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About 14,914,533 results

Unseen Burden of Injury: Post-Hospitalization Mortality in Geriatric Trauma Patients.
https://doi.org/10.1177/00031348211046886
The American Surgeon; Huntington CR, Kao AM et. al.

Sep 25th, 2021 - Older adults are at risk for adverse outcomes after trauma, but little is known about post-acute survival as state and national trauma registries collect only inpatient or 30-day outcomes. This study investigates long-term, out-of-hospital mortality in geriatric trauma patients. Level I Trauma Center registry data were matched to the US Social Security Death Index (SSDI) to determine long-term ...

Modulation of Immune Reaction in Hydrodynamic Gene Therapy for Hemophilia A.
https://doi.org/10.1089/hum.2021.145
Human Gene Therapy; Zhao M, Sun YD et. al.

Sep 25th, 2021 - Hemophilia A (HA) is a monogenic disease characterized by plasma clotting factor 8 (F8) deficiency due to F8 mutation. We have been attempting to cure HA permanently using a CRISPR-Cas9 gene-editing strategy. Here, we induced targeted integration of BDDF8 (B-domain-deleted F8) gene into the albumin locus of HA mice by hydrodynamic tail vein injection of editing plasmid vectors. One week after t...

Genetic variations as molecular diagnostic factors for idiopathic male infertility: cur...
https://doi.org/10.1080/14737159.2021.1985469
Expert Review of Molecular Diagnostics; Karimian M, Parvaresh L et. al.

Sep 25th, 2021 - Infertility is a major health problem, worldwide, which affects 10-15% of couples. About half percent of infertility cases are related to male-related factors. Male infertility is a complex disease that is the result of various insults as lifestyle issues, genetics, and epigenetic factors. Idiopathic infertility is responsible for 30% of total cases. The genetic factors responsible for male inf...

Emerging agents for the treatment and prevention of stroke: progress in clinical trials.
https://doi.org/10.1080/13543784.2021.1985463
Expert Opinion on Investigational Drugs; Safouris A, Magoufis G et. al.

Sep 25th, 2021 - Recent years have witnessed unprecedented progress in stroke care, but unmet needs persist regarding the efficacy of acute treatment and secondary prevention. Novel approaches are being tested to enhance the efficacy of thrombolysis or provide neuroprotection in non-thrombolized patients. The current review highlights pharmaceutical agents under evaluation in clinical trials concerning the acut...

Association between adherence to statin therapy and low-density lipoprotein cholesterol...
https://doi.org/10.1080/03007995.2021.1984222
Current Medical Research and Opinion; Irawati S, Emmens JE et. al.

Sep 25th, 2021 - To investigate whether statin adherence (defined as proportion days covered, PDC) is associated with LDL-c response in statin initiators on standard and low starting-dose of statins, and to detect a possible interaction with sex. An inception cohort study was conducted using the PharmLines Initiative, a linkage between the Lifelines Cohort Study and University of Groningen's IAD.nl (prescriptio...

Ankylosing Spondylitis Patients Display Aberrant ERAP1 Gene DNA Methylation and Express...
https://doi.org/10.1080/08820139.2021.1982965
Immunological Investigations; Ma Y, Fan D et. al.

Sep 25th, 2021 - Endoplasmic reticulum aminopeptidase 1 (ERAP1) is known to participate in the pathogenesis of ankylosing spondylitis (AS). This study aimed to evaluate the relationship between promoter methylation and mRNA levels of ERAP1 and AS susceptibility. DNA methylation levels of 100 AS patients and 100 healthy controls (HCs) were tested using a targeted bisulfite sequencing assay. To verify the results...

Toxicological analysis of synthetic dye orange red on expression of NFκB-mediated infla...
https://doi.org/10.1080/01480545.2021.1979579
Drug and Chemical Toxicology; Khan IS, Ali S et. al.

