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About 117,865 results

Stereotactic radiosurgery for post operative brain metastasic surgical cavities: a sing...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9513906
Radiation Oncology (London, England); Cantaloube M, Boucekine M et. al.

Sep 27th, 2022 - The standard therapy for brain metastasis was surgery combined with whole brain radiotherapy (WBRT). The latter is however, associated with important neurocognitive toxicity. To reduce this toxicity, postoperative stereotactic radiosurgery (SRS) is a promising technique. We assessed the efficacy and the tolerance to postoperative Gamma Knife radiosurgery (GK) on the tumor bed after resection of...

Real-world analysis of different intracranial radiation therapies in non-small cell lun...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508739
BMC Cancer; Chen Z, Zhou L et. al.

Sep 25th, 2022 - Stereotactic radiosurgery (SRS) has become a standard approach for the treatment of patients with few metastatic brain lesions. However, the optimal treatment approach for the use radiotherapy in the treatment of non-small cell lung cancer (NSCLC) patients with brain metastases (BMs) remain unclear. This study aimed to compare the survival outcomes and intracranial local control in NSCLC patien...

Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497847
Current Oncology (Toronto, Ont.); Matsuda R, Hasegawa M et. al.

Sep 23rd, 2022 - this study aimed to evaluate the prognostic factors associated with long-term survival after linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator for brain metastasis (BM). This single-center retrospective study included 226 consecutive patients with BM who were treated with linac-based SRS or fSRT w...

Association between Temporal Muscle Thickness and Overall Survival in Non-Small Cell Lu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9497949
Current Oncology (Toronto, Ont.); Kim YI, Shin JY et. al.

Sep 23rd, 2022 - Temporal muscle thickness (TMT) has recently been suggested as a novel biomarker of sarcopenia in head and neck malignancies. However, few studies have evaluated TMT as a prognostic marker in patients with brain metastasis. This study investigated the association of TMT with overall survival (OS) in non-small cell lung cancer (NSCLC) patients with brain metastasis. The records of all NSCLC pati...

TGFB2-AS1 inhibits triple-negative breast cancer progression via interaction with SMARC...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522332
Proceedings of the National Academy of Sciences of the Un... Zhou C, Wang D et. al.

Sep 21st, 2022 - Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype for its high rates of relapse, great metastatic potential, and short overall survival. How cancer cells acquire metastatic potency through the conversion of noncancer stem-like cells into cancer cells with stem-cell properties is poorly understood. Here, we identified the long noncoding RNA (lncRNA) TGFB2-AS1 as ...

The prognostic impact of lead times in colorectal cancer patients undergoing cytoreduct...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484226
World Journal of Surgical Oncology; Jansson Y, Graf W et. al.

Sep 19th, 2022 - National lead time goals have been implemented across Sweden to standardize and improve cancer patient care. However, the prognostic impact of lead times has not yet been studied in patients with colorectal cancer and peritoneal metastases scheduled for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). To study the correlation between lead times and overall surv...

A network meta-analysis of curative effect of different treatment methods on patients w...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9439797
Medicine Wu A, Zhang F et. al.

Sep 16th, 2022 - Breast cancer (BC) is a malignant tumor with the highest incidence rate worldwide, and its incidence of breast cancer brain metastases is increased in recent years. Although significant progress has been made in the systematic treatment of BC that of breast cancer brain metastases is still very difficult. Organically integrating local and systemic therapies remains an urgent problem to be solve...

Stereotactic body radiotherapy versus conventional radiotherapy for painful bone metast...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472415
Radiation Oncology (London, England); Ito K, Saito T et. al.

Sep 14th, 2022 - Stereotactic body radiotherapy (SBRT) is a promising approach in treating painful bone metastases. However, the superiority of SBRT over conventional external beam radiotherapy (cEBRT) remains controversial. Therefore, this systematic review and meta-analysis of randomised controlled trials was conducted to compare SBRT and cEBRT for the treatment of bone metastases. A search was conducted usin...

Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472156
Journal for Immunotherapy of Cancer; Conway JW, Rawson RV et. al.

Sep 13th, 2022 - The liver is a known site of resistance to immunotherapy and the presence of liver metastases is associated with shorter progression-free and overall survival (OS) in melanoma, while lung metastases have been associated with a more favorable outcome. There are limited data available regarding the immune microenvironment at different anatomical sites of melanoma metastases. This study sought to ...

Exosomal lncRNA PCAT1 Promotes Tumor Circulating Cell-Mediated Colorectal Cancer Liver ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453099
Journal of Immunology Research; Fang X, Xu Y et. al.

Sep 13th, 2022 - This study explored the colorectal cancer exosome lncRNA prostate cancer associated transcript 1- (PCAT1) mediated circulating tumors and the mechanism of cell colorectal cancer liver metastasis. Exosomes were extracted from the primary colorectal cancer (CRC) cell lines HCT116 and SW480 and cultured with T84 and human umbilical vein endothelial (HUVE) cells. The expression of PCAT1 and miR-329...

Palliative radiotherapy of bone metastases in octogenarians: How do the oldest olds res...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450461
Radiation Oncology (London, England); Rühle A, Nya Yompang VA et. al.

