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About 85,895 results

Vascular damage control at the thoracic outlet.
https://doi.org/10.1308/rcsann.2020.7100
Annals of the Royal College of Surgeons of England; McMonagle MP, Sarani B et. al.

Sep 1st, 2021 - Penetrating injuries to the subclavian artery carry a high mortality rate, especially when the patient presents in shock. Rapid and effective haemorrhage control is challenging due to the anatomical location at the thoracic outlet. Historically, vessel ligation has been used to control bleeding, but this is often performed late, when metabolic exhaustion is established, and is associated with u...

Breast reconstruction during the COVID-19 pandemic: A systematic review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376341
Medicine Sun P, Luan F et. al.

Aug 21st, 2021 - The novel coronavirus disease 2019 (COVID-19) has changed people's way of life and posed great challenges to plastic surgery. Most of plastic surgeries are considered elective surgeries and are recommended to be delayed. But breast reconstruction in plastic surgery is special. Doctors' associations from different countries have different rules on whether breast reconstruction surgery should be ...

DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373879
Nature Communications; Trotman-Grant AC, Mohtashami M et. al.

Aug 20th, 2021 - T cells are pivotal effectors of the immune system and can be harnessed as therapeutics for regenerative medicine and cancer immunotherapy. An unmet challenge in the field is the development of a clinically relevant system that is readily scalable to generate large numbers of T-lineage cells from hematopoietic stem/progenitor cells (HSPCs). Here, we report a stromal cell-free, microbead-based a...

Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373964
Nature Communications; Nakajima T, Nakahata A et. al.

Aug 20th, 2021 - Tendon self-renewal is a rare occurrence because of the poor vascularization of this tissue; therefore, reconstructive surgery using autologous tendon is often performed in severe injury cases. However, the post-surgery re-injury rate is relatively high, and the collection of autologous tendons leads to muscle weakness, resulting in prolonged rehabilitation. Here, we introduce an induced plurip...

Meniscal Allograft Transplantation.
https://doi.org/10.1097/JSA.0000000000000302
Sports Medicine and Arthroscopy Review; Yow BG, Donohue M et. al.

Aug 17th, 2021 - Meniscal allograft transplantation provides treatment options for patients with a meniscus-deficient knee with lifestyle-limiting symptoms in the absence of advanced degenerative changes. Meniscal transplantation helps to restore the native biomechanics of the involved knee, which may provide chondroprotective effects and restoring additional knee stability. Improvements in pain, function, and ...

A Systematic Review and Meta-Analysis of Complications Associated With Autogenous Diced...
https://doi.org/10.1093/asj/sjab117
Aesthetic Surgery Journal; Keyhan SO, Ramezanzade S et. al.

Aug 14th, 2021 - Nasal dorsum augmentation is a highly challenging rhinoplastic procedure. Problems encountered in this surgery, such as residual humps, irregularities, and asymmetry, account for a significant number of revision rhinoplasties. The aim of this meta-analysis was to assess complication rates and graft harvesting site morbidity and revision rates. We carried out a systematic review of the literatur...

Comparison of free vascularized fibular flaps and allograft fibular strut grafts to sup...
https://doi.org/10.1302/0301-620X.103B8.BJJ-2020-2302.R1
The Bone & Joint Journal; Wellings EP, Houdek MT et. al.

Aug 3rd, 2021 - Orthopaedic and reconstructive surgeons are faced with large defects after the resection of malignant tumours of the sacrum. Spinopelvic reconstruction is advocated for resections above the level of the S1 neural foramina or involving the sacroiliac joint. Fixation may be augmented with either free vascularized fibular flaps (FVFs) or allograft fibular struts (AFSs) in a cathedral style. Howeve...

Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutane...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324783
Nature Communications; Guo DH, Yamamoto M et. al.

Aug 1st, 2021 - Visceral obesity increases risk of cognitive decline in humans, but subcutaneous adiposity does not. Here, we report that beige adipocytes are indispensable for the neuroprotective and anti-inflammatory effects of subcutaneous fat. Mice lacking functional beige fat exhibit accelerated cognitive dysfunction and microglial activation with dietary obesity. Subcutaneous fat transplantation also pro...

Hair Transplantation in Endocrine Therapy-Induced Alopecia.
https://doi.org/10.1097/DSS.0000000000002459
Dermatologic Surgery : Official Publication for American ... Bouhanna P, Larif M et. al.

