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About 209,153 results

Evaluation of the toxic effects of thimerosal and/or aluminum hydroxide in SH-SY5Y cell...
https://doi.org/10.1177/09603271221136206
Human & Experimental Toxicology; Öztürk ME, Yirün A et. al.

Nov 22nd, 2022 - In this study, we aimed to evaluate possible toxic effects of thimerosal, aluminum and combination of thimerosal and aluminum in SH-SY5Y cells. Inhibitory concentrations were determined by MTT assay; reactive oxygen species (ROS) were determined by a fluorometric kit and antioxidant/oxidant parameters were measured by spectrophotometric kits. Nuclear factor erythroid 2-associated factor 2 (Nrf2...

PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675736
Nature Communications; Geng Y, Li L et. al.

Nov 20th, 2022 - Pulmonary fibrosis is a chronic interstitial lung disease that causes irreversible and progressive lung scarring and respiratory failure. Activation of fibroblasts plays a central role in the progression of pulmonary fibrosis. Here we show that platelet endothelial aggregation receptor 1 (PEAR1) in fibroblasts may serve as a target for pulmonary fibrosis therapy. Pear1 deficiency in aged mice s...

Constitutively active microglial populations limit anorexia induced by the food contami...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675145
Journal of Neuroinflammation; Gaige S, Barbouche R et. al.

Nov 20th, 2022 - Microglia are involved in neuroinflammatory processes during diverse pathophysiological conditions. To date, the possible contribution of these cells to deoxynivalenol (DON)-induced brain inflammation and anorexia has not yet been evaluated. DON, one of the most abundant trichothecenes found in cereals, has been implicated in mycotoxicosis in both humans and farm animals. DON-induced toxicity i...

Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206+ macrophagesI...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677986
Gut Microbes; Jia DJ, Wang QW et. al.

Nov 19th, 2022 - Imbalance of gut microbiota homeostasis is related to the occurrence of ulcerative colitis (UC), and probiotics are thought to modulate immune microenvironment and repair barrier function. Here, in order to reveal the interaction between UC and gut microbiota, we screened a new probiotic strain by 16S rRNA sequencing from Dextran Sulfate Sodium (DSS)-induced colitis mice, and explored the mecha...

In vitro and in vivo acute toxicity of a novel citrate-coated magnetite nanoparticle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671459
PloS One; Rocha JMV, de Souza VB et. al.

Nov 18th, 2022 - Magnetic nanoparticles (MNps) have become powerful tools for multiple biomedical applications such as hyperthermia drivers, magnetic resonance imaging (MRI) vectors, as well as drug-delivery systems. However, their toxic effects on human health have not yet been fully elucidated, especially in view of their great diversity of surface modifications and functionalizations. Citrate-coating of MNps...

Silica Nanoparticles Cause Activation of NLRP3 Inflammasome in-vitro Model-Using Microg...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661917
International Journal of Nanomedicine; Hou S, Li C et. al.

Nov 18th, 2022 - Silica nanoparticles (SiNPs) have been widely used in food, cosmetics, medicine and other fields; however, there have been growing concerns regarding their potential adverse effects on health. A large number of studies have confirmed that SiNPs with small particle diameters can pass through the blood brain barrier, causing irreversible damage to the nervous system. This study aims to further ex...

A review of chemical warfare agents linked to respiratory and neurological effects expe...
https://doi.org/10.1080/08958378.2022.2147257
Inhalation Toxicology; Cruz-Hernandez A, Roney A et. al.

Nov 18th, 2022 - Over 40% of veterans from the Persian Gulf War (GW) (1990-1991) suffer from Gulf War Illness (GWI). Thirty years since the GW, the exposure and mechanism contributing to GWI remain unclear. One possible exposure that has been attributed to GWI are chemical warfare agents (CWAs). While there are treatments for isolated symptoms of GWI, the number of respiratory and cognitive/neurological issues ...

How to make plastic less of an environmental burden.
https://doi.org/10.1038/d41586-022-03644-1
Nature DeWeerdt S

Nov 18th, 2022 - How to make plastic less of an environmental burden.|2022|DeWeerdt S,|adverse effects,toxicity,adverse effects,toxicity,trends,

IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664718
Respiratory Research; Milara J, Roger I et. al.

Nov 16th, 2022 - Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on pulmonary vessels is unknown. Here we analyzed the contribution of IL-11 to PH in patients with IPF and the potential mechanism implicated. Pulmonary arteries, lung tissue and serum of control subjects (n = 20), IPF (n = 20) a...

Black Cohosh Herbal Extract and Hematologic Alterations in B6C3F1/N Mice.
https://doi.org/10.1177/01926233221133549
Toxicologic Pathology; Cora M

Nov 15th, 2022 - Black cohosh is a readily available dietary supplement currently marketed as a remedy for dysmenorrhea and menopausal symptoms and is one of the top-selling herbal supplements in the United States. Black cohosh extract (BCE) was nominated to the National Toxicology Program (NTP) by the National Cancer Institute and the National Institute of Environmental Health Sciences due to its widespread us...

Cytoprotective Effects of the Tiger's Milk Mushroom Lignosus rhinocerotis (Agaricomycet...
https://doi.org/10.1615/IntJMedMushrooms.2022045352
International Journal of Medicinal Mushrooms; Tan YH, Lim CSY et. al.

