About 307,593 results

A male-killing gene encoded by a symbiotic virus of Drosophila.
Nature Communications; Kageyama D, Harumoto T et. al.

Mar 15th, 2023 - In most eukaryotes, biparentally inherited nuclear genomes and maternally inherited cytoplasmic genomes have different evolutionary interests. Strongly female-biased sex ratios that are repeatedly observed in various arthropods often result from the male-specific lethality (male-killing) induced by maternally inherited symbiotic bacteria such as Spiroplasma and Wolbachia. However, despite some ...

How the brain senses a flu infection - and orders the body to rest.
Nature Drew L

Mar 9th, 2023 - How the brain senses a flu infection - and orders the body to rest.|2023|Drew L,|physiology,physiopathology,virology,physiology,

US COVID-origins hearing renews debate over lab-leak hypothesis.
Nature Lenharo M, Wolf L

Mar 9th, 2023 - US COVID-origins hearing renews debate over lab-leak hypothesis.|2023|Lenharo M,Wolf L,|epidemiology,virology,isolation & purification,

Indoor air is full of flu and COVID viruses. Will countries clean it up?
Nature Lewis D

Mar 8th, 2023 - Indoor air is full of flu and COVID viruses. Will countries clean it up?|2023|Lewis D,|adverse effects,prevention & control,prevention & control,virology,prevention & control,virology,isolation & purification,isolation & purification,

Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-...
Microbiome Armstrong H, Rahbari M et. al.

Mar 4th, 2023 - Following viral infection, genetically manipulated mice lacking immunoregulatory function may develop colitis and dysbiosis in a strain-specific fashion that serves as a model for inflammatory bowel disease (IBD). We found that one such model of spontaneous colitis, the interleukin (IL)-10 knockout (IL-10-/-) model derived from the SvEv mouse, had evidence of increased Mouse mammary tumor virus...

CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection.
Nature Communications; Ayyar BV, Ettayebi K et. al.

Mar 1st, 2023 - Globally, most cases of gastroenteritis are caused by pandemic GII.4 human norovirus (HuNoV) strains with no approved therapies or vaccines available. The cellular pathways that these strains exploit for cell entry and internalization are unknown. Here, using nontransformed human jejunal enteroids (HIEs) that recapitulate the physiology of the gastrointestinal tract, we show that infectious GII...

Differences in the pathogenicity of Chinese virulent genotype GIIa and GIIb porcine epi...
Archives of Virology; Zhang L, Yu R et. al.

Feb 28th, 2023 - We evaluated differences in the pathology and humoral immune status in one- and two-month-old weaned pigs infected with virulent Chinese genotype GIIa and GIIb strains of porcine epidemic diarrhea virus (PEDV). All pigs infected with the GIIa strain developed severe diarrhea (100%), while the morbidity of the GIIb strain in one- and two-month-old weaned pigs was 80% (4/5) and 40% (2/5), respect...

Change over Time in the Risk of Death among Japanese COVID-19 Cases Caused by the Omicr...
International Journal of Environmental Research and Publi... Takahashi Y, Tanaka H et. al.

Feb 26th, 2023 - To assess temporal changes to the risk of death in COVID-19 cases caused by the Omicron variant, we calculated age-standardized case fatality rates (CFR) in patients aged ≥40 years over nine diagnostic periods (3 January to 28 August 2022) in ten Japanese prefectures (14.8 million residents). Among 552,581 study subjects, we found that there were 1836 fatalities during the isolation period (up ...

Identification and Genetic Characterization of MERS-Related Coronavirus Isolated from N...
International Journal of Environmental Research and Publi... Speranskaya AS, Artiushin IV et. al.

Feb 26th, 2023 - Being diverse and widely distributed globally, bats are a known reservoir of a series of emerging zoonotic viruses. We studied fecal viromes of twenty-six bats captured in 2015 in the Moscow Region and found 13 of 26 (50%) samples to be coronavirus positive. Of P. nathusii (the Nathusius' pipistrelle), 3 of 6 samples were carriers of a novel MERS-related betacoronavirus. We sequenced and assemb...

Isolation, characterization, therapeutic potency, and genomic analysis of a novel bacte...
Annals of Clinical Microbiology and Antimicrobials; Mohammadi M, Saffari M et. al.

