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About 112,660 results

Mutational characteristics of bone metastasis of lung cancer.
https://doi.org/10.21037/apm-21-1595
Annals of Palliative Medicine; Huang X, Shi X et. al.

Sep 8th, 2021 - Roughly 30-40% of lung cancer (LC) patients develop bone metastasis during the course of disease. The genetic differences between primary LC and matched bone metastasis are not yet fully understood. A total of 40 LC patients with bone metastasis were collected and 450 targeted cancer-related genes were sequenced for genomic-alteration (GA) identification. Among the 40 LC patients, 33 had adenoc...

E-Cadherin and Angiopoietin-2 as Potential Biomarkers for Colorectal Cancer With Perito...
https://doi.org/10.21873/anticanres.15260
Anticancer Research; Kim HK, Yang Y et. al.

Sep 4th, 2021 - E-Cadherin has been implicated in cell-cell adhesion, and soluble E-cadherin is involved in angiogenesis and resistance to anti-angiogenic therapy in several cancer types. This study aimed to investigate the expression and clinical significance of soluble E-cadherin and other angiogenesis-related factors in plasma and malignant ascites of colorectal cancer (CRC) in patients with peritoneal carc...

Associations Between ADC Texture Analysis and Tumor Infiltrating Lymphocytes in Brain M...
https://doi.org/10.21873/anticanres.15267
Anticancer Research; Meyer HJ, Hohn AK et. al.

Sep 4th, 2021 - Tumor infiltrating lymphocytes (TILs) are an important prognostic factor in brain metastasis (BM). This study elucidated associations between apparent diffusion coefficient (ADC) texture analysis and TIL in BM. Eleven patients with BM were retrospectively included into the study. TIL levels were analyzed with Leucocyte-common antigen staining. Clinical routine magnetic resonance imaging was use...

Tumor Vascular Microenvironment of Colorectal Hepatic Metastasis and Chemotherapy Respo...
https://doi.org/10.21873/anticanres.15261
Anticancer Research; Okamoto H, Shiba S et. al.

Sep 4th, 2021 - The tumor vascular microenvironment has an important role in tumor progression and metastasis. The objective of this study was to assess the significance of metastatic hepatic tumor vascular microenvironment in relation to the response to systemic fluorouracil-based chemotherapy [folinic acid/fluorouracil/oxaliplatin (FOLFOX) or folinic acid/fluorouracil/irinotecan (FOLFIRI)]. A total of 48 con...

Frailty Can Predict Prognosis After Hepatectomy in Patients With Colorectal Liver Metas...
https://doi.org/10.21873/anticanres.15277
Anticancer Research; Tokuda K, Morine Y et. al.

Sep 4th, 2021 - The aim of this study was to investigate frailty as a prognostic factor in patients with colorectal liver metastasis undergoing hepatectomy. Eighty-seven patients who underwent hepatectomy at our institution were enrolled. Frailty was defined as a score of ≥4 on a clinical frailty scale. Patients were divided into frailty (n=29) and non-frailty (n=58) groups. Overall and cancer-specific surviva...

Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulat...
https://doi.org/10.1038/s41467-021-25552-0 10.1136/bmj.2.4888.607 10.1093/jnci/91.1.80 10.1038/nrc3793 10.1038/ncb2767 10.1038/nrc3910 10.1038/nrclinonc.2012.207 10.1016/j.cell.2013.10.029 10.1038/nrc2933 10.1038/nature12628 10.1038/ncb2861 10.1016/j.cell.2012.06.035 10.1038/s41556-017-0021-z 10.1038/ncomms7170 10.1016/j.ccr.2011.11.002 10.1038/ncb3465 10.1038/s41556-020-0474-3 10.1016/j.cell.2016.02.025 10.1016/j.gde.2009.08.005 10.3389/fendo.2012.00125 10.1007/978-1-4614-1445-2_8 10.1038/s41556-019-0309-2 10.1016/j.ccr.2012.10.012 10.1073/pnas.0530291100 10.1016/j.stem.2007.08.014 10.1016/j.stemcr.2013.11.009 10.1016/j.ccr.2012.11.009 10.1016/j.ccr.2013.04.017 10.1038/s41590-018-0207-y 10.1038/s41467-020-16966-3 10.1038/s41556-019-0311-8 10.1016/j.ccell.2016.03.010 10.1038/ncb3595 10.1038/s41588-018-0252-3 10.1038/s41598-017-12716-6 10.1038/s41388-018-0586-4 10.1111/jcmm.13605 10.1111/jcmm.14386 10.1002/jcb.29435 10.18632/aging.102563 10.1038/cddis.2017.72 10.1023/A:1006461422273 10.1016/j.ccell.2019.02.001 10.1007/s00285-014-0754-2 10.1093/nar/gkm391 10.1038/nature03799 10.1038/nature14136 10.1186/s13058-018-1049-0 10.1371/journal.pone.0035569 10.1101/gr.5211806 10.1371/journal.pcbi.1003442 10.1016/j.bbagrm.2019.04.006 10.1016/j.molmet.2014.05.002 10.4161/cc.7.14.6271 10.1007/s00018-015-1938-7 10.1038/nmeth.1611 10.1093/nar/gku359 10.1093/bioinformatics/btn544 10.1093/nar/gkx279 10.1093/nar/gky329 10.1073/pnas.1110977109 10.1074/jbc.M112.408104 10.1038/ncb1722 10.1038/ncb3040 10.1111/j.1349-7006.2010.01700.x 10.1016/j.molonc.2015.11.009 10.1158/1078-0432.CCR-15-0876 10.1038/nature08460 10.1007/s10549-016-4013-7 10.1056/NEJMoa021967 10.1016/j.ccr.2012.09.022 10.1038/s41586-019-1526-3 10.1126/sciadv.aav4275 10.4161/cc.8.6.7851 10.1016/j.cell.2009.08.048 10.1016/j.ccr.2009.11.008 10.1093/nar/gkh449 10.1186/1471-2105-15-29 10.1186/1758-3284-2-9 10.1002/hed.23380
Nature Communications; Liu Y, Zhang P et. al.

