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A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia

Corona Virus Disease 2019 (COVID-19) was first reported in late December 2019, in Wuhan, China. There are over 1,800,000 confirmed cases worldwide.1 The pathological process of severe COVID-19 pneumonia is an inflammation reaction characterized by the destruction of the deep airway and alveolar.2 It is currently considered that lung injury is not only associated with the direct virus-induced da...

COVID-19: disease pathways and gene expression changes predict methylprednisolone can improve outcome in severe cases

Current management efforts of COVID-19 include: early diagnosis, use of antivirals and immune modulation. After the initial viral phase of the illness, identification of the patients developing cytokine storm syndrome is critical. Treatment of this hyper-inflammation in these patients using existing, approved therapies with proven safety profiles could address the immediate need to reduce th...

Hospitalist Teams Provide Backup, Especially during Surges Like COVID-19

As emergency departments face an unprecedented patient surge in the COVID-19 pandemic, a partnership between emergency physicians and hospitalists holds potential for lightening the burden on EPs and enhancing care for patients.

Dexamethasone reduces death in hospitalised patients with severe respiratory complications of COVID-19

In March 2020, the RECOVERY (Randomised Evaluation of COVid-19 thERapY) trial was established as a randomised clinical trial to test a range of potential treatments for COVID-19, including low-dose dexamethasone (a steroid treatment). Over 11,500 patients have been enrolled from over 175 NHS hospitals in the UK.

Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial

There is no proven specific pharmacological treatment for patients with the acute respiratory distress syndrome (ARDS). The efficacy of corticosteroids in ARDS remains controversial. We aimed to assess the effects of dexamethasone in ARDS, which might change pulmonary and systemic inflammation and result in a decrease in duration of mechanical ventilation and mortality.

Heparin therapy improving hypoxia in COVID-19 patients: a case series

Elevated D-dimer is a predictor of severity and mortality in COVID-19 patients and heparin use during in-hospital stay has been associated with decreased mortality. COVID19 patient autopsies have revealed thrombi in the microvasculature, suggesting intravascular coagulation as a prominent feature of organ failure in these patients. Interestingly, in COVID19, pulmonary compliance is preserved ...

CURE Drug Repurposing Collaboratory

The CURE Drug Repurposing Collaboratory (CDRC) is a public-private partnership initiated in June 2020 by C-Path and the U.S. Food and Drug Administration (FDA) in partnership with the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH). CDRC, in partnership with the FDA-NCATS CURE ID* platform, is a dedicated initiative designed to ca...

Update Alert: Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers

This is the first monthly update alert for a living review on the epidemiology of and risk factors for coronavirus infections in health care workers (HCWs) (1). Searches were updated from 24 April 2020 to 24 May 2020, using the same search strategies as the original review, and we identified 1125 citations. Applying the same inclusion criteria, we identified 37 additional studies for this updat...

COVID-19 Risk Factors Among Health Workers: A Rapid Review

Coronavirus disease 2019 (Covid-19) poses an important occupational health risk to health workers (HWs) that has attracted global scrutiny. To date, several thousand HWs globally have been reported as infected with the severe acute respiratory syndrome coronavirus 2 virus that causes the disease. It is therefore a public health priority for policymakers to understand risk factors for this vulne...

COVID-19 What Healthcare Personnel Should Know about Caring for Patients

Healthcare personnel (HCP) are on the front lines of caring for patients with confirmed or possible infection with coronavirus disease 2019 (COVID-19) and therefore have an increased risk of exposure to this virus. HCPs can minimize their risk of exposure when caring for confirmed or possible COVID-19 patients by following Interim Infection Prevention and Control Recommendations for Patients...

For the Frontlines

Health care professionals and essential workers are showing up on the frontlines during the coronavirus pandemic—risking their health every day to help other people. They need fast, free crisis counseling at their fingertips, 24/7. Crisis Text Line, Shout, and Kids Help Phone are here for the frontlines. Text FRONTLINE for support to dealing with anxiety, stress, fear, isolation, or other d...

Project Parachute

Health care workers across the country are facing unprecedented challenges as they work to contain COVID-19. I'm Stephanie Zerwas, a psychologist in private practice at Flourish Chapel Hill as well as an Associate Professor at UNC Psychiatry. In cooperation with Eleos Health, we aim to provide pro-bono therapy for front line health care professionals.

Physician Support Line

1 (888) 409-0141 Helping our colleagues all over the U.S. on the front lines of COVID-19 Free & Confidential | No appointment necessary

COVID-19 Emergency Declaration Blanket Waivers for Health Care Providers

The Trump Administration is taking aggressive actions and exercising regulatory flexibilities to help healthcare providers contain the spread of 2019 Novel Coronavirus Disease (COVID-19). CMS is empowered to take proactive steps through 1135 waivers as well as, where applicable, authority granted under section 1812(f) of the Social Security Act (the Act) and rapidly expand the Administratio...

AMA Telehealth Implementation Playbook

“With the evolving Covid-19 pandemic and its impact on access to medical care, there is no better time to help physicians navigate and implement telemedicine into their practices and enhance their ability to care for patients. Through telemedicine, we can triage patients and help avoid unnecessary visits to health care settings, thereby reducing exposure to the COVID virus and helping to ke...

Coalition: Advocacy for prospective clinical trials to test the post-exposure potential of hydroxychloroquine against COVID-19

Our coalition of public health experts, doctors, and scientists worldwide want to draw attention to the need for high-quality evaluation protocols of the potential beneficial effect of hydroxychloroquine (HCQ) as a post-exposure drug for exposed people. In the absence of an approved, recognized effective pre or post-exposure prophylactic drug or vaccine for COVID-19, nor of any approved and val...

Health & Human Services HIPAA & COVID-19 Resources

The HHS Office for Civil Rights (OCR) has provided Bulletins, Notifications of Enforcement Discretion, Guidance, and Resources that help explain how patient health information may be used and disclosed in response to the COVID-19 nationwide public health emergency.

Reopening Guidance for Cleaning and Disinfecting Public Spaces, Workplaces, Businesses, Schools, and Homes

This guidance is intended for all Americans, whether you own a business, run a school, or want to ensure the cleanliness and safety of your home. Reopening America requires all of us to move forward together by practicing social distancing and other daily habits to reduce our risk of exposure to the virus that causes COVID-19. Reopening the country also strongly relies on public health strategi...

Covid Through the Eyes of Dr. Leif and Dr. Griffin

Our two doctors, as noted in the New York Times, now take you across the full arc of their harrowing journey through New York City’s battle with Covid. Only after requesting permission from both of them did we show their identities. Most Bongoers, and all our other healthcare professionals, have remained anonymous, expressing everything without being revealed. Meet them here.

Surgical Treatment of Levodopa-induced Dyskinesia in Parkinson's Disease

The treatment of motor manifestations of Parkinson's disease (PD) is essentially a trade-off between adequate relief of motor symptoms and prevention and control of motor complications, particularly levodopa-induced dyskinesia (LID). Progression of PD is paralleled by a progressive difficulty in achieving the balance. Functional neurosurgical procedures provide sustained relief of LID in carefu...