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About 61,270 results

Chronic kidney disease: summary of updated NICE guidance.
https://doi.org/10.1136/bmj.n1992
BMJ (Clinical Research Ed.); Martinez YV, Benett I et. al.

Sep 8th, 2021 - Chronic kidney disease: summary of updated NICE guidance.|2021|Martinez YV,Benett I,Lewington AJP,Wierzbicki AS, ,|therapeutic use,therapeutic use,urine,diagnosis,physiopathology,therapy,therapeutic use,

Prominence of urinary biomarkers for bladder cancer in the COVID-19 era: From the comme...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421991
Investigative and Clinical Urology; Piao XM, Kang H et. al.

Sep 7th, 2021 - Molecular markers detected in urine may improve our understanding of the evolution of bladder cancer (BCa) and its micro- and macroenvironment. Detection of such markers will identify disease earlier, allow stratification of patients according to risk, and improve prognostication and prediction of outcomes, thereby facilitating targeted therapy. However, current guidelines have yet to embrace s...

N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic ...
https://www.ncbi.nlm.nih.gov/pubmed/34452888
Annals of Clinical and Laboratory Science; Guo Y, Abdoulaye IA et. al.

Aug 29th, 2021 - To compare the e!cacy and functional outcomes of dl-3-n-Butylphthalide (NBP) and human urinary kallidinogenase (HUK) on ischemic stroke patients and to determine their effects on serum tumor necrosis factor-alpha (TNF-α) and vascular endothelial growth factor (VEGF). A prospective study was conducted on 57 ischemic stroke patients. Functional outcomes were assessed by the National Institute Hea...

Distinct Regulation of U-ACE2 and P-ACE2 (Urinary and Plasma Angiotensin-Converting Enz...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415520
Hypertension (Dallas, Tex. : 1979); Furuhashi M, Sakai A et. al.

Aug 24th, 2021 - [Figure: see text].

Clinical and Diagnostic Value of Highly Sensitive Cardiac Troponins in Arterial Hyperte...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336985
Vascular Health and Risk Management; Chaulin A

Aug 10th, 2021 - In modern laboratory diagnostics of cardiovascular diseases (CVD), there is a clear tendency toward an increase in the sensitivity of methods for determining key CVD biomarkers, among which highly sensitive cardiac troponins (hs-Tn) deserve special attention. The introduction of the latter into clinical practice made it possible not only to improve the early diagnosis of acute myocardial infarc...

Turning Purple with Pain.
https://doi.org/10.1056/NEJMcps2105278
The New England Journal of Medicine; Fredrick TW, Braga Neto MB et. al.

Aug 5th, 2021 - Turning Purple with Pain.|2021|Fredrick TW,Braga Neto MB,Johnsrud DO,Camilleri M,Chedid VG,|etiology,etiology,therapeutic use,etiology,urine,complications,diagnosis,

Noninvasive Urine Oxygen Monitoring and the Risk of Acute Kidney Injury in Cardiac Surg...
https://doi.org/10.1097/ALN.0000000000003663
Anesthesiology Silverton NA, Lofgren LR et. al.

Jul 31st, 2021 - Acute kidney injury (AKI) is a common complication of cardiac surgery. An intraoperative monitor of kidney perfusion is needed to identify patients at risk for AKI. The authors created a noninvasive urinary oximeter that provides continuous measurements of urinary oxygen partial pressure and instantaneous urine flow. They hypothesized that intraoperative urinary oxygen partial pressure measurem...

Extracellular vesicles and exosomes generated from cystic renal epithelial cells promot...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316472
Nature Communications; Ding H, Li LX et. al.

Jul 29th, 2021 - Autosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal allele. However, if and how null ADPKD gene renal epithelial cells affect the biology and function of neighboring cells, including heterozygous renal epithelial cells, fibroblasts and macrophages during cyst initiation and ex...

Urine drug screening: A guide to monitoring Tx with controlled substances.
https://doi.org/10.12788/jfp.0168
The Journal of Family Practice; Hayes J, Fox K

Jul 28th, 2021 - Avoid error by ordering the appropriate test at a risk-based frequency. Be alert to sources of false-positives and adulteration. Be careful not to overreact to unexpected results.

Ceruloplasmin Levels in Cancer Tissues and Urine Are Significant Biomarkers of Patholog...
https://doi.org/10.21873/anticanres.15174
Anticancer Research; Mukae Y, Ito H et. al.

Jul 21st, 2021 - A previous report showed that immune complex-ceruloplasmin (CP) in urine is associated with carcinogenesis and malignant behavior in bladder cancer (BC). We investigated the pathological significance and prognostic roles of urine and tissue levels of CP protein in BC patients. Urine CP levels were measured using an enzyme-linked immunosorbent assay in 97 patients. CP expression in BC tissues wa...

Relationship Between HbA1c Level and Effectiveness of SGLT2 Inhibitors in Decompensated...
https://doi.org/10.1536/ihj.20-764
International Heart Journal; Nakagaito M, Imamura T et. al.

