×
About 118,065 results

Survival of Patients With Inoperable Non-Small Cell Lung Cancer With Baseline Severe Pu...
https://doi.org/10.46883/2023.25920983
Oncology (Williston Park, N.Y.); Deng Q, Zhang Y et. al.

Feb 2nd, 2023 - Currently, there is no standard treatment for patients with lung cancer with deteriorated pulmonary function. In this study, we aimed to assess the efficacy of thoracic radiotherapy for unresectable non-small cell lung cancer (NSCLC) with baseline severe pulmonary dysfunction and severe acute radiation pneumonitis (SARP). Patients were categorized into a radiotherapy group and a nonradiotherapy...

High proportion of circulating CD8 + CD28- senescent T cells is an independent predicto...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887944
Journal of Translational Medicine; Xu X, Wei F et. al.

Feb 2nd, 2023 - Nasopharyngeal carcinoma (NPC) is a kind of epithelial carcinoma that is common in East and Southeast Asia. Distant metastasis after radiotherapy remains the main cause of treatment failure and preradiotherapy immune system function can influence prognosis. Our study aimed to identify immune-related prognostic factors for NPC after radiotherapy and establish a prognostic model to predict progre...

Extraskeletal myxoid chondrosarcoma in the pelvis successfully treated with proton beam...
https://doi.org/10.1136/bcr-2022-250218
BMJ Case Reports; Honda Y, Katagiri H et. al.

Feb 1st, 2023 - The standard treatment for extraskeletal myxoid chondrosarcoma is wide excision. However, extraskeletal myxoid chondrosarcoma is often located in the deep layers of the extremities and pelvis, so functional impairment due to wide resection is unavoidable in many cases. In addition, the efficacy of radiotherapy and chemotherapy has not been defined, so no treatment method is established for unre...

Randomised phase II trial of stereotactic body radiotherapy in combination with checkpo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887717
BMJ Open; Spindler NJ, Persson GF et. al.

Jan 31st, 2023 - Immunotherapy with checkpoint inhibitors (CPIs) has revolutionised cancer treatment but has no convincing effect in metastatic castration-resistant prostate cancer (mCRPC). It has been suggested that a combination of CPI and hypofractionated stereotactic body radiotherapy (SBRT) may work synergistically, and recent trials have supported this. We hypothesise that adding SBRT to CPI treatment can...

Combined anti-C1-INH and radiotherapy against glioblastoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887755
BMC Cancer; Liljedahl E, Konradsson E et. al.

Jan 31st, 2023 - A more effective immune response against glioblastoma is needed in order to achieve better tumor control. Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects. The complement system can function as a bridge between innate and adaptive immune responses. Combining radiotherapy and complement activating therapy is theoretically interesting. Radioth...

A review of diffusion-weighted magnetic resonance imaging in head and neck cancer patie...
https://doi.org/10.1186/s13014-022-02178-0
Radiation Oncology (London, England); Ermongkonchai T, Khor R et. al.

Jan 31st, 2023 - The incidence of head and neck cancers (HNC) is rising worldwide especially with HPV-related oropharynx squamous cell carcinoma. The standard of care for the majority of patients with locally advanced pharyngeal disease is curative-intent radiotherapy (RT) with or without concurrent chemotherapy. RT-related toxicities remain a concern due to the close proximity of critical structures to the tum...

Pomegranate Peel Extract Sensitizes Hepatocellular Carcinoma Cells to Ionizing Radiatio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893067
Integrative Cancer Therapies; Elbakry MMM, ElBakary NM et. al.

Jan 31st, 2023 - Tumor resistance is typically blamed for the failure of radiotherapy and chemotherapy to treat cancer in clinic patients. To improve the cytotoxicity of tumor cells using radiation in conjunction with specific tumor-selective cytotoxic drugs is crucial. Pomegranate has received overwhelmingly positive feedback as a highly nutritious food for enhancing health and treating a variety of ailments. ...

G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblast...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884419
Radiation Oncology (London, England); Cetin MH, Rieckmann T et. al.

Jan 29th, 2023 - The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 2-7 (EGFRvIII) being amongst the most common genomic mutations. EGFRvIII is heterogeneously expressed in GBM. We already showed that EGFRvIII expression has an impact on chemosensitivity, replication stress, and the DNA damage response. Wee1 kinase i...

High resolution dermal ultrasound (US) combined with superficial radiation therapy (SRT...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883932
BMC Cancer; Yu L, Moloney M et. al.

Jan 29th, 2023 - To compare the effectiveness of high-resolution dermal ultrasound (US) guided superficial radiotherapy (SRT) to non-image-guided radiotherapy in the treatment of early-stage Non-Melanoma Skin Cancer (NMSC). A high-resolution dermal ultrasound (US) image guided form of superficial radiation therapy (designated here as US-SRT) was developed in 2013 where the tumor configuration and depth can be v...

The oligometastatic paradigm and the role of radiotherapy.
https://doi.org/10.7861/clinmed.2022-0559
Clinical Medicine (London, England); Nugent K, Good J

Jan 26th, 2023 - Most cancer-related deaths are due to metastatic disease. There is now an emerging evidence base suggesting that a subgroup of metastatic patients benefit significantly from local resection (surgery) or ablation (stereotactic ablative body radiation, SABR) of their metastatic sites. These patients are in what has been termed the 'oligometastatic state', a transitional window between local and d...

Comparison of Two Cisplatin Regimens for Chemoradiation in Patients With Squamous-cell ...
https://doi.org/10.21873/anticanres.16220
Anticancer Research; Zwaan I, Soror T et. al.

