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Impact of Superspreaders on dissemination and mitigation of COVID-19

The severity of the Covid-19 pandemic has led to the use of extreme control measures which has halted the spread, but at enormous socioeconomic cost. We set out to explore whether a model that includes 'superspreader' could explain aspects of mitigation strategies that explain the dramatic effect. Methods: We developed an age structured agent-based model that includes persons who spread the dis...

COVID-19 What Healthcare Personnel Should Know about Caring for Patients

Healthcare personnel (HCP) are on the front lines of caring for patients with confirmed or possible infection with coronavirus disease 2019 (COVID-19) and therefore have an increased risk of exposure to this virus. HCPs can minimize their risk of exposure when caring for confirmed or possible COVID-19 patients by following Interim Infection Prevention and Control Recommendations for Patients...

Surgical Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease

The treatment of motor manifestations of Parkinson's disease (PD) is essentially a trade-off between adequate relief of motor symptoms and prevention and control of motor complications, particularly levodopa-induced dyskinesia (LID). Progression of PD is paralleled by a progressive difficulty in achieving the balance. Functional neurosurgical procedures provide sustained relief of LID in carefu...

Effects of temperature and humidity on the daily new cases and new deaths of COVID-19 in 166 countries

The coronavirus disease 2019 (COVID-19) pandemic is the defining global health crisis of our time and the greatest challenge facing the world. Meteorological parameters are reportedly crucial factors affecting respiratory infectious disease epidemics; however, the effect of meteorological parameters on COVID-19 remains controversial. This study investigated the effects of temperature and relati...

Masks are effective only if you wear them properly. Here's the right (and wrong) way

So, about masks -- they do next to nothing if you don't wear them properly. Yep, even the cloth coverings touted as the best thing since social distancing have instructions. We've laid them out below, based on guidance from the Centers for Disease Control and Prevention and the World Health Organization. And remember: Masks are effective only if they cover your mouth, nose and chin. And how...

A Cheap, Simple Way to Control the Coronavirus

Simple at-home tests for the coronavirus, some that involve spitting into a small tube of solution, could be the key to expanding testing and impeding the spread of the pandemic. The Food and Drug Administration should encourage their development and then fast track approval.

Coronavirus Rumor Control

SCHOOLS FOR HEALTH: Risk Reduction Strategies for Reopening Schools
https://www.wasa-oly.org/WASA/images/WASA/6.0 Resources/Hanover/Harvard Report for Reopening Schools---June 2020.pdf

Schools will eventually need to reopen. Keeping schools closed comes with massive, long-term individual and societal costs. Many children cannot effectively learn, grow, engage, socialize, be active, eat healthy food, or get support until schools reopen. Parents and caregivers cannot go back to work until children go back to school. Knowing that schools will reopen at some point, we set out...

Clinical features and multidisciplinary treatment outcome of COVID-19 pneumonia: A report of three cases

The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic threatening global public health. In the current paper, we describe our successful treatment of three COVID-19 pneumonia patients cases including severe cases and cases with mortality risk factors. One 32-year-old male COVID-19 patient was diagnosed with sev...

COVID-19 receptor ACE2 is expressed in human conjunctival tissue, expecially in diseased conjunctival

COVID-19 virus has currently caused major outbreaks worldwide. ACE2 is a major cellular-entry receptor for the COVID-19 virus. Although ACE2 is known to be expressed in many organs, whether it is expressed by the conjunctival tissue is largely unknown. Human conjunctival tissues from 68 subjects were obtained, which included 10 subjects with conjunctival nevi, 20 subjects with conjunctiviti...

Recommendations to Optimize the Safety of Elective Surgical Care While Limiting the Spread of COVID-19: Primum Non Nocere

COVID-19 has drastically altered our lives in an unprecedented manner, shuttering industries and leaving most of the country in isolation as we adapt to the evolving crisis. Orthopedic surgery has not been spared from these effects, with the postponement of elective procedures in an attempt to mitigate disease transmission and preserve hospital resources as the pandemic continues to expand. Dur...

