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About 62,578 results

Psychosocial stress and neuroendocrine biomarker concentrations among women living with...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8699620
PloS One; Levy ME, Waters A et. al.

Dec 24th, 2021 - Women living with HIV (WLWH) experience psychosocial stress related to social-structural vulnerabilities. To investigate neuroendocrine pathways linking stress and increased cardiovascular disease risk among WLWH, we evaluated associations between psychosocial stress (i.e., perceived stress, posttraumatic stress, and experiences of race- and gender-based harassment) and a composite neuroendocri...

Evaluation of Urinalysis-Based Screening for Urothelial Carcinoma in Patients With Lync...
https://doi.org/10.1097/DCR.0000000000002062
Diseases of the Colon and Rectum; Chouhan H, Abbass MA et. al.

Dec 10th, 2021 - Approximately 5% to 10% of patients with Lynch syndrome develop urothelial carcinoma. Current screening recommendations vary and are based on expert opinion. Practices need to be evaluated for clinical effectiveness. Our program utilizes urinalysis as a screening test, followed by additional evaluation of microscopic hematuria. This study aimed to determine the clinical utility of a urinalysis-...

Current clinical practice in adapted automated peritoneal dialysis (aAPD)-A prospective...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659299
PloS One; Vera M, Cheak BB et. al.

Dec 10th, 2021 - Adapted automated peritoneal dialysis (aAPD), comprising a sequence of dwells with different durations and fill volumes, has been shown to enhance both ultrafiltration and solute clearance compared to standard peritoneal dialysis with constant time and volume dwells. The aim of this non-interventional study was to describe the different prescription patterns used in aAPD in clinical practice an...

Urinary schistosomiasis in a child from Central Africa.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648366
CMAJ : Canadian Medical Association Journal = Journal De ... Couture F, Desjardins A et. al.

Dec 8th, 2021 - Urinary schistosomiasis in a child from Central Africa.|2021|Couture F,Desjardins A,Richard PO,|therapeutic use,therapeutic use,diagnostic imaging,drug therapy,urine,

Salt loading decreases urinary excretion and increases intracellular accumulation of ur...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689196
Clinical Science (London, England : 1979); Mary S, Boder P et. al.

Dec 7th, 2021 - Uromodulin (UMOD) is the most abundant renal protein secreted into urine by the thick ascending limb (TAL) epithelial cells of the loop of Henle. Genetic studies have demonstrated an association between UMOD risk variants and hypertension. We aimed to dissect the role of dietary salt in renal UMOD excretion in normotension and chronic hypertension. Normotensive Wistar-Kyoto rats (WKY) and strok...

Prenatal Nicotine or Cannabis Exposure and Offspring Neurobehavioral Outcomes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715943
Obstetrics and Gynecology; Smid MC, Metz TD et. al.

Dec 3rd, 2021 - To study the association between nicotine or cannabis metabolite presence in maternal urine and child neurodevelopmental outcomes. We conducted a secondary analysis of two parallel multicenter randomized controlled trials of treatment for hypothyroxinemia or subclinical hypothyroidism among pregnant individuals enrolled at 8-20 weeks of gestation. All maternal-child dyads with a maternal urine ...

Notes from the Field: Testing for Nonprescribed Fentanyl and Percentage of Positive Tes...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612509
MMWR. Morbidity and Mortality Weekly Report; Niles JK, Gudin J et. al.

Nov 25th, 2021 - Notes from the Field: Testing for Nonprescribed Fentanyl and Percentage of Positive Test Results Among Patients with Opioid Use Disorder - United States, 2019-2020.|2021|Niles JK,Gudin J,Vivolo-Kantor AM,Gladden RM,Mustaquim D,|statistics & numerical data,therapeutic use,urine,drug therapy,epidemiology,statistics & numerical data,epidemiology,

Hematopoietic Stem- and Progenitor-Cell Gene Therapy for Hurler Syndrome.
https://doi.org/10.1056/NEJMoa2106596
The New England Journal of Medicine; Gentner B, Tucci F et. al.

Nov 18th, 2021 - Allogeneic hematopoietic stem-cell transplantation is the standard of care for Hurler syndrome (mucopolysaccharidosis type I, Hurler variant [MPSIH]). However, this treatment is only partially curative and is associated with complications. We are conducting an ongoing study involving eight children with MPSIH. At enrollment, the children lacked a suitable allogeneic donor and had a Developmenta...

Insights into Salt Handling and Blood Pressure.
https://doi.org/10.1056/NEJMra2030212
The New England Journal of Medicine; Ellison DH, Welling P

Nov 18th, 2021 - Insights into Salt Handling and Blood Pressure.|2021|Ellison DH,Welling P,|physiology,physiology,metabolism,metabolism,metabolism,metabolism,metabolism,urine,metabolism,physiology,

A randomised, double-blind, sham-controlled study of left prefrontal cortex 15 Hz repet...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594832
PloS One; Lolli F, Salimova M et. al.

Nov 17th, 2021 - Cocaine use disorder (CUD) is a global health issue with no effective treatment. Repetitive Transcranial Magnetic Stimulation (rTMS) is a recently proposed therapy for CUD. We conducted a single-center, randomised, sham-controlled, blinded, parallel-group research with patients randomly allocated to rTMS (15 Hz) or Sham group (1:1) using a computerised block randomisation process. We enrolled 6...

