American Journal of Clinical Oncology; Bittner NHJ, Cox BW et. al.
May 20th, 2022 - The American College of Radiology (ACR), American Brachytherapy Society (ABS), and American Society for Radiation Oncology (ASTRO) have jointly developed the following practice parameter for transperineal permanent brachytherapy of prostate cancer. Transperineal permanent brachytherapy of prostate cancer is the interstitial implantation of low-dose rate radioactive seeds into the prostate gland...
American Journal of Clinical Oncology; Nelson B, Tadesse DG et. al.
May 20th, 2022 - We hypothesize that hematologic toxicity will be lower in anal cancer patients treated definitively with intensity modulated proton therapy (IMPT) compared with patients treated with intensity modulated radiation therapy (IMRT). Patients enrolled on a prospective feasibility trial assessing the use of IMPT for anal cancer were compared with contemporaneous patients treated with IMRT. Blood coun...
Radiation Research; He D, Zhao Z et. al.
May 20th, 2022 - Radiotherapy is one of the main treatment modalities for cancer. However, some cancer patients will gradually develop resistance to radiotherapy, leading to tumor recurrence and metastasis. Radiation therapy usually promotes the secretion of exosomes from tumor cells and causes changes in their internal components. Accumulating evidence reveals that exosomes-mediated radiation-induced bystander...
Clinical Medicine (London, England); Kirresh A, White L et. al.
May 19th, 2022 - Accelerated coronary artery disease seen following radiation exposure is termed 'radiation-induced coronary artery disease' (RICAD) and results from both the direct and indirect effects of radiation exposure. Long-term data are available from survivors of nuclear explosions and accidents, nuclear workers as well as from radiotherapy patients. The last group is, by far, the biggest cause of RICA...
Pancreas Hendifar AE, Mehr SH et. al.
May 19th, 2022 - Neuroendocrine tumors (NETs) are rare, diverse malignancies; approximately two thirds originate in the gastrointestinal tract and pancreas and are known as gastroenteropancreatic NET. Most cases are diagnosed in the advanced or metastatic setting and overexpress somatostatin receptors. Recommended first-line treatment is somatostatin analogs; however, disease progression is common. [177Lu]Lu-DO...
Disease Markers; Yang C, Xiao Y et. al.
May 18th, 2022 - To investigate the radioactive iodine-125 (I-125) seed on migrating and invading of hepatocellular carcinoma (HCC) cells and its mechanism, the irradiation of PLC and Huh7 cells was carried out with I-125 seeds in vitro. Cell counting kit 8 assay was employed to measure cell viability. Cell migration was evaluated by using wound-healing assay. Cell invasion was detected by Transwell assay; RT-P...
BMJ Case Reports; Hietala A, Joutsen J et. al.
May 18th, 2022 - According to the current understanding, radiotherapy can enhance the effectiveness of cancer immunotherapy due to radiation-induced release of tumour-associated antigens. Here, we present a case with a metastatic urothelial carcinoma who received nivolumab and palliative radiotherapy to a residual tumour in the vagina and to a large metastatic visceral lymph node. The treatment resulted in a ra...
Clinical Advances in Hematology & Oncology : H&O; Lee P
May 18th, 2022 - Radiation therapy and immunotherapy in locally advanced NSCLC.|2022|Lee P,|radiotherapy,radiotherapy,
Radiation Oncology (London, England); Bloom JR, Castillejos AG et. al.
May 18th, 2022 - Radium-223 is used for the treatment of osseous metastases in castrate-resistant prostate cancer, and has been shown to increase time to the first skeletal-related event, reduce the rate of hospitalization, and improve quality of life. It is well tolerated, with hematologic toxicity as the main adverse event. Thus far, no ocular complication has been reported in the literature after initial adm...
Cancer Biology & Therapy; Cheng X, Yu H et. al.
May 17th, 2022 - Mediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs, exploring functionally relevant biomarkers is essential. Previous studies have demonstrated that mutations in DNA-damage repair (DDR) genes, ...
