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About 196,420 results

COVID-19 and Air Pollution: A Spatial Analysis of Particulate Matter Concentration and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744860
International Journal of Environmental Research and Publi... Bossak BH, Andritsch S

Jan 12th, 2022 - In 2019, a novel coronavirus, SARS-CoV-2, was first reported in Wuhan, China. The virus causes the disease commonly known as COVID-19, and, since its emergence, it has infected over 252 million individuals globally and taken the lives of over 5 million in the same time span. Primary research on SARS-CoV-2 and COVID-19 focused on understanding the biomolecular composition of the virus. This rese...

Analysis of Consumer Exposure Cases for Alcohol-Based Disinfectant and Hand Sanitizer U...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750816
International Journal of Environmental Research and Publi... Kweon H, Choi JW et. al.

Jan 12th, 2022 - The development and distribution of vaccines and treatments as well as the use of disinfectants and hand sanitizers to cope with coronavirus disease 2019 (COVID-19) infection has increased rapidly. As the use of disinfectants and hand sanitizers increased, the number of unintended exposures to these substances also increased. A total of 8016 cases of toxic exposure to disinfectants and hand san...

The Social and Natural Environment's Impact on SARS-CoV-2 Infections in the UK Biobank.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744630
International Journal of Environmental Research and Publi... Scalsky RJ, Chen YJ et. al.

Jan 12th, 2022 - COVID-19 has caused a global pandemic with considerable impact. Studies have examined the influence of socioeconomic status and air pollution on COVID-19 risk but in low detail. This study seeks to further elucidate the nuances of socioeconomic status, as defined by the Index of Multiple Deprivation (IMD), air pollution, and their relationship. We examined the effect of IMD and air pollution on...

Assessment of Flexural Strength and Cytotoxicity of Heat Cure Denture Base Resin Modifi...
https://www.ncbi.nlm.nih.gov/pubmed/35000947
The Journal of Contemporary Dental Practice; Raj V, Bhat V et. al.

Jan 11th, 2022 - To assess the effect of titanium dioxide nanoparticles (NPs) on flexural strength and cytotoxicity of heat-cured polymethyl methacrylate (PMMA) resins. Sixty-four rectangular and 12 circular specimens were fabricated from metal dies to test flexural strength and cytotoxicity, respectively. The rectangular specimens were grouped into four (16 specimens each)-control group (Group 1), Group 2 with...

Temporal Exposure of Dermal Fibroblasts to Silver Diamine Fluoride and Fluorine NMR Qua...
https://doi.org/10.17796/1053-4625-45.6.6
The Journal of Clinical Pediatric Dentistry; Ml C, S D et. al.

Jan 8th, 2022 - Silver diamine fluoride has been advocated as a caries arresting material for Early Childhood Caries (ECC) and has received considerable public attention as the "silver bullet". However, cytotoxicity tests on the current concentrations of Silver Diamine Fluoride (SDF) to soft tissue have not been thoroughly assessed and analyzed at selected time intervals. The level of fluoride that is present ...

SHED's Response to Various Pulpotomy Materials: Cytotoxicity and Gene Expression Analysis.
https://doi.org/10.17796/1053-4625-45.6.7
The Journal of Clinical Pediatric Dentistry; Maru V, Shetty O et. al.

Jan 8th, 2022 - To examine the cytotoxicity and genetic expression of SHEDs cultured in eluates of various calcium silicate based pulpotomy materials. MTT assay, flow cytometry, alizarin red staining and scratch assay was used to assess the cellular viability, apoptosis, calcium matrix deposits and cell migration respectively. The gene expression of ALP, OCN and BMP -2, were measured with rtPCR. One way ANNOVA...

Amoebicidal Activity of Poly-Epsilon-Lysine Functionalized Hydrogels.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742527
Investigative Ophthalmology & Visual Science; Kennedy SM, Deshpande P et. al.

