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Examination of Protein Quantity and Protein Distribution across the Day on Ad Libitum Carbohydrate and Fat Intake in Overweight Women
https://academic.oup.com/cdn/article/1/12/e001933/4772174

The effects of meal-specific protein quantity and protein distribution throughout the day on daily food intake are relatively unknown.

Kinetics of viral load and antibody response in relation to COVID-19 severity
https://dm5migu4zj3pb.cloudfront.net/manuscripts/138000/138759/cache/138759.1-20200701111152-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf

The SARS-CoV-2 is the causative agent for COVID-19 pneumonia. Little is known about the 60 kinetics, tissue distribution, cross-reactivity and neutralization antibody response in COVID61 19 patients. Two groups of RT-PCR confirmed COVID-19 patients were enrolled in this study, 62 including 12 severe patients in ICUs who needed mechanical ventilation and 11 mild patients 63 in isolation wards...

E-cigarette Use Among Middle and High School Students — United States, 2020
https://www.cdc.gov/mmwr/volumes/69/wr/mm6937e1.htm?s_cid=mm6937e1_x

The use of any tobacco product by youths is unsafe, including electronic cigarettes (e-cigarettes) (1). Most e-cigarettes contain nicotine, which is highly addictive, can harm the developing adolescent brain, and can increase risk for future addiction to other drugs (1). E-cigarette use has increased considerably among U.S. youths since 2011 (1,2). Multiple factors have contributed to this incr...

Protein Distribution and Muscle-Related Outcomes: Does the Evidence Support the Concept?
https://www.mdpi.com/2072-6643/12/5/1441/htm

There is a shift in thinking about dietary protein requirements from daily requirements to individual meal requirements. Per meal, stimulation of muscle protein synthesis has a saturable dose relationship with the quantity of dietary protein consumed. Protein intake above the saturable dose does not further contribute to the synthetic response; the “excess” amino acids are predominantly oxidize...

Medications: Distribution of Sample Medications in the Practice Setting
https://www.medicalmutual.com/risk/practice-tips/tip/medications-distribution-of-sample-medications-in-the-practice-setting/81

Many physician offices accept sample medications from pharmaceutical drug representatives and dispense them to their patient population. Compliance with providing sample medications to patients in a safe manner requires a significant administrative effort. When the physician office practice dispenses sample medications to its patients, the practice is acting as a pharmacy and is required to fol...

Face mask use in the general population and optimal resource allocation during the COVID-19 pandemic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426871/

The ongoing novel coronavirus disease (COVID-19) pandemic has already infected millions worldwide and, with no vaccine available, interventions to mitigate transmission are urgently needed. While there is broad agreement that travel restrictions and social distancing are beneficial in limiting spread, recommendations around face mask use are inconsistent. Here, we use mathematical modeling to e...

Epidemiology, treatment and prevention of herpes zoster: A comprehensive review
http://www.ijdvl.com/article.asp?issn=0378-6323;year=2018;volume=84;issue=3;spage=251;epage=262;aulast=Koshy

Herpes zoster is a major health burden that can affect individuals of any age. It is seen more commonly among individuals aged ≥50 years, those with immunocompromised status, and those on immunosuppressant drugs. It is caused by a reactivation of varicella zoster virus infection. Cell-mediated immunity plays a role in this reactivation. Fever, pain, and itch are common symptoms before the onset...

Children and COVID-19: State-Level Data Report
https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/

State-level reports are the best publicly available data on child COVID-19 cases in the United States. The American Academy of Pediatrics and the Children’s Hospital Association are collaborating to collect and share all publicly available data from states on child COVID-19 cases (definition of “child” case is based on varying age ranges reported across states; see report Appendix for details a...

New Helpline and Ordering Pathway for Evusheld
https://aspr.hhs.gov/COVID-19/Therapeutics/updates/Pages/important-update-27July2022.aspx
Administration for Strategic Preparedness and Response (ASPR)

Jul 27th, 2022 - HHS/ASPR has partnered with AstraZeneca to establish an additional pathway for providers to access the COVID-19 drug Evusheld for use with eligible patients. Individual providers and smaller sites of care that do not currently receive Evusheld through the HHS Health Partner Order Portal (or HPOP) distribution process can now order small, limited quantities of product (1-3 patient courses).

The use of Ivermectin for the treatment of COVID-19: Panacea or enigma?
https://pubmed.ncbi.nlm.nih.gov/35694631/
Clinical Epidemiology and Global Health; Onyeaka H, Tamasiga P et. al.

Jul 23rd, 2022 - The outbreak of SARS-CoV-2 pandemic has triggered unprecedented social, economic and health challenges. To control and reduce the infection rate, countries employed non-pharmaceutical measures such as social distancing, isolation, quarantine, and the use of masks, hand and surface sanitisation. Since 2021 a global race for COVID-19 vaccination ensued, mainly due to a lack of equitable vaccine p...