International Journal of Radiation Oncology, Biology, Phy... Jia AY, Spratt DE
May 16th, 2022 - Bicalutamide Monotherapy With Radiation Therapy for Localized Prostate Cancer: A Non-Evidence-Based Alternative.|2022|Jia AY,Spratt DE,|therapeutic use,therapeutic use,therapeutic use,drug therapy,radiotherapy,therapeutic use,
International Journal of Radiation Oncology, Biology, Phy... Berghen C, De Meerleer G
May 16th, 2022 - Postoperative Radiation Therapy in Prostate Cancer: Timing, Duration of Hormonal Treatment and the Use of PSMA PET-CT.|2022|Berghen C,De Meerleer G,|diagnostic imaging,radiotherapy,
International Journal of Radiation Oncology, Biology, Phy... Zelefsky MJ
May 16th, 2022 - Are We Ready for Focal Dose Radio-Ablation in the Treatment of Localized Prostate Cancer?|2022|Zelefsky MJ,|radiotherapy,surgery,
International Journal of Radiation Oncology, Biology, Phy... Taylor CL, Price JM
May 16th, 2022 - The Tooth Hurts: Dental Health After Radiation Therapy for Head and Neck Cancer.|2022|Taylor CL,Price JM,|radiotherapy,
Lancet (London, England); Pollack A, Karrison TG et. al.
May 16th, 2022 - In men with a detectable prostate-specific antigen (PSA) level after prostatectomy for prostate cancer, salvage prostate bed radiotherapy (PBRT) results in about 70% of patients being free of progression at 5 years. A three-group randomised trial was designed to determine whether incremental gains in patient outcomes can be achieved by adding either 4-6 months of short-term androgen deprivation...
International Journal of Radiation Oncology, Biology, Phy... McDowell L, Chua MLK et. al.
May 16th, 2022 - A Bit More Here and a Little Less There: The Trials (and Tribulations) of Adjuvant and Neoadjuvant Head and Neck Studies in 2021.|2022|McDowell L,Chua MLK,Beadle BM,Ma DJ,Mierzwa M,|radiotherapy,
BMC Women's Health; Zhong X, Zhang L et. al.
May 14th, 2022 - To determine the incidence, clinical and MRI features of sacral insufficiency fracture (SIF) after radiotherapy (RT) in patients with cervical cancer. Our study included 167 patients with cervical cancer after radiotherapy that underwent pelvic MRI for follow-up. MRIs included pre-enhanced T1-weighted, coronal fat-Suppressed T2-weighted (FS-T2W) and enhanced T1-weighted imaging. The clinical an...
BMC Cancer; Wang C, Zhu S et. al.
May 14th, 2022 - To investigate pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) safety and efficacy in preventing hematological toxicity during concurrent chemoradiotherapy (CCRT) for small-cell lung cancer (SCLC). We retrospectively assessed 80 SCLC patients treated with CCRT from January 2013 to December 2018 who received PEG-rhG-CSF within 48 hours after the end of chemotherap...
BMC Medical Imaging; Chen M, Wang L et. al.
May 14th, 2022 - To analyse the changes in brain white matter before and after radiotherapy (RT) by applying multisequence MR radiomics features and to establish a relationship between the changes in radiomics features and radiation dose. Eighty-eight patients with brain tumours who had undergone RT were selected in this study, and MR images (T1, T1+C, T2FLAIR, T2, DWI, and ASL) before and after RT were obtaine...
BMC Cancer; Brügemann D, Lehner B et. al.
May 14th, 2022 - The standard of care treatment for soft tissue sarcoma of the extremities is a wide resection in combination with pre- or postoperative radiotherapy with high local control rates, sparing patients the necessity of amputation without compromising on overall survival rates. The currently preferred timing of radiotherapy is under debate. Albeit having higher rates of acute wound complications, lat...