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About 228,348 results

Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111164
Emerging Infectious Diseases; Corman VM, Jores J et. al.

Jul 30th, 2014 - Dromedary camels are a putative source for human infections with Middle East respiratory syndrome coronavirus. We showed that camels sampled in different regions in Kenya during 1992-2013 have antibodies against this virus. High densities of camel populations correlated with increased seropositivity and might be a factor in predicting long-term virus maintenance.

Sofosbuvir and ribavirin in HCV genotypes 2 and 3.
https://doi.org/10.1056/NEJMoa1316145
The New England Journal of Medicine; Zeuzem S, Dusheiko GM et. al.

May 5th, 2014 - In clinical trials, treatment with a combination of the nucleotide polymerase inhibitor sofosbuvir and the antiviral drug ribavirin was associated with high response rates among patients with hepatitis C virus (HCV) genotype 2 infection, with lower response rates among patients with HCV genotype 3 infection. We conducted a study involving patients with HCV genotype 2 or 3 infection, some of who...

Needle-free jet injection for administration of influenza vaccine: a randomised non-inf...
https://doi.org/10.1016/S0140-6736(14)60524-9
Lancet (London, England); McAllister L, Anderson J et. al.

Jun 2nd, 2014 - Administration of vaccines by needle-free technology such as jet injection might offer an alternative to needles and syringes that avoids the issue of needle phobia and the risk of needle-stick injury. We aimed to assess the immunogenicity and safety of trivalent influenza vaccine given by needle-free jet injector compared with needle and syringe. For this randomised, comparator-controlled tria...

Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transp...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236912
Annals of Internal Medicine; Henrich TJ, Hanhauser E et. al.

Jul 22nd, 2014 - It is unknown whether the reduction in HIV-1 reservoirs seen after allogeneic hematopoietic stem cell transplantation (HSCT) with susceptible donor cells is sufficient to achieve sustained HIV-1 remission. To characterize HIV-1 reservoirs in blood and tissues and perform analytic antiretroviral treatment interruptions to determine the potential for allogeneic HSCT to lead to sustained, antiretr...

Transmission of MERS-coronavirus in household contacts.
https://doi.org/10.1056/NEJMoa1405858
The New England Journal of Medicine; Drosten C, Meyer B et. al.

Aug 27th, 2014 - Strategies to contain the Middle East respiratory syndrome coronavirus (MERS-CoV) depend on knowledge of the rate of human-to-human transmission, including subclinical infections. A lack of serologic tools has hindered targeted studies of transmission. We studied 26 index patients with MERS-CoV infection and their 280 household contacts. The median time from the onset of symptoms in index patie...

Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted ...
https://doi.org/10.1016/S0140-6736(14)60920-X
Lancet (London, England); Skinner SR, Szarewski A et. al.

Sep 5th, 2014 - Although adolescent girls are the main population for prophylactic human papillomavirus (HPV) vaccines, adult women who remain at risk of cervical cancer can also be vaccinated. We report data from the interim analysis of the ongoing VIVIANE study, the aim of which is to assess the efficacy, safety, and immunogenicity of the HPV 16/18 AS04-adjuvanted vaccine in adult women. In this phase 3, mul...

Outbreak of hepatitis A in the USA associated with frozen pomegranate arils imported fr...
https://doi.org/10.1016/S1473-3099(14)70883-7
The Lancet. Infectious Diseases; Collier MG, Khudyakov YE et. al.

Sep 9th, 2014 - In May, 2013, an outbreak of symptomatic hepatitis A virus infections occurred in the USA. Federal, state, and local public health officials investigated the cause of the outbreak and instituted actions to control its spread. We investigated the source of the outbreak and assessed the public health measures used. We interviewed patients, obtained their shopping information, and did genetic anal...

Emergence of Zaire Ebola virus disease in Guinea.
https://doi.org/10.1056/NEJMoa1404505
The New England Journal of Medicine; Baize S, Pannetier D et. al.

Apr 17th, 2014 - In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to t...

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214273
Nature Qiu X, Wong G et. al.

Aug 29th, 2014 - Without an approved vaccine or treatments, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission. These approaches, however, have yet to end the 2014 outbreak of Ebola after its prolonged presence in West Africa. Here we show that a combination of monoclonal antibodies (ZMapp), optimized from two previous antibody cocktails, is able to rescue ...

Accuracy of urinary human papillomavirus testing for presence of cervical HPV: systemat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166201
BMJ (Clinical Research Ed.); Pathak N, Dodds J et. al.

Sep 18th, 2014 - To determine the accuracy of testing for human papillomavirus (HPV) DNA in urine in detecting cervical HPV in sexually active women. Systematic review and meta-analysis. Searches of electronic databases from inception until December 2013, checks of reference lists, manual searches of recent issues of relevant journals, and contact with experts. Test accuracy studies in sexually active women tha...

Sofosbuvir plus ledispasvir for recurrent hepatitis C in liver transplant recipients.
https://doi.org/10.1002/lt.24614
Liver Transplantation : Official Publication of the Ameri... Kwok RM, Ahn J et. al.

