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About 105,918 results

Radiation Therapy for Local Cutaneous Melanoma.
https://doi.org/10.1016/j.cps.2021.05.008
Clinics in Plastic Surgery; Dabestani PJ, Dawson AJ et. al.

Sep 11th, 2021 - While primary treatment for melanoma consists of surgical resection and chemotherapeutics, radiation can be used as either definitive or adjuvant therapy in certain clinical scenarios. This chapter aims to explore the indications for primary definitive radiotherapy as well as adjuvant treatment following resection. Delivery, dose, fractionation, and toxicity of radiation treatment will be discu...

Sleep Disorders Prior to Adjuvant Radiation Therapy for Gynecological Malignancies.
https://doi.org/10.21873/anticanres.15246
Anticancer Research; Rades D, Kopelke S et. al.

Sep 4th, 2021 - Many patients with gynecological malignancies receive postoperative radiotherapy, which can lead to fear and sleep disorders. We aimed to identify the prevalence of and risk factors for sleep disorders. Sixty-two patients assigned to radiotherapy for gynecological malignancies were retrospectively evaluated. Seventeen characteristics were analyzed for associations with pre-radiotherapy sleep di...

Evaluation of Pre-radiotherapy Sleep Disorders in Patients With Rectal or Anal Cancer.
https://doi.org/10.21873/anticanres.15251
Anticancer Research; Rades D, Kopelke S et. al.

Sep 4th, 2021 - Radiotherapy and radiochemotherapy are common treatments for rectal and anal cancer. Anticipation of treatment may cause distress and sleep disorders. This study aimed to identify risk factors for sleep disorders. In 42 patients with rectal or anal cancer scheduled for radiotherapy, 16 characteristics were analyzed for associations with pre-radiotherapy sleep disorders including age, gender, pe...

Comparison of Dose Distribution Between VMAT-SBRT and Scanning Carbon-ion Radiotherapy ...
https://doi.org/10.21873/anticanres.15270
Anticancer Research; Yoshida D, Kusunoki T et. al.

Sep 4th, 2021 - The purpose of this study was to compare the dose distribution between scanning carbon-ion radiotherapy (sCIRT) and volumetric-modulated arc therapy with stereotactic body radiation therapy (VMAT-SBRT) for stage I non-small cell lung cancer (NSCLC). Fifteen patients with early-stage NSCLC who underwent sCIRT at Kanagawa Cancer Center between 2018-2020 were enrolled. Dose-volume histogram parame...

Primary small cell neuroendocrine carcinoma in the nasal cavity: A CARE-compliant case ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415994
Medicine Chen LY, Chang SL et. al.

Sep 4th, 2021 - Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses is a rare but aggressive neoplasm with a poor prognosis and a strong propensity for regional recurrence and distant metastasis. Diagnosis is challenging and relies on immunohistochemical study. Treatment includes surgical resection, radiation therapy, chemotherapy, or a combination of these modalities. However, the op...

Technique and results after immediate orthotopic replantation of extracorporeally irrad...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408934
BMC Musculoskeletal Disorders; Klein A, Bakhshai Y et. al.

Sep 2nd, 2021 - Reconstruction of the skeletal defects resulting from the resection of bone tumors remains a considerable challenge and one of the possibilities is the orthotopic replantation of the irradiated bone autograft. One technical option with this technique is the addition of a vital autologous fibular graft, with or without microvascular anastomosis. The aim of our study was to evaluate the clinical ...

Whole-body hyperthermia combined with chemotherapy and intensity-modulated radiotherapy...
https://doi.org/10.1080/02656736.2021.1971778
International Journal of Hyperthermia : the Official Jour... Zheng N, Xu A et. al.

Sep 2nd, 2021 - Several studies have reported the combination of intracavity or cervical lymph node hyperthermia with chemoradiotherapy (CRT) to improve clinical outcomes in nasopharyngeal carcinoma (NPC), but the combination with whole-body hyperthermia (WBH) for treating NPC is unexplored. We aimed to assess the efficacy of the combination of radiotherapy, chemotherapy and WBH in patients with locoregionally...

Fractionated Irradiation Enhances Invasion and Migration by Inducing Epithelial-Mesench...
https://www.ncbi.nlm.nih.gov/pubmed/34452890
Annals of Clinical and Laboratory Science; Liu L, Shang M et. al.

Aug 29th, 2021 - Radioresistance-induced locoregional recurrence remains a major cause of low survival rates. However, the mechanism of treatment failure in these lung cancer patients has not been determined. In the current study, we tried to explore the potential molecular mechanism. The fractionated irradiations were continued until the total concentration reached 80 Gy, and we established radioresistant subc...

Biological consequences of cancer radiotherapy in the context of oral squamous cell car...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8390213
Head & Face Medicine; Feller G, Khammissa RAG et. al.

Aug 28th, 2021 - Approximately 50% of subjects with cancer have been treated with ionizing radiation (IR) either as a curative, adjuvant, neoadjuvant or as a palliative agent, at some point during the clinical course of their disease. IR kills cancer cells directly by injuring their DNA, and indirectly by inducing immunogenic cell killing mediated by cytotoxic T cells; but it can also induce harmful biological ...

Long-term survival of patients with mantle cell lymphoma after autologous haematopoieti...
https://doi.org/10.1016/S2352-3026(21)00195-2
The Lancet. Haematology; Zoellner AK, Unterhalt M et. al.

Aug 28th, 2021 - Autologous haematopoietic stem-cell transplantation (HSCT) in first remission is the current standard treatment in fit patients with mantle cell lymphoma. In this long-term follow-up study, we aimed to evaluate the efficacy of autologous HSCT versus interferon alfa maintenance after chemotherapy without or with rituximab in patients with primary advanced-stage mantle cell lymphoma. We did a pos...

