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About 205,078 results

Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by...
https://doi.org/10.1186/s12974-022-02523-w 10.1038/s41579-020-0433-9 10.1016/j.cell.2014.03.011 10.1016/j.cell.2015.08.059 10.1038/nm.4185 10.1016/j.molmed.2014.05.002 10.1016/j.cell.2013.11.024 10.1016/j.cell.2015.02.047 10.1084/jem.20180794 10.1038/s41380-020-0729-1 10.1126/sciadv.aba0466 10.1073/pnas.0711891105 10.1038/nn.4606 10.1016/j.celrep.2018.01.006 10.1097/j.pain.0000000000001855 10.1002/cpz1.78 10.1097/j.pain.0000000000000366 10.1126/science.288.5464.306 10.1038/nn.4030 10.1016/j.neuron.2013.12.011 10.1126/science.aaf8924 10.1038/nn1992 10.2174/1570159X19666210215123239 10.1371/journal.pone.0170814 10.1002/glia.22349 10.1007/s12264-012-1219-5 10.1016/j.cell.2013.11.042 10.1038/ncomms2478 10.1177/1352458514541579 10.1038/nature14462 10.1038/nchembio.767 10.1038/s41564-018-0307-3 10.1038/s41388-020-1341-1 10.1016/j.ebiom.2019.11.051
Journal of Neuroinflammation; Ma P, Mo R et. al.

Jun 29th, 2022 - Gut microbiota has been found involved in neuronal functions and neurological disorders. Whether and how gut microbiota impacts chronic somatic pain disorders remain elusive. Neuropathic pain was produced by different forms of injury or diseases, the chronic constriction injury (CCI) of the sciatic nerves, oxaliplatin (OXA) chemotherapy, and streptozocin (STZ)-induced diabetes in mice. Continuo...

RNA-seq based elucidation of mechanism underlying Mesona chinensis Benth polysaccharide...
https://doi.org/10.1016/j.foodres.2022.111383
Food Research International (Ottawa, Ont.); Chen X, Shen M et. al.

Jun 29th, 2022 - The homeostasis of oxidative stress is vital to the physiological behavior of normal human or animal cells, and its underlying molecular mechanism is contributed to the exploitation of functional food used in chronic diseases. Thus, the mechanism of protective effect of Mesona chinensis Benth polysaccharides (MP) in H2O2-induced oxidative damage was investigated thoroughly. Results showed that ...

Acrylamide induced glucose metabolism disorder in rats involves gut microbiota dysbiosi...
https://doi.org/10.1016/j.foodres.2022.111405
Food Research International (Ottawa, Ont.); Yue Z, Chen Y et. al.

Jun 29th, 2022 - Acrylamide (AA) is a common food contaminant that causes glucose metabolism disorders (GMD). However, the underlying mechanism remains unclear. Female Sprague Dawley (SD) rats were treated with AA via gavage for 21 days, and the glucose and insulin levels, gut microbiota, intestinal barrier, and metabolism were analyzed. The results revealed that AA elevated serum glucose levels, reduced insuli...

Cannabinoid Vaping Products Present Novel Challenges for Assessment of Respiratory Heal...
https://doi.org/10.1093/toxsci/kfac050
Toxicological Sciences : an Official Journal of the Socie... Love CA, Schichlein KD et. al.

Jun 29th, 2022 - Cannabinoid Vaping Products Present Novel Challenges for Assessment of Respiratory Health Effects.|2022|Love CA,Schichlein KD,Clapp PW,Jaspers I,|toxicity,adverse effects,

Simvastatin cardioprotection in cyclophosphamide-induced toxicity via the modulation of...
https://doi.org/10.1177/09603271221111440
Human & Experimental Toxicology; Refaie MM, El-Hussieny M et. al.

Jun 29th, 2022 - Drug-induced cardiotoxicity is a serious adverse effect that occurs during the administration of chemotherapeutic agents such as cyclophosphamide (CYC). Therefore, there is a critical need to find cardioprotective agents to keep the heart healthy. The current study aimed to investigate the protective effect of simvastatin (SIM) against CYC-induced heart damage and evaluate different mechanisms ...