Oct 26th, 2016 - Hepatitis C virus (HCV) recurrence after liver transplantation (LT) is associated with worse outcomes. The combination of ledipasvir (LDV) and sofosbuvir (SOF) has been approved for HCV treatment after LT, but there are limited data on the effectiveness and safety of LDV/SOF in the "real-world" setting. This multicenter study is the largest report to date on the effectiveness and safety of LDV/...

Population-Based Surveillance of Birth Defects Potentially Related to Zika Virus Infect...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812309
MMWR. Morbidity and Mortality Weekly Report; Delaney A, Mai C et. al.

Jan 25th, 2018 - Zika virus infection during pregnancy can cause serious birth defects, including microcephaly and brain abnormalities (1). Population-based birth defects surveillance systems are critical to monitor all infants and fetuses with birth defects potentially related to Zika virus infection, regardless of known exposure or laboratory evidence of Zika virus infection during pregnancy. CDC analyzed dat...

Hepatitis B reactivation in patients with previous hepatitis B virus exposure undergoin...
https://doi.org/10.1200/JCO.2014.56.7081
Journal of Clinical Oncology : Official Journal of the Am... Seto WK, Chan TS et. al.

Oct 7th, 2014 - Patterns of hepatitis B virus (HBV) reactivation in hepatitis B surface antigen (HBsAg) -negative, antihepatitis B core antigen antibody (anti-HBc) -positive patients with lymphoma receiving rituximab-containing chemotherapy have not been well described. HBsAg-negative, anti-HBc-positive Chinese patients with undetectable serum HBV DNA (< 10 IU/mL), diagnosed with hematologic malignancies and r...

Chimpanzee adenovirus vaccine generates acute and durable protective immunity against e...
https://doi.org/10.1038/nm.3702
Nature Medicine; Stanley DA, Honko AN et. al.

Sep 9th, 2014 - Ebolavirus disease causes high mortality, and the current outbreak has spread unabated through West Africa. Human adenovirus type 5 vectors (rAd5) encoding ebolavirus glycoprotein (GP) generate protective immunity against acute lethal Zaire ebolavirus (EBOV) challenge in macaques, but fail to protect animals immune to Ad5, suggesting natural Ad5 exposure may limit vaccine efficacy in humans. He...

Human Papillomavirus Prevalence in Unvaccinated Heterosexual Men After a National Femal...
https://doi.org/10.1093/infdis/jiw530
The Journal of Infectious Diseases; Machalek DA, Chow EP et. al.

Nov 6th, 2016 - In Australia, high uptake of the quadrivalent human papillomavirus (4vHPV) vaccine has led to reductions in the prevalence of human papillomavirus (HPV) genotypes 6, 11, 16, and 18 in women and girls aged ≤25 years. We evaluated the impact of the program impact on HPV prevalence in unvaccinated male subjects. Sexually active heterosexual male subjects aged 16-35 years were recruited in 2014-201...

Sequential Acquisition of Anal Human Papillomavirus (HPV) Infection Following Genital I...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034951
The Journal of Infectious Diseases; Pamnani SJ, Nyitray AG et. al.

Aug 4th, 2016 - The purpose of this study was to assess the risk of sequential acquisition of anal human papillomavirus (HPV) infection following a type-specific genital HPV infection for the 9-valent vaccine HPV types and investigate factors associated with sequential infection among men who have sex with women (MSW). Genital and anal specimens were available for 1348 MSW participants, and HPV genotypes were ...

Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection.
https://doi.org/10.1056/NEJMoa1316366
The New England Journal of Medicine; Afdhal N, Reddy KR et. al.

Apr 14th, 2014 - Effective treatment for hepatitis C virus (HCV) genotype 1 infection in patients who have not had a sustained virologic response to prior interferon-based therapy represents an unmet medical need. We conducted a phase 3, randomized, open-label study involving patients infected with HCV genotype 1 who had not had a sustained virologic response after treatment with peginterferon and ribavirin, wi...

Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis.
https://doi.org/10.1056/NEJMoa1402355
The New England Journal of Medicine; Kowdley KV, Gordon SC et. al.

Apr 11th, 2014 - High rates of sustained virologic response were observed among patients with hepatitis C virus (HCV) infection who received 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor ledipasvir. This study examined 8 weeks of treatment with this regimen. In this phase 3, open-label study, we randomly assigned 647 previously untreated patients with...

Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection.
https://doi.org/10.1056/NEJMoa1402454
The New England Journal of Medicine; Afdhal N, Zeuzem S et. al.

Apr 14th, 2014 - In phase 2 studies, treatment with the all-oral combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A inhibitor ledipasvir resulted in high rates of sustained virologic response among previously untreated patients with hepatitis C virus (HCV) genotype 1 infection. We conducted a phase 3, open-label study involving previously untreated patients with chronic HCV genotype 1 in...

Antibodies against MERS coronavirus in dromedary camels, United Arab Emirates, 2003 and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966379
Emerging Infectious Diseases; Meyer B, Müller MA et. al.

Mar 24th, 2014 - Middle East respiratory syndrome coronavirus (MERS-CoV) has caused an ongoing outbreak of severe acute respiratory tract infection in humans in the Arabian Peninsula since 2012. Dromedary camels have been implicated as possible viral reservoirs. We used serologic assays to analyze 651 dromedary camel serum samples from the United Arab Emirates; 151 of 651 samples were obtained in 2003, well bef...