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About 306,638 results

Circulation and seasonality of influenza viruses in different transmission zones in Afr...
https://doi.org/10.1186/s12879-022-07727-2
BMC Infectious Diseases; Belizaire MRD, N'gattia AK et. al.

Nov 8th, 2022 - Influenza is responsible for more than 5 million severe cases and 290,000 to 650,000 deaths every year worldwide. Developing countries account for 99% of influenza deaths in children under 5 years of age. This paper aimed to determine the dynamics of influenza viruses in African transmission areas to identify regional seasonality for appropriate decision-making and the development of regional p...

Effectiveness of Aedes-borne infectious disease control in Latin America and the Caribb...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629598
PloS One; Mulderij-Jansen V, Pundir P et. al.

Nov 3rd, 2022 - Aedes aegypti and Aedes albopictus are primary vectors of emerging or re-emerging arboviruses that threaten public health worldwide. Many efforts have been made to develop interventions to control these Aedes species populations. Still, countries in the Latin America and the Caribbean (LAC) region struggle to create/design/develop sustainable and effective control strategies. This scoping revie...

Straw-Colored Fruit Bats (Eidolon helvum) and Their Bat Flies (Cyclopodia gre...
https://doi.org/10.1089/vbz.2022.0025
Vector Borne and Zoonotic Diseases (Larchmont, N.Y.); Kamani J, González-Miguel J et. al.

Nov 1st, 2022 - Background: Bat flies (Diptera: Hippoboscoidea: Nycteribiidae and Streblidae) are increasingly appreciated as hosts of "bat-associated" viruses. We studied straw-colored fruit bats (Eidolon helvum) and their nycteribiid bat flies (Cyclopodia greefi) in Nigeria to investigate the role of bat flies in vectoring or maintaining viruses. Methods:...

On the lookout for viruses that could leap from animals into humans.
https://doi.org/10.1038/d41586-022-03357-5
Nature Makin S

Oct 27th, 2022 - On the lookout for viruses that could leap from animals into humans.|2022|Makin S,|classification,isolation & purification,virology,

Delayed encephalopathy after COVID-19: A case series of six patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592135
Medicine Akimoto T, Hara M et. al.

Oct 26th, 2022 - Acute encephalopathy is a severe neurological complication of coronavirus disease 2019 (COVID-19). Most cases of acute encephalopathy associated with COVID-19 occur within several weeks of COVID-19 onset. We describe a case series of 6 patients who developed delayed encephalopathy (DE) after COVID-19. We evaluated patients who recovered from COVID-19 and showed acute disturbance of consciousnes...

Viral Shedding 1 Year Following First-Episode Genital HSV-1 Infection.
https://doi.org/10.1001/jama.2022.19061
JAMA Johnston C, Magaret A et. al.

Oct 23rd, 2022 - Herpes simplex virus type 1 (HSV-1) is the leading cause of first-episode genital herpes in many countries. To inform counseling messages regarding genital HSV-1 transmission, oral and genital viral shedding patterns among persons with first-episode genital HSV-1 infection were assessed. The trajectory of the development of HSV-specific antibody and T-cell responses was also characterized. Pros...

HPV 16 E7 alters translesion synthesis signaling.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583550
Virology Journal; Wendel SO, Stoltz A et. al.

Oct 22nd, 2022 - A subset of human papillomaviruses (HPVs) are the cause of virtually every cervical cancer. These so-called "high-risk" HPVs encode two major oncogenes (HPV E6 and E7) that are necessary for transformation. Among "high-risk" HPVs, HPV16 causes most cervical cancers and is often used as a representative model for oncogenic HPVs. The HPV16 E7 oncogene facilitates the HPV16 lifecycle by binding an...

Intradermal vaccination of HPV-16 E6 synthetic peptides conjugated to an optimized Toll...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9582304
Journal for Immunotherapy of Cancer; Speetjens FM, Welters MJP et. al.

Oct 20th, 2022 - Amplivant is a molecularly optimized Toll-like receptor 2 ligand that can be covalently conjugated to tumor peptide antigens. In preclinical models, amplivant-adjuvanted synthetic long peptides (SLPs) strongly enhanced antigen presentation by dendritic cells, T cell priming and induction of effective antitumor responses. The current study is a first-in-human trial to investigate safety and immu...

Association of mRNA Vaccination With Clinical and Virologic Features of COVID-19 Among ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579910
JAMA , Thompson MG et. al.

Oct 19th, 2022 - Data on the epidemiology of mild to moderately severe COVID-19 are needed to inform public health guidance. To evaluate associations between 2 or 3 doses of mRNA COVID-19 vaccine and attenuation of symptoms and viral RNA load across SARS-CoV-2 viral lineages. A prospective cohort study of essential and frontline workers in Arizona, Florida, Minnesota, Oregon, Texas, and Utah with COVID-19 infec...

