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About 305,260 results

Technologies for HIV-1 drug resistance testing: inventory and needs.
https://doi.org/10.1097/COH.0000000000000737
Current Opinion in HIV and AIDS; Metzner KJ

Jun 29th, 2022 - HIV-1 drug resistance (HIV DR) testing is routinely performed by genotyping plasma viruses using Sanger population sequencing. Next-generation sequencing (NGS) is increasingly replacing standardized Sanger sequencing. This opens up new opportunities, but also brings challenges. The number of NGS applications and protocols for HIV DR testing is increasing. All of them are noninferior to Sanger s...

MHBSt167 induced autophagy promote cell proliferation and EMT by activating the immune ...
https://doi.org/10.1186/s12985-022-01840-z 10.1186/s12885-019-5916-6 10.1093/carcin/bgs365 10.1093/jnci/djp180 10.1053/j.gastro.2007.09.002 10.1016/j.jhep.2014.04.041 10.1136/gut.2008.174029 10.1093/ndt/gfp737 10.1002/j.1460-2075.1992.tb05369.x 10.3892/ol.2014.2190 10.1056/NEJMra2022774 10.1016/j.jhep.2019.08.026 10.1038/nrc3262 10.1002/hep.31209 10.2217/hep-2019-0007 10.1038/s41590-020-0622-8 10.1016/j.jhep.2011.06.028 10.1038/s41586-020-03056-z 10.1016/j.molcel.2010.09.023 10.1083/jcb.201002021 10.1016/j.tig.2017.08.004 10.1158/1541-7786.MCR-07-0098 10.1093/carcin/bgr296 10.3390/md14090166 10.1002/hep.20615 10.1101/gr.978703 10.1101/cshperspect.a012872 10.1080/10409230591008161 10.1016/j.semcancer.2019.11.007 10.3390/cells8010016 10.3390/cancers12030562 10.21037/tgh.2018.06.09 10.1002/hep.25592 10.1038/s41416-019-0441-6 10.1038/s41575-019-0145-7 10.1016/j.cellimm.2017.12.007 10.1038/nature07205 10.4161/onci.20304 10.1038/nature09782 10.1038/cmi.2018.2 10.1126/science.1136880 10.1073/pnas.0807694106 10.1073/pnas.0911267106 10.1016/j.ccell.2016.09.004 10.1172/JCI120888 10.1080/15548627.2018.1427398
Virology Journal; Cheng B, Wang Q et. al.

Jun 28th, 2022 - Hepatitis B virus can induce hepatocellular carcinoma (HCC) by inducing a host immune response against infected hepatocytes. C-terminally truncated middle surface protein (MHBSt) has been reported to contribute to HCC through transcriptional activation in epidemiology studies, while the underlying mechanism of MHBSt-induced HCC is unknown. In this study, a premature stop at codon 167 in MHBS (M...

Expression of fatty acid synthase genes and their role in development and arboviral inf...
https://doi.org/10.1186/s13071-022-05336-1 10.1371/journal.pone.0024970
Parasites & Vectors; Chotiwan N, Brito-Sierra CA et. al.

Jun 28th, 2022 - Fatty acids are the building blocks of complex lipids essential for living organisms. In mosquitoes, fatty acids are involved in cell membrane production, energy conservation and expenditure, innate immunity, development and reproduction. Fatty acids are synthesized by a multifunctional enzyme complex called fatty acid synthase (FAS). Several paralogues of FAS were found in the Aedes aegypti mo...

Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation ...
https://doi.org/10.1073/pnas.2202370119
Proceedings of the National Academy of Sciences of the Un... Beucher G, Blondot ML et. al.

Jun 25th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract, where infections can cause an acute respiratory distress syndrome with a high degree of mortality in elderly patients. We used reconstituted primary bronchial epithelia from adult and child donors to follow the...

Convergent evolution of antiviral machinery derived from endogenous retrovirus truncate...
https://doi.org/10.1073/pnas.2114441119
Proceedings of the National Academy of Sciences of the Un... Miyake A, Ngo MH et. al.

Jun 25th, 2022 - Host genetic resistance to viral infection controls the pathogenicity and epidemic dynamics of infectious diseases. Refrex-1 is a restriction factor against feline leukemia virus subgroup D (FeLV-D) and an endogenous retrovirus (ERV) in domestic cats (ERV-DC). Refrex-1 is encoded by a subset of ERV-DC loci with truncated envelope genes and secreted from cells as a soluble protein. Here, we iden...

Harnessing anti-cytomegalovirus immunity for local immunotherapy against solid tumors.
https://doi.org/10.1073/pnas.2116738119
Proceedings of the National Academy of Sciences of the Un... Çuburu N, Bialkowski L et. al.

Jun 25th, 2022 - Tumor infiltration by T cells profoundly affects cancer progression and responses to immunotherapy. However, the tumor immunosuppressive microenvironment can impair the induction, trafficking, and local activity of antitumor T cells. Here, we investigated whether intratumoral injection of virus-derived peptide epitopes could activate preexisting antiviral T cell responses locally and promote an...

