Current Opinion in HIV and AIDS; Metzner KJ
Jun 29th, 2022 - HIV-1 drug resistance (HIV DR) testing is routinely performed by genotyping plasma viruses using Sanger population sequencing. Next-generation sequencing (NGS) is increasingly replacing standardized Sanger sequencing. This opens up new opportunities, but also brings challenges. The number of NGS applications and protocols for HIV DR testing is increasing. All of them are noninferior to Sanger s...
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Virology Journal; Cheng B, Wang Q et. al.
Jun 28th, 2022 - Hepatitis B virus can induce hepatocellular carcinoma (HCC) by inducing a host immune response against infected hepatocytes. C-terminally truncated middle surface protein (MHBSt) has been reported to contribute to HCC through transcriptional activation in epidemiology studies, while the underlying mechanism of MHBSt-induced HCC is unknown. In this study, a premature stop at codon 167 in MHBS (M...
Parasites & Vectors; Chotiwan N, Brito-Sierra CA et. al.
Jun 28th, 2022 - Fatty acids are the building blocks of complex lipids essential for living organisms. In mosquitoes, fatty acids are involved in cell membrane production, energy conservation and expenditure, innate immunity, development and reproduction. Fatty acids are synthesized by a multifunctional enzyme complex called fatty acid synthase (FAS). Several paralogues of FAS were found in the Aedes aegypti mo...
Proceedings of the National Academy of Sciences of the Un... Beucher G, Blondot ML et. al.
Jun 25th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract, where infections can cause an acute respiratory distress syndrome with a high degree of mortality in elderly patients. We used reconstituted primary bronchial epithelia from adult and child donors to follow the...
Proceedings of the National Academy of Sciences of the Un... Miyake A, Ngo MH et. al.
Jun 25th, 2022 - Host genetic resistance to viral infection controls the pathogenicity and epidemic dynamics of infectious diseases. Refrex-1 is a restriction factor against feline leukemia virus subgroup D (FeLV-D) and an endogenous retrovirus (ERV) in domestic cats (ERV-DC). Refrex-1 is encoded by a subset of ERV-DC loci with truncated envelope genes and secreted from cells as a soluble protein. Here, we iden...
Proceedings of the National Academy of Sciences of the Un... Çuburu N, Bialkowski L et. al.
Jun 25th, 2022 - Tumor infiltration by T cells profoundly affects cancer progression and responses to immunotherapy. However, the tumor immunosuppressive microenvironment can impair the induction, trafficking, and local activity of antitumor T cells. Here, we investigated whether intratumoral injection of virus-derived peptide epitopes could activate preexisting antiviral T cell responses locally and promote an...
Proceedings of the National Academy of Sciences of the Un... Kapoor K, Chen T et. al.
Jun 24th, 2022 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein is the prime target for vaccines, diagnostics, and therapeutic antibodies against the virus. While anchored in the viral envelope, for effective virulence, the spike needs to maintain structural flexibility to recognize the host cell surface receptors and bind to them, a property that can heavily depend upon the dyn...
https://doi.org/10.1038/d41586-022-01627-w 10.1016/j.cell.2022.01.024 10.1021/acschemneuro.0c00210 10.1126/sciadv.abc5801 10.1183/13993003.01948-2020 10.1016/j.cell.2021.10.027 10.1126/scitranslmed.abf8396 10.1038/s41588-021-00986-w 10.1021/acschemneuro.1c00542 10.1126/scitranslmed.abq3059
Nature Dolgin E
Jun 23rd, 2022 - The science behind COVID's assault on smell.|2022|Dolgin E,|physiopathology,virology,pathogenicity,
Emerging Infectious Diseases; Queirós J, Barros SC et. al.
Jun 23rd, 2022 - Bagaza virus emerged in Spain in 2010 and was not reported in other countries in Europe until 2021, when the virus was detected by molecular methods in a corn bunting and several red-legged partridges in Portugal. Sequencing revealed high similarity between the 2021 strains from Portugal and the 2010 strains from Spain.
Journal for Immunotherapy of Cancer; Chinn HK, Gardell JL et. al.
