May 28th, 2020 - Frontline avelumab (Bavencio) has potential to treat patients with gestational trophoblastic tumors (GTTs) that resist chemotherapy. According to finding from a cohort of the ongoing phase 2 TROPIMMUN trial, avelumab is the first immunotherapy to demonstrate efficacy in this patient population.
May 20th, 2020 - The recipient of this year’s ASCO-American Cancer Society Award is Timothy Rebbeck, PhD. ASCO and the American Cancer Society bestow this award on an individual who has made a significant contribution to cancer prevention and control, research, or practice.
May 19th, 2020 - In this meta-analysis that included 12 trials with 92 135 participants for the primary outcome measure, blood pressure lowering with antihypertensive agents, compared with control, was associated with the development of a composite dementia or cognitive impairment outcome in 7.0% vs 7.5% of patients over a mean trial follow-up of 4.1 years, a difference that was statistically significant.
Journal of Human Hypertension; Anyfanti P
May 7th, 2020 - Hypertension is a major modifiable risk factor for cardiovascular disease. Autoimmune rheumatic diseases confer increased cardiovascular risk, which is at least partially mediated by traditional cardiovascular risk factors. We examined the prevalence, awareness, treatment, and control rates of hypertension in a large cohort of patients with rheumatic diseases.
Centers for Disease Control and Prevention;
Apr 27th, 2020 - The COVID-19 pandemic is a serious global health threat and CDC is committed to stopping the global spread. CDC has a long history of improving public health capacity throughout the world to contain outbreaks at their source and minimize their impact.
JMIR Mhealth Uhealth; Abeler J
Apr 20th, 2020 - We discuss the implementation of app-based contact tracing to control the coronavirus disease (COVID-19) pandemic and discuss its data protection and user acceptability aspects.
Current Opinion in Neurobiology;
Mar 4th, 2008 - The crucial role of dopamine (DA) in movement control is illustrated by the spectrum of motor disorders caused by either a deficiency or a hyperactivity of dopaminergic transmission in the basal ganglia. The degeneration of nigrostriatal DA neurons in Parkinson's disease causes poverty and slowness of movement. These symptoms are greatly improved by pharmacological DA replacement with l-3,4-dih...
This section provides guidance for healthcare workers and employers. This guidance supplements the general interim guidance for workers and employers of workers at increased risk of occupational exposure to SARS-CoV-2. Employers should remain alert of changing outbreak conditions, including as they relate to community spread of the virus and testing availability, and implement infection prev...
https://www.sfndt.org/sites/www.sfndt.org/files/medias/documents/Hong et al. Ann Lab Med Avril 2020.pdf
Annals of Laboratory Medicine;
The outbreak of coronavirus disease 2019 (COVID-19), which began in December 2019, is still ongoing in Korea, with >9,000 confirmed cases as of March 25, 2020. COVID-19 is a severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, and real-time reverse transcription-PCR is currently the most reliable diagnostic method for COVID-19 around the world. Korean Society for Laborato...
Nationally, in 2018, there were over 67,000 drug overdose deaths with opioids representing nearly 70% of all overdose deaths. 67% of all opioid-involved overdose deaths involved synthetic opioids. Data released from the Centers for Disease Control and Prevention (CDC) displays a decrease in fatal overdoses from 2017 to 2018, however, there is an absent methodology nationally to track non-fatal ...
The emergence of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has required an unprecedented response to control the spread of the infection and protect the most vulnerable within society. Whilst the pandemic has focused society on the threat of emerging infections and hand hygiene, certain infection control and antimicrobial stewardship policies may have to be relaxed. It is...
Health systems are being confronted with rapidly increasing demand generated by the COVID-19 outbreak. When health systems are overwhelmed, both direct mortality from an outbreak and indirect mortality from vaccine-preventable and treatable conditions increase dramatically. Analyses from the 2014-2015 Ebola outbreak suggest that the increased number of deaths caused by measles, malaria, HIV/...
The objective was to describe a novel composite continuous glucose monitoring index (COGI) and to evaluate its utility, in adults with type 1 diabetes, during hybrid closed-loop (HCL) therapy and multiple daily injections (MDI) therapy combined with real-time continuous glucose monitoring (CGM).
Journal of Neurology;
Chronic dopamine replacement therapies in Parkinson’s disease can induce side effects, such as levodopa-induced dyskinesias and impulse control disorders. A dysfunction of inhibitory brain networks has been related to both disorders; however, there is no clear behavioral evidence supporting this hypothesis. We aimed to determine whether PD patients with levodopa-induced dyskinesias show feature...
Continuous Glucose Monitoring (CGM) has been recently applied in the clinical diabetic practice. Authors have continued research of glucose variability. In this study, 51 year-old female patient with Type 1 diabetes mellitus (T1DM) was investigated. She has given multiple daily insulin injection (MDI) for long and her recent daily glucose profile was unstable. After applied with FreeStyle Libre...
CDC has developed a new laboratory test kit for use in testing patient specimens for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19. The test kit is called the “Centers for Disease Control and Prevention (CDC) 2019-Novel Coronavirus (2019-nCoV) Real-Time Reverse Transcriptase (RT)-PCR Diagnostic Panel.” It is intended for use with the Applied Biosys...
Since February 12, 2020, approximately 6.5 million cases of SARS-CoV-2 infection, the cause of coronavirus disease 2019 (COVID-19), and 190,000 SARS-CoV-2–associated deaths have been reported in the United States (1,2). Symptoms associated with SARS-CoV-2 infection are milder in children compared with adults (3). Persons aged <21 years constitute 26% of the U.S. population (4), and this report ...
These recommendations represent the first statement by the Advisory Committee on Immunization Practices (ACIP) on the use of a live attenuated vaccine for the prevention of herpes zoster (zoster) (i.e., shingles) and its sequelae, which was licensed by the U.S. Food and Drug Administration (FDA) on May 25, 2006. This report summarizes the epidemiology of zoster and its sequelae, describes the z...
Got the shingles vaccine? The vaccine boosts a group of cells that trigger an immune response to the shingles virus, but don’t expect it to protect you against coronavirus. Shingles vaccines, like Shingrix, are recommended by the Centers of Disease Control and Prevention for people over 60. Doctors believe that as you age, your number of Cd4 cells, or T-cells, can decline.
So, about masks -- they do next to nothing if you don't wear them properly. Yep, even the cloth coverings touted as the best thing since social distancing have instructions. We've laid them out below, based on guidance from the Centers for Disease Control and Prevention and the World Health Organization. And remember: Masks are effective only if they cover your mouth, nose and chin. And how...