Posttranslational modifications optimize the ability of SARS-CoV-2 spike for effective ...
https://doi.org/10.1073/pnas.2119761119
Proceedings of the National Academy of Sciences of the Un... Kapoor K, Chen T et. al.

Jun 24th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein is the prime target for vaccines, diagnostics, and therapeutic antibodies against the virus. While anchored in the viral envelope, for effective virulence, the spike needs to maintain structural flexibility to recognize the host cell surface receptors and bind to them, a property that can heavily depend upon the dyn...

The science behind COVID's assault on smell.
https://doi.org/10.1038/d41586-022-01627-w 10.1016/j.cell.2022.01.024 10.1021/acschemneuro.0c00210 10.1126/sciadv.abc5801 10.1183/13993003.01948-2020 10.1016/j.cell.2021.10.027 10.1126/scitranslmed.abf8396 10.1038/s41588-021-00986-w 10.1021/acschemneuro.1c00542 10.1126/scitranslmed.abq3059
Nature Dolgin E

Jun 23rd, 2022 - The science behind COVID's assault on smell.|2022|Dolgin E,|physiopathology,virology,pathogenicity,

Bagaza Virus in Wild Birds, Portugal, 2021.
https://doi.org/10.3201/eid2807.212408
Emerging Infectious Diseases; Queirós J, Barros SC et. al.

Jun 23rd, 2022 - Bagaza virus emerged in Spain in 2010 and was not reported in other countries in Europe until 2021, when the virus was detected by molecular methods in a corn bunting and several red-legged partridges in Portugal. Sequencing revealed high similarity between the 2021 strains from Portugal and the 2010 strains from Spain.

Hypoxia-inducible lentiviral gene expression in engineered human macrophages.
https://doi.org/10.1136/jitc-2021-003770
Journal for Immunotherapy of Cancer; Chinn HK, Gardell JL et. al.

Jun 22nd, 2022 - Human immune cells, including monocyte-derived macrophages, can be engineered to deliver proinflammatory cytokines, bispecific antibodies, and chimeric antigen receptors to support immune responses in different disease settings. When gene expression is regulated by constitutively active promoters, lentiviral payload gene expression is unregulated, and can result in potentially toxic quantities ...

How months-long COVID infections could seed dangerous new variants.
https://doi.org/10.1038/d41586-022-01613-2 10.1038/s41467-022-30163-4 10.1126/scitranslmed.abh1803 10.1038/s41586-021-03291-y 10.1056/NEJMc2031364 10.7554/eLife.69091 10.1093/molbev/msac061 10.1038/s41586-022-04474-x 10.1093/ve/veab091 10.1038/s41467-022-29104-y 10.1016/S2666-5247(21)00030-6 10.1007/s10875-021-01158-5
Nature Callaway E

Jun 16th, 2022 - How months-long COVID infections could seed dangerous new variants.|2022|Callaway E,|virology,classification,genetics,

Chapare Hemorrhagic Fever and Virus Detection in Rodents in Bolivia in 2019.
https://doi.org/10.1056/NEJMoa2110339
The New England Journal of Medicine; Loayza Mafayle R, Morales-Betoulle ME et. al.

Jun 16th, 2022 - In June 2019, the Bolivian Ministry of Health reported a cluster of cases of hemorrhagic fever that started in the municipality of Caranavi and expanded to La Paz. The cause of these cases was unknown. We obtained samples for next-generation sequencing and virus isolation. Human and rodent specimens were tested by means of virus-specific real-time quantitative reverse-transcriptase-polymerase-c...

Does This Patient With Acute Infectious Conjunctivitis Have a Bacterial Infection?: The...
https://doi.org/10.1001/jama.2022.7687
JAMA Johnson D, Liu D et. al.

Jun 15th, 2022 - Acute infectious conjunctivitis is characterized by ocular redness and discharge, and is a common clinical entity. Evidence-based tools to aid the clinical diagnosis of viral vs bacterial conjunctivitis are lacking and may contribute to overprescribing of topical antibiotics. To determine the relative prevalence of viral vs bacterial conjunctivitis in adults and children, and to determine which...

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.
https://doi.org/10.1073/pnas.2201980119
Proceedings of the National Academy of Sciences of the Un... Simonetti B, Daly JL et. al.

Jun 14th, 2022 - Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic scr...

Host protease activity classifies pneumonia etiology.
https://doi.org/10.1073/pnas.2121778119
Proceedings of the National Academy of Sciences of the Un... Anahtar M, Chan LW et. al.

Jun 14th, 2022 - Community-acquired pneumonia (CAP) has been brought to the forefront of global health priorities due to the COVID-19 pandemic. However, classification of viral versus bacterial pneumonia etiology remains a significant clinical challenge. To this end, we have engineered a panel of activity-based nanosensors that detect the dysregulated activity of pulmonary host proteases implicated in the respo...