Nov 15th, 2022 - Lignosus rhinocerotis (Cooke) Ryvarden has been reported to possess numerous pharmacological effects. However, little is known about its potential role in mitigating the detrimental effects of oxidative stress. The present study investigated the cytoprotective effects of L. rhinocerotis extracts against hydrogen peroxide (H2O2)-induced oxidative stress of rat pheochromocytoma (PC12) cells. In t...

Interventions to reduce cadmium exposure in low- and middle-income countries during pre...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653536
Journal of Global Health; Sripada K, Lager AM

Nov 13th, 2022 - Exposure to the toxic metal cadmium is widespread globally and especially prevalent in low- and middle-income countries (LMICs). Early life (from pregnancy through childhood) is a vulnerable window for exposure. Therefore, interventions in low- and middle-income countries to prevent or reduce early life exposure to cadmium may be relevant for improving public health. We systematically reviewed ...

Combined effects of multiple metals on hearing loss: A Bayesian kernel machine regressi...
https://doi.org/10.1016/j.ecoenv.2022.114279
Ecotoxicology and Environmental Safety; Liang M, Guo X et. al.

Nov 12th, 2022 - Exposure to heavy elements is considered one of the risks of hearing loss. The combined effect of multiple metals on different hearing losses has not been extensively studied. This study deals with the association between different metals (Ba, Cd, Co, Cs, Mo, Pb, Mn, Sn, Sb, Tl, W) and hearing loss in the 2013-2018 National Health and Nutrition Examination Survey (NHANES). Associations were est...

Curcumin alleviates experimental colitis via a potential mechanism involving memory B c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639655
World Journal of Gastroenterology; Wei SY, Wu TT et. al.

Nov 11th, 2022 - Immune dysfunction is the crucial cause in the pathogenesis of inflammatory bowel disease (IBD), which is mainly related to lymphocytes (T or B cells, incl-uding memory B cells), mast cells, activated neutrophils, and macrophages. As the precursor of B cells, the activation of memory B cells can trigger and differentiate B cells to produce a giant variety of inducible B cells and tolerant B cel...

Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639657
World Journal of Gastroenterology; El-Harakeh M, Saliba J et. al.

Nov 11th, 2022 - Inflammatory bowel disease (IBD) constitutes a substantial risk factor for colorectal cancer. Connexin 43 (Cx43) is a protein that forms gap junction (GJ) complexes involved in intercellular communication, and its expression is altered under pathological conditions, such as IBD and cancer. Recent studies have implicated epigenetic processes modulating DNA methylation in the pathogenesis of dive...

Does Hypochlorous Acid Cause Ototoxicity? An Experimental Study.
https://doi.org/10.1097/MAO.0000000000003734
Otology & Neurotology : Official Publication of the Ameri... Mutlu A, Gunduz AY et. al.

Nov 10th, 2022 - Hypochlorous acid (HOCl) is a weak acid that ionizes in water. It is an effective antiseptic exhibiting low toxicity on living tissues. We aimed to investigate the ototoxic effects of HOCl on an animal model by using electrophysiological and histological methods. The study comprised 32 Sprague-Dawley rats, which were separated into four groups: control group (A), saline solution group (B), 70% ...

Methylmercury Toxicity During Heart Development: A Combined Analysis of Morphological a...
https://doi.org/10.1007/s12012-022-09772-4
Cardiovascular Toxicology; Ronconi-Krüger N, Pinheiro J et. al.

Nov 10th, 2022 - The heart of higher vertebrates develops early as a tubular structure, which requires cellular and molecular events for proliferation, differentiation and apoptosis for growth, and individualization of cardiac chambers. Exposure to different stressors can cause disturbances in the normal development and functionality of the cardiovascular system. This study aimed to characterize the impact of m...

Health risk implications of iron in wastewater soil-food crops grown in the vicinity of...
https://doi.org/10.1371/journal.pone.0275497
PloS One; Akhtar S, Luqman M et. al.

Nov 9th, 2022 - Irrigation using sewage water can be beneficial, as it can increase the productivity of crops but has negative consequences on crops, soil contamination, and human health. It contains a variety of toxins, such as chemicals and heavy metals, which damage the soil and crops. In this regard, the aim of the research was to assess the potential health hazards of iron (Fe) metal in food crops (leafy ...

PM2.5 activated NLRP3 inflammasome and IL-1β release in MH-S cells by facilitating auto...
https://doi.org/10.1177/03946320221137464
International Journal of Immunopathology and Pharmacology; Yuan G, Liu Y et. al.

Nov 9th, 2022 - Particulate matter 2.5 (PM2.5)-induced pulmonary inflammation is an important issue worldwide. NLRP3 inflammasome activation has been found to be involved in pulmonary inflammation development. However, whether PM2.5 induces pulmonary inflammation by activating the NLRP3 inflammasome has not yet been fully elucidated. This study researched whether PM2.5 induces the NLRP3 inflammasomes activatio...

Coronary thrombosis after European adder bite in a patient on dual antiplatelet therapy...
https://doi.org/10.1016/j.toxicon.2022.106961
Toxicon : Official Journal of the International Society O... Bernasconi L, Schicchi A et. al.

Nov 9th, 2022 - Until now very few cases of an adverse cardiovascular event have been described following European viper envenomation (Aravanis et al., 1982) (Aravanis et al., 1982) (Aravanis et al., 1982) (Aravanis et al., 1982). In fact, cardiac toxicity following snake bite is rare and primary reported from tropical and subtropical areas with only twenty-one cases of myocardial infarction reported in litera...