Jul 31st, 2021 - Hair Transplantation in Endocrine Therapy-Induced Alopecia.|2021|Bouhanna P,Larif M,Guichard A,|chemically induced,surgery,adverse effects,therapeutic use,drug therapy,methods,transplantation,

Measurement Method to Determine the Difference in Tear Trough and Palpebromalar Groove ...
https://doi.org/10.1097/SCS.0000000000007541
The Journal of Craniofacial Surgery; Ye C, Jiecong W et. al.

Jul 29th, 2021 - This study designed an efficient measurement method to evaluate the outcome of transconjunctival fat reposition in the tear trough and palpebromalar groove. A total of 41 patients (82 eyes) who underwent transconjunctival fat reposition surgery between January 2016 and March 2019 were retrospectively analyzed. Preoperative and postoperative (at least six months) standardized digital images were...

Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncog...
https://doi.org/10.1038/s41588-021-00897-w 10.1101/gad.309013.117 10.1038/nrc3811 10.1038/ng.1102 10.1038/nature10833 10.1016/j.cell.2010.01.003 10.1038/nrm.2016.148 10.1038/nrg3673 10.1016/j.ccell.2017.08.017 10.1038/s41591-018-0086-7 10.1038/ncomms11185 10.1016/j.ccell.2017.09.014 10.1016/j.ccell.2018.11.015 10.1007/s00401-016-1545-1 10.1101/cshperspect.a026443 10.1126/science.1232245 10.1101/gad.326066.119 10.1016/j.ceb.2015.10.003 10.1101/gad.217778.113 10.1016/j.ccr.2013.10.006 10.1038/ncomms11316 10.1073/pnas.1911775116 10.1038/ng.2647 10.1016/j.molcel.2020.09.028 10.1038/s41467-019-09140-x 10.1038/nm.4293 10.1038/nm.4296 10.1016/j.ccell.2019.04.004 10.1016/j.ccr.2012.08.024 10.1016/j.stem.2021.01.016 10.1101/gad.415507 10.1158/1541-7786.MCR-16-0389 10.1016/j.cell.2013.08.061 10.7554/eLife.36696 10.1038/nature09692 10.1016/j.molcel.2013.10.030 10.1016/j.molcel.2019.08.030 10.1038/nmeth.4396 10.1038/s41588-019-0531-7 10.1016/j.ccell.2017.03.011 10.1038/nm.3855 10.1016/j.sbi.2020.10.017 10.1016/j.molcel.2019.08.012 10.1016/j.molcel.2019.07.031 10.1126/sciadv.aau5935 10.1186/s13059-020-01957-w 10.1371/journal.pbio.0030283 10.1016/j.stem.2009.03.014 10.1038/nmeth.1923 10.1016/j.celrep.2014.10.018 10.1093/bioinformatics/btp352 10.1093/nar/gkw257 10.1093/bioinformatics/btq033 10.1016/j.molcel.2010.05.004 10.1038/nsmb.3180 10.1016/j.cell.2013.03.035 10.1016/j.cell.2013.03.036 10.1038/s41587-019-0201-4 10.1093/bioinformatics/btt656 10.1186/s13059-014-0550-8 10.1093/bioinformatics/btw354 10.1186/s13072-020-00342-y 10.1093/nar/gkv1191 10.1093/bioinformatics/btz931
Nature Genetics; Brien GL, Bressan RB et. al.

Jul 24th, 2021 - Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms by which H3-K27M causes tumor initiation remain unclear. Here, we use human hindbrain neural stem cells to model the consequences of H3.3-K27M on the epigenomic landscape in a relevant developmental context. Genome...

Presence of Donor Lymph Nodes Within Vascularized Composite Allotransplantation Amelior...
https://doi.org/10.1097/TP.0000000000003601
Transplantation Olariu R, Tsai C et. al.

Jul 23rd, 2021 - The lymphatic system plays an active role in modulating inflammation in autoimmune diseases and organ rejection. In this work, we hypothesized that the transfer of donor lymph node (LN) might be used to promote lymphangiogenesis and influence rejection in vascularized composite allotransplantation (VCA). Hindlimb transplantations were performed in which (1) recipient rats received VCA containin...

Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292391
Nature Communications; Jeong SH, Yang MJ et. al.