Sep 25th, 2021 - Orange red is a food and cosmetic coloring agent made by the amalgamation of two azo dyes carmoisine and sunset yellow.The current study demonstrates the effect of different concentrations of orange red on antioxidant status, inflammatory biomarkers (TNFα, IFNγ, IL1β, IL6, COX-2, iNOS, and NFκB/p65), biochemical enzymes, and liver histology. In totality, 25 male Wistar rats were procured and ar...

Sun-Dried and Air-Dried Kappaphycus alvarezii Attenuates 5-Fluorouracil-Induced Intesti...
https://doi.org/10.1080/01635581.2021.1981403
Nutrition and Cancer; Zhang Q, Yang R et. al.

Sep 25th, 2021 - 5-fluorouracil (5-FU)-induced intestinal mucositis (IM) often makes chemotherapy patients suffer from physical and psychological suffering. Kappaphycus alvarezii (KA) is known for its potent multiple biological activities from decades. In the current study, we explored the effect of sun-dried and air-dried Kappaphycus alvarezii as a whole food supplement on 5-FU-induced IM. Diets supplemented w...

CONSEQUENCES OF mTOR INHIBITION ON AAV HEPATIC TRANSDUCTION EFFICACY.
https://doi.org/10.1089/hum.2021.171
Human Gene Therapy; Perez-Iturralde A, Carte B et. al.

Sep 25th, 2021 - The efficiency of recombinant Adeno-associated virus vectors (AAV) transducing host cells is very low, limiting their therapeutic potential in patients. There are several cellular pathways interacting and interfering with the journey of the AAV from the cell surface to the nucleus, opening the possibility to enhance AAV transduction by modifying these interactions. In this study, we explored th...

Lessons from a mature acellular pertussis vaccination program and strategies to overcom...
https://doi.org/10.1080/14760584.2021.1984891
Expert Review of Vaccines; Zerbo O, Fireman B et. al.

Sep 25th, 2021 - Despite high vaccination coverage among children and adolescents, pertussis remains a public health problem, with large outbreaks occurring periodically in the US and other developed countries. We examined lessons learned more than 20 years after implementation of programs which use only acellular pertussis vaccines and proposed avenues for possible effective use of acellular pertussis vaccine ...

microRNA-26a-5p Prevents Retinal Neuronal Cell Death in Diabetic Mice by Targeting PTEN.
https://doi.org/10.1080/02713683.2021.1975760
Current Eye Research; Shi R, Liu DD et. al.

Sep 25th, 2021 - To explore the role of microRNA-26a-5p (miR-26a) in early diabetic retinal neuronal cell death and reveal the underlying mechanism(s). A streptozotocin (STZ)-induced diabetic mouse model was established using C57BL/6 J mice. Control or miR-26a mimic was intravitreally injected. Hematoxylin-eosin (H&E) and transmission electron microscopy (TEM) were used to observe the morphologic alterations in...

Interindividual and intraindividual variability in amnestic mild cognitive impairment (...
https://doi.org/10.1080/13803395.2021.1982867
Journal of Clinical and Experimental Neuropsychology; LaPlume AA, Paterson TSE et. al.

Sep 25th, 2021 - Mean cognitive performance is worse in amnestic mild cognitive impairment (aMCI) compared to control groups. However, studies on variability of cognitive performance in aMCI have yielded inconclusive results, with many differences in variability measures and samples from one study to another. We examined variability in aMCI using an existing older adult sample (n = 91; 51 with aMCI, 40 with nor...

Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2...
https://doi.org/10.1186/s10020-021-00377-1 10.1016/j.lfs.2020.117331 10.1007/s00109-019-01851-4 10.1016/j.neuint.2011.11.010 10.1111/acel.12951 10.1159/000479571 10.1016/j.mce.2017.05.035 10.1016/j.redox.2019.101295 10.1016/j.redox.2020.101453 10.3390/ijms18112482 10.1042/BJ20150568 10.1016/j.taap.2018.03.020 10.3389/fimmu.2018.02762 10.1038/cdd.2014.150 10.1007/s00213-014-3440-6 10.1080/15548627.2020.1712108 10.1016/j.redox.2018.03.005 10.1210/endocr/bqaa178 10.1016/j.jsbmb.2018.11.017 10.1038/s41598-019-50877-8 10.1016/j.steroids.2020.108586 10.1016/j.freeradbiomed.2020.03.012 10.4161/15548627.2014.981787 10.1016/j.ynstr.2018.09.006 10.1186/s12974-019-1668-0 10.3389/fphar.2019.01551 10.1002/tox.22726 10.1073/pnas.2010430117 10.1124/jpet.115.228106 10.1016/j.redox.2018.11.005 10.1002/mnfr.201801014 10.1016/j.phrs.2020.104655 10.3389/fphar.2020.00097 10.2147/DDDT.S179227
Molecular Medicine (Cambridge, Mass.); Cui C, Wang C et. al.

Sep 25th, 2021 - The present study aimed to further explore the potential interaction between oxidative stress and autophagy in the progression of traumatic brain injury (TBI) and therapeutic mechanism of calcitriol, the active form of vitamin D (VitD). Neuroprotective effects of calcitriol were examined following TBI. We further evaluated the impacts of TBI and calcitriol treatment on autophagic process and nu...

Clinical Considerations of the Evangelical Purity Movement's Impact on Female Sexuality.
https://doi.org/10.1080/0092623X.2021.1977445
Journal of Sex & Marital Therapy; Estrada LL

Sep 25th, 2021 - Evangelical Protestant Christianity is the most prevalent religion in America, with women being the dominant practitioners. The Evangelical Purity Movement that gained prominence in the 1990s sought to provide moral and religious based sexual education through private and public policies to both Christian and non-religious youth. This movement directly stressed the concept of abstinence-only un...

Intracolic ultrasound molecular imaging: a novel method for assessing colonic tumor nec...
https://doi.org/10.1186/s10020-021-00379-z 10.1158/0008-5472.CAN-13-0002 10.1053/j.gastro.2011.08.032 10.1038/nm.3462 10.1053/j.gastro.2005.11.009 10.1016/j.autrev.2013.06.002 10.1371/journal.pone.0068876 10.1093/ecco-jcc/jjw101 10.1038/ncomms15384 10.1148/radiol.11110323 10.1093/ecco-jcc/jjw168 10.1148/radiol.2441060773 10.1053/j.gastro.2015.03.042 10.2967/jnumed.111.099754 10.1093/ecco-jcc/jjw147 10.1161/hc4201.097061 10.1053/gast.2001.29271 10.7150/thno.13048 10.1136/gutjnl-2015-310187 10.1080/17474124.2018.1494573 10.1016/S0140-6736(17)32448-0 10.1016/j.cyto.2009.02.001 10.3109/08830185.2013.853764 10.1016/j.crohns.2013.02.020 10.1111/ajt.14345 10.1093/ecco-jcc/jjv131 10.1053/j.gastro.2008.10.051 10.1016/j.jconrel.2004.03.002 10.1016/j.jconrel.2012.10.021 10.1136/gut.2006.105379 10.1148/radiol.13122509 10.1038/nm.4307 10.1200/JCO.2016.71.9997 10.1200/JCO.2016.70.8594 10.1182/blood-2015-01-624833 10.1200/JCO.2007.15.6521
Molecular Medicine (Cambridge, Mass.); Miao X, Mao R et. al.

Sep 25th, 2021 - While anti-tumor necrosis factor alpha (TNF-α) therapy has been proven effective in inflammatory bowel disease (IBD), approximately 40% of patients lose the response. Transmembrane TNF-α (mTNF-α) expression in the intestinal mucosa is correlated with therapeutic efficacy, and quantification of mTNF-α expression is significant for predicting response. However, conventional intravenous applicatio...

