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About 999,191 results

Efficacy of Laparoscopic Nissen Fundoplication vs Transoral Incisionless Fundoplication...
https://doi.org/10.1053/j.gastro.2017.12.021
Gastroenterology Richter JE, Kumar A et. al.

Jan 6th, 2018 - The effects of transoral incisionless fundoplication (TIF) and laparoscopic Nissen fundoplication (LNF) have been compared with those of proton pump inhibitors (PPIs) or a sham procedure in patients with gastroesophageal reflux disease (GERD), but there has been no direct comparison of TIF vs LNF. We performed a systematic review and network meta-analysis of randomized controlled trials to comp...

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations.
https://doi.org/10.1053/j.gastro.2017.12.012
Gastroenterology Hadjiliadis D, Khoruts A et. al.

Dec 31st, 2017 - Improved therapy has substantially increased survival of persons with cystic fibrosis (CF). But the risk of colorectal cancer (CRC) in adults with CF is 5-10 times greater compared to the general population, and 25-30 times greater in CF patients after an organ transplantation. To address this risk, the CF Foundation convened a multi-stakeholder task force to develop CRC screening recommendatio...

Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.
https://doi.org/10.1056/NEJMoa1612645
The New England Journal of Medicine; Masuda N, Lee SJ et. al.

May 31st, 2017 - Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)-negative breast cancer have poor prognoses. The benefit of adjuvant chemotherapy in these patients remains unclear. We randomly assigned 910 patients with HER2-negative residual invasive breast cancer after neoadjuvant chemotherapy (containing anthracyc...

History of breast feeding and risk of incident endometriosis: prospective cohort study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574033
BMJ (Clinical Research Ed.); Farland LV, Eliassen AH et. al.

Aug 30th, 2017 - Objective To investigate the association between lifetime breast feeding, exclusive breast feeding, postpartum amenorrhea, and incidence of endometriosis among parous women.Design Prospective cohort study.Setting Nurses' Health Study II, 1989-2011.Participants 72 394women who reported having one or more pregnancies that lasted at least six months, 3296 of whom had laparoscopically confirmed end...

Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818853
JAMA Maret-Ouda J, Wahlin K et. al.

Sep 12th, 2017 - Cohort studies, mainly based on questionnaires and interviews, have reported high rates of reflux recurrence after antireflux surgery, which may have contributed to a decline in its use. Reflux recurrence after laparoscopic antireflux surgery has not been assessed in a long-term population-based study of unselected patients. To determine the risk of reflux recurrence after laparoscopic antirefl...

Effect of Mechanically Expanded vs Self-Expanding Transcatheter Aortic Valve Replacemen...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833545
JAMA Feldman TE, Reardon MJ et. al.

Jan 3rd, 2018 - Transcatheter aortic valve replacement (TAVR) is established for selected patients with severe aortic stenosis. However, limitations such as suboptimal deployment, conduction disturbances, and paravalvular leak occur. To evaluate if a mechanically expanded valve (MEV) is noninferior to an approved self-expanding valve (SEV) in high-risk patients with aortic stenosis undergoing TAVR. The REPRISE...

FXR is a molecular target for the effects of vertical sleeve gastrectomy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016120
Nature Ryan KK, Tremaroli V et. al.

Mar 28th, 2014 - Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are at present the most effective therapy for the treatment of obesity, and are associated with considerable improvements in co-morbidities, including type-2 diabetes mellitus. The underlying molecular mechanisms contributing to these benefits remain largely undetermined, despite offering the potential to reveal new targe...

Risk of cerebral arteriovenous malformation rupture during pregnancy and puerperium.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035708
Neurology Liu XJ, Wang S et. al.

Apr 24th, 2014 - To determine whether the risk of arteriovenous malformation (AVM) rupture is increased during pregnancy and puerperium. Participants included 979 female patients with intracranial AVM admitted to Beijing Tiantan Hospital between 1960 and 2010. Two neurosurgery residents reviewed medical records for each case. Of them, 393 patients with ruptured AVM between 18 and 40 years of age were used for c...

Melanoma patients with an unknown primary tumor site have a better outcome than those w...
https://doi.org/10.1245/s10434-014-3679-5
Annals of Surgical Oncology; van der Ploeg AP, Haydu LE et. al.

May 7th, 2014 - Several reports in the literature suggest a difference in outcome between melanoma patients with macroscopic (clinically palpable) nodal disease from an unknown primary (MUP) and a known primary (MKP). The purpose of this study was to compare the outcomes for MUP and MKP patients after therapeutic lymph node dissection (TLND) for macroscopic nodal disease. From a large, prospective, single-inst...

Anterior cruciate ligament injuries: diagnosis, treatment, and prevention.
https://doi.org/10.1542/peds.2014-0623
Pediatrics LaBella CR, Hennrikus W et. al.

Apr 29th, 2014 - The number of anterior cruciate ligament (ACL) injuries reported in athletes younger than 18 years has increased over the past 2 decades. Reasons for the increasing ACL injury rate include the growing number of children and adolescents participating in organized sports, intensive sports training at an earlier age, and greater rate of diagnosis because of increased awareness and greater use of a...

Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145431
Journal of Neurology, Neurosurgery, and Psychiatry; Nuttin B, Wu H et. al.

