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About 87,488 results

Use of muscular flaps for the treatment of hip prosthetic joint infection: a systematic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705100
BMC Musculoskeletal Disorders; Rovere G, De Mauro D et. al.

Dec 25th, 2021 - Deep periprosthetic infection after total hip arthroplasty (THA) is a serious and challenging complication for the orthopedic surgeon. Muscular flaps may represent a valid management option for the treatment of this condition. We present a systematic literature review about the use of muscular flaps for the treatment of hip prosthetic joint infection. The review is reported according to the Pre...

Corneal perforation in ocular cicatricial pemphigoid: A CARE-compliant case report.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8702268
Medicine Hwang S, Kuo SC

Dec 24th, 2021 - Ocular cicatricial pemphigoid (OCP) is a potentially blinding, rare systemic autoimmune disease. The definite etiology of OCP remains under debate, early diagnosis is important to prevent rapid deterioration. The majority of the discussion has been focused on its medical therapeutic strategy, while little effort has been made to study the role of amniotic membrane transplantation (AMT). We desc...

Syndactyly Release in the Hand: Surgical Technique.
https://doi.org/10.1097/PRS.0000000000008689
Plastic and Reconstructive Surgery; Sood RF, Irwin TJ et. al.

Dec 23rd, 2021 - Syndactyly is one of the most common congenital differences treated by hand surgeons. Although dozens of techniques for syndactyly release have been described, a reliable method is based on a dorsal rectangular flap for commissure construction and a combination of interdigitating zigzag flaps and skin grafts for digital coverage. In this article, the authors present a detailed description of sy...

Microvascular Free Tissue Transfer for Reconstruction of Complex Abdominal Wall Defects.
https://doi.org/10.1097/PRS.0000000000008669
Plastic and Reconstructive Surgery; Bauder A, Othman S et. al.

Dec 23rd, 2021 - Patients with significant loss of abdominal wall soft tissue represent a reconstructive challenge. The purpose of this study was to describe the authors' experience using microvascular free tissue transfer to repair complex abdominal wall defects with insufficient overlying soft tissue. In this report, the authors highlight their techniques and experiences in performing microvascular free tissu...

Should Antiplatelet Therapy Be Withheld Perioperatively? The First Study Examining Outc...
https://doi.org/10.1097/PRS.0000000000008666
Plastic and Reconstructive Surgery; Mishu MD, Zolper EG et. al.

Dec 23rd, 2021 - Antiplatelet agents are typically withheld perioperatively because of bleeding concerns. Dual antiplatelet therapy, such as aspirin and clopidogrel, has significant morbidity and mortality benefits in patients with ischemic heart disease or peripheral vascular disease. This study aims to evaluate the impact of perioperative dual antiplatelet therapy in the lower extremity free tissue transfer p...

Pushing the Limits in Extremity Reconstruction Using Virtual Surgical Planning: A Case ...
https://doi.org/10.1097/PRS.0000000000008690
Plastic and Reconstructive Surgery; Pereira N, Kufeke M et. al.

Dec 23rd, 2021 - Technology is advancing in benefit to solving complex problems. Preoperative planning is essential in any reconstructive process given the importance of achieving good results. New technologies facilitate the process to anticipate intraoperative findings. Virtual surgical planning has contributed in the evolution of craniomaxillofacial surgery. However, limited reports have been published regar...

Split Buccal Fat Flap in Modified Furlow Palatoplasty: Surgical Technique and Early Res...
https://doi.org/10.1097/PRS.0000000000008648
Plastic and Reconstructive Surgery; Denadai R, Lo LJ

Dec 23rd, 2021 - Encouraging results have been described for the use of pedicled buccal fat pad flap in primary cleft palate repair. This retrospective study describes the surgical technique and early results of a technical innovation utilizing the split buccal fat flaps in modified Furlow palatoplasty with small double-opposing Z-plasty. This technique introduces buccal fat tissue for coverage of lateral denud...

Aesthetic Repair of Unilateral Cleft Lip using the Modified Inferior Triangle and Adjun...
https://doi.org/10.1097/PRS.0000000000008688
Plastic and Reconstructive Surgery; Parsaei Y, Chandler L et. al.

Dec 23rd, 2021 - Surgical management of unilateral cleft lip is challenging. Correction requires a comprehensive approach to ensure optimal aesthetic outcomes. Various techniques have been proposed for the repair of cleft lip. This article and video vignette highlight the senior author's (D.S.) preferred method for repair of a unilateral cleft lip using a modified inferior triangle technique, a Noordhoff triang...

Association between aqueous humor cytokines and postoperative corneal endothelial cell ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675763
PloS One; Okabe T, Kobayashi W et. al.

Dec 17th, 2021 - This study measured the intraoperative anterior aqueous humor concentrations of various cytokines during corneal endothelial transplantation and searched for relationships between these concentrations and postoperative corneal endothelial cell (CEC) depletion. We recruited 30 consecutive patients who underwent corneal endothelial transplantation with Descemet's stripping automated endothelial k...

Transgenic Epidermal Cultures for Junctional Epidermolysis Bullosa - 5-Year Outcomes.
https://doi.org/10.1056/NEJMoa2108544
The New England Journal of Medicine; Kueckelhaus M, Rothoeft T et. al.

Dec 10th, 2021 - Inherited junctional epidermolysis bullosa is a severe genetic skin disease that leads to epidermal loss caused by structural and mechanical fragility of the integuments. There is no established cure for junctional epidermolysis bullosa. We previously reported that genetically corrected autologous epidermal cultures regenerated almost an entire, fully functional epidermis on a child who had a d...