The sesquiterpenoid valerenic acid protects neuronal cells from the detrimental effects...
https://doi.org/10.1177/09603271221101038
Human & Experimental Toxicology; Kara M, Öztaş E et. al.

Jun 29th, 2022 - Valerenic acid (VA), a sesquiterpenoid of the plant Valeriana officinalis, has attracted attention of the research community due to its potential positive role against neurodegenerative diseases induced by chemicals. However, the relevant evidence in the literature is scarce. Therefore, this study aimed to examine the putative protective role of VA on the toxic effects of the fungicide benomyl ...

Exposure to Asbestos and Increased Intrahepatic Cholangiocarcinoma Risk: Growing Eviden...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205375
Annals of Global Health; Brandi G, Straif K et. al.

Jun 28th, 2022 - To date the true global incidence of intrahepatic cholangiocarcinoma (iCCA) and the underlying risk factors remain to be fully defined, in particular, the role of occupational and environmental factors. Currently, the putative role of asbestos exposure as a risk factor for iCCA is gaining increased attention in the international scientific community and agencies. In this commentary we review an...

Inducible nitric oxide synthase regulates macrophage polarization via the MAPK signals ...
https://doi.org/10.1002/iid3.643
Immunity, Inflammation and Disease; Yao X, Jin G et. al.

Jun 28th, 2022 - Acute liver inflammatory reactions contribute to many health problems; thus, it is critical to understand the underlying pathogenic mechanisms of acute hepatitis. In this study, an experimental in vivo model of concanavalin A (ConA)-induced hepatitis was used. C57BL/6 (wild-type, WT) or inducible nitric oxide synthase-deficient (iNOS- /- ) mice were injected with PBS or 15 mg/kg ConA via tail v...

TRPM7 promotes lipopolysaccharide-induced inflammatory dysfunction in renal tubular epi...
https://doi.org/10.1002/iid3.641
Immunity, Inflammation and Disease; Sun Y, Chen X et. al.

Jun 28th, 2022 - Sepsis-associated acute kidney injury (S-AKI) has been reported to affect 30%-50% of all sepsis patients; this condition is associated with a notable fatality rate. Following lipopolysaccharide (LPS) stimulation, the expression of transient receptor potential cation channel subfamily M member 7 (TRPM7), a nonselective cation channel expressed by the renal tubular epithelial cells (RTECs) was fo...

Laundry detergent promotes allergic skin inflammation and esophageal eosinophilia in mice.
https://doi.org/10.1371/journal.pone.0268651
PloS One; Tanzer J, Meng D et. al.

Jun 28th, 2022 - The prevalence of allergic diseases is on the rise, yet the environmental factors that contribute to this increase are still being elucidated. Laundry detergent (LD) that contains cytotoxic ingredients including microbial enzymes continuously comes into contact with the skin starting in infancy. An impaired skin barrier has been suggested as a route of allergic sensitization. We hypothesized th...

Glycyrrhiza uralensis promote the metabolism of toxic components of Aconitum carmichael...
https://doi.org/10.1371/journal.pone.0270069
PloS One; Ni L, Miao P et. al.

Jun 28th, 2022 - Aconitum, as "the first drug of choice for invigorating Yang and saving lives", has been widely used for the treatment of heart failure. However, toxic components of Aconitum can easily lead to serious arrhythmia, even death (Y. CT., 2009; Zhang XM., 2018). In this study, a High Performance Liquid Chromatography (HPLC) method for the determination of aconitine (AC), mesaconitine (MA) and hypaco...

The Pyruvate Dehydrogenase Complex Mitigates LPS-Induced Endothelial Barrier Dysfunctio...
https://doi.org/10.1097/SHK.0000000000001931
Shock (Augusta, Ga.); Mao L, Sun M et. al.

