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About 118,580 results

SLERT, as a novel biomarker, orchestrates endometrial cancer metastasis via regulation ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9887878
World Journal of Surgical Oncology; Tian J, Cheng H et. al.

Feb 2nd, 2023 - Recent evidence suggests that the box H/ACA small nucleolar RNA (snoRNA)-ended long noncoding RNA (lncRNA), SLERT, plays a critical role in gene regulation. However, its role in cancer remains undetermined. Herein, we explored its implication in human endometrial cancer (EC). EC plasma and tissue samples were collected for the detection of SLERT expression using qRT-PCR method. The functional i...

Changes in the characteristics of patients treated for brain metastases with repeat ste...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885681
Radiation Oncology (London, England); Kuntz L, Le Fèvre C et. al.

Feb 1st, 2023 - Brain metastases (BMs) are the leading cause of intracranial malignant neoplasms in adults. WHO, Karnofsky performance status (KPS), age, number of BMs, extracerebral progression (ECP), recursive partitioning analysis (RPA), diagnosis-specific graded prognostic assessment (Ds-GPA) are validated prognostic tools to help clinicians decide on treatment. No consensus exists for repeat stereotactic ...

Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875956
Medicine Tang L, Liu B

Jan 28th, 2023 - Osteosarcoma (OS) is a malignant tumor originating from the mesenchymal tissue. Simultaneous reports of lung and bone metastases (BM) in OS are rare in the literature. A total of 353 new cases of lung metastases (LM), 93 new cases of BM, and 59 new cases of LM and BM were diagnosed in the Surveillance, Epidemiology and End Results (SEER) database from 2010 to 2019. Univariate and multivariate l...

Deep learning based identification of bone scintigraphies containing metastatic bone di...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9875407
Cancer Imaging : the Official Publication of the Internat... Ibrahim A, Vaidyanathan A et. al.

Jan 27th, 2023 - Metastatic bone disease (MBD) is the most common form of metastases, most frequently deriving from prostate cancer. MBD is screened with bone scintigraphy (BS), which have high sensitivity but low specificity for the diagnosis of MBD, often requiring further investigations. Deep learning (DL) - a machine learning technique designed to mimic human neuronal interactions- has shown promise in the ...

Time to Pain Relapse After Palliative Radiotherapy for Bone Metastasis: A Prospective M...
https://doi.org/10.21873/anticanres.16229
Anticancer Research; Saito AI, Hirai T et. al.

Jan 26th, 2023 - Low risk asymptomatic bone metastasis (LRABM) without gross osteolytic changes tends to be out of indication for radiotherapy. The aim of this study was to evaluate the time between the end of palliative radiotherapy of bone metastasis (BM) until the start of new pain, in patients with painful BM. Patients with BM were prospectively assessed for location and strength of pain every month for one...

Independent Validation of a Risk Stratification Model Predicting Survival in Elderly Pa...
https://doi.org/10.21873/anticanres.16213
Anticancer Research; Nieder C, Stanisavljevic L et. al.

Jan 26th, 2023 - Many patients with bone metastases receive palliative radiotherapy. However, treatment personalization tools are needed, due to heterogeneous survival. The aim of this study was to analyze the validity of the prognostic survival model, originally developed by Rades et al., because international variations in clinical practice and survival outcomes may impact on the performance of predictive too...

Prognostic Factors and Independent Validation of a Risk Stratification Model in Octogen...
https://doi.org/10.21873/anticanres.16214
Anticancer Research; Nieder C, Dalhaug A

Jan 26th, 2023 - This study aimed at validation of a prognostic model, originally developed by Rades et al., in an age-restricted, particularly vulnerable subgroup of patients with brain metastases, because international variations in clinical practice and survival outcomes may impact on the performance of survival prediction tools. Retrospectively, data from a single institution were analyzed. The study includ...

Comparison of Three Survival Scores in a Series of Patients ≥80 Years of Age Irradiated...
https://doi.org/10.21873/anticanres.16221
Anticancer Research; Rades D, Delikanli C et. al.

Jan 26th, 2023 - Very elderly patients irradiated for bone metastases likely benefit from individualized treatments. A specific survival score was created for this group and compared to existing instruments. Ninety-six patients aged 80+ irradiated for bone metastases were retrospectively evaluated. Dose-fractionation regimen plus twelve characteristics were evaluated for survival. In the Cox regression model, p...

Risk of seizures in a population of women with BRCA-positive metastatic breast cancer f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872301
BMC Cancer; Liede A, Sebby W et. al.

Jan 24th, 2023 - Incidence and risk factors for seizures among women with advanced breast cancer (BC) and brain metastases are not well characterized across treatment-related or clinical subtypes. This study leveraged a large real-world dataset to describe incidence and risk factors for seizures in BRCA-associated metastatic breast cancer. The Optum® de-identified electronic health records database was used. Fe...

Efficacy and Safety of East Asian Herbal Medicine for Brain Metastases in Non-small Cel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893100
Integrative Cancer Therapies; Xu B, Ge Y et. al.

Jan 24th, 2023 - Brain metastasis (BM) is a significant risk factor for survival and prognosis in non-small cell lung cancer (NSCLC). While surgical resection and radiotherapy are the primary treatment modalities, the overall prognosis in NSCLC patients with BM remains poor, and all therapies lead to adverse events. East Asian herbal medicine (EAHM) has broad prospects as an adjuvant treatment, but its efficacy...