Jan 8th, 2022 - To determine the amoebicidal activity of functionalized poly-epsilon-lysine hydrogels (pɛK+) against Acanthamoeba castellanii. A. castellanii trophozoites and cysts were grown in the presence of pɛK solution (0-2.17 mM), pɛK or pɛK+ hydrogels, or commercial hydrogel contact lens (CL) for 24 hours or 7 days in PBS or Peptone-Yeast-Glucose (PYG) media (nutrient-deplete or nutrient-replete culture...

Investigation of the Effects of Trehalose on Glycemic Indices in Streptozotocin-Induced...
https://doi.org/10.1007/978-3-030-73234-9_33 10.1056/NEJMoa1610187 10.1002/jcp.27278 10.2337/dc14-1432 10.1186/s12902-018-0328-1 10.3390/ijms20102467 10.1016/j.redox.2017.09.007 10.1351/pac200274071263 10.1016/S0008-6215(00)86024-3 10.1021/jp002722i 10.1002/jps.22458 10.3177/jnsv.62.380 10.1186/s12937-017-0233-x 10.1016/j.nutres.2010.10.009 10.1016/j.dsx.2019.05.023 10.1258/002367797780600297 10.1258/002367796780739871 10.1093/jn/129.1.158 10.2337/diab.46.3.519 10.1016/j.biopha.2018.06.069 10.3390/molecules21030334 10.1002/jcp.26583 10.1039/C5RA27689F 10.1038/s41419-018-0749-9 10.1016/j.reprotox.2019.02.005 10.3177/jnsv.59.393 10.1016/j.archoralbio.2009.05.003 10.1186/s12937-020-00586-0 10.1017/S0007114511006714 10.3177/jnsv.62.380 10.3390/ijms160613729
Advances in Experimental Medicine and Biology; Radbakhsh S, Momtazi-Borojeni AA et. al.

Jan 5th, 2022 - Diabetes is a chronic metabolic disorder with considerable morbidity and mortality because of its associated complications that has become a challenging health problem worldwide. Trehalose (mycose) is a nonreducing disaccharide with a unique therapeutic potency without adverse effects, which has been found to improve glucose metabolism and homeostasis in different diabetes models. We hypothesiz...

IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism i...
https://doi.org/10.1186/s10194-021-01374-9 10.1212/wnl.0000000000007371 10.1016/j.jconrel.2018.05.005 10.1016/s0140-6736(20)31404-5 10.1056/NEJMra1915327 10.1111/j.1468-2982.2009.01864.x 10.1523/jneurosci.0373-15.2015 10.1186/s12974-020-01736-1 10.2174/1381612825666190709204107 10.1007/s00221-020-05923-7 10.1016/j.pain.2013.03.038 10.1155/2019/3258572 10.1007/s11916-018-0693-5 10.1016/j.pneurobio.2019.02.002 10.1002/jat.727 10.1111/head.13300 10.1016/j.autrev.2018.12.004 10.1038/s41582-019-0216-y 10.1186/s10194-021-01353-0 10.1038/s41593-017-0059-z 10.1080/1028415x.2019.1627768 10.1093/cercor/bhz227 10.1038/nri2550 10.1016/j.nbd.2020.105157 10.1186/s10194-018-0879-6 10.1097/j.pain.0000000000002147 10.1111/j.1468-2982.2005.00836.x 10.1007/s10753-019-01115-w 10.2147/dddt.s117166 10.1038/nri.2016.144 10.3389/fncel.2019.00136 10.1186/s10194-016-0631-z 10.1212/wnl.0000000000009169 10.1016/j.bbi.2019.07.026 10.1186/s10194-019-1070-4 10.1016/j.immuni.2019.03.021 10.1038/s41593-019-0369-4 10.1016/j.euroneuro.2015.04.001 10.1016/j.pain.2013.10.004 10.1111/j.1468-2982.2004.00639.x 10.1212/wnl.0000000000003963 10.1093/brain/aww097 10.1186/s10194-016-0624-y 10.1002/jnr.24331 10.1016/j.nbd.2020.105080 10.1155/2017/9547056 10.1007/s00401-015-1402-7 10.1177/0333102417728873 10.3892/etm.2019.8201 10.1186/s12974-019-1673-3
The Journal of Headache and Pain; Chen H, Tang X et. al.