Jun 28th, 2022 - Sepsis is a fatal health issue induced by an aberrant host response to infection, and it correlates with organ damage and a high mortality rate. Endothelial barrier dysfunction and subsequent capillary leakage play major roles in sepsis-induced multiorgan dysfunction. Anaerobic glycolysis is the primary metabolic mode in sepsis and the pyruvate dehydrogenase complex (PDHC) serves as a critical ...

Comparative physiological and metabolomic analyses reveal that Fe3O4 and ZnO nanopartic...
https://doi.org/10.1186/s12951-022-01509-3 10.1016/j.molp.2021.09.016 10.1016/j.jhazmat.2021.128169 10.1016/j.envpol.2019.03.063 10.1016/j.scitotenv.2021.151099 10.1065/espr2002.11.141.2 10.4161/psb.5.6.11425 10.1146/annurev.arplant.53.100301.135154 10.1016/j.tibtech.2018.03.009 10.1186/1477-3155-2-3 10.1186/s12951-021-00892-7 10.1016/j.cj.2021.06.002 10.1016/j.scitotenv.2018.02.313 10.1021/acs.jafc.9b06615 10.3390/nano11010026 10.1021/es800924c 10.1016/j.chemosphere.2016.05.083 10.1007/s11738-013-1369-8 10.3109/17435390.2010.489206 10.1016/j.ecoenv.2019.01.118 10.3390/su9050790 10.1016/j.jece.2013.11.029 10.1039/C4EN00064A 10.1021/es800422x 10.1021/acs.est.5b03330 10.1016/j.scitotenv.2016.10.017 10.1021/acs.est.8b06641 10.1039/D0EN00723D 10.1039/D0EN00582G 10.1016/j.envpol.2019.02.031 10.1016/j.cej.2019.123802 10.1186/s12951-021-00820-9 10.1186/s12864-020-07028-5 10.1186/s40529-016-0138-6 10.1016/j.ecoenv.2013.12.013 10.1016/j.chemosphere.2005.09.005 10.1111/jipb.12784 10.1016/j.envexpbot.2021.104602 10.1186/s12870-020-2255-3 10.1039/C8EN00014J 10.1007/s11356-021-14541-x 10.1002/pro.4172 10.3389/fpls.2021.663477 10.1016/j.jhazmat.2021.127168 10.1016/j.febslet.2011.10.048 10.3389/fpls.2021.770398 10.1007/s00344-017-9752-0 10.1016/j.ecoenv.2013.04.013 10.1111/nph.12434 10.1016/j.plaphy.2019.12.015 10.1016/j.pbi.2012.05.005 10.1016/S1360-1385(00)01741-6 10.3389/fpls.2020.00928 10.1007/s11738-015-1921-9 10.1111/tpj.14175 10.3390/molecules23040762 10.1890/0012-9658(2002)083[0505:CODITC]2.0.CO;2 10.1016/j.tplants.2013.01.001 10.3390/metabo11060383 10.4103/0250-474X.84592 10.1016/j.pbi.2020.04.004 10.1104/pp.126.2.524 10.3389/fpls.2018.00618 10.1105/tpc.009464 10.1104/pp.011155 10.1016/j.jhazmat.2019.04.018 10.1093/nar/gky310 10.1016/j.scienta.2021.110414
Journal of Nanobiotechnology; Zou C, Lu T et. al.

Jun 28th, 2022 - Heavy metals repress tobacco growth and quality, and engineered nanomaterials have been used for sustainable agriculture. However, the underlying mechanism of nanoparticle-mediated cadmium (Cd) toxicity in tobacco remains elusive. Herein, we investigated the effects of Fe3O4 and ZnO nanoparticles (NPs) on Cd stress in tobacco cultivar 'Yunyan 87' (Nicotiana tabacum). Cd severely repressed tobac...

Concept for the Evaluation of Carcinogenic Substances in Population-Based Human Biomoni...
https://doi.org/10.3390/ijerph19127235
International Journal of Environmental Research and Publi... Wollin KM, Apel P et. al.