Cutoff point of neutrophil-to-lymphocyte ratio for predicting survival in nasopharyngea...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389933
Medicine Setakornnukul J, Chanvimalueng W et. al.

Aug 28th, 2021 - Neutrophil-to-lymphocyte ratio (NLR) was reported as an independent prognostic factor in many studies, but its cutoff point was not yet concluded. We set forth to prove and validate cutoff point of NLR as a poor prognostic factor for overall survival (OS) in nonmetastatic nasopharyngeal carcinoma (NPC) patients.Retrospective cohort of nonmetastatic NPC adult patients treated with intensity-modu...

Effect of the dwell time deviation constraint on brachytherapy treatment planning for c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385595
The Journal of International Medical Research; Yan G, Kang S et. al.

Aug 24th, 2021 - This study aimed to quantify the effect of the dwell time deviation constraint (DTDC) on brachytherapy treatment for cervical cancer. A retrospective study was carried out on 20 patients with radical cervical cancer. The DTDC values changed from 0.0 to 1.0 by a step size of 0.2. We adjusted the optimization objectives to ensure that all plans were optimized to a high-risk clinical target volume...

Evaluation of the salivary flow of patients undergoing conventional radiotherapy for he...
https://www.ncbi.nlm.nih.gov/pubmed/34424207
General Dentistry; Lima MHCT, Ribeiro LN et. al.

Aug 24th, 2021 - The purpose of this cross-sectional, quantitative study was to evaluate the salivary flow of 20 patients undergoing conventional 2-dimensional radiotherapy in the head and neck region. Unstimulated salivary flow was measured with the spitting technique. In addition, xerostomia was evaluated through the Eisbruch grading system and the Xerostomia Inventory (XI). The patients were evaluated 3 time...

Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381428
The Journal of International Medical Research; Wang Z, Ren Y et. al.

Aug 20th, 2021 - A 57-year-old woman was diagnosed with IDH-wildtype (IDHwt) astrocytoma (World Health Organization grade II) with the molecular characteristics of glioblastoma. She underwent concurrent radiotherapy and chemotherapy according to the Stupp protocol in combination with a multi-target antiangiogenic drug and additional intrathecal chemotherapy using methotrexate. During treatment, the patient's tu...

Central nervous system metastases: a rare presentation of nasopharyngeal carcinoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372796
BMJ Case Reports; Abrar S, Ali N et. al.

Aug 19th, 2021 - We report a case of a male patient. He presented with nasal obstruction and epistaxis. The MRI of the brain showed a mass in the nasopharynx and enlarged cervical lymph nodes. Besides this, there was an extra-axial, dural-based lesion in brain and subcentimetre nodules in both lungs. He received induction chemotherapy followed by chemoradiation therapy to the primary site and dural-based metast...

Successful management of small cell neuroendocrine carcinoma of the ureter with neoadju...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375734
BMJ Case Reports; Farooq M, Daniel S et. al.

Aug 19th, 2021 - Neuroendocrine tumours (NETs) of the urinary tract are rare, and the urinary bladder is the the most common primary site. Primary ureteric NET is rarer with under 80 cases reported in the literature thus far. Most of these tumours are of the high-grade small cell neuroendocrine carcinoma subtype, which has a worse prognosis. Neoadjuvant chemotherapy has a proven role in the management of NET of...

Circulating tumor cells counts are associated with CD8+ T cell levels in programmed dea...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294890
Medicine Liu Q, Zhao C et. al.

Aug 17th, 2021 - This study aimed to explore the dynamics of circulating tumor cells (CTCs) and CD8+ T cells in stage II-III non-small cell lung cancer patients with CTCs in different programmed death-ligand 1 (PD-L1) status treated with radiotherapy and evaluate the correlation between CTCs and CD8+ T cells.This study was a retrospective study which reviewed 69 stage II-III non-small cell lung cancer patients ...

The role of radiotherapy in locally advanced pancreatic cancer.
https://doi.org/10.1259/bjr.20210044
The British Journal of Radiology; Huguet F, Dabout V et. al.

Aug 11th, 2021 - At diagnosis, about 15% of patients with pancreatic cancer present with a resectable tumour, 50% have a metastatic tumour, and 35% a locally advanced tumour, non-metastatic but unresectable due to vascular invasion, or borderline resectable. Despite the technical progress made in the field of radiation therapy and the improvement of the efficacy of chemotherapy, the prognosis of these patients ...

Fe3O4 magnetic nanoparticle-enhanced radiotherapy for lung adenocarcinoma via delivery ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351328
Journal of Translational Medicine; Chen S, Han F et. al.

Aug 11th, 2021 - Radiotherapy is the mainstay treatment for lung adenocarcinoma, yet remains highly susceptible to resistance. Fe3O4 magnetic nanoparticles (MNPs) possess the ability to induce biological therapeutic effects. Herein, the current study set out to explore the effects of Fe3O4 MNPs on radiosensitivity of lung adenocarcinoma cells. Fe3O4 MNPs loaded with both negatively-charged small interfering RNA...

Bcl-2-associated transcription factor 1 Ser290 phosphorylation mediates DNA damage resp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351323
Journal of Translational Medicine; Liu J, Li J et. al.

Aug 11th, 2021 - DNA damage response plays critical roles in tumor pathogenesis and radiotherapy resistance. Protein phosphorylation is a critical mechanism in regulation of DNA damage response; however, the key mediators for radiosensitivity in gastric cancer still needs further exploration. A quick label-free phosphoproteomics using high-resolution mass spectrometry and an open search approach was applied to ...