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About 149,102 results

Pregnancy outcome following in utero exposure to lithium: a prospective, comparative, o...
https://doi.org/10.1176/appi.ajp.2014.12111402
The American Journal of Psychiatry; Diav-Citrin O, Shechtman S et. al.

May 1st, 2014 - The authors conducted a prospective, comparative observational study to evaluate the risk of major anomalies following exposure to lithium during pregnancy. A total of 183 lithium-exposed pregnancies of women who contacted the Israeli Teratology Information Service were followed up (90.2% in the first trimester) and compared with 72 disease-matched and 748 nonteratogenic-exposed pregnancies. Th...

Assessment of musculoskeletal toxicity 5 years after therapy with levofloxacin.
https://doi.org/10.1542/peds.2013-3636
Pediatrics Bradley JS, Kauffman RE et. al.

Jun 11th, 2014 - Safety concerns for fluoroquinolones exist from animal studies demonstrating cartilage injury in weight-bearing joints, dependent on dose and duration of therapy. For children treated with levofloxacin or comparator in randomized, prospective, comparative studies for acute otitis media and community-acquired pneumonia, this 5-year follow-up safety study was designed to assess the presence/absen...

Pediatric exposure to laundry detergent pods.
https://doi.org/10.1542/peds.2014-0057
Pediatrics Valdez AL, Casavant MJ et. al.

Nov 11th, 2014 - Laundry detergent pods are a new product in the US marketplace. This study investigates the epidemiologic characteristics and outcomes of laundry detergent pod exposures among young children in the United States. Using data from the National Poison Data System, exposures to laundry detergent pods among children younger than 6 years of age during 2012-2013 were investigated. There were 17 230 ch...

Notes from the Field: Pediatric Emergency Department Visits for Buprenorphine/Naloxone ...
https://doi.org/10.15585/mmwr.mm6541a5
MMWR. Morbidity and Mortality Weekly Report; Budnitz DS, Lovegrove MC et. al.

Oct 20th, 2016 - Expanding access to office-based medication-assisted treatment with buprenorphine/naloxone for opioid dependence is a key part of the national strategy to address the opioid abuse epidemic (1). However, as buprenorphine/naloxone prescribing increased, emergency department (ED) visits and hospitalizations for unsupervised ingestions by young children began to increase, with buprenorphine/naloxon...

Tropospheric winds from northeastern China carry the etiologic agent of Kawasaki diseas...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050536
Proceedings of the National Academy of Sciences of the Un... Rodó X, Curcoll R et. al.

May 20th, 2014 - Evidence indicates that the densely cultivated region of northeastern China acts as a source for the wind-borne agent of Kawasaki disease (KD). KD is an acute, coronary artery vasculitis of young children, and still a medical mystery after more than 40 y. We used residence times from simulations with the flexible particle dispersion model to pinpoint the source region for KD. Simulations were g...

Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487826
Neuropsychopharmacology : Official Publication of the Ame... Stuart SA, Butler P et. al.

Mar 5th, 2015 - The biochemical targets for antidepressants are relatively well established, but we lack a clear understanding of how actions at these proteins translate to clinical benefits. This study used a novel rodent assay to investigate how different antidepressant drugs act to modify affective biases that have been implicated in depression. In this bowl-digging task, rats encounter two equal value lear...

d-serine levels in Alzheimer's disease: implications for novel biomarker development.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471283
Translational Psychiatry; Madeira C, Lourenco MV et. al.

May 5th, 2015 - Alzheimer's disease (AD) is a severe neurodegenerative disorder still in search of effective methods of diagnosis. Altered levels of the NMDA receptor co-agonist, d-serine, have been associated with neurological disorders, including schizophrenia and epilepsy. However, whether d-serine levels are deregulated in AD remains elusive. Here, we first measured D-serine levels in post-mortem hippocamp...

Genome-Wide DNA Methylation Profiling Reveals Epigenetic Changes in the Rat Nucleus Acc...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864634
Neuropsychopharmacology : Official Publication of the Ame... Watson CT, Szutorisz H et. al.

Jun 5th, 2015 - Drug exposure during critical periods of development is known to have lasting effects, increasing one's risk for developing mental health disorders. Emerging evidence has also indicated the possibility for drug exposure to even impact subsequent generations. Our previous work demonstrated that adolescent exposure to Δ(9)-tetrahydrocannabinol (THC), the main psychoactive component of marijuana (...

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and ta...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718588
Nature Kondo A, Shahpasand K et. al.

Jul 15th, 2015 - Traumatic brain injury (TBI), characterized by acute neurological dysfunction, is one of the best known environmental risk factors for chronic traumatic encephalopathy and Alzheimer's disease, the defining pathologic features of which include tauopathy made of phosphorylated tau protein (P-tau). However, tauopathy has not been detected in the early stages after TBI, and how TBI leads to tauopat...

Association of Prenatal Exposure to Air Pollution With Autism Spectrum Disorder.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583438
JAMA Pediatrics; Pagalan L, Bickford C et. al.