Jul 20th, 2021 - The DAPA-HF trial demonstrated that sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduced worsening heart failure (HF) events in chronic HF patients with or without type 2 diabetic mellitus (T2DM). However, it remains unclear whether the effectiveness of SGLT2i is also observed in patients with decompensated HF irrespective of HbA1c level. Eighty-one T2DM patients hospitalized due to decom...

Exposure to environmental phenols and parabens, and relation to body mass index, eczema...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278607
Environmental Health : a Global Access Science Source; Vindenes HK, Svanes C et. al.

Jul 15th, 2021 - Many phenols and parabens are applied in cosmetics, pharmaceuticals and food, to prevent growth of bacteria and fungi. Whether these chemicals affect inflammatory diseases like allergies and overweight is largely unexplored. We aimed to assess the associations of use of personal care products with urine biomarkers levels of phenols and paraben exposure, and whether urine levels (reflecting body...

Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarke...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424663
American Journal of Physiology. Renal Physiology; Kim Y, Wang Z et. al.

Jul 13th, 2021 - Autosomal dominant tubulointerstitial kidney disease (ADTKD)-uromodulin (UMOD) is the most common nonpolycystic genetic kidney disease, but it remains unrecognized due to its clinical heterogeneity and lack of screening test. Moreover, the fact that the clinical feature is a poor predictor of disease outcome further highlights the need for the development of mechanistic biomarkers in ADTKD. How...

Simultaneous LC-MS/MS screening for multiple phenethylamine-type conventional drugs and...
https://doi.org/10.1016/j.forsciint.2021.110884
Forensic Science International; Fan SY, Zang CZ et. al.

Jul 11th, 2021 - New psychoactive substances are being launched in the drug market at a rapidly growing pace. More than 950 new psychoactive substances have been reported to the United Nations Office on Drugs and Crime. The development of new psychoactive substance abuse has drawn risks on public health and safety. Phenethylamines, along with other stimulants, accounted for the majority of the new psychoactive ...

Advantages of plasmatic CXCL-10 as a prognostic and diagnostic biomarker for the risk o...
https://doi.org/10.1016/j.clim.2021.108792
Clinical Immunology (Orlando, Fla.); Millán O, Rovira J et. al.

Jul 5th, 2021 - This study evaluate the potential of plasmatic CXCL-10 (pCXCL-10) as a pre&post transplantation prognostic and diagnostic biomarker of T-cell-mediated rejection (TCMR), antibody-mediated rejection (ABMR) and subclinical rejection (SCR) risk in adult kidney recipients considering BKV and CMV infections as possible clinical confounder factors. Twenty-eight of 100 patients included experienced rej...

Persistence of SARS-CoV-2 RNA in the nasopharyngeal, blood, urine, and stool samples of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248752
Virology Journal; Joukar F, Yaghubi Kalurazi T et. al.

Jul 3rd, 2021 - The persistence of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) RNA in the body fluids of patients with the novel coronavirus disease 2019 (COVID-19) may increase the potential risk of viral transmission. There is still uncertainty on whether the recommended quarantine duration is sufficient to reduce the risk of transmission. This study aimed to investigate the persistence of S...

Dose-response evaluation of urinary cadmium and kidney injury biomarkers in Chinese res...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247151
Environmental Health : a Global Access Science Source; Qing Y, Yang J et. al.

Jul 2nd, 2021 - Cadmium (Cd) is a common heavy metal that mainly causes renal damage. There is a lack of research on the large-scale and systematic evaluation of the association between urinary Cd (U-Cd) and various effect biomarkers among Chinese residents. Based on the establishment process of dietary Cd limit standards by European Food Safety Authority (EFSA), the dose-response relationships between U-Cd an...

A Brewing Back Pain.
https://doi.org/10.1056/NEJMcps2034802
The New England Journal of Medicine; Pischel L, Geirsson A et. al.

Jul 1st, 2021 - A Brewing Back Pain.|2021|Pischel L,Geirsson A,Magaldi J,Martinello RA,Lee AI,|etiology,etiology,complications,diagnosis,pathology,etiology,pathology,complications,diagnosis,pathology,blood,urine,isolation & purification,diagnostic imaging,pathology,diagnosis,pathology,

Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA): A Rand...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240005
JAMA Florian J, Matta MK et. al.

Jun 29th, 2021 - In 2019, the US Food and Drug Administration (FDA) received a citizen petition indicating that ranitidine contained the probable human carcinogen N-nitrosodimethylamine (NDMA). In addition, the petitioner proposed that ranitidine could convert to NDMA in humans; however, this was primarily based on a small clinical study that detected an increase in urinary excretion of NDMA after oral ranitidi...

Clinical and prognostic values of urinary alpha1-microglobulin as a tubular marker in a...
https://doi.org/10.1016/j.ijcard.2021.06.041
International Journal of Cardiology; Ishiwata S, Matsue Y et. al.

Jun 29th, 2021 - Although urinary alpha-1-microglobulin has been used as a marker of tubular dysfunction, its clinical and prognostic values in patients with acute heart failure have not been validated. We analyzed 623 patients (74 ± 13 years old, 60.0% male) with acute heart failure in whom urinary alpha-1-microglobulin (A1MG) levels were measured as tubular markers at the time of admission. The primary endpoi...