Sep 4th, 2021 - Disseminated tumor cells often fall into a long term of dormant stage, characterized by decreased proliferation but sustained survival, in distant organs before awakening for metastatic growth. However, the regulatory mechanism of metastatic dormancy and awakening is largely unknown. Here, we show that the epithelial-like and mesenchymal-like subpopulations of breast cancer stem-like cells (BCS...

Intrabony mandibular metastases caused by papillary thyroid carcinoma masquerading as a...
https://doi.org/10.1308/rcsann.2020.7091
Annals of the Royal College of Surgeons of England; Wareing J, Dawoud B et. al.

Sep 1st, 2021 - Papillary carcinoma is the most common type of thyroid cancer, accounting for 80-90% of cases. Distant metastasis of papillary thyroid cancer is uncommon, but when it does occur, it is most commonly to the lungs, liver and bone. Bone metastases to the mandible are rarely reported. We present a 68-year-old man who was referred due to a right parotid mass. Appropriate imaging and biopsy revealed ...

Composite Neuroblastoma Metastatic to a Lymph Node: The Novel Histopathologic Diagnosis...
https://www.ncbi.nlm.nih.gov/pubmed/34452899
Annals of Clinical and Laboratory Science; Kurtz JL, Shimada H et. al.

Aug 29th, 2021 - Composite neuroblastoma is a tumor composed of multiple tumoral clones within the neuroblastoma family. To date, establishing this unique histopathologic diagnosis has required the evaluation of the primary tumor mass. We report a case of composite neuroblastoma diagnosed by evaluation of a metastatic lymph node. One abdominal lymph node involved by tumor was evaluated in a 6-year-old boy. The ...

Skeletal muscle metastasis from a gastrointestinal stromal tumor: A case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389935
Medicine Zhu G, Sun W et. al.

Aug 28th, 2021 - Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Common sites for metastasis are the liver and peritoneum, whereas skeletal muscle metastases are rare. A 59-year-old man with skeletal muscle metastasis was diagnosed during a period of adjuvant imatinib therapy following the recurrence of GIST of the small intestine. The patient was di...

Long-term survival following radiofrequency ablation of lung metastases in an elderly p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389876
Medicine Futani H, Takaki H et. al.

Aug 28th, 2021 - Recently, the number of osteosarcomas has been increasing in elderly patients due to human longevity. Lung metastases are the primary cause of death from osteosarcomas. Complete resection of lung metastases can prolong the survival. However, complete resection in elderly patients is often difficult due to high risk of operative complications. Computed tomography (CT) guided radiofrequency ablat...

Predictors for survival in patients with bone metastasis of small cell lung cancer: A p...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389941
Medicine Xue M, Chen G et. al.

Aug 28th, 2021 - The objective of the current study is to analyze the clinical and demographic characteristics of patients with bone metastasis of small cell lung cancer (SCLC) and explore their survival predictors.We retrospectively extracted patients with bone metastasis of SCLC from the Surveillance, Epidemiology, and End Results database. We applied Cox regression analyses to identify independent survival p...

Expression of ANCR in nasopharyngeal carcinoma patients and its clinical significance.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376304
Medicine Guo C, Ma X et. al.

