMs) underwent labeling changes in response to safety concerns, including fatalities, reported in children exposed to CCMs. The objective of this study is to describe fatalities associated with exposures to CCMs in children <12 years old that were detected by a safety surveillance system from 2008 to 2016. Fatalities in children <12 years o...

Emergency Department Pediatric Visits in Alberta for Cannabis After Legalization.
https://doi.org/10.1542/peds.2020-045922
Pediatrics Yeung MEM, Weaver CG et. al.

Sep 22nd, 2021 - Canada legalized nonmedical cannabis possession and sale in October 2018. In the United States, state legalization has been tied to an increase in cannabis-related emergency department (ED) visits; however, little research exists on provincial changes in pediatric visits after nationwide legislation. We compared pre- and postlegalization trends in pediatric cannabis-related ED visits and presen...

The Spice of Death: Sudden Cardiac Arrest After Novel Psychoactive Substance Exposure.
https://doi.org/10.1097/PEC.0000000000002316
Pediatric Emergency Care; Steele RW, Moran JH et. al.

Sep 18th, 2021 - Novel psychoactive substances (NPSs), commonly referred to as "K2" or "spice," are a relatively new toxicology challenge for pediatricians. Adolescents often incorrectly believe that these drugs are safe and can be used without major adverse effects. Although recent legislation attempts to ensure that these drugs are not commercially available, many are able to be purchased online as "not fit f...

Notes from the Field: Xylazine, a Veterinary Tranquilizer, Identified as an Emerging No...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445375
MMWR. Morbidity and Mortality Weekly Report; Thangada S, Clinton HA et. al.

Sep 17th, 2021 - Notes from the Field: Xylazine, a Veterinary Tranquilizer, Identified as an Emerging Novel Substance in Drug Overdose Deaths - Connecticut, 2019-2020.|2021|Thangada S,Clinton HA,Ali S,Nunez J,Gill JR,|epidemiology,mortality,poisoning,poisoning,poisoning,

Notes from the Field: Xylazine Detection and Involvement in Drug Overdose Deaths - Unit...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445380
MMWR. Morbidity and Mortality Weekly Report; Kariisa M, Patel P et. al.

Sep 17th, 2021 - Notes from the Field: Xylazine Detection and Involvement in Drug Overdose Deaths - United States, 2019.|2021|Kariisa M,Patel P,Smith H,Bitting J,|mortality,epidemiology,isolation & purification,poisoning,

COVID-19 pandemic and methanol poisoning outbreak in Iranian children and adolescents: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653331
Alcoholism, Clinical and Experimental Research; Mahdavi SA, Kolahi AA et. al.

Sep 7th, 2021 - During the first wave of COVID-19, many Iranians were poisoned by ingesting hand sanitizers and/or alcoholic beverages to avoid viral infection. To assess whether the COVID-19 pandemic resulted in an increased prevalence of accidental hand sanitizer/alcoholic beverage exposure in children and adolescents, we compared pediatric hospitalization rates during COVID-19 and the previous year. For poi...

Impact of co-ingestion of ethanol on the clinical symptomatology and severity of patien...
https://doi.org/10.1016/j.ajem.2021.08.046
The American Journal of Emergency Medicine; Supervía A, Ibrahim-Achi D et. al.

Sep 6th, 2021 - Investigate whether there are differences in the drugs involved, symptomatology and severity of drug intoxication in patients with co-ingestion of alcohol attended in hospital emergency departments (ED). Patients attended in 11 Spanish EDs due to drug intoxication were included. Sociodemographic and clinical characteristics were collected. A combined adverse event of cardiorespiratory arrest, n...

Relationship between cocaine and cocaethylene blood concentration with the severity of ...
https://doi.org/10.1016/j.ajem.2021.08.057
The American Journal of Emergency Medicine; Zucoloto AD, Eller S et. al.

Sep 5th, 2021 - Poisonings resulting from the abuse of drugs currently represent a serious problem for public health. Among the main agents involved, cocaine stands out. It became one of the most abused drugs around the world, and one of the main reasons for visits to the emergency department due to the use of illicit substances. The use of cocaine is primarily in combination with alcoholic beverages. There ar...

Toxicological detection of pholcodine in blood, urine and hair in three cases of fatal ...
https://doi.org/10.1016/j.forsciint.2021.110975
Forensic Science International; Epain M, Cartiser N et. al.

Sep 4th, 2021 - Pholcodine is an opioid antitussive reputed for its low toxicity and absence of addictive effect. We report three cases of pholcodine intoxication with fatal outcome. Large concentrations of pholcodine were quantified by gas chromatography coupled to mass spectrometry (GC/MS) in peripheral postmortem blood (respectively 2890 ng/mL, 979 ng/mL and 12,280 ng/mL). Segmental hair analyses by GC/MS a...

A 54-year-old woman with chronic lithium toxicity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432309
CMAJ : Canadian Medical Association Journal = Journal De ... Kobylianskii J, Austin E et. al.

Sep 1st, 2021 - A 54-year-old woman with chronic lithium toxicity.|2021|Kobylianskii J,Austin E,Gold WL,Wu PE,|administration & dosage,poisoning,drug therapy,etiology,therapy,methods,blood,administration & dosage,poisoning,methods,

Technical Note: Glycolic Acid Exacerbates the Analytical Performance of Lactate Assay.
https://www.ncbi.nlm.nih.gov/pubmed/34452901
Annals of Clinical and Laboratory Science; Rohr D, Ali M

Aug 29th, 2021 - In this study, we evaluated the analytical interference of glycolic acid on several lactate assays that use lactate oxidase and dehydrogenase. Herein, we tested the effect of different concentrations of glycolic acid (0.01-46mM) on the lactate assay by using central lab and point of care (POCT) analyzers: Radiometer ABL 800, Beckman AU480, Roche Cobas c502, and Abbott i-STAT. Glycolic acid conc...

Trends in Nonfatal and Fatal Overdoses Involving Benzodiazepines - 38 States and the Di...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389388
MMWR. Morbidity and Mortality Weekly Report; Liu S, O'Donnell J et. al.

Aug 27th, 2021 - Nonfatal and fatal drug overdoses increased overall from 2019 to 2020 (1).* Illicit benzodiazepines (e.g., etizolam, flualprazolam, and flubromazolam)† were increasingly detected among postmortem and clinical samples in 2020, often with opioids,§ and might have contributed to overall increases in drug overdoses. Availability of recent multistate trend data on nonfatal benzodiazepine-involved ov...

Association between opioid-related deaths and prescribed opioid dose and psychotropic m...
https://doi.org/10.1016/j.bja.2021.06.049
British Journal of Anaesthesia; Chen TC, Knaggs RD et. al.

Aug 23rd, 2021 - Opioid-overdose deaths are associated with poisoning with prescription and illicit opioids in the USA. In contrast, opioid-related deaths (ORDs) in the UK often involve drugs and substances of misuse, and may not be associated with a high dose of prescribed opioids. This study aimed to investigate the association between prescribed opioid dose and ORDs in UK primary care. This case-crossover st...

Agrochemicals interact synergistically to increase bee mortality.
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Nature Siviter H, Bailes EJ et. al.

Aug 6th, 2021 - Global concern over widely documented declines in pollinators1-3 has led to the identification of anthropogenic stressors that, individually, are detrimental to bee populations4-7. Synergistic interactions between these stressors could substantially amplify the environmental effect of these stressors and could therefore have important implications for policy decisions that aim to improve the he...