Paternal long-term PM2.5 exposure causes hypertension via increased renal AT1R expressi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628185
Clinical Science (London, England : 1979); Hu C, Tao Y et. al.

Nov 16th, 2021 - Maternal exposure to fine particulate matter (PM2.5) causes hypertension in offspring. However, paternal contribution of PM2.5 exposure to hypertension in offspring remains unknown. In the present study, male Sprague-Dawley rats were treated with PM2.5 suspension (10 mg/ml) for 12 weeks and/or fed with tap water containing an antioxidant tempol (1 mM/L) for 16 weeks. The blood pressure, 24 h-ur...

Using genetics to understand the role of kidney function in COVID-19: a mendelian rando...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590376
BMC Nephrology; Zhao JV, Schooling CM

Nov 15th, 2021 - Kidney dysfunction occurs in severe COVID-19, and is a predictor of COVID-19 mortality. Whether kidney dysfunction causes severe COVID-19, and hence is a target of intervention, or whether it is a symptom, is unclear because conventional observational studies are open to confounding. To obtain unconfounded estimates, we used Mendelian randomization to examine the role of kidney function in seve...

Urinary C3 levels associated with sepsis and acute kidney injury-A pilot study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589214
PloS One; Pajenda S, Zawedde F et. al.

Nov 13th, 2021 - Acute kidney injury (AKI) is an abrupt deterioration of renal function often caused by severe clinical disease such as sepsis, and patients require intensive care. Acute-phase parameters for systemic inflammation are well established and used in routine clinical diagnosis, but no such parameters are known for AKI and inflammation at the local site of tissue damage, namely the nephron. Therefore...

γENaC/CD9 in urinary extracellular vesicles as a potential biomarker of MR activity.
https://doi.org/10.1530/JOE-21-0228
The Journal of Endocrinology; Hayakawa T, Fukuhara A et. al.

Nov 11th, 2021 - Primary aldosteronism (PA) is caused by autonomous overproduction of aldosterone, which induces organ damage directly via activation of the mineralocorticoid receptor (MR); however, no specific or sensitive biomarkers are able to reflect MR activity. Recently, it is found that urinary extracellular vesicles (uEVs) are secreted by multiple cell types in the kidney and are an enriched source of k...

Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease.
https://doi.org/10.1056/NEJMoa2110730
The New England Journal of Medicine; Agarwal R, Sinha AD et. al.

Nov 6th, 2021 - Little evidence has been available to support the use of thiazide diuretics to treat hypertension in patients with advanced chronic kidney disease. We randomly assigned patients with stage 4 chronic kidney disease and poorly controlled hypertension, as confirmed by 24-hour ambulatory blood-pressure monitoring, in a 1:1 ratio to receive chlorthalidone at an initial dose of 12.5 mg per day, with ...

Use of bile acids as potential markers of liver dysfunction in humans: A systematic rev...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519223
Medicine Azer SA, Hasanato R

Nov 4th, 2021 - This study aimed to determine the effectiveness of using total, individual serum, or urinary bile acids (BA) as potential markers of liver dysfunction. We searched the PubMed and Web of Science databases using the following keywords- "serum bile acids," "liver dysfunction," "liver injury," "liver disease," "traditional liver function tests," "Chronic liver disease," "acute liver injury". The se...

Association between uric acid level and incidence of albuminuria in patients with type ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8519260
Medicine Lai YJ, Chen YY et. al.

Nov 4th, 2021 - Using animal models and molecular biology researches, hyperuricemia has been shown to instruct renal arteriolopathy, arterial hypertension, and microvascular injury involving the renin-angiotensin system and resulting in renal function impairment. Nevertheless, the association between uric acid levels and the development of albuminuria has been under-investigated in patients with type 2 diabete...

The association between maternal cytomegalovirus urinary excretion and congenital infec...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559400
BMC Pregnancy and Childbirth; Zlatkin R, Bilavsky E et. al.

Nov 3rd, 2021 - In utero Cytomegalovirus (CMV) vertical transmission occurs predominantly during primary maternal infection. There are no known non-invasive methods for diagnosis of fetal infection before delivery, however some risk factors have been suggested. We aimed to evaluate the association between maternal CMV urinary excretion and congenital CMV infection. A retrospective cohort study of all women who...

Glomerular Endothelial Cell-Derived microRNA-192 Regulates Nephronectin Expression in I...
https://doi.org/10.1681/ASN.2020121699
Journal of the American Society of Nephrology : JASN; Müller-Deile J, Sopel N et. al.

Oct 31st, 2021 - Autoantibodies binding to podocyte antigens cause idiopathic membranous glomerulonephritis (iMGN). However, it remains elusive how autoantibodies reach the subepithelial space because the glomerular filtration barrier (GFB) is size selective and almost impermeable for antibodies. Kidney biopsies from patients with iMGN, cell culture, zebrafish, and mouse models were used to investigate the role...

Predictive model for recurrence of renal cell carcinoma by comparing pre- and postopera...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748223
Cancer Science; Morozumi K, Kawasaki Y et. al.

Oct 29th, 2021 - To improve treatment outcomes in real practice, useful biomarkers are desired when predicting postoperative recurrence for renal cell carcinoma (RCC). We collected data from patients who underwent definitive surgery for RCC and for benign urological tumor at our department between November 2016 and December 2019. We evaluated the differences in pre- and postoperative urinary metabolites with ou...