Expansion of a retrovirus lineage in the koala genome.
https://doi.org/10.1073/pnas.2201844119
Proceedings of the National Academy of Sciences of the Un... Lillie M, Hill J et. al.

Jun 14th, 2022 - Retroviruses have left their legacy in host genomes over millions of years as endogenous retroviruses (ERVs), and their structure, diversity, and prevalence provide insights into the historical dynamics of retrovirus-host interactions. In bioinformatic analyses of koala (Phascolarctos cinereus) whole-genome sequences, we identify a recently expanded ERV lineage (phaCin-β) that is related to the...

Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike...
https://doi.org/10.1186/s13054-022-04034-9 10.1186/s40246-021-00304-9 10.1002/jmv.25785 10.1161/CIRCRESAHA.120.317015 10.1016/j.cell.2020.03.045 10.1371/journal.pone.0179177 10.1016/j.biopha.2020.110678 10.3389/fchem.2021.740702 10.1016/j.pharmthera.2020.107527 10.1038/s41388-018-0563-y 10.1113/jphysiol.2010.203075 10.1016/j.intimp.2017.02.016 10.1016/j.jep.2019.112470 10.1016/j.ijid.2020.09.041 10.1007/s11427-020-1643-8 10.1186/s13054-020-03015-0 10.3389/fimmu.2021.625732 10.1038/nature03712 10.1038/nm1267 10.1038/ncomms4594 10.1038/ncomms4595 10.1016/S2213-2600(20)30418-5 10.1038/s41392-020-00374-6 10.1073/pnas.2010146117 10.1371/journal.pbio.3001284 10.1038/s41586-020-2708-8 10.1371/journal.ppat.1009195 10.1016/j.ebiom.2021.103406 10.1016/j.cell.2020.09.050 10.3389/fmicb.2021.770935 10.7150/ijbs.63329 10.1080/17435390.2018.1513094 10.2147/IJN.S250367 10.1165/rcmb.2009-0210ST 10.1038/cddis.2017.337 10.1056/NEJMra1608077 10.1016/S2213-2600(19)30417-5 10.1007/s00109-006-0094-9 10.1016/j.cell.2008.02.043 10.1161/hc0302.102618 10.1152/physrev.00038.2017 10.1038/cmi.2014.89 10.1038/s41385-018-0021-8 10.2337/db07-1579 10.3389/fonc.2018.00160 10.1001/jama.2020.11301 10.1161/CIRCRESAHA.120.317134 10.3389/fmed.2021.703661 10.1056/NEJMsr2005760 10.1038/s41467-021-22713-z 10.1126/science.abe0075 10.1016/j.cell.2020.04.004 10.15252/emmm.202013426 10.1073/pnas.2016093117 10.1056/NEJMoa1704154 10.1186/s13054-020-02862-1 10.1165/rcmb.2012-0451OC 10.1089/152308602762197443 10.1161/01.RES.74.6.1141 10.1056/NEJMoa2002032 10.1016/j.redox.2020.101655 10.1152/ajplung.00124.2020 10.1152/ajplung.00251.2019 10.1038/cdd.2010.63 10.1186/s13058-019-1154-8
Critical Care (London, England); Zhang L, Zhang Y et. al.

Jun 11th, 2022 - SARS-CoV-2 infection leads to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Both clinical data and animal experiments suggest that the renin-angiotensin system (RAS) is involved in the pathogenesis of SARS-CoV-2-induced ALI. Angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2 and a crucial negative regulator of RAS. Recombinant ACE2 protein...

Mosquito  saliva enhances virus infection through sialokinin-dependent vascular leakage.
https://doi.org/10.1073/pnas.2114309119
Proceedings of the National Academy of Sciences of the Un... Lefteri DA, Bryden SR et. al.

Jun 9th, 2022 - Viruses transmitted by Aedes mosquitoes are an increasingly important global cause of disease. Defining common determinants of host susceptibility to this large group of heterogenous pathogens is key for informing the rational design of panviral medicines. Infection of the vertebrate host with these viruses is enhanced by mosquito saliva, a complex mixture of salivary-gland-derived factors and ...

Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I i...
https://doi.org/10.1371/journal.ppat.1010228
PLoS Pathogens; Hiller BE, Yin Y et. al.

Jun 9th, 2022 - Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors. Fibroblast growth factor-9 (FGF9) is required for lung development, can display antiviral activity in vitro, and is upregulated in asymptomatic ...

Hepatitis E virus infects brain microvascular endothelial cells, crosses the blood-brai...
https://doi.org/10.1073/pnas.2201862119
Proceedings of the National Academy of Sciences of the Un... Tian D, Li W et. al.

Jun 8th, 2022 - Hepatitis E virus (HEV) is an important but understudied zoonotic virus causing both acute and chronic viral hepatitis. A proportion of HEV-infected individuals also developed neurological diseases such as Guillain-Barré syndrome, neuralgic amyotrophy, encephalitis, and myelitis, although the mechanism remains unknown. In this study, by using an in vitro blood-brain barrier (BBB) model, we firs...