Jan 21st, 2014 - For patients with psychiatric illnesses remaining refractory to 'standard' therapies, neurosurgical procedures may be considered. Guidelines for safe and ethical conduct of such procedures have previously and independently been proposed by various local and regional expert groups. To expand on these earlier documents, representative members of continental and international psychiatric and neuro...

Cervical spine injury patterns in children.
https://doi.org/10.1542/peds.2013-3505
Pediatrics Leonard JR, Jaffe DM et. al.

Apr 29th, 2014 - Pediatric cervical spine injuries (CSIs) are rare and differ from adult CSIs. Our objective was to describe CSIs in a large, representative cohort of children. We conducted a 5-year retrospective review of children <16 years old with CSIs at 17 Pediatric Emergency Care Applied Research Network hospitals. Investigators reviewed imaging reports and consultations to assign CSI type. We described c...

Cancer risk after resection of polypoid dysplasia in patients with longstanding ulcerat...
https://doi.org/10.1016/j.cgh.2013.07.024
Clinical Gastroenterology and Hepatology : the Official C... Wanders LK, Dekker E et. al.

Aug 7th, 2013 - American and European guidelines propose complete endoscopic resection of polypoid dysplasia (adenomas or adenoma-like masses) in patients with longstanding colitis, with close endoscopic follow-up. The incidence of cancer after detection of flat low-grade dysplasia or dysplasia-associated lesion or mass is estimated at 14 cases/1000 years of patient follow-up. However, the risk for polypoid dy...

Effect of PET before liver resection on surgical management for colorectal adenocarcino...
https://doi.org/10.1001/jama.2014.3740
JAMA Moulton CA, Gu CS et. al.

May 15th, 2014 - Patients with colorectal cancer with liver metastases undergo hepatic resection with curative intent. Positron emission tomography combined with computed tomography (PET-CT) could help avoid noncurative surgery by identifying patients with occult metastases. To determine the effect of preoperative PET-CT vs no PET-CT (control) on the surgical management of patients with resectable metastases an...

Isolated free fluid on abdominal computed tomography in blunt trauma: watch and wait or...
https://doi.org/10.1016/j.jamcollsurg.2014.04.020
Journal of the American College of Surgeons; Gonser-Hafertepen LN, Davis JW et. al.

Aug 15th, 2014 - Isolated free fluid (FF) on abdominal CT in stable blunt trauma patients can indicate the presence of hollow viscus injury. No criteria exist to differentiate treatment by operative exploration vs observation. The goals of this study were to determine the incidence of isolated FF and to identify factors that discriminate between patients who should undergo operative exploration vs observation. ...

Five-year outcomes in patients with left main disease treated with either percutaneous ...
https://doi.org/10.1161/CIRCULATIONAHA.113.006689
Circulation Morice MC, Serruys PW et. al.

Apr 4th, 2014 - Current guidelines recommend coronary artery bypass graft surgery (CABG) when treating significant de novo left main coronary artery (LM) stenosis; however, percutaneous coronary intervention (PCI) has a class IIa indication for unprotected LM disease in selected patients. This analysis compares 5-year clinical outcomes in PCI- and CABG-treated LM patients in the Synergy Between PCI With Taxus ...

Screening for abdominal aortic aneurysm: U.S. Preventive Services Task Force recommenda...
https://doi.org/10.7326/M14-1204
Annals of Internal Medicine; LeFevre ML,

Jun 24th, 2014 - Update of the 2005 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for abdominal aortic aneurysm (AAA). The USPSTF commissioned a systematic review that assessed the evidence on the benefits and harms of screening for AAA and strategies for managing small (3.0 to 5.4 cm) screen-detected AAAs. These recommendations apply to asymptomatic adults aged 50 years or older. The...

A comparison of cosmetic outcomes of lacerations on the extremities and trunk using abs...
https://doi.org/10.1111/acem.12387
Academic Emergency Medicine : Official Journal of the Soc... Tejani C, Sivitz AB et. al.

Jul 21st, 2014 - The primary objective was to compare the cosmetic outcomes of traumatic trunk and extremity lacerations repaired using absorbable versus nonabsorbable sutures. The secondary objective was to compare complication rates between the two groups. This was a randomized controlled trial comparing wounds repaired with Vicryl Rapide and Prolene sutures. Pediatric and adult patients with lacerations were...

Local recurrence after endoscopic mucosal resection of nonpedunculated colorectal lesio...
https://doi.org/10.1055/s-0034-1364970
Endoscopy Belderbos TD, Leenders M et. al.

Mar 28th, 2014 - Local recurrence has been observed after endoscopic mucosal resection (EMR) of nonpedunculated colorectal lesions. The indications for follow-up colonoscopy and the optimal time interval are currently unclear. The aims of this systematic review were to assess the frequency of local recurrence after EMR, to identify risk factors for recurrence, and to provide follow-up recommendations. A literat...

Initial cholecystectomy vs sequential common duct endoscopic assessment and subsequent ...
https://doi.org/10.1001/jama.2014.7587
JAMA Iranmanesh P, Frossard JL et. al.

Jul 9th, 2014 - The optimal management of treatment for patients at intermediate risk of a common duct stone (including increased liver function tests but bilirubin <4 mg/dL and no cholangitis) is a matter of debate. Many stones migrate spontaneously into the duodenum, making preoperative common duct investigations unnecessary. To compare strategies of cholecystectomy first vs a sequential endoscopic common du...