Overexpression of GINS4 is associated with poor prognosis and survival in glioma patients.
https://doi.org/10.1186/s10020-021-00378-0 10.1038/s41418-020-00658-y 10.2174/1871520619666191021112042 10.1074/jbc.M111.256289 10.3390/cells9061451 10.2147/OTT.S275649 10.1007/s10143-016-0709-8 10.1089/gtmb.2020.0226 10.1016/j.gene.2017.07.056 10.1016/j.bbrc.2018.01.048 10.1002/eji.201646875 10.1371/journal.pone.0154612 10.18632/oncotarget.20777 10.1002/ijc.30830 10.1159/000222090 10.1089/dna.2018.4163 10.1007/s00432-012-1323-y 10.3171/2012.12.FOCUS12349 10.1016/j.cellsig.2016.08.018 10.1016/j.canlet.2019.07.012 10.1215/15228517-2007-016 10.1111/jcmm.16553 10.1042/BSR20181178 10.1080/15384101.2020.1762038 10.1371/journal.pone.0063610 10.3892/ol.2020.12195 10.1007/s00401-016-1545-1 10.1042/BJ20091531 10.1038/nrcardio.2017.206 10.1097/WCO.0000000000000033 10.1093/neuonc/nou087 10.1007/s00401-010-0736-4 10.1111/cas.14341 10.1186/s40659-018-0185-4 10.1073/pnas.0506580102 10.1101/gad.1065903 10.1080/00365510701724871 10.1016/j.yexcr.2017.07.031 10.1016/j.bbamcr.2006.07.001 10.1186/s13046-019-1276-y 10.1186/s13046-019-1319-4 10.1038/s41598-021-95068-6 10.1016/j.prp.2019.152508 10.1111/cas.13996 10.1002/iub.2126 10.7150/thno.36256
Molecular Medicine (Cambridge, Mass.); Liu B, Liu Z et. al.

Sep 25th, 2021 - GINS4, an indispensable component of the GINS complex, is vital for a variety of cancer. However, no known empirical research has focused on exploring relationships between GINS4 and glioma. Thus, this study aims to understand and explain the role of GINS4 in glioma. First, we used the data in the CGGA, TCGA, GEO, GEPIA, and HPA databases to explore the expression level of GINS4 in glioma, the ...

REDuction of Antibiotic RESistance (REDARES) in urinary tract infections using treatmen...
https://doi.org/10.1186/s12879-021-06660-0 10.3399/bjgp15X686965 10.1016/j.ijantimicag.2019.06.015 10.1186/s12879-020-05377-w 10.1186/s12879-015-1282-4 10.1136/bmj.c2096 10.3310/hta8060 10.1136/bmj.d8173 10.1038/npjpcrm.2015.83 10.1503/cmaj.150601 10.1136/bmjqs.2010.047357 10.1001/jama.294.18.2305 10.1016/S0140-6736(16)00215-4 10.1371/journal.pmed.1002825 10.1503/cmaj.081233 10.1186/1745-6215-15-267 10.1136/bmj.a1655 10.1186/1472-6963-14-89 10.1186/s40900-019-0172-0
BMC Infectious Diseases; Gágyor I, Greser A et. al.

Sep 25th, 2021 - Urinary tract infections (UTIs) are a common cause of prescribing antibiotics in family medicine. In Germany, about 40% of UTI-related prescriptions are second-line antibiotics, which contributes to emerging resistance rates. To achieve a change in the prescribing behaviour among family physicians (FPs), this trial aims to implement the guideline recommendations in German family medicine. In a ...