Jan 5th, 2022 - Chronic migraine places a disabling burden on patients, which is extensively modeled by the nitroglycerin (NTG)-treated animal model. Although the NF-κB pathway is involved in an increase in CGRP levels and activation of the trigeminal system in the NTG model, the relationship between NTG and neuroinflammation remains unclear. This study aimed to optimize a chronic NTG rat model with hyperalges...

Investigation of the Effects of Difluorinated Curcumin on Glycemic Indices in Streptozo...
https://doi.org/10.1007/978-3-030-73234-9_9
Advances in Experimental Medicine and Biology; Radbakhsh S, Momtazi-Borojeni AA et. al.

Jan 5th, 2022 - Curcumin is an antioxidant agent that improves glycemia in animal models of diabetes. Clinically curcumin use is limited due to poor solubility, weak absorption, and low bioavailability; therefore, this study to investigate the effects of curcumin's analog, difluorinated curcumin (CDF), on fasting blood glucose (FBG), oral glucose tolerance test (OGTT), and insulin tolerance test (ITT), in stre...

Evaluation of the Effect of Crocin on Doxorubicin-Induced Cardiotoxicity.
https://doi.org/10.1007/978-3-030-73234-9_10 10.1038/s41568-019-0186-9 10.1016/j.canlet.2018.03.010 10.1371/journal.pone.0187925 10.1371/journal.pone.0184360 10.1007/s12012-019-09554-5 10.1007/s13402-020-00539-z 10.1186/1471-2407-10-337 10.1016/j.ejphar.2017.10.043 10.1016/j.toxlet.2019.02.013 10.1038/nm.2919 10.1089/ars.2020.8016 10.3390/nu10010044 10.1139/cjpp-2019-0031 10.1016/j.biopha.2017.12.077 10.1016/j.pharep.2019.07.007 10.1016/j.eujim.2015.12.008 10.1002/jcb.26806 10.1016/j.biopha.2017.12.077 10.1101/pdb.prot095505 10.1002/jbt.22030 10.7150/thno.38198 10.1002/ejhf.1439 10.1016/j.lfs.2019.116623 10.1111/bph.15039 10.1016/j.brainresbull.2019.05.023 10.1002/biof.1557 10.1016/j.biopha.2017.07.052 10.1016/j.bcp.2019.01.023 10.1007/s11064-018-2644-2 10.1016/j.cbi.2018.02.001 10.1186/1471-2261-12-63 10.1016/j.cbi.2016.01.014
Advances in Experimental Medicine and Biology; Motlagh PE, Novin AG et. al.

Jan 5th, 2022 - Despite newer advances in cancer treatment, chemotherapy is still one of the most widely used treatment strategies in this field. However, this treatment strategy faces major challenges. Doxorubicin (Dox) is an effective chemotherapeutic agent used to treat various cancers. However, several studies have shown that the use of Dox in therapeutic concentrations is associated with serious side effe...

Axonal Protection by Netarsudil, a ROCK Inhibitor, Is Linked to an AMPK-Autophagy Pathw...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742515
Investigative Ophthalmology & Visual Science; Kitaoka Y, Sase K et. al.

Jan 5th, 2022 - Netarsudil, a Rho kinase inhibitor with norepinephrine transport inhibitory effect, lowers intraocular pressure, however, its effect on axon damage remains to be elucidated. The aim of the current study was to investigate the effect of netarsudil on TNF-induced axon loss and to examine whether it affects phosphorylated-AMP-activated kinase (p-AMPK) and autophagy in the optic nerve. Intravitreal...

Association of Acute Respiratory Infections with Indoor Air Pollution from Biomass Fuel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718271
Journal of Environmental and Public Health; Addisu A, Getahun T et. al.

Jan 4th, 2022 - Most of the households in developing countries burn biomass fuel in traditional stoves with incomplete combustion that leads to high indoor air pollution and acute respiratory infections. Acute respiratory infection is the most common cause of under-five morbidity and mortality accounting for 2 million deaths worldwide and responsible for 18% of deaths among under-five children in Ethiopia. Alt...

