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About 299,523 results

Impact of exposure time in awake prone positioning on clinical outcomes of patients wit...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740872
Critical Care (London, England); Esperatti M, Busico M et. al.

Jan 9th, 2022 - In patients with COVID-19-related acute respiratory failure (ARF), awake prone positioning (AW-PP) reduces the need for intubation in patients treated with high-flow nasal oxygen (HFNO). However, the effects of different exposure times on clinical outcomes remain unclear. We evaluated the effect of AW-PP on the risk of endotracheal intubation and in-hospital mortality in patients with COVID-19-...

The First Lady Presses for Cancer Screening to Get Back On Track.
https://doi.org/10.1158/1940-6207.CAPR-21-0548
Cancer Prevention Research (Philadelphia, Pa.); DuBois LA, DuBois RN

Jan 8th, 2022 - The First Lady of the United States, Dr. Jill Biden, visited the Hollings Cancer Center at the Medical University of South Carolina on October 25, 2021. This Commentary remarks on the administration's goal of directing public attention to cancer screening and prevention as part of an overall effort to recover ground lost in the COVID-19 pandemic, particularly in underserved communities.

Obesity as a mortality risk factor in the medical ward: a case control study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8733434
BMC Endocrine Disorders; Soffer S, Zimlichman E et. al.

Jan 8th, 2022 - Research regarding the association between severe obesity and in-hospital mortality is inconsistent. We evaluated the impact of body mass index (BMI) levels on mortality in the medical wards. The analysis was performed separately before and during the COVID-19 pandemic. We retrospectively retrieved data of adult patients admitted to the medical wards at the Mount Sinai Health System in New York...

Spontaneous Intracerebral Hemorrhage (ICH) associated with pregnancy and SARS-CoV-2 inf...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8731675
BMC Pregnancy and Childbirth; Dini P, Aminimoghaddam S et. al.

Jan 7th, 2022 - Coronavirus Disease 2019 (COVID-19) is predominately known as a respiratory disease associated with pneumonia, acute respiratory distress syndrome and multiorgan failure. However, extra-pulmonary complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are increasingly being recognized. In this regard, some studies implied the hemostatic and vascular involvements in patient...

Respiratory effects of lung recruitment maneuvers depend on the recruitment-to-inflatio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727044
Critical Care (London, England); Zerbib Y, Lambour A et. al.

Jan 6th, 2022 - In the context of acute respiratory distress syndrome (ARDS), the response to lung recruitment maneuvers (LRMs) varies considerably from one patient to another and so is difficult to predict. The aim of the study was to determine whether or not the recruitment-to-inflation (R/I) ratio could differentiate between patients according to the change in lung mechanics during the LRM. We evaluated the...

Persistence of live virus in critically ill patients infected with SARS-COV-2: a prospe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724747
Critical Care (London, England); Funk DJ, Bullard J et. al.

Jan 6th, 2022 - Research on the duration of infectivity of ICU patients with COVID-19 has been sparse. Tests based on Reverse Transcriptase polymerase chain reaction (RT-PCR) detect both live virus and non-infectious viral RNA. We aimed to determine the duration of infectiousness based on viral culture of nasopharyngeal samples of patients with COVID-19. Prospective observational study in adult intensive care ...

Analytical performances of the AMPLIQUICK® Respiratory Triplex assay for simultaneous d...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730414
PloS One; Mboumba Bouassa RS, Tonen-Wolyec S et. al.

Jan 6th, 2022 - Although patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A, influenza B and respiratory syncytial virus (RSV) show comparable or very similar manifestations, the therapeutic approaches of these respiratory viral infections are different, which requires an accurate diagnosis. Recently, the novel multiplex real-time reverse transcription-polymerase c...

Dry heat sterilization as a method to recycle N95 respirator masks: The importance of fit.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730429
PloS One; Yuen JG, Marshilok AC et. al.

Jan 6th, 2022 - In times of crisis, including the current COVID-19 pandemic, the supply chain of filtering facepiece respirators, such as N95 respirators, are disrupted. To combat shortages of N95 respirators, many institutions were forced to decontaminate and reuse respirators. While several reports have evaluated the impact on filtration as a measurement of preservation of respirator function after decontami...

Spectral image contrast-based flow digital nanoplasmon-metry for ultrasensitive antibod...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724237
Journal of Nanobiotechnology; Wang SH, Kuo CW et. al.

Jan 6th, 2022 - Gold nanoparticles (AuNPs) have been widely used in local surface plasmon resonance (LSPR) immunoassays for biomolecule sensing, which is primarily based on two conventional methods: absorption spectra analysis and colorimetry. The low figure of merit (FoM) of the LSPR and high-concentration AuNP requirement restrict their limit of detection (LOD), which is approximately ng to μg mL-1 in antibo...

Feasibility of SARS-CoV-2 Surveillance Testing Among Children and Childcare Workers at ...
https://doi.org/10.1001/jamanetworkopen.2021.42057
JAMA Network Open; Forster J, Streng A et. al.

Jan 5th, 2022 - Closure of day care centers has been implemented globally to contain the COVID-19 pandemic but has negative effects on children's health and psychosocial well-being. To investigate the feasibility of surveillance among children and childcare workers and to model the efficacy of surveillance on viral spread prevention. This nonrandomized controlled trial was conducted at 9 day care centers in Wu...