Aug 21st, 2021 - Anti-differentiation non-coding RNA (ANCR), a long non-coding RNA, is involved in the development, progression and metastasis of various human cancers. However, its clinical significance in nasopharyngeal carcinoma (NPC) still remains unknown. This study aimed to investigate ANCR expression and its clinical significance in NPC.Totally, 96 NPC tissues and 24 non-cancerous nasopharyngeal mucosa t...

Case reports of robot-assisted laparoscopic radical nephrectomy and inferior vena cava ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376354
Medicine Ma S, Jia W et. al.

Aug 21st, 2021 - Renal cell carcinoma is one common type of urologic cancers. It has tendencies to invade into the inferior vena cava (IVC) and usually requires an open surgery procedure. High rates of operative complications and mortality are usually associated with an open surgery procedure. The recently emerged robot-assisted laparoscopic radical nephrectomy (RAL-RN) and IVC tumor thrombectomy have shown to ...

Expression and clinical significance of AURKB gene in lung adenocarcinoma: Analysis bas...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341284
Medicine Gao X, Jiang A et. al.

Aug 17th, 2021 - This study aimed to investigate the expression and clinical significance of aurora B kinase (AURKB) gene in lung adenocarcinoma (LUAD) by collecting relevant data in Oncomine database.Firstly, mRNA expression level of AURKB in LUAD was systematically analyzed using the ONCOMINE and the cancer genome atlas databases. Then, the association between AURKB expression and clinical parameters was inve...

Bilateral adrenal metastasis of renal cell carcinoma 4 years after radical nephrectomy:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341217
Medicine Li Y, Ji Z et. al.

Aug 17th, 2021 - Renal cell carcinoma (RCC) almost metastasizes to every organ, the possibility of adrenal metastasis is relatively low in patients that have undergone radical nephrectomy, only a few cases of bilateral adrenal metastasis are reported on literature. Although surgical treatment of metastases from RCC is preferred and contributes to the rate of survival, it is considered challenging to manage such...

Retrospective review of cutaneous metastasis among 11,418 patients with solid malignanc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294925
Medicine Teyateeti P, Ungtrakul T

Aug 17th, 2021 - Cutaneous metastasis (CM) occurs infrequently and usually presents during the later stages of cancer, and has a poor prognosis. Although there are insufficient current data, cancer treatment changes could have a positive impact on the outcome. This retrospective study aimed to review the pattern and prognosis of CM in patients with solid malignancy in a tertiary cancer center in Thailand.We rev...

Durable response to immunotherapy plus chemotherapy in a patient with untreated, brain-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294870
Medicine Nong J, Gu Y et. al.

Aug 17th, 2021 - Epidermal growth factor receptor (EGFR) 20 exon insertion is the second most common EGFR aberrations in non-small cell lung cancer (NSCLC). Despite some novel EGFR inhibitors, clinically obtainable management for this subset of patients remains an unmet need. there are no previous reports of upfront combination therapy with immunotherapy and chemotherapy for lung adenocarcinoma with brain metas...

ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358026
Nature Communications; Taftaf R, Liu X et. al.

Aug 13th, 2021 - Circulating tumor cell (CTC) clusters mediate metastasis at a higher efficiency and are associated with lower overall survival in breast cancer compared to single cells. Combining single-cell RNA sequencing and protein analyses, here we report the profiles of primary tumor cells and lung metastases of triple-negative breast cancer (TNBC). ICAM1 expression increases by 200-fold in the lung metas...

Choriocarcinoma brain metastasis in a patient in the third trimester: a case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320190
Journal of Medical Case Reports; Shen C, Ai L et. al.

Jul 31st, 2021 - Metastatic choriocarcinoma in the third trimester of pregnancy is extremely rare. A 25-year-old Chinese woman (gravida 3, para 0) who was 28 weeks pregnant was admitted for sudden convulsion, aconuresis, and unconsciousness. The decision was made to perform an emergency cesarean delivery and craniotomy, hematoma clearance, and decompression. Pathological examination confirmed choriocarcinoma wi...

Treatment efficacy and safety of regorafenib plus drug-eluting beads-transarterial chem...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397621
Journal of Cancer Research and Clinical Oncology; Cao F, Zheng J et. al.

Jul 25th, 2021 - This study aimed to evaluate the efficacy and safety of regorafenib plus drug-eluting beads-transarterial chemoembolization (DEB-TACE) versus regorafenib monotherapy in colorectal cancer liver metastases (CRLM) patients who failed standard treatment regimens. Totally, 76 eligible CRLM patients were analyzed, among which 42 patients received regorafenib monotherapy (as regorafenib group) and 34 ...