Aesthetic root coverage with acellular dermal matrix allograft: a shield for gingival r...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655591
BMJ Case Reports; Sachdeva S, Saluja H et. al.

Dec 9th, 2021 - Awareness about root coverage is increasing in day-to-day clinical practice. Patients are more motivated and concerned about aesthetics nowadays along with the issues of sensitivity of teeth. The conventional flap designs and techniques including lateral sliding flaps, coronally advanced flap, subepithelial connective tissue grafts and free gingival grafts are being adopted for root coverage. T...

Successful Total Tracheal Replacement by Cryopreserved Aortic Allograft in a Patient Po...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640260
Chest Menna C, Andreetti C et. al.

Dec 8th, 2021 - This is the first report to our knowledge of a successful total tracheal replacement in a post-COVID-19 patient by cryopreserved aortic allograft. The graft was anastomosed to the cricoid and carina; a silicon stent was inserted to ensure patency. The patient was extubated on the operative table and was immediately able to breathe, speak, and swallow. No immunosuppression was administered. Thre...

Nerve recovery from treatment with a vascularized nerve graft compared to an autologous...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638852
PloS One; Broeren BO, Duraku LS et. al.

Dec 3rd, 2021 - Treatment of nerve injuries proves to be a worldwide clinical challenge. Vascularized nerve grafts are suggested to be a promising alternative for bridging a nerve gap to the current gold standard, an autologous non-vascularized nerve graft. However, there is no adequate clinical evidence for the beneficial effect of vascularized nerve grafts and they are still disputed in clinical practice. To...

Middle hepatic vein reconstruction in adult living donor liver transplantation: a rando...
https://doi.org/10.1093/bjs/znab346
The British Journal of Surgery; Durairaj MS, Shaji Mathew J et. al.

Dec 2nd, 2021 - In adult right lobe living donor liver transplantation (LDLT), venous drainage of the anterior sector is usually reconstructed on the bench to form a neo-middle hepatic vein (MHV). Reconstruction of the MHV for drainage of the anterior sector is crucial for optimal graft function. The conduits used for reconstruction include cryopreserved allografts, synthetic grafts, or the recipient portal ve...

Reconstruction of Through-and-Through Mandibular Defects with the Fibula Osteocutaneous...
https://doi.org/10.1097/PRS.0000000000008620
Plastic and Reconstructive Surgery; Shahzad F, Kiwanuka E et. al.

Dec 1st, 2021 - Reconstruction of Through-and-Through Mandibular Defects with the Fibula Osteocutaneous and Lower Lateral Leg Perforator Free Flaps.|2021|Shahzad F,Kiwanuka E,Marano A,Boyle J,Matros E,|pathology,surgery,transplantation,transplantation,blood supply,surgery,pathology,surgery,pathology,surgery,transplantation,etiology,surgery,

The Cart before the Horse: Upfront Fillet Flap Harvest and Revascularization.
https://doi.org/10.1097/PRS.0000000000008622
Plastic and Reconstructive Surgery; Teven CM, Goulding K et. al.

Dec 1st, 2021 - The Cart before the Horse: Upfront Fillet Flap Harvest and Revascularization.|2021|Teven CM,Goulding K,Rebecca AM,|blood supply,transplantation,surgery,surgery,methods,surgery,surgery,methods,

Minimal Impact Double Incision with Free Nipple Graft Technique for Gender-Affirming To...
https://doi.org/10.1097/PRS.0000000000008618
Plastic and Reconstructive Surgery; Knudson SA, DeLeon A et. al.

Dec 1st, 2021 - Minimal Impact Double Incision with Free Nipple Graft Technique for Gender-Affirming Top Surgery.|2021|Knudson SA,DeLeon A,Crane CN,Santucci RA,|psychology,surgery,transplantation,methods,psychology,

Novel therapeutic options for treatment of recurrent implantation failure.
https://doi.org/10.1016/j.fertnstert.2021.10.025
Fertility and Sterility; Turocy J, Williams Z

Nov 28th, 2021 - Despite the challenges in studying recurrent implantation failure, progress is currently being made in therapeutic options to help those who suffer from recurrent implantation failure. Three of the most promising therapeutic options for recurrent implantation failure include immune therapies such as peripheral blood mononuclear cells, platelet rich plasma and subcutaneous granulocyte-colony sti...

CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626495
Nature Communications; Tsagkaraki E, Nicoloro SM et. al.

Nov 28th, 2021 - Obesity and type 2 diabetes are associated with disturbances in insulin-regulated glucose and lipid fluxes and severe comorbidities including cardiovascular disease and steatohepatitis. Whole body metabolism is regulated by lipid-storing white adipocytes as well as "brown" and "brite/beige" adipocytes that express thermogenic uncoupling protein 1 (UCP1) and secrete factors favorable to metaboli...

LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8613218
Nature Communications; Liu Y, Debo B et. al.

Nov 26th, 2021 - Exhausted CD8+ T cells are key targets of immune checkpoint blockade therapy and their ineffective reinvigoration limits the durable benefit in some cancer patients. Here, we demonstrate that histone demethylase LSD1 acts to enforce an epigenetic program in progenitor exhausted CD8+ T cells to antagonize the TCF1-mediated progenitor maintenance and to promote terminal differentiation. Consequen...