Jun 25th, 2022 - The Human Biomonitoring (HBM) Commission at the German Environment Agency holds the opinion that for environmental carcinogens for which no exposure levels can be assumed and are harmless to health, health-based guidance values corresponding to the classical definition of the HBM-I or HBM-II value cannot be established. Therefore, only reference values have been derived so far for genotoxic car...

Use of Generalized Weighted Quantile Sum Regressions of Tumor Necrosis Factor Alpha and...
https://doi.org/10.3390/ijerph19127399
International Journal of Environmental Research and Publi... Luo KH, Tu HP et. al.

Jun 25th, 2022 - Exposure to heavy metals could lead to adverse health effects by oxidative reactions or inflammation. Some essential elements are known as reactors of anti-inflammatory enzymes or coenzymes. The relationship between tumor necrosis factor alpha (TNF-α) and heavy metal exposures was reported. However, the interaction between toxic metals and essential elements in the inflammatory response remains...

Pesticide Exposure in Relation to the Incidence of Abnormal Glucose Regulation: A Retro...
https://doi.org/10.3390/ijerph19127550
International Journal of Environmental Research and Publi... Kim SK, Oh HJ et. al.

Jun 25th, 2022 - Diabetes and prediabetes (called abnormal glucose regulation (AGR)) are adverse health effects associated with exposure to pesticides. However, there are few epidemiological studies on the relationship between pesticide use and the incidence of AGR. We examined the causal relationship between pesticide use and AGR incidence in a rural population using data from a Korean Farmers' Cohort study of...

Comprehensive Analysis of Metabolic Changes in Male Mice Exposed to Sodium Valproate Ba...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9211130
Drug Design, Development and Therapy; Gao Y, Jiang D et. al.

Jun 25th, 2022 - Sodium valproate (VPA) is the most widely used broad-spectrum antiepileptic first-line drug in clinical practice and is effective against various types of epilepsy. However, VPA can induce severe cardiotoxicity, nephrotoxicity, hepatotoxicity, and neurotoxicity, which limits its use. Metabolomic studies of VPA-induced toxicity have focused primarily on changes in serum and urine metabolites but...

Agmatine mitigates palmitate (PA)-induced mitochondrial and metabolic dysfunction in mi...
https://doi.org/10.1177/09603271221110857
Human & Experimental Toxicology; Zhang D, Li J et. al.

Jun 25th, 2022 - Agmatine is an arginine metabolite that has neuroprotective capacity. Recently, it has been found to ameliorate atherosclerosis progression in rabbits. However, further molecular mechanisms of its anti-atherosclerotic properties remain unclear. High plasma levels of free fatty acids (FFAs) are an important risk factor for atherosclerosis due to their detrimental effects on vascular endothelial ...

Short-term control of diet affects cisplatin-induced acute kidney injury through modula...
https://doi.org/10.14814/phy2.15348
Physiological Reports; Kim JS, Han YK et. al.

Jun 25th, 2022 - Obesity affects acute kidney injury (AKI) induced by various clinical settings, including transplantation and cisplatin-cancer therapy. However, the effect of short-term food intake change remains to be defined. Here, we investigated the effects of short-term high-fat diet intake and food restriction on cisplatin-induced AKI. Mice were fed either a high-fat diet (HFD) or a low-fat diet (LFD) fo...

The Role of Grass Compost and Zea Mays in Alleviating Toxic Effects of Tetracycline on ...
https://doi.org/10.3390/ijerph19127357
International Journal of Environmental Research and Publi... Wyszkowska J, Borowik A et. al.

Jun 25th, 2022 - Given their common use for disease treatment in humans, and particularly in animals, antibiotics pose an exceptionally serious threat to the soil environment. This study aimed to determine the response of soil bacteria and oxidoreductases to a tetracycline (Tc) contamination, and to establish the usability of grass compost (G) and Zea mays (Zm) in mitigating adverse Tc effects on selected micro...