Sep 8th, 2022 - Accompanied by the demographic change, the number of octogenarian cancer patients with bone metastases will increase in the future. Palliative radiotherapy constitutes an effective analgesic treatment; however, as pain perception and bone metabolism change with increasing age, the analgesic efficacy of radiotherapy may be altered in elderly patients. We therefore investigated the treatment outc...

Clinical characteristics and outcomes in those with primary extrahepatic malignancy and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446745
BMC Gastroenterology; Alshuwaykh O, Cheung A et. al.

Sep 6th, 2022 - Malignancy-related ascites accounts for approximately 10% of causes of ascites. Our AIM was to characterize the ascites fluid and correlate clinical outcomes in those with extrahepatic malignancy and ascites. 241 subjects with extrahepatic solid tumors and ascites were reviewed from 1/1/2000 to 12/31/2019, 119 without liver metastasis and 122 with liver metastasis. Ascites fluid consistent with...

Breast Cancer Patients with Brain Metastases: A Cross-Sectional Study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9417791
The Breast Journal; Simsek M, Aliyev A et. al.

Sep 3rd, 2022 - The prognosis of breast cancer patients with brain metastasis is poor. It was aimed to define the clinicopathological features of breast cancer patients with brain metastases and to determine the risk factors and survival outcomes associated with brain metastasis. This is a single-center, retrospective, cross-sectional study. A total number of 127 patients diagnosed with breast cancer and who d...

Comparison of Proportion of Elevated Carcinoembryonic Antigen Levels in Patients With A...
https://doi.org/10.21873/anticanres.15922
Anticancer Research; Cristaudo AT, Jennings SB et. al.

Aug 31st, 2022 - The proportion of patients with liver metastases in patients with appendiceal versus colorectal adenocarcinomas was 3.1 percent and 24 percent, respectively, in our peritonectomy centre. From our internal analyses, carcinoembryonic antigen (CEA) was potentially involved. A hypothesis was proposed regarding the natural progression of appendiceal adenocarcinoma. To support this, a systematic revi...

Comparison of Microwave and Radiofrequency Ablation in the Treatment of Pulmonary Metas...
https://doi.org/10.21873/anticanres.15959
Anticancer Research; Tan C, Fisher OM et. al.

Aug 31st, 2022 - Radiofrequency ablation (RFA) for colorectal cancer pulmonary metastases (CRCPulM) has been shown to be safe. Microwave ablation (MWA) has emerged in the treatment for CRCPulM. However, short to long-term efficacy of both modalities have yet to be understood. This is a retrospective study of 203 patients who received RFA and MWA from 2000-2018 at a major tertiary hospital in Australia. A total ...

Fusion-negative rhabdomyosarcoma with diffuse bony metastases and remarkable chemosensi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9438076
BMJ Case Reports; Kube P, Parisio K et. al.

Aug 30th, 2022 - In this report, we describe the case of an adolescent male with an unusual case of fusion-negative, paratesticular alveolar rhabdomyosarcoma who presented with spontaneous tumour lysis syndrome and diffuse bony metastases throughout the axial and appendicular skeleton with additional significant bone marrow involvement. Both spontaneous tumour lysis syndrome and diffuse bony metastases are extr...

Use of First-Line Immune Checkpoint Inhibitors and Association With Overall Survival Am...
https://doi.org/10.1001/jamanetworkopen.2022.25459
JAMA Network Open; Lamba N, Ott PA et. al.

Aug 26th, 2022 - In 2015, first-line programmed cell death 1 (PD-1) immune checkpoint inhibitors (ICI) were Food and Drug Administration (FDA)-approved and National Comprehensive Cancer Network (NCCN)-recommended for patients with stage IV melanoma. Few studies have assessed the overall survival (OS) and usage rate associated with first-line ICI following 2015. To determine the rates of ICI use for metastatic m...

Gene expression profile of human colorectal cancer identified NKTR as a biomarker for l...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467399
Aging Bai R, Shi Z et. al.

Aug 26th, 2022 - Liver metastasis is one of the prognostic factors of colorectal cancer (CRC). The aim of this study is to identify biomarkers that facilitate easier detection of liver metastasis. Significance Analysis of Microarrays (SAM) and Array Data Analyzer (ADA) were applied used for the analysis of differentially differently expressed mRNAs. mRNA expression was verified by quantitative real-timer revers...

Outcomes and Molecular Features of Brain Metastasis in Gastroesophageal Adenocarcinoma.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403772
JAMA Network Open; Tsai C, Nguyen B et. al.

Aug 25th, 2022 - Brain metastasis (BrM) in gastroesophageal adenocarcinoma (GEA) is a rare and poorly understood phenomenon associated with poor prognosis. To examine the clinical and genomic features of patients with BrM from GEA and evaluate factors associated with survival. In this single-institution retrospective cohort study, 68 patients with BrM from GEA diagnosed between January 1, 2008, and December 31,...

RAB27A and RAB27B Expression May Predict Lymph Node Metastasis and Survival in Patients...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353728
Cancer Genomics & Proteomics; An HJ, Lee JS et. al.

Aug 20th, 2022 - RAB27A and RAB27B are involved in exosome secretion. To date, there have been many attempts to elucidate the roles of RAB27A and RAB27B in the prognosis of various cancer types. The association of RAB27A and RAB27B expression with the clinical and pathological features was evaluated in patients with stomach cancer. A total of 360 patients who had undergone surgery for stomach cancer between Jan...