The British Journal of Surgery; Bjørnelv GMW, Zolic-Karlsson Z et. al.
May 17th, 2022 - Cost-effectiveness of liver transplantation versus last-resort systemic therapy for colorectal liver metastases.|2022|Bjørnelv GMW,Zolic-Karlsson Z,Dueland S,Line PD,Aas E,|surgery,drug therapy,secondary,surgery,
BMC Cancer; Pereira F, Serrano A et. al.
May 14th, 2022 - The French PRODIGE 7 trial, published on January 2021, has raised doubts about the specific survival benefit provided by HIPEC with oxaliplatin 460 mg/m2 (30 minutes) for the treatment of peritoneal metastases from colorectal cancer. However, several methodological flaws have been identified in PRODIGE 7, specially the HIPEC protocol or the choice of overall survival as the main endpoint, so it...
Radiation Oncology (London, England); Nieder C, Stanisavljevic L et. al.
May 14th, 2022 - Established prognostic models, such as the diagnosis-specific graded prognostic assessment, were not designed to specifically address very short survival. Therefore, a brain metastases-specific 30-day mortality model may be relevant. We hypothesized that in-depth evaluation of a carefully defined cohort with short survival, arbitrarily defined as a maximum of 3 months, may provide signals and i...
Nature Communications; de Gooyer JM, Elekonawo FMK et. al.
May 14th, 2022 - In patients with colorectal peritoneal metastases scheduled for cytoreductive surgery, accurate preoperative estimation of tumor burden and subsequent intraoperative detection of all tumor deposits remains challenging. In this study (ClinicalTrials.gov NCT03699332) we describe the results of a phase I clinical trial evaluating [111In]In-DOTA-labetuzumab-IRDye800CW, a dual-labeled anti-carcinoem...
International Journal of Biological Sciences; Bao Z, Zeng W et. al.
May 12th, 2022 - Background: There is increasing evidence that tumour-associated macrophages (TAMs) are critical in the formation of lung metastases. However, the molecular mechanisms of tumour interactions with TAMs via EMT are largely unknown. Methods: The mechanism of lung metastasis was studied in patient tissues. The mechanism of SNAIL regulation of the interaction between mesenchymal cells and M2 macropha...
Journal of the National Comprehensive Cancer Network : JN... Chang JY, Verma V
May 12th, 2022 - Metastatic non-small cell lung cancer (NSCLC) is highly heterogeneous, and there are patients with limited areas of metastases (oligometastases) or progression (oligoprogression) whose natural history and prognosis can be considerably more favorable. As a result, local therapy may offer these patients a chance at clinically meaningful disease control and/or cure. This review begins by describin...
Nature Communications; Zhang L, Qu J et. al.
May 11th, 2022 - Bone metastases occur in 50-70% of patients with late-stage breast cancers and effective therapies are needed. The expression of enhancer of zeste homolog 2 (EZH2) is correlated with breast cancer metastasis, but its function in bone metastasis hasn't been well-explored. Here we report that EZH2 promotes osteolytic metastasis of breast cancer through regulating transforming growth factor beta (...
Canadian Journal of Gastroenterology & Hepatology; Qiu YY, Peng D et. al.
May 10th, 2022 - The lung is the most common extra-abdominal metastasis site of colorectal cancer (CRC). This study aimed to investigate the genetic variation of pulmonary metastases (PM) and primary tumors in resectable CRC. The clinical data of 410 patients with PM after CRC surgery and 33 paraffin-embedded tissue samples from January 2012 to July 2019 in our hospital were collected retrospectively. Next, 450...
Radiation Oncology (London, England); Xu Y, Xu Y et. al.
May 8th, 2022 - This study implemented a piecewise volumetric modulated arc therapy (P-VMAT) for realizing whole-brain radiation therapy (WBRT) with simultaneous integrated boost (SIB) for multiple brain metastases (> 40 metastases) with a conventional C-arm linear accelerator. This study retrospectively analyzed 10 patients with multiple brain metastases (40-120 metastases, median 76), who underwent WBRT and ...
American Society of Clinical Oncology Educational Book. A... Alvarez-Breckenridge C, Remon J et. al.
May 7th, 2022 - The diagnosis of brain metastases has historically been a dreaded, end-stage complication of systemic disease. Additionally, with the increasing effectiveness of systemic therapies that prolong life expectancy and improved imaging tools, the incidence of intracranial progression is becoming more common. Within this context, there has been increasing attention directed at understanding the molec...
