×
About 463,455 results

Examination of Protein Quantity and Protein Distribution across the Day on Ad Libitum Carbohydrate and Fat Intake in Overweight Women
https://academic.oup.com/cdn/article/1/12/e001933/4772174

The effects of meal-specific protein quantity and protein distribution throughout the day on daily food intake are relatively unknown.

Kinetics of viral load and antibody response in relation to COVID-19 severity
https://dm5migu4zj3pb.cloudfront.net/manuscripts/138000/138759/cache/138759.1-20200701111152-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf

The SARS-CoV-2 is the causative agent for COVID-19 pneumonia. Little is known about the 60 kinetics, tissue distribution, cross-reactivity and neutralization antibody response in COVID61 19 patients. Two groups of RT-PCR confirmed COVID-19 patients were enrolled in this study, 62 including 12 severe patients in ICUs who needed mechanical ventilation and 11 mild patients 63 in isolation wards...

E-cigarette Use Among Middle and High School Students — United States, 2020
https://www.cdc.gov/mmwr/volumes/69/wr/mm6937e1.htm?s_cid=mm6937e1_x

The use of any tobacco product by youths is unsafe, including electronic cigarettes (e-cigarettes) (1). Most e-cigarettes contain nicotine, which is highly addictive, can harm the developing adolescent brain, and can increase risk for future addiction to other drugs (1). E-cigarette use has increased considerably among U.S. youths since 2011 (1,2). Multiple factors have contributed to this incr...

Protein Distribution and Muscle-Related Outcomes: Does the Evidence Support the Concept?
https://www.mdpi.com/2072-6643/12/5/1441/htm

There is a shift in thinking about dietary protein requirements from daily requirements to individual meal requirements. Per meal, stimulation of muscle protein synthesis has a saturable dose relationship with the quantity of dietary protein consumed. Protein intake above the saturable dose does not further contribute to the synthetic response; the “excess” amino acids are predominantly oxidize...

Medications: Distribution of Sample Medications in the Practice Setting
https://www.medicalmutual.com/risk/practice-tips/tip/medications-distribution-of-sample-medications-in-the-practice-setting/81

Many physician offices accept sample medications from pharmaceutical drug representatives and dispense them to their patient population. Compliance with providing sample medications to patients in a safe manner requires a significant administrative effort. When the physician office practice dispenses sample medications to its patients, the practice is acting as a pharmacy and is required to fol...

Face mask use in the general population and optimal resource allocation during the COVID-19 pandemic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426871/

The ongoing novel coronavirus disease (COVID-19) pandemic has already infected millions worldwide and, with no vaccine available, interventions to mitigate transmission are urgently needed. While there is broad agreement that travel restrictions and social distancing are beneficial in limiting spread, recommendations around face mask use are inconsistent. Here, we use mathematical modeling to e...

Epidemiology, treatment and prevention of herpes zoster: A comprehensive review
http://www.ijdvl.com/article.asp?issn=0378-6323;year=2018;volume=84;issue=3;spage=251;epage=262;aulast=Koshy

Herpes zoster is a major health burden that can affect individuals of any age. It is seen more commonly among individuals aged ≥50 years, those with immunocompromised status, and those on immunosuppressant drugs. It is caused by a reactivation of varicella zoster virus infection. Cell-mediated immunity plays a role in this reactivation. Fever, pain, and itch are common symptoms before the onset...

Children and COVID-19: State-Level Data Report
https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/

State-level reports are the best publicly available data on child COVID-19 cases in the United States. The American Academy of Pediatrics and the Children’s Hospital Association are collaborating to collect and share all publicly available data from states on child COVID-19 cases (definition of “child” case is based on varying age ranges reported across states; see report Appendix for details a...

Back to our roots or sowing new seeds: thinking anew on the paradigms of health, harm a...
https://doi.org/10.1093/pubmed/fdac093
Journal of Public Health (Oxford, England); van Schalkwyk MCI, Zenone M et. al.

Dec 6th, 2022 - Health, harms and disease are intimately linked, and their promotion and distribution are determined by the social, political and physical worlds in which people live. Yet, the popular narrative on health is still dominated by a biological model that focuses on a disease-causing 'pathogen' or 'agent' that leads to pathology which is diagnosable and amenable to intervention at the individual lev...

Allocation to pediatric recipients around the world: An IPTA global survey of current p...
https://doi.org/10.1111/petr.14317
Pediatric Transplantation; Hernández Benabe S, Batsis I et. al.

Dec 6th, 2022 - There has not been a comprehensive global survey of pediatric-deceased donor allocation practices across all organs since the advent of deceased donor transplantation at the end of the 20th century. As an international community that is responsible for transplanting children, we set out to survey the existing landscape of allocation. We aimed to summarize current practices and provide a snapsho...

Pediatric impacts of multiorgan transplant allocation policy in the United States.
https://doi.org/10.1111/petr.14253
Pediatric Transplantation; Engen RM, Kirmani S

Dec 6th, 2022 - Multiorgan transplantation is increasingly common, driving recent increased attention to multiorgan allocation policies. In this review, we summarize current multiorgan transplant allocation policies in the United States, with attention to recent and proposed changes and their impact on pediatric candidates. Existing multiorgan transplant policies attempt to balance equity and utility. Currentl...