Persistent SARS-CoV-2 infection in patients with secondary antibody deficiency: success...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717300
Annals of Clinical Microbiology and Antimicrobials; Taha Y, Wardle H et. al.

Jan 1st, 2022 - There is growing evidence that antibody responses play a role in the resolution of SARS-CoV-2 infection. Patients with primary or secondary antibody deficiency are at increased risk of persistent infection. This challenging clinical scenario is associated with adverse patient outcome and potentially creates an ecological niche for the evolution of novel SARS-CoV-2 variants with immune evasion c...

Integrating digital and field surveillance as complementary efforts to manage epidemic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719698
PloS One; Tizzani M, Muñoz-Gómez V et. al.

Jan 1st, 2022 - SARS-CoV-2 has clearly shown that efficient management of infectious diseases requires a top-down approach which must be complemented with a bottom-up response to be effective. Here we investigate a novel approach to surveillance for transboundary animal diseases using African Swine (ASF) fever as a model. We collected data both at a population level and at the local level on information-seekin...

Mac-2 Binding Protein Glycosylation Isomer as a Prognostic Marker for Hepatocellular Ca...
https://doi.org/10.21873/anticanres.15479
Anticancer Research; Harimoto N, Itoh S et. al.

Jan 1st, 2022 - Mac2-binding protein glycosylation isomer (M2BPGi) is a non-invasive marker for assessing liver fibrosis. This was a retrospective study investigating whether M2BPGi predicts recurrence of hepatocellular carcinoma (HCC) after hepatectomy in patients with HCC who achieved a sustained virological response (SVR). We retrospectively reviewed the clinicopathological factors from 60 patients who unde...

Clinicopathological Analysis of Non-B Non-C Hepatocellular Carcinoma Focusing on Cellul...
https://doi.org/10.21873/anticanres.15503
Anticancer Research; Mizuochi S, Akiba J et. al.

Jan 1st, 2022 - Non-B non-C hepatocellular carcinomas (NBNC-HCCs) are larger than hepatitis virus-related HCCs. We conducted a clinicopathological study of patients who underwent curative NBNC-HCC resection, including proliferative activity assessments, such as nuclear grade and Ki-67 labelling index (LI). Histopathological findings of 197 patients were examined, including 56 NBNC-HCCs, 45 hepatitis B virus (H...

Olaparib-induced Apoptosis Through EBNA1-ATR-p38 MAPK Signaling Pathway in Epstein-Barr...
https://doi.org/10.21873/anticanres.15513
Anticancer Research; Moon SH, Park NS et. al.

Jan 1st, 2022 - Epstein-Barr virus (EBV)-associated gastric cancer has been identified as a cancer subtype with definitive clinical and molecular characteristics. Although olaparib, a poly ADP ribose polymerase (PARP) inhibitor, is considered a potential effective agent for gastric cancer, the effect and underlying mechanism of olaparib on gastric cancer depending on EBV infection is not fully understood. EBV-...

Investigation of a SARS-CoV-2 B.1.1.529 (Omicron) Variant Cluster - Nebraska, November-...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8736273
MMWR. Morbidity and Mortality Weekly Report; Jansen L, Tegomoh B et. al.

Dec 31st, 2021 - The B.1.1.529 (Omicron) variant of SARS-CoV-2 (the virus that causes COVID-19) was first detected in specimens collected on November 11, 2021, in Botswana and on November 14 in South Africa;* the first confirmed case of Omicron in the United States was identified in California on December 1, 2021 (1). On November 29, the Nebraska Department of Health and Human Services was notified of six proba...

Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children.
https://doi.org/10.1056/NEJMoa2108793
The New England Journal of Medicine; Turkova A, White E et. al.

Dec 30th, 2021 - Children with human immunodeficiency virus type 1 (HIV-1) infection have limited options for effective antiretroviral treatment (ART). We conducted an open-label, randomized, noninferiority trial comparing three-drug ART based on the HIV integrase inhibitor dolutegravir with standard care (non-dolutegravir-based ART) in children and adolescents starting first- or second-line ART. The primary en...

Adaptation and psychometric evaluation of Hungarian version of the Fear of COVID-19 Scale.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716026
PloS One; Stankovic M, Papp L et. al.

Dec 30th, 2021 - COVID-19 pandemic has had a global major healthcare, social and economic impact. In present study we aim to adapt the Fear of COVID-19 Scale to Hungarian. Forward-backward translation method was used to translate the English version of the scale to Hungarian. Participants were a convenience sample of 2175 university students and employees. The study was conducted between January 18th and Februa...

Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8711287
Molecular Medicine (Cambridge, Mass.); Chapoval SP, Keegan AD

Dec 29th, 2021 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly ma...

The Outcomes of Patients Incidentally Confirmed with Covid-19 After Cardiac Surgery.
https://doi.org/10.1532/hsf.4259
The Heart Surgery Forum; Uysal A, Erturk E et. al.

Dec 29th, 2021 - The aim of this study was to investigate the clinical outcomes of cardiac surgery in patients who were incidentally diagnosed with Covid-19 in the postoperative period. We performed 826 open cardiac surgeries in five tertiary centers. Most of the surgeries were elective coronary artery bypass grafting (CABG) (93.8%). A preoperative RT-PCR test and transcutaneous oxygen saturation were routinely...