Operation Nasal Vaccine—Lightning speed to counter COVID-19
https://www.science.org/doi/10.1126/sciimmunol.add9947
Science Immunology; Topol EJ.

Jul 21st, 2022 - Just 10 months after the initial genome sequencing of the SARS-CoV-2 virus, two mRNA vaccines were demonstrated to provide 95% efficacy against symptomatic infections via randomized, placebo-controlled trials of more than 74,000 participants (1). That unprecedented success was, in part, fueled by the $10 billion governmental investment in Operation Warp Speed (OWS) in March 2020 to accelerate t...

Monkeypox in Africa: the science the world ignored
https://www.nature.com/articles/d41586-022-01686-z
Nature Kozlov M.

Jun 23rd, 2022 - After monkeypox cases exploded last month in countries such as Portugal, Spain and the United Kingdom — where outbreaks don’t usually occur — a rapid, global response followed, including the distribution of vaccines in some countries. But monkeypox outbreaks have been occurring in parts of Central and West Africa for years, leaving African researchers there disheartened that such resources have...

Generalized Essential Telangiectasia
http://emedicine.medscape.com/article/1083313-overview

Aug 12th, 2022 - Practice Essentials A telangiectasis refers to a visibly dilated blood vessel on the skin or mucosal surface. Telangiectases that develop in the absence of any preceding or coexisting cutaneous or systemic disease are considered to be primary or essential. Telangiectases resulting from or in association with a known disease state are classified as secondary. Different presentations of primary t...

Generalized Essential Telangiectasia
https://emedicine.medscape.com/article/1083313-print

Aug 12th, 2022 - Practice Essentials A telangiectasis refers to a visibly dilated blood vessel on the skin or mucosal surface. Telangiectases that develop in the absence of any preceding or coexisting cutaneous or systemic disease are considered to be primary or essential. Telangiectases resulting from or in association with a known disease state are classified as secondary. Different presentations of primary t...

Respirable Clofazimine Particles Produced by Air Jet Milling Technique Are Efficacious ...
https://doi.org/10.1128/aac.00186-22
Antimicrobial Agents and Chemotherapy; Brunaugh AD, Walz A et. al.

Aug 10th, 2022 - Tuberculosis (TB) remains a major cause of morbidity and mortality, particularly in low- and middle-income countries where access to health care workers, cold-chain storage, and sterile water sources may be limited. Inhaled drug delivery is a promising alternative to systemic delivery of antimycobacterial drugs, as it enables rapid achievement of high infection-site drug concentrations. The off...

Single-Center Analysis of Pegfilgrastim-induced Aortitis Using a Drug Prescription Data...
https://doi.org/10.1148/radiol.220357
Radiology Takamatsu A, Yoshida K et. al.

Aug 10th, 2022 - Background Pegfilgrastim-induced aortitis is a rare but serious adverse event in patients undergoing anticancer therapy with granulocyte colony-stimulating factor analogs. Despite previous case series and systemic reviews, the exact incidence, clinical presentation, and CT manifestations of pegfilgrastim-induced aortitis remain unclear. Purpose To clarify the incidence and clinicoradiologic cha...

Chronic Pain in Young People With Cerebral Palsy: Activity Limitations and Coping Strat...
https://doi.org/10.1097/PEP.0000000000000943
Pediatric Physical Therapy : the Official Publication of ... Carozza L, Anderson-Mackay E et. al.

Aug 10th, 2022 - To describe the effect of chronic pain on the activities of children and adolescents with cerebral palsy, to describe coping strategies, and to examine associations between effect of pain on activities, coping strategies, and level of pain. Using an online survey, 27, 8- to 18-year-olds with cerebral palsy and chronic pain or their parents reported pain intensity, distribution, activity limitat...

Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Function...
https://doi.org/10.1001/jama.2022.12584
JAMA , Qiu Z et. al.

Aug 10th, 2022 - Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban is effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy. To assess the efficacy and adverse events of intravenous tirofiban bef...

Use of mixed-type data clustering algorithm for characterizing temporal and spatial dis...
https://doi.org/10.1371/journal.pone.0272413
PloS One; Kachigunda B, Mengersen K et. al.

Aug 10th, 2022 - Appropriate inspection protocols and mitigation strategies are a critical component of effective biosecurity measures, enabling implementation of sound management decisions. Statistical models to analyze biosecurity surveillance data are integral to this decision-making process. Our research focuses on analyzing border interception biosecurity data collected from a Class A Nature Reserve, Barro...

q value and parent energy optimization using a low-voltage ionization approach increase...
https://doi.org/10.1002/jms.4876
Journal of Mass Spectrometry : JMS; Madama S, Falletta E et. al.

Aug 10th, 2022 - In this work, the isolation step in the linear ion trap was performed using different "q values" conditions at a low collision-induced dissociation (CID) energy leading to the parent ion resolution improvements, reasonably due to better ion energy distribution. According to the results, we obtained a greater resolution and mass accuracy operating in both traditional electrospray and low voltage...