Thermal Limits Determination for Zooplankton Using a Heat Block.
https://doi.org/10.3791/64762
Journal of Visualized Experiments : JoVE; Chan KYK, Jorgensen BK et. al.

Dec 6th, 2022 - Thermal limits and breadth have been widely used to predict species distribution. As the global temperature continues to rise, understanding how thermal limit changes with acclimation and how it varies between life stages and populations are vital for determining the vulnerability of species to future warming. Most marine organisms have complex life cycles that include early planktonic stages. ...

Impact of hepatitis C virus eradication with direct-acting antivirals on glycidic metab...
https://doi.org/10.20945/2359-3997000000543
Archives of Endocrinology and Metabolism; Sparvoli JMH, Sparvoli AC et. al.

Dec 6th, 2022 - To compare the glucose metabolism of patients with chronic hepatitis C virus infection treated with direct-acting antivirals (DAAs) in pretreatment and sustained viral response (SVR) periods. This was an intervention pre-post study of 273 patients with chronic hepatitis C virus infection treated with DAAs from March 2018 to December 2019. Glycidic metabolism was evaluated through homeostasis mo...

Subcellular diversity of Nav1.5 in cardiomyocytes: distinct functions, mechanisms and t...
https://doi.org/10.1113/JP283086
The Journal of Physiology; Marchal GA, Remme CA

Dec 6th, 2022 - In cardiomyocytes, the rapid depolarisation of the membrane potential is mediated by the α-subunit of the cardiac voltage-gated Na+ channel (NaV 1.5), encoded by the gene SCN5A. This ion channel allows positively charged Na+ ions to enter the cardiomyocyte, resulting in the fast upstroke of the AP and is therefore crucial for cardiac excitability and electrical propagation. This essential role ...

Prevalence and outcomes of atrial fibrillation in older people living in care homes in ...
https://doi.org/10.1093/ageing/afac252
Age and Ageing; Ritchie LA, Harrison SL et. al.

Dec 6th, 2022 - To determine atrial fibrillation (AF) prevalence and temporal trends, and examine associations between AF and risk of adverse health outcomes in older care home residents. Retrospective cohort study using anonymised linked data from the Secure Anonymised Information Linkage Databank on CARE home residents in Wales with AF (SAIL CARE-AF) between 2003 and 2018. Fine-Gray competing risk models wer...

Determining whether older adults use similar strategies to young adults in theory of mi...
https://doi.org/10.1093/geronb/gbac187
The Journals of Gerontology. Series B, Psychological Scie... Krendl AC, Mannering W et. al.

Dec 6th, 2022 - Theory of mind - the ability to infer others' mental states - declines over the lifespan, potentially due to cognitive decline. However, it is unclear whether deficits emerge because older adults use the same strategies as young adults, albeit less effectively, or use different or no strategies. The current study compared the similarity of older adults' theory of mind errors to young adults' an...

Disparate selection of mutations in the dihydrofolate reductase gene (dhfr) of Plasmodi...
https://doi.org/10.1371/journal.pntd.0010977
PLoS Neglected Tropical Diseases; Chen J, Ma X et. al.

Dec 6th, 2022 - Plasmodium ovale curtisi and P. ovale wallikeri are both endemic in sub-Saharan Africa, the Middle East and Southeast Asia. Molecular surveillance data for drug resistance in P. ovale spp. is limited at present. We analysed polymorphisms in the podhfr, pocrt and pocytb genes of P. ovale spp. in 147 samples collected from travelers returning to China from Africa. Two podhfr mutations, S58R and S...

A systematic review and global analysis of the seasonal activity of Phlebotomus (Paraph...
https://doi.org/10.1371/journal.pntd.0010886
PLoS Neglected Tropical Diseases; Karmaoui A, Sereno D et. al.

Dec 6th, 2022 - Phlebotomus (Paraphlebotomus) sergenti is a widespread proven vector of Leishmania pathogens causing anthroponotic cutaneous leishmaniasis (ACL), due to L. tropica, in the old world. The activity of P. (Par.) sergenti is seasonal and sensitive to general variations in climate. Phenological data sets can thus provide a baseline for continuing investigations on P. (Par.) sergenti population dynam...

Mitochondrial carbonic anhydrase VA and VB: Properties and roles in health and disease.
https://doi.org/10.1113/JP283579
The Journal of Physiology; Aspatwar A, Supuran CT et. al.

Dec 6th, 2022 - Carbonic anhydrase V (CA V), a mitochondrial enzyme, was first isolated from guinea pig liver and subsequently identified in mice and humans. Later, studies revealed that the mouse genome contains two mitochondrial CA sequences, named Car5A and Car5B. The CA VA enzyme is most highly expressed in the liver, whereas CA VB shows a broad tissue distribution. Car5A knockout mice showed a predominant...

Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor ...
https://doi.org/10.2174/1389200224666221201123254
Current Drug Metabolism; Wei H, Wu L et. al.

Dec 6th, 2022 - 101BHG-D01 is a novel selective anti-muscarinic (M) 3 receptor-blocking drug. 101BHG-D01 nasal spray is intended to be used to relieve sneezing and runny nose symptoms caused by allergic rhinitis. In this study, we examined the plasma pharmacokinetics, tissue distribution, and major excretion mode of 101BHG-D01 in Beagle dogs and rats following nasal spray and intranasal administration, respect...