Contrast Media & Molecular Imaging; Wang D, Yang Y et. al.
May 3rd, 2022 - Our study aims to compare the diagnostic value of 18F-NaF positron emission tomography-computed tomography (PET/CT), 18F-NaF PET, and planar 99mTc-MDP bone scintigraphy for detection of bone metastases in patients with newly diagnosed nasopharyngeal carcinoma (NPC). Our study retrospectively analyzed 58 patients with pathologically proven NPC. They all underwent both 18F-NaF PET/CT and planar 9...
Anticancer Research; Tate S, Nishikimi K et. al.
May 1st, 2022 - Brain metastases from ovarian cancer remain rare and the appropriate treatment is unknown. We investigated survival outcomes following salvage chemotherapy before and after bevacizumab approval to evaluate the efficacy of bevacizumab in patients with brain metastasis from ovarian cancer. We investigated 23 consecutive patients with brain metastasis from ovarian cancer at our hospital between 20...
BMC Cancer; Anderson AB, Grazal C et. al.
May 1st, 2022 - Prognostic indicators, treatments, and survival estimates vary by cancer type. Therefore, disease-specific models are needed to estimate patient survival. Our primary aim was to develop models to estimate survival duration after treatment for skeletal-related events (SREs) (symptomatic bone metastasis, including impending or actual pathologic fractures) in men with metastatic bone disease due t...
BMJ Case Reports; Campoverde LE, Batalini F et. al.
Apr 30th, 2022 - A woman in her 50s previously treated for early-stage breast cancer, parotid mucoepidermoid carcinoma and Caroli's disease was diagnosed with stage IV pancreatic ductal adenocarcinoma (PDAC) metastatic to the liver and was found to harbour a BRCA1 germline mutation. She had palliative chemotherapy, initially with 5-fluorouracil, leucovorin, irinotecan and oxaliplatin, and then FOLFIRI and capec...
Journal of Immunology Research; Sun Y, Zhang XX et. al.
Apr 29th, 2022 - Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the leading cause of death in PDAC. Diet-induced obesity (DIO) is a risk factor for PDAC, and it remains unclear whether and how DIO contributes to liver metastasis of ...
BMC Pulmonary Medicine; Yuan J, Cheng Z et. al.
Apr 29th, 2022 - The aim of this study was to explore risk factors for the prognosis of lung cancer with simple brain metastasis (LCSBM) patients and to establish a prognostic predictive nomogram for LCSBM patients. Three thousand eight hundred and six cases of LCSBM were extracted from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015 using SEER Stat 8.3.5. Lung cancer patients ...
PloS One; Ahmed AA, Strong MJ et. al.
Apr 28th, 2022 - Roughly 400,000 people in the U.S. are living with bone metastases, the vast majority occurring in the spine. Metastases to the spine result in fractures, pain, paralysis, and significant health care costs. This predilection for cancer to metastasize to the bone is seen across most cancer histologies, with the greatest incidence seen in prostate, breast, and lung cancer. The molecular process i...
Cancer O'Rourke K
Apr 26th, 2022 - Relatlimab plus nivolumab beneficial for previously untreated metastatic or unresectable melanoma.|2022|O'Rourke K,|therapeutic use,drug therapy,secondary,therapeutic use,
World Journal of Surgical Oncology; Javed S, Benoist S et. al.
Apr 25th, 2022 - BRAF V600E-mutant colorectal cancers (CRCs) are associated with shorter survival than BRAF wild-type tumors. Therapeutic decision-making for colorectal liver metastases (CRLM) harboring this mutation remains difficult due to the scarce literature. The aim was to study a large cohort of BRAF V600E-mutant CRLM patients in order to see if surgery extend overall survival among others prognostic fac...
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Breast Cancer Research and Treatment; Puri A, Mylavarapu C et. al.
Apr 24th, 2022 - Leptomeningeal metastases (LM) are an aggressive complication of metastatic breast cancer (MBC) with brain metastases (BM), with a short survival of weeks to months. Studies suggest that surgical resection of BM may increase the risk of LM, especially in infratentorial metastases. In this retrospective study, we examine this and other factors which may be associated with increased risk of LM. A...