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About 291,300 results

Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426591
Molecular Medicine (Cambridge, Mass.); Duarte RRR, Copertino DC et. al.

Sep 11th, 2021 - Vaccination programs have been launched worldwide to halt the spread of COVID-19. However, the identification of existing, safe compounds with combined treatment and prophylactic properties would be beneficial to individuals who are waiting to be vaccinated, particularly in less economically developed countries, where vaccine availability may be initially limited. We used a data-driven approach...

Using Wastewater Surveillance Data to Support the COVID-19 Response - United States, 20...
https://doi.org/10.15585/mmwr.mm7036a2
MMWR. Morbidity and Mortality Weekly Report; Kirby AE, Walters MS et. al.

Sep 10th, 2021 - Wastewater surveillance, the measurement of pathogen levels in wastewater, is used to evaluate community-level infection trends, augment traditional surveillance that leverages clinical tests and services (e.g., case reporting), and monitor public health interventions (1). Approximately 40% of persons infected with SARS-CoV-2, the virus that causes COVID-19, shed virus RNA in their stool (2); t...

Application of the amplification-free SERS-based CRISPR/Cas12a platform in the identifi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424404
Journal of Nanobiotechnology; Liang J, Teng P et. al.

Sep 10th, 2021 - The control of contagious or refractory diseases requires early, rapid diagnostic assays that are simple, fast, and easy-to-use. Here, easy-to-implement CRISPR/Cas12a-based diagnostic platform through Raman transducer generated by Raman enhancement effect, term as SERS-CRISPR (S-CRISPR), are described. The S-CRISPR uses high-activity noble metallic nanoscopic materials to increase the sensitivi...

Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Sy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428573
PloS One; Kulkarni R, Chen WC et. al.

Sep 10th, 2021 - COVID-19 in humans is caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that belongs to the beta family of coronaviruses. SARS-CoV-2 causes severe respiratory illness in 10-15% of infected individuals and mortality in 2-3%. Vaccines are urgently needed to prevent infection and to contain viral spread. Although several mRNA- and adenovirus-based vaccines are highly effective...

Kids and COVID: why young immune systems are still on top.
https://doi.org/10.1038/d41586-021-02423-8 10.7189/jogh.11.05013 10.1172/jci.insight.148694 10.1126/scitranslmed.abd5487 10.1038/s41467-021-24938-4 10.1038/s41467-021-21414-x 10.1038/s41587-021-01037-9 10.1126/science.abd4570 10.1126/science.abd4585 10.1126/sciimmunol.abl4340 10.1038/s41467-021-22236-7
Nature Mallapaty S

Sep 9th, 2021 - Kids and COVID: why young immune systems are still on top.|2021|Mallapaty S,|epidemiology,genetics,immunology,virology,immunology,virology,genetics,immunology,genetics,immunology,metabolism,genetics,immunology,genetics,immunology,immunology,immunology,epidemiology,virology,immunology,

Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and i...
https://doi.org/10.1073/pnas.2106845118
Proceedings of the National Academy of Sciences of the Un... Dalvie NC, Rodriguez-Aponte SA et. al.

Sep 9th, 2021 - Global containment of COVID-19 still requires accessible and affordable vaccines for low- and middle-income countries (LMICs). Recently approved vaccines provide needed interventions, albeit at prices that may limit their global access. Subunit vaccines based on recombinant proteins are suited for large-volume microbial manufacturing to yield billions of doses annually, minimizing their manufac...

Characteristics of SARS-CoV-2 Infections in Israeli Children During the Circulation of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424472
JAMA Network Open; Somekh I, Stein M et. al.

Sep 8th, 2021 - Characteristics of SARS-CoV-2 Infections in Israeli Children During the Circulation of Different SARS-CoV-2 Variants.|2021|Somekh I,Stein M,Karakis I,Simões EAF,Somekh E,|epidemiology,virology,statistics & numerical data,statistics & numerical data,

Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like recepto...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418785
Virology Journal; Pessoa NL, Bentes AA et. al.

Sep 7th, 2021 - Covid-19 has the respiratory tract as the main target of infection, and patients present mainly dyspnea, pneumonia, dry cough, and fever. Nevertheless, organs outside the respiratory tract had been reported in recent studies, including the gastrointestinal tract and liver. The host innate immune system recognizes pathogen-associated molecular patterns (PAMPs) through their pattern recognition r...

Cutaneous manifestations associated with SARS-CoV-2: an emerging topic in a pandemic era.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420694
BMJ Case Reports; Luís H, Barros C et. al.

Sep 5th, 2021 - A 70-year-old man was admitted to our COVID-19 ward with thoracalgia, productive mucus cough, fatigue and erythematous-violaceous macules on the inner side of feet and interdigital regions. The patient was started on oxygen and dexamethasone. On the day of discharge, he maintained the skin changes despite the resolution of COVID-19 symptoms. A 57-year-old woman initially presented with diffuse ...

Spontaneous massive hemothorax as a complication of necrotizing pneumonia in a patient ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415192
Journal of Medical Case Reports; Jung C, Gillmann HJ et. al.

Sep 5th, 2021 - We present an unusual bleeding complication in a patient with severe acute respiratory distress syndrome in coronavirus disease 2019. The patient, a 63-year-old Caucasian man, received venovenous extracorporeal membrane oxygenation support after rapid deterioration of lung function on day 6 after admission to hospital. After initial stabilization on lung protective ventilation and prone positio...