Feb 25th, 2023 - Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a significant clinical problem, given the lack of therapeutic options. The CRKP strains have emerged as an essential worldwide healthcare issue during the last 10 years. Global expansion of the CRKP has made it a significant public health hazard. We must consider to novel therapeutic techniques. Bacteriophages are potent restorative cases aga...

Third patient free of HIV after receiving virus-resistant cells.
Nature Reardon S

Feb 23rd, 2023 - Third patient free of HIV after receiving virus-resistant cells.|2023|Reardon S,|therapy,virology,isolation & purification,

COVID-19 Vaccination During Pregnancy Protected Infants.
JAMA Harris E

Feb 23rd, 2023 - COVID-19 Vaccination During Pregnancy Protected Infants.|2023|Harris E,|complications,prevention & control,administration & dosage,therapeutic use,prevention & control,virology,methods,prevention & control,virology,

Marburg virus outbreak: researchers race to test vaccines.
Nature Callaway E

Feb 16th, 2023 - Marburg virus outbreak: researchers race to test vaccines.|2023|Callaway E,|prevention & control,statistics & numerical data,epidemiology,prevention & control,virology,

Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatoc...
BMC Cancer; Rehman A, Shabbir M et. al.

Feb 15th, 2023 - The protein kinase C (PKC) family of serine/threonine kinases contains more than ten isozymes that are involved in multiple signaling pathways, including cell cycle regulation and carcinogenesis. The PKCε isozyme is an oncogene known to be upregulated in various signaling pathways involved in hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC). However, there is no known association ...

Prevalence and genetic diversity in bovine parechovirus infecting Japanese cattle.
Archives of Virology; Oba M, Obinata S et. al.

Feb 15th, 2023 - The first bovine parechovirus (Bo_ParV) was reported in 2021, and currently, only two nearly complete genome sequences of Bo_ParV are available. In this study, we detected Bo_ParVs in 10 out of 158 bovine fecal samples tested using real-time RT-PCR, and Bo_ParVs were isolated from three of these samples using MA104 cells. Analysis of the P1 region revealed that Bo_ParVs shared high pairwise ami...

What to Know About Vibrio vulnificus.
JAMA Walter K

Feb 11th, 2023 - What to Know About Vibrio vulnificus.|2023|Walter K,|virology,

Molecular characterization of a novel victorivirus (order Ghabrivirales, family Totivir...
Archives of Virology; da Silva Camargo M, Geremia F et. al.

Feb 10th, 2023 - Here, we report the occurrence and complete genome sequence of a novel victorivirus infecting Metarhizium anisopliae, named "Metarhizium anisopliae victorivirus 1" (MaVV1). The genome is 5353 bp in length and contains two open reading frames (ORFs), encoding a coat protein and an RNA-dependent RNA polymerase (RdRp), that overlap at the octanucleotide sequence AUGAGUAA. These ORFs showed sequenc...

SARS-CoV-2 multi-antigen protein microarray for detailed characterization of antibody r...
PloS One; Celikgil A, Massimi AB et. al.

Feb 10th, 2023 - Antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) target multiple epitopes on different domains of the spike protein, and other SARS-CoV-2 proteins. We developed a SARS-CoV-2 multi-antigen protein microarray with the nucleocapsid, spike and its domains (S1, S2), and variants with single (D614G, E484K, N501Y) or double substitutions (N501Y/Deletion69/70), allowing a...

Heterogeneous Nuclear Protein U Degraded the m6A Methylated TRAF3 Transcript by YTHDF2 ...
Journal of Virology; Zhou H, Yan Y et. al.

Feb 9th, 2023 - Porcine epidemic diarrhea virus (PEDV) belongs to the genus Alphacoronavirus of the Coronaviridae family and can cause fatal watery diarrhea in piglets, causing significant economic losses. Heterogeneous nuclear protein U (HNRNPU) is a novel RNA sensor involved in sensing viral RNA in the nucleus and mediating antiviral immunity. However, it remains elusive whether and how cytoplasmic PEDV can ...

Amino Acid Variation at Hemagglutinin Position 193 Impacts the Properties of H9N2 Avian...
Journal of Virology; Wan Z, Zhao Z et. al.

Feb 8th, 2023 - Despite active control strategies, including the vaccination program in poultry, H9N2 avian influenza viruses possessing mutations in hemagglutinin (HA) were frequently isolated. In this study, we analyzed the substitutions at HA residue 193 (H3 numbering) of H9N2 and investigated the impact of these mutations on viral properties. Our study indicated that H9N2 circulating in the Chinese poultry...