Primary Cutaneous Ewing Sarcoma of the Scalp With Metastasis to the Lung: An Unusual Ma...
https://doi.org/10.1097/DAD.0000000000002348
The American Journal of Dermatopathology; Regmi A, Raouf M et. al.

Jan 21st, 2023 - A 32-year-old G2P1L1 (5 months pregnant) woman presented with a 3-month history of a slow-growing cystic lesion on her scalp vertex. Similar lesions in the exact location were excised twice in the past with a diagnosis of trichilemmal carcinoma (TC). A biopsy of the scalp lesion showed morphology and immunoprofile consistent with previously diagnosed TC. Staging PET/CT demonstrated a 4.7 cm rig...

The prognostic significance of clinicopathological characteristics in early-onset versu...
https://doi.org/10.1007/s00384-023-04317-9
International Journal of Colorectal Disease; Li YT, Wang XY et. al.

Jan 20th, 2023 - This study aimed to explore the prognostic significance of clinicopathological characteristics in early-onset versus late-onset colorectal liver metastases (CRLM). The data of CRLM patients who underwent hepatectomy from September 2010 to September 2020 were retrospectively analyzed. According to the age of primary cancer diagnosis, patients were divided into early-onset CRLM (EOCRLM) and late-...

Endobronchial metastasis secondary to occulting renal cell carcinoma: literature review...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850687
BMC Pulmonary Medicine; Abdul Rahman SA, Abdul Rahman A et. al.

Jan 19th, 2023 - Endobronchial Metastasis from extrathoracic tumors is a rare neoplasm that accounts for approximately 1.1% of total endobronchial malignancies. The most common primary tumors associated with EBM are from the colorectal, breast, and kidney regions. Although it represents a late manifestation in the context of tumor progression, it can rarely antedate the diagnosis of the primary tumor. A 67-year...

Where Are We Now with Liver Transplantation in Neuroendocrine Neoplasms? The Place of L...
https://doi.org/10.1007/s11912-022-01343-8
Current Oncology Reports; Shah T, Manas DM et. al.

Jan 18th, 2023 - This review outlines the role of liver transplantation in selected patients with unresectable neuroendocrine tumour liver metastases. It discusses the international consensus on eligibility criteria and outlines the efforts taking place in the UK and Ireland to develop effective national liver transplant programmes for neuroendocrine tumour patients. In the early history of liver transplantatio...

Improvement of sleep quality in isolated metastatic patients with spinal cord compressi...
https://doi.org/10.1186/s12957-023-02895-0
World Journal of Surgical Oncology; Cao S, Xin B et. al.

Jan 17th, 2023 - This study aimed to assess changes in quality of sleep (QoS) in isolated metastatic patients with spinal cord compression following two different surgical treatments and identify potential contributing factors associated with QoS improvement. We reviewed 49 patients with isolated spinal metastasis at our spinal tumor center between December 2017 and May 2021. Total en bloc spondylectomy (TES) a...

Combination of radiotherapy and targeted therapy for HER2-positive breast cancer brain ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841677
European Journal of Medical Research; Yang X, Ren H et. al.

Jan 16th, 2023 - Radiotherapy and targeted therapy are essential treatments for patients with brain metastases from human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, the combination of radiotherapy and targeted therapy still needs to be investigated, and neurotoxicity induced by radiotherapy for brain metastases has also become an important issue of clinical concern. It remained u...

Enhancer RNA promotes resistance to radiotherapy in bone-metastatic prostate cancer by ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830431
Theranostics Zhao Y, Wen S et. al.

Jan 13th, 2023 - Rationale: Prostate cancer metastasizes to the bone with the highest frequency and exhibits high resistance to 177Lu-prostate-specific membrane antigen (PSMA) radioligand therapy. Little is known about bone metastatic prostate cancer (mPCa) resistance to radiation. Methods: We filtered the metastatic eRNA using RNA-seq, MeRIP-seq, RT-qPCR and bioinformation. Western blot, RT-qPCR, CLIP, co-IP a...

Peritoneal carcinomatosis secondary to metastatic lung cancer complicated with acute su...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9750620
Medicine Fu JX, Wang XJ et. al.

Jan 11th, 2023 - Lung cancer (LC) is a malignant tumor with the highest morbidity and mortality in the world. The most common metastatic sites of LC are the brain (47%), bone (36%), liver (22%), adrenal glands (15%), thoracic cavity (11%) and distant lymph nodes (10%). Peritoneal carcinomatosis (PC) is a rare clinical event in LC patients. Considering the rarity and nonspecific clinical symptoms of peritoneal m...

Acute toxicities and cumulative dose to the brain of repeated sessions of stereotactic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830690
Radiation Oncology (London, England); Kuntz L, Le Fèvre C et. al.

Jan 11th, 2023 - Stereotactic radiation therapy (SRT) is a focal treatment for brain metastases (BMs); thus, 20 to 40% of patients will require salvage treatment after an initial SRT session, either because of local or distant failure. SRT is not exempt from acute toxicity, and the acute toxicities of repeated SRT are not well known. The objective of this study was to analyze the acute toxicities of repeated co...

Ten-year trends in the treatment and intervention timing for patients with metastatic s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832741
Journal of Orthopaedic Surgery and Research; Hirota R, Teramoto A et. al.

Jan 11th, 2023 - Cancer treatment has recently evolved due to the advances in comprehensive therapies, including chemotherapy and radiotherapy. The aspect of cancer-related bone metastasis has undergone a paradigm shift with the transformation of orthopedic interventions for spinal metastasis. We performed this retrospective observational study to investigate the changes in patient status and metastatic spine-t...