Spontaneous Pneumomediastinum and Pneumothorax in Nonintubated COVID-19 Patients: A Mul...
https://doi.org/10.12659/AJCR.933405
The American Journal of Case Reports; Iuorio A, Nagar F et. al.

Sep 5th, 2021 - BACKGROUND COVID-19 caused by SARS-CoV-2 has become a global pandemic. Diagnosis is based on clinical features, nasopharyngeal swab analyzed with real-time reverse transcription-polymerase chain reaction, and computer tomography (CT) scan pathognomonic signs. The most common symptoms associated with COVID-19 include fever, coughing, and dyspnea. The main complications are acute respiratory dist...

Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2.
https://doi.org/10.1073/pnas.2101071118
Proceedings of the National Academy of Sciences of the Un... Melvin WJ, Audu CO et. al.

Sep 5th, 2021 - COVID-19 induces a robust, extended inflammatory "cytokine storm" that contributes to an increased morbidity and mortality, particularly in patients with type 2 diabetes (T2D). Macrophages are a key innate immune cell population responsible for the cytokine storm that has been shown, in T2D, to promote excess inflammation in response to infection. Using peripheral monocytes and sera from human ...

Acute liver failure due to herpes simplex virus: diagnostic clues and potential role of...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416005
Medicine Chávez SM, Poniachik JM et. al.

Sep 4th, 2021 - Acute liver failure (ALF) is a life-threatening condition that remains challenging for physicians despite several advances in supportive care. Etiologies vary worldwide, with herpes simplex virus (HSV) hepatitis representing less than 1% of cases. Despite its low incidence, ALF is a lethal cause of acute necrotizing hepatitis and has a high mortality. Early antiviral treatment is beneficial for...

Von Hippel-Lindau gene single nucleotide polymorphism (rs1642742) may be related to the...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415925
Medicine Chen X, Zhang H et. al.

Sep 4th, 2021 - It is well-known that microRNAs are able to regulate the expression of target mRNAs through complementary base-pairing to their 3'-untranslated regions (3'UTR) sequences. This study aimed to investigate whether single nucleotide polymorphisms resided in the 3'UTR sequences in patients with chronic hepatitis B viruses (HBV) infection are associated with the development and metastasis of hepatoce...

Multiple Variants of SARS-CoV-2 in a University Outbreak After Spring Break - Chicago, ...
https://doi.org/10.15585/mmwr.mm7035a3
MMWR. Morbidity and Mortality Weekly Report; Doyle K, Teran RA et. al.

Sep 3rd, 2021 - To prevent transmission of SARS-CoV-2, the virus that causes COVID-19, colleges and universities have implemented multiple strategies including testing, isolation, quarantine, contact tracing, masking, and vaccination. In April 2021, the Chicago Department of Public Health (CDPH) was notified of a large cluster of students with COVID-19 at an urban university after spring break. A total of 158 ...

Outbreak Associated with SARS-CoV-2 B.1.617.2 (Delta) Variant in an Elementary School -...
https://doi.org/10.15585/mmwr.mm7035e2
MMWR. Morbidity and Mortality Weekly Report; Lam-Hine T, McCurdy SA et. al.

Sep 3rd, 2021 - On May 25, 2021, the Marin County Department of Public Health (MCPH) was notified by an elementary school that on May 23, an unvaccinated teacher had reported receiving a positive test result for SARS-CoV-2, the virus that causes COVID-19. The teacher reported becoming symptomatic on May 19, but continued to work for 2 days before receiving a test on May 21. On occasion during this time, the te...

Association Between COVID-19 and Myocarditis Using Hospital-Based Administrative Data -...
https://doi.org/10.15585/mmwr.mm7035e5
MMWR. Morbidity and Mortality Weekly Report; Boehmer TK, Kompaniyets L et. al.

Sep 3rd, 2021 - Viral infections are a common cause of myocarditis, an inflammation of the heart muscle (myocardium) that can result in hospitalization, heart failure, and sudden death (1). Emerging data suggest an association between COVID-19 and myocarditis (2-5). CDC assessed this association using a large, U.S. hospital-based administrative database of health care encounters from >900 hospitals. Myocarditi...

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vacc...
https://doi.org/10.1073/pnas.2106433118
Proceedings of the National Academy of Sciences of the Un... King HAD, Joyce MG et. al.

Sep 3rd, 2021 - Emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for next-generation vaccines able to elicit broad and durable immunity. Here we report the evaluation of a ferritin nanoparticle vaccine displaying the receptor-binding domain of the SARS-CoV-2 spike protein (RFN) adjuvanted with Army Liposomal Formulation QS-21 (ALFQ). RFN vacci...

Delayed positive COVID19 nasopharyngeal test, a case study with clinical and pathologic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406010
BMC Pulmonary Medicine; Zhang L, Vunnamadala SP et. al.

Sep 2nd, 2021 - There are various reasons for delayed positive nasopharyngeal PCR tests for coronavirus disease 2019 (COVID19) in not only asymptomatic but also severely diseased patients. The pathophysiological attributes are not known. We explore this possibility through a case report. A 64-year-old male with history of pulmonary fungal infection, asthma and chronic pulmonary obstructive disease (COPD), diab...

US COVID origins report: researchers pleased with scientific approach.
https://doi.org/10.1038/d41586-021-02366-0
Nature Maxmen A

Sep 2nd, 2021 - US COVID origins report: researchers pleased with scientific approach.|2021|Maxmen A,|epidemiology,virology,epidemiology,virology,genetics,isolation & purification,transmission,virology,organization & administration,