Safety and tolerability of IRL790 in Parkinson’s disease with levodopa-induced dyskinesia—a phase 1b trial
NPJ Parkinson's Disease;

IRL790 is a novel compound with psychomotor stabilizing properties primarily targeting the dopamine D3 receptor. IRL790 is developed as an experimental treatment for levodopa-induced dyskinesia (LID), impulse control disorder, and psychosis in Parkinson’s disease (PD). The primary objective was to investigate the safety and tolerability of IRL790 in PD patients with LID in a randomized controll...

Dysfunctional inhibitory control in Parkinson’s disease patients with levodopa-induced dyskinesias
Journal of Neurology;

Chronic dopamine replacement therapies in Parkinson’s disease can induce side effects, such as levodopa-induced dyskinesias and impulse control disorders. A dysfunction of inhibitory brain networks has been related to both disorders; however, there is no clear behavioral evidence supporting this hypothesis. We aimed to determine whether PD patients with levodopa-induced dyskinesias show feature...

Impact of COVID-19 Attributable Deaths on Longevity, Premature Mortality and DALY: Estimates of USA, Italy, Sweden and Germany

In a short span of four months, the COVID-19 pandemic has added over 0.4 million deaths worldwide, which are untimely, premature and unwarranted. The USA, Italy, Germany and Sweden are four worst affected countries, accounting to over 40% of COVID-19 deaths globally. The main objective of this study is to examine the impact of COVID-19 attributable deaths on longevity, years of potential li...

Clinical determinants for fatality of 44,672 patients with COVID-19

Using meta-analysis to explore clinical determinants for death of COVID-19 patients has been a problem due to insufficient sample size and overlapped cases [1]. In the study, we re-analyzed the largest confirmed case series reported publicly by the Chinese center for disease control and prevention (44,672 laboratory confirmed cases updated through February 11, 2020, [2]), to explore the clinica...

Preventing Varicella-Zoster Virus (VZV) Transmission from Herpes Zoster in Healthcare Settings

Infection-control measures depend on whether the patient with herpes zoster is immunocompetent or immunocompromised and whether the rash is localized or disseminated (defined as appearance of lesions outside the primary or adjacent dermatomes). In all cases, follow standard infection-control precautions. Use the chart below to determine if any additional infection-protocol precautions are re...

Will the shingles vaccine help me fight coronavirus? No. Here’s why

Got the shingles vaccine? The vaccine boosts a group of cells that trigger an immune response to the shingles virus, but don’t expect it to protect you against coronavirus. Shingles vaccines, like Shingrix, are recommended by the Centers of Disease Control and Prevention for people over 60. Doctors believe that as you age, your number of Cd4 cells, or T-cells, can decline.

Recommendations of the Advisory Committee on Immunization Practices (ACIP)

These recommendations represent the first statement by the Advisory Committee on Immunization Practices (ACIP) on the use of a live attenuated vaccine for the prevention of herpes zoster (zoster) (i.e., shingles) and its sequelae, which was licensed by the U.S. Food and Drug Administration (FDA) on May 25, 2006. This report summarizes the epidemiology of zoster and its sequelae, describes the z...

Management of Herpes Zoster (Shingles) and Postherpetic Neuralgia

Herpes zoster (commonly referred to as “shingles”) and postherpetic neuralgia result from reactivation of the varicella-zoster virus acquired during the primary varicella infection, or chickenpox. Whereas varicella is generally a disease of childhood, herpes zoster and post-herpetic neuralgia become more common with increasing age. Factors that decrease immune function, such as human immunodefi...

Herpes Zoster (Shingles)

Herpes zoster is commonly known as shingles. It is a viral disease caused by reactivation of varicella-zoster virus which remains dormant in the sensory ganglia of the cranial nerve or the dorsal root ganglia after a previous varicella infection. Varicella is commonly known as chickenpox; it occurs in children while herpes zoster occurs in adults or the elderly. It is believed that zoster oc...