Jan 26th, 2023 - Many patients with squamous-cell carcinoma of the head and neck receive cisplatin-based chemoradiation. This retrospective study compared two chemoradiation programs to help identify the optimal cisplatin-regimen. Forty-one patients assigned to chemoradiation with two cycles of 20 mg/m2/days(d)1-5 were compared to 78 patients assigned to chemoradiation with two cycles of 25 mg/m2/d1-4. Groups w...

Breast Conserving Surgery in Combination With Targeted Intraoperative Radiotherapy Comp...
https://doi.org/10.21873/anticanres.16212
Anticancer Research; Kolberg HC, Niesing H et. al.

Jan 26th, 2023 - Mastectomy is the standard treatment of in-breast-recurrence of breast cancer after breast conserving surgery (BCS) and external beam radiation therapy (EBRT). In selected cases, it is possible to preserve the breast if targeted intraoperative radiotherapy (TARGIT-IORT) can be given during the second lumpectomy. This is a comparative analysis of overall survival and quality of life (QoL). Patie...

Time to Pain Relapse After Palliative Radiotherapy for Bone Metastasis: A Prospective M...
https://doi.org/10.21873/anticanres.16229
Anticancer Research; Saito AI, Hirai T et. al.

Jan 26th, 2023 - Low risk asymptomatic bone metastasis (LRABM) without gross osteolytic changes tends to be out of indication for radiotherapy. The aim of this study was to evaluate the time between the end of palliative radiotherapy of bone metastasis (BM) until the start of new pain, in patients with painful BM. Patients with BM were prospectively assessed for location and strength of pain every month for one...

Independent Validation of a Risk Stratification Model Predicting Survival in Elderly Pa...
https://doi.org/10.21873/anticanres.16213
Anticancer Research; Nieder C, Stanisavljevic L et. al.

Jan 26th, 2023 - Many patients with bone metastases receive palliative radiotherapy. However, treatment personalization tools are needed, due to heterogeneous survival. The aim of this study was to analyze the validity of the prognostic survival model, originally developed by Rades et al., because international variations in clinical practice and survival outcomes may impact on the performance of predictive too...

Carbon Ion Radiotherapy Versus Perioperative Adjuvant Chemotherapy and Curative Surgery...
https://doi.org/10.21873/anticanres.16222
Anticancer Research; Yamamoto N, Oshima T et. al.

Jan 26th, 2023 - The standard treatment for resectable pancreatic cancer is preoperative adjuvant chemotherapy (NAC) + curative surgery + adjuvant chemotherapy. Although excellent local control results of carbon ion radiotherapy (CIRT) for pancreatic cancer have been reported, no reports have compared CIRT with the standard treatment for resectable pancreatic cancer. In this study, we compared the results of CI...

Evaluation of the Impact of Smoking and Alcohol Consumption on Toxicity and Outcomes of...
https://doi.org/10.21873/anticanres.16224
Anticancer Research; Rades D, Zwaan I et. al.

Jan 26th, 2023 - Smoking and alcohol abuse may impair outcomes of chemoradiation for squamous cell head and neck cancer (SCCHN). Potential associations with toxicity, loco-regional control (LRC), and overall survival (OS) were investigated. Ninety-six patients were retrospectively analyzed for impacts of pre-radiotherapy (pre-RT) smoking history, smoking during radiotherapy, and pre-RT alcohol abuse on toxicity...

Comparison of Three Survival Scores in a Series of Patients ≥80 Years of Age Irradiated...
https://doi.org/10.21873/anticanres.16221
Anticancer Research; Rades D, Delikanli C et. al.

Jan 26th, 2023 - Very elderly patients irradiated for bone metastases likely benefit from individualized treatments. A specific survival score was created for this group and compared to existing instruments. Ninety-six patients aged 80+ irradiated for bone metastases were retrospectively evaluated. Dose-fractionation regimen plus twelve characteristics were evaluated for survival. In the Cox regression model, p...

Real world practice of postoperative radiotherapy for patients with completely resected...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875489
Radiation Oncology (London, England); Zhou S, Zhai Y et. al.

Jan 26th, 2023 - Results from Lung ART and PORT-C trials suggest that postoperative radiotherapy (PORT) cannot routinely be recommended as standard treatment in completely resected pIIIA-N2 NSCLC patients, but their effects on the real-world practice of PORT in China remain unclear. A national cross-section survey was conducted by using an online survey service. Participants were voluntarily recruited using a r...

Robustness of VMAT to setup errors in postmastectomy radiotherapy of left-sided breast ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873183
PloS One; He Y, Chen S et. al.

Jan 25th, 2023 - Volumetric modulated arc therapy (VMAT) with varied bolus thicknesses has been employed in postmastectomy radiotherapy (PMRT) of breast cancer to improve superficial target coverage. However, impact of bolus thickness on plan robustness remains unclear. The study enrolled ten patients with left-sided breast cancer who received radiotherapy using VMAT with 5 mm and 10 mm bolus (VMAT-5B and VMAT-...

Observation of the delineation of the target volume of radiotherapy in adult-type diffu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872393
Radiation Oncology (London, England); Liu H, Zhang L et. al.

Jan 24th, 2023 - Radiation therapy is the cornerstone of treatment for adult-type diffuse gliomas, but recurrences are inevitable. Our study assessed the prognosis and recurrence pattern of different radiotherapy volumes after temozolomide-based chemoradiation in our institution. The treatment plans were classified into two groups, the plan 1 intentionally involved the entire edema area while plan 2 did not. Re...