Jul 22nd, 2021 - Stimulator of interferon genes (STING) promotes anti-tumour immunity by linking innate and adaptive immunity, but it remains unclear how intratumoural treatment with STING agonists yields anti-tumour effects. Here we demonstrate that intratumoural injection of the STING agonist cGAMP induces strong, rapid, and selective apoptosis of tumour endothelial cells (ECs) in implanted LLC tumour, melano...

Prognostic Factors for Advanced/Recurrent Breast Cancer Treated With Immune-cell Therapy.
https://doi.org/10.21873/anticanres.15216
Anticancer Research; Takimoto R, Kamigaki T et. al.

Jul 21st, 2021 - Advanced/recurrent breast cancer (ARBC) still has a poor prognosis; therefore, new treatment strategies are required. In this retrospective study, we aimed to investigate the efficacy of immune-cell therapy using T lymphocytes activated in vitro with or without dendritic cell vaccination in combination with standard therapies in terms of the survival of patients with ARBC. A total of 127 patien...

Engineered macrophages as near-infrared light activated drug vectors for chemo-photodyn...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280231
Nature Communications; Huang Y, Guan Z et. al.

Jul 16th, 2021 - Patients with primary and bone metastatic breast cancer have significantly reduced survival and life quality. Due to the poor drug delivery efficiency of anti-metastasis therapy and the limited response rate of immunotherapy for breast cancer, effective treatment remains a formidable challenge. In this work, engineered macrophages (Oxa(IV)@ZnPc@M) carrying nanomedicine containing oxaliplatin pr...

Local delivery of fingolimod through PLGA nanoparticles and PuraMatrix-embedded neural ...
https://doi.org/10.1111/ejn.15391
The European Journal of Neuroscience; Zeraatpisheh Z, Mirzaei E et. al.

Jul 13th, 2021 - Spinal cord injury (SCI) is a devastating clinical problem that can lead to permanent motor dysfunction. Fingolimod (FTY720) is a sphingosine structural analogue, and recently, its therapeutic benefits in SCI have been reported. The present study aimed to evaluate the therapeutic efficacy of fingolimod-incorporated poly lactic-co-glycolic acid (PLGA) nanoparticles (nanofingolimod) delivered loc...

Inflammatory monocytes promote pre-engraftment syndrome and tocilizumab can therapeutic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260612
Nature Communications; Jin L, Sun Z et. al.

Jul 8th, 2021 - Unrelated cord blood transplantation (UCBT) is an effective treatment for hematopoietic disorders. However, this attractive approach is frequently accompanied by pre-engraftment syndrome (PES), severe cases of PES are associated with enhanced mortality and morbidity, but the pathogenesis of PES remains unclear. Here we show that GM-CSF produced by cord blood-derived inflammatory monocytes drive...

Residual Motion and Graft Type Do Not Influence Patient-reported Outcomes Following One...
https://doi.org/10.1097/BRS.0000000000003918
Spine Couch BK, Wawrose RA et. al.

Jul 7th, 2021 - Prospective cohort. The aim of this study was to determine the effect of graft type on residual motion and the relationship among residual motion, smoking, and patient-reported outcome (PRO) scores following anterior cervical discectomy and fusion (ACDF). Although most patients develop solid fusion based on static imaging following ACDF, dynamic imaging has revealed that many patients continue ...

Validation and reliability testing of the Breast-Q latissimus dorsi questionnaire: cros...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254980
Health and Quality of Life Outcomes; Kamya L, Hansson E et. al.

Jul 5th, 2021 - The main aim of post-mastectomy breast reconstruction is to improve the patient's quality of life, which makes high-quality and validated patient-reported outcome measurements essential. None of the established instruments include evaluation of donor-site morbidity, such as impact on upper extremity and back function, when a latissimus dorsi (LD) muscle is used; and BREAST-Q LD questionnaire wa...

Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant gliom...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328944
The Lancet. Oncology; Fares J, Ahmed AU et. al.

Jul 3rd, 2021 - Malignant glioma is the most common and lethal primary brain tumour, with dismal survival rates and no effective treatment. We examined the safety and activity of NSC-CRAd-S-pk7, an engineered oncolytic adenovirus delivered by neural stem cells (NSCs), in patients with newly diagnosed high-grade glioma. This was a first-in-human, open-label, phase 1, dose-escalation trial done to determine the ...