Jun 22nd, 2022 - Human immune cells, including monocyte-derived macrophages, can be engineered to deliver proinflammatory cytokines, bispecific antibodies, and chimeric antigen receptors to support immune responses in different disease settings. When gene expression is regulated by constitutively active promoters, lentiviral payload gene expression is unregulated, and can result in potentially toxic quantities ...
https://doi.org/10.1038/d41586-022-01613-2 10.1038/s41467-022-30163-4 10.1126/scitranslmed.abh1803 10.1038/s41586-021-03291-y 10.1056/NEJMc2031364 10.7554/eLife.69091 10.1093/molbev/msac061 10.1038/s41586-022-04474-x 10.1093/ve/veab091 10.1038/s41467-022-29104-y 10.1016/S2666-5247(21)00030-6 10.1007/s10875-021-01158-5
Nature Callaway E
Jun 16th, 2022 - How months-long COVID infections could seed dangerous new variants.|2022|Callaway E,|virology,classification,genetics,
The New England Journal of Medicine; Loayza Mafayle R, Morales-Betoulle ME et. al.
Jun 16th, 2022 - In June 2019, the Bolivian Ministry of Health reported a cluster of cases of hemorrhagic fever that started in the municipality of Caranavi and expanded to La Paz. The cause of these cases was unknown. We obtained samples for next-generation sequencing and virus isolation. Human and rodent specimens were tested by means of virus-specific real-time quantitative reverse-transcriptase-polymerase-c...
JAMA Johnson D, Liu D et. al.
Jun 15th, 2022 - Acute infectious conjunctivitis is characterized by ocular redness and discharge, and is a common clinical entity. Evidence-based tools to aid the clinical diagnosis of viral vs bacterial conjunctivitis are lacking and may contribute to overprescribing of topical antibiotics. To determine the relative prevalence of viral vs bacterial conjunctivitis in adults and children, and to determine which...
Proceedings of the National Academy of Sciences of the Un... Simonetti B, Daly JL et. al.
Jun 14th, 2022 - Endosomal sorting maintains cellular homeostasis by recycling transmembrane proteins and associated proteins and lipids (termed "cargoes") from the endosomal network to multiple subcellular destinations, including retrograde traffic to the trans-Golgi network (TGN). Viral and bacterial pathogens subvert retrograde trafficking machinery to facilitate infectivity. Here, we develop a proteomic scr...
Proceedings of the National Academy of Sciences of the Un... Anahtar M, Chan LW et. al.
Jun 14th, 2022 - Community-acquired pneumonia (CAP) has been brought to the forefront of global health priorities due to the COVID-19 pandemic. However, classification of viral versus bacterial pneumonia etiology remains a significant clinical challenge. To this end, we have engineered a panel of activity-based nanosensors that detect the dysregulated activity of pulmonary host proteases implicated in the respo...
Proceedings of the National Academy of Sciences of the Un... Lillie M, Hill J et. al.
Jun 14th, 2022 - Retroviruses have left their legacy in host genomes over millions of years as endogenous retroviruses (ERVs), and their structure, diversity, and prevalence provide insights into the historical dynamics of retrovirus-host interactions. In bioinformatic analyses of koala (Phascolarctos cinereus) whole-genome sequences, we identify a recently expanded ERV lineage (phaCin-β) that is related to the...
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Critical Care (London, England); Zhang L, Zhang Y et. al.
Jun 11th, 2022 - SARS-CoV-2 infection leads to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Both clinical data and animal experiments suggest that the renin-angiotensin system (RAS) is involved in the pathogenesis of SARS-CoV-2-induced ALI. Angiotensin-converting enzyme 2 (ACE2) is the functional receptor for SARS-CoV-2 and a crucial negative regulator of RAS. Recombinant ACE2 protein...
Proceedings of the National Academy of Sciences of the Un... Lefteri DA, Bryden SR et. al.
Jun 9th, 2022 - Viruses transmitted by Aedes mosquitoes are an increasingly important global cause of disease. Defining common determinants of host susceptibility to this large group of heterogenous pathogens is key for informing the rational design of panviral medicines. Infection of the vertebrate host with these viruses is enhanced by mosquito saliva, a complex mixture of salivary-gland-derived factors and ...
PLoS Pathogens; Hiller BE, Yin Y et. al.
Jun 9th, 2022 - Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors. Fibroblast growth factor-9 (FGF9) is required for lung development, can display antiviral activity in vitro, and is upregulated in asymptomatic ...
Proceedings of the National Academy of Sciences of the Un... Tian D, Li W et. al.
Jun 8th, 2022 - Hepatitis E virus (HEV) is an important but understudied zoonotic virus causing both acute and chronic viral hepatitis. A proportion of HEV-infected individuals also developed neurological diseases such as Guillain-Barré syndrome, neuralgic amyotrophy, encephalitis, and myelitis, although the mechanism remains unknown. In this study, by using an in vitro blood-brain barrier (BBB) model, we firs...