Insights into pandemic respiratory viruses: manipulation of the antiviral interferon re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472579
Current Opinion in Immunology; Liu G, Gack MU

Oct 11th, 2022 - The outbreak of the COVID-19 pandemic one year after the centennial of the 1918 influenza pandemic reaffirms the catastrophic impact respiratory viruses can have on global health and economy. A key feature of SARS-CoV-2 and influenza A viruses (IAV) is their remarkable ability to suppress or dysregulate human immune responses. Here, we summarize the growing knowledge about the interplay of SARS...

Manipulation of Interleukin-6 (IL-6) and Transforming Growth Factor Beta-1(TGFβ-1) towa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550071
PloS One; Badshah Y, Shabbir M et. al.

Oct 11th, 2022 - Hepatocellular carcinoma (HCC) is the most common liver malignancy. Early diagnosis of HCC has always been challenging. This study aims to assess the pathogenicity and the prevalence of IL-6 -174G/C (rs1800795) and TGFβ-1 +29C/T (rs1800470) polymorphisms in HCV-infected HCC patients. Experimental strategies are integrated with computational approaches to analyse the pathogenicity of the TGFβ-1 ...

Omicron variant of SARS-CoV-2 infection elicits cross-protective immunity in people who...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551331
International Journal of Immunopathology and Pharmacology; Chowdhury S, Chowdhury MS et. al.

Oct 11th, 2022 - The B.1.1.529 (Omicron) variant of SARS-CoV-2 is the most antigenically unique SARS-CoV-2 variant of concern to date, which is currently widespread across the world. Omicron variant and its sublineages contain a plethora of mutations than other variants of concern, which increases their transmissibility and virulence. Concerns regarding potential immunological evasion have been reignited by eme...

SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533993
Nature Kee J, Thudium S et. al.

Oct 6th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID-19), in part because of its ability to effectively suppress host cell responses1-3. In rare cases, viral proteins dampen antiviral responses by mimicking critical regions of human histone proteins4-8, particularly those containing ...

The introduction of mutations in the wild type coxsackievirus B3 (CVB3) IRES RNA leads ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529112
PloS One; Gharbi J, Almalki MA et. al.

Oct 4th, 2022 - Coxsackievirus B3 (CVB3) is a principal causative agent of viral myocarditis, meningitis and pancreatitis. There is no vaccine available for clinical use. It has been demonstrated that the primary molecular determinant of virulence phenotype is located in the 5' UTR of the viral genome. Translation initiation of CVB3 RNA is directed by the IRES element situated in the 5'UTR. In the present stud...

Prolonged diarrhea among under-five children in Bangladesh: Burden and risk factors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529139
PloS One; Hossain MI, Faruque ASG et. al.

Oct 4th, 2022 - Prolonged (duration >7 to 13 days) diarrhea (ProD) in under-five children is a universal health problem including Bangladesh. Data on epidemiology and associated or risk factors of ProD are limited, particularly in Bangladesh where a high burden of ProD is reported. This study intended to assess the case load of ProD and its associated or risk factors compared to acute diarrhea (AD, duration ≤7...

Viruses inhibit TIR gcADPR signalling to overcome bacterial defence.
https://doi.org/10.1038/s41586-022-05375-9
Nature Leavitt A, Yirmiya E et. al.

Sep 30th, 2022 - The Toll/interleukin-1 receptor (TIR) domain is a key component of immune receptors that identify pathogen invasion in bacteria, plants and animals1-3. In the bacterial antiphage system Thoeris, as well as in plants, recognition of infection stimulates TIR domains to produce an immune signalling molecule whose molecular structure remains elusive. This molecule binds and activates the...

Structure of the Ebola virus polymerase complex.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517992
Nature Yuan B, Peng Q et. al.

Sep 29th, 2022 - Filoviruses, including Ebola virus, pose an increasing threat to the public health. Although two therapeutic monoclonal antibodies have been approved to treat the Ebola virus disease1,2, there are no approved broadly reactive drugs to control diverse filovirus infection. Filovirus has a large polymerase (L) protein and the cofactor viral protein 35 (VP35), which constitute the basic functional ...

Systematic evaluation of plasma signaling cascades by functional proteomics approaches:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537801
Proteomics. Clinical Applications; Juanes-Velasco P, García-Vaquero ML et. al.

Sep 29th, 2022 - Acute phase reactants (APRs) play a critical role in inflammation. The difference in their physiological functions or the different dynamic ranges of these proteins in plasma makes it difficult to detect them simultaneously and to use several of these proteins as a tool in clinical practice. A novel multiplex assay has been designed and optimized to carry out a high-throughput and simultaneous ...

These scientists traced a new coronavirus lineage to one office - through sewage.
https://doi.org/10.1038/d41586-022-02996-y
Nature Callaway E

Sep 28th, 2022 - These scientists traced a new coronavirus lineage to one office - through sewage.|2022|Callaway E,|epidemiology,virology,classification,genetics,isolation & purification,virology,

Long-term Household Contamination With Monkeypox Virus Investigated.
https://doi.org/10.1001/jama.2022.14726
JAMA Kuehn BM

Sep 28th, 2022 - Long-term Household Contamination With Monkeypox Virus Investigated.|2022|Kuehn BM,|virology,transmission,isolation & purification,