Nov 19th, 2018 - The etiology of autism spectrum disorder (ASD) is poorly understood, but prior studies suggest associations with airborne pollutants. To evaluate the association between prenatal exposures to airborne pollutants and ASD in a large population-based cohort. This population-based cohort encompassed nearly all births in Metro Vancouver, British Columbia, Canada, from 2004 through 2009, with follow-...

Detergent Pod-Related Eye Injuries Among Preschool-Aged Children.
https://doi.org/10.1001/jamaophthalmol.2016.5694
JAMA Ophthalmology; Haring RS, Sheffield ID et. al.

Feb 5th, 2017 - Detergent Pod-Related Eye Injuries Among Preschool-Aged Children.|2017|Haring RS,Sheffield ID,Frattaroli S,|epidemiology,chemically induced,epidemiology,chemically induced,epidemiology,toxicity,chemically induced,

Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in chil...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425996
BMJ (Clinical Research Ed.); von Ehrenstein OS, Ling C et. al.

Mar 21st, 2019 - To examine associations between early developmental exposure to ambient pesticides and autism spectrum disorder. Population based case-control study. California's main agricultural region, Central Valley, using 1998-2010 birth data from the Office of Vital Statistics. 2961 individuals with a diagnosis of autism spectrum disorder based on the Diagnostic and Statistical Manual of Mental Disorders...

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706297
Neuron Kim S, Kwon SH et. al.

Jun 30th, 2019 - Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α-synucleinopathy in the brain in a novel gut-to-brain α-syn transmission mouse model, where pathological α-syn preformed fibrils were injected into the duodenal and pyloric muscularis layer. Spread of pathologic ...

Management of Suspected Opioid Overdose With Naloxone in Out-of-Hospital Settings: A Sy...
https://doi.org/10.7326/M17-2224
Annals of Internal Medicine; Chou R, Korthuis PT et. al.

Nov 28th, 2017 - Naloxone is effective for reversing opioid overdose, but optimal strategies for out-of-hospital use are uncertain. To synthesize evidence on 1) the effects of naloxone route of administration and dosing for suspected opioid overdose in out-of-hospital settings on mortality, reversal of overdose, and harms, and 2) the need for transport to a health care facility after reversal of overdose with n...

Neuropsychiatric Sequelae in Adolescents With Acute Synthetic Cannabinoid Toxicity.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697124
Pediatrics Anderson SAR, Oprescu AM et. al.

Jul 9th, 2019 - Adolescents represent the largest age group that presents to emergency departments (ED) for synthetic cannabinoid (SC) toxicity; however, the neurotoxic effects of acute SC exposures in this group are understudied. Our aim was to characterize the neuropsychiatric presentation of adolescents with SC-related exposure in the ED compared with those with traditional cannabis exposure. A multicenter ...

Dose-dependent progression of parkinsonism in manganese-exposed welders.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272970
Neurology Racette BA, Searles Nielsen S et. al.

Dec 29th, 2016 - To determine whether the parkinsonian phenotype prevalent in welders is progressive, and whether progression is related to degree of exposure to manganese (Mn)-containing welding fume. This was a trade union-based longitudinal cohort study of 886 American welding-exposed workers with 1,492 examinations by a movement disorders specialist, including 398 workers with 606 follow-up examinations up ...

Critical Illness Secondary to Synthetic Cannabinoid Ingestion.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372325
JAMA Network Open; Kourouni I, Mourad B et. al.

Jul 20th, 2020 - Synthetic cannabinoids (SCs), commonly known as K2, spice, or fake weed, are cheap, artificially manufactured recreational drugs that have emerged as a major public health threat in various regions of the US. To describe the clinical manifestations of SC intoxication. This case series assessed adults admitted to the intensive care unit from 2014 to 2016 with acute life-threatening complications...

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641217
Nature Shi Y, Yamada K et. al.

Sep 29th, 2017 - APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE independently influences tau pathology, the other major proteinopathy of Alzheimer disease and other tauopathies, or tau-mediated neurodegeneration, is not clear. By generating P301S tau transgenic mice on either a human Ap...

Residential Proximity to Heavy-Traffic Roads, Benzene Exposure, and Childhood Leukemia-...
https://doi.org/10.1093/aje/kwv111
American Journal of Epidemiology; Houot J, Marquant F et. al.

Sep 17th, 2015 - Childhood leukemia may be associated with traffic-related environmental exposure to benzene, and additional data are needed. The Géolocalisation des Cancers Pédiatriques (GEOCAP) Study, a nationwide French case-control study, was designed to avoid selection bias due to differential participation and misclassification. The study compared the 2,760 childhood leukemia cases diagnosed in France bet...

Endothelial-to-mesenchymal transition in pulmonary hypertension.
https://doi.org/10.1161/CIRCULATIONAHA.114.008750
Circulation Ranchoux B, Antigny F et. al.

Jan 16th, 2015 - The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle actin-expressing cells. In situ evidence of EndoMT in human PAH was obtained by using con...