Leveraging high-resolution 7-tesla MRI to derive quantitative metrics for the trigemina...
https://doi.org/10.1186/s10194-021-01325-4 10.1177/1756285609359317 10.1016/j.neurad.2012.08.006 10.2147/TCRM.S37592 10.1007/BF00383719 10.1007/s00234-014-1463-7 10.1016/j.wneu.2015.04.063 10.1097/SCS.0000000000002310 10.4103/0975-5950.79226 10.1097/00000658-198010000-00010 10.3171/2014.1.JNS131410 10.3171/2014.11.JNS141741 10.1586/ern.11.156 10.1212/01.wnl.0000326598.83183.04 10.1586/14737175.7.11.1565 10.1148/radiol.2382042214 10.3171/2008.8.JNS08522 10.1097/j.pain.0000000000000156 10.1016/j.wneu.2016.10.104 10.1016/j.neuron.2007.07.012 10.1177/0333102419877659 10.1093/brain/aww100 10.3390/medicines6030091 10.1016/j.mri.2003.08.027 10.1016/j.neuroimage.2018.08.012 10.3389/fnbeh.2018.00060 10.1016/S0301-0082(98)00003-3 10.1016/j.neubiorev.2011.08.007 10.3389/fneur.2020.00271 10.1016/j.neubiorev.2021.02.043 10.1002/hipo.20154 10.1523/JNEUROSCI.10-04-01286.1990 10.1016/j.neuroscience.2005.12.054 10.1016/j.psyneuen.2016.09.028 10.1093/cercor/bhn100 10.1016/j.neuroimage.2009.09.046 10.1001/archpsyc.57.10.925 10.5214/ans.0972.7531.210206 10.1089/brain.2014.0304
The Journal of Headache and Pain; Alper J, Seifert AC et. al.

Sep 25th, 2021 - Trigeminal Neuralgia (TN) is a chronic neurological disease that is strongly associated with neurovascular compression (NVC) of the trigeminal nerve near its root entry zone. The trigeminal nerve at the site of NVC has been extensively studied but limbic structures that are potentially involved in TN have not been adequately characterized. Specifically, the hippocampus is a stress-sensitive reg...

Re-emergence of syphilis in women of reproductive age and its association with the incr...
https://doi.org/10.1186/s12879-021-06680-w 10.1016/S0140-6736(16)32411-4 10.2471/BLT.18.228486 10.21149/spm.v57i4.7577 10.2471/BLT.18.228486 10.1017/S0950268819000281 10.1097/OLQ.0000000000001355 10.1016/j.pop.2020.02.013 10.15585/mmwr.ss6708a1 10.1136/sti.78.suppl_1.i3 10.1086/425288 10.2471/BLT.19.238170 10.1097/OLQ.0000000000000702
BMC Infectious Diseases; García-Cisneros S, Herrera-Ortiz A et. al.

Sep 25th, 2021 - Syphilis is a sexually transmitted infection that is re-emerging in different parts of the world. This infection can be transmitted during pregnancy, causing neonatal syphilis. The objective of this study was to examine trend in syphilis, congenital syphilis, and neonatal deaths among the Mexican population during 2010-2019. An ecological study was carried out to collect information about the i...

Case report of restless anal syndrome as restless legs syndrome variant after COVID-19.
https://doi.org/10.1186/s12879-021-06683-7 10.1007/s00405-020-05965-1 10.1016/j.jinf.2020.02.018 10.1001/jamaneurol.2020.1127 10.1016/j.ajp.2020.102350 10.3389/fnagi.2020.588872 10.1016/j.sleep.2014.03.025 10.1002/mds.22274 10.1016/j.parkreldis.2009.02.014 10.4103/jfmpc.jfmpc_640_20 10.1186/s12883-020-01875-1 10.2169/internalmedicine.55.6815 10.1016/j.jneuroim.2021.577658 10.1016/j.bbi.2020.05.062 10.1002/acn3.51210 10.1111/j.1479-8425.2008.00349.x 10.1111/j.1440-1819.2005.01399.x 10.1016/j.nbscr.2020.100057 10.1111/nmo.12520 10.1016/j.smrv.2017.03.007 10.1016/j.jns.2012.07.007 10.1136/bcr-2020-240686 10.12998/wjcc.v9.i19.4969 10.1016/j.sleep.2008.09.015
BMC Infectious Diseases; Nakamura I, Itoi T et. al.

Sep 25th, 2021 - Coronavirus disease 2019 (COVID-19) has a broad spectrum from respiratory and nasopharyngeal symptoms, cerebrovascular diseases, impaired consciousness, and skeletal muscle injury. Emerging evidence has indicated the neural spread of this novel coronavirus. Restless legs syndrome (RLS) is a common neurological, sensorimotor disorder, but highly under diagnosis disorder. Restless anal syndrome a...