Rapid development of a salivary calculus in submandibular gland and its potential cause...
https://doi.org/10.1016/j.toxicon.2021.12.018
Toxicon : Official Journal of the International Society O... Arathisenthil SV, Senthilkumaran S et. al.

Jan 4th, 2022 - Russell's viper bites are known to cause a range of haemotoxic, neurotoxic, myotoxic, cytotoxic and nephrotoxic complications. However, the impact of Russell's viper bites as well as bites from other venomous snakes on sialolithiasis has not been previously reported. Here, we present an interesting case where a Russell's viper bite induced the rapid development of a calculus in submandibular gl...

Uptake and toxicity of polystyrene micro/nanoplastics in gastric cells: Effects of part...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719689
PloS One; Banerjee A, Billey LO et. al.

Jan 1st, 2022 - Toxicity of micro or nanoplastics (MP/NP) in aquatic life is well-documented, however, information about the consequences of exposure to these particles in terrestrial species is scarce. This study was used to evaluate the uptake and/or toxicity of polystyrene MP/NP in human gastric cells, comparing doses, particle sizes (50, 100, 200, 500, 1000 or 5000 nm) and surface functionalization (aminat...

Human Rights Perspective on Pesticide Exposure and Poisoning in Children: A Case Study ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694309
Health and Human Rights; Utyasheva L, Bhullar L

Dec 31st, 2021 - Pesticide exposure and poisoning among children can lead to devastating long-lasting health effects that impact their human rights, with communities in low- and middle-income countries experiencing the negative impacts of pesticides more profoundly than those in high-income countries. While United Nations agencies recommend banning highly hazardous pesticides responsible for serious pesticide p...

Involvement of caspase in patulin-induced hepatotoxicity in vitro and in vivo.
https://doi.org/10.1016/j.toxicon.2021.12.017
Toxicon : Official Journal of the International Society O... Zhang B, Huang C et. al.

Dec 31st, 2021 - Patulin (PAT) a kind of mycotoxin, is a widely disseminated mycotoxin found in agricultural products and could cause liver damage. However, evidence on the underlying mechanisms of patulin is still lacking. In the present study, Human liver cancer cells (HepG2) together with a mouse model were used to explore the possible effect and mechanism. The results demonstrated that PAT treatment inhibit...

Changes in chromatin accessibility landscape and histone H3 core acetylation during val...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711205
Epigenetics & Chromatin; Baumann C, Zhang X et. al.

Dec 28th, 2021 - Directed differentiation of mouse embryonic stem cells (mESCs) or induced pluripotent stem cells (iPSCs) provides powerful models to dissect the molecular mechanisms leading to the formation of specific cell lineages. Treatment with histone deacetylase inhibitors can significantly enhance the efficiency of directed differentiation. However, the mechanisms are not well understood. Here, we use C...

Targeting mitochondrial permeability transition pore ameliorates PM2.5-induced mitochon...
https://doi.org/10.1016/j.envpol.2021.118720
Environmental Pollution (Barking, Essex : 1987); Liang Y, Chu PH et. al.

Dec 27th, 2021 - Particulate matter with aerodynamic diameter not larger than 2.5 μm (PM2.5) escalated the risk of respiratory diseases. Mitochondrial dysfunction may play a pivotal role in PM2.5-induced airway injury. However, the potential effect of PM2.5 on mitochondrial permeability transition pore (mPTP)-related airway injury is still unknown. This study aimed to investigate the role of mPTP in PM2.5-induc...

Is severity of Daboia (Vipera) palaestinae snakebites influenced by season of exposure?
https://doi.org/10.1016/j.toxicon.2021.12.016
Toxicon : Official Journal of the International Society O... Agajany N, Kozer E et. al.

Dec 27th, 2021 - The most common venomous snake in Israel, both in geographic spread and in number of snakebite incidents, is Daboia (Vipera) palaestinae. The clinical presentation of D. palaestinae envenomation varies and includes both local and systemic symptoms. Studies conducted on D. palaestinae revealed different amounts of venom in the snakes' glands in different seasons, however little is known regardin...