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Interim Guidance for Businesses and Employers Responding to Coronavirus Disease 2019 (COVID-19), May 2020
https://www.cdc.gov/coronavirus/2019-ncov/community/guidance-business-response.html
CDC

This interim guidance is based on what is currently known about the coronavirus disease 2019 (COVID-19). COVID-19 is a respiratory illness that can spread from person to person. The outbreak first started in China, but the virus continues to spread internationally and in the United States. There is much more to learn about the transmissibi...

Food Safety and the Coronavirus Disease 2019 (COVID-19)
https://www.fda.gov/food/food-safety-during-emergencies/food-safety-and-coronavirus-disease-2019-covid-19

The following are resources available to industry members and consumers on Coronavirus Disease 2019 (COVID-19) and food safety. FDA

Fraudulent Coronavirus Disease 2019 (COVID-19) Products
https://www.fda.gov/consumers/health-fraud-scams/fraudulent-coronavirus-disease-2019-covid-19-products

The U.S. Food and Drug Administration is issuing warning letters to firms for selling fraudulent products with claims to prevent, treat, mitigate, diagnose or cure coronavirus disease 2019 (COVID-19). We are actively monitoring for any firms marketing products with fraudulent COVID-19 prevention and treatment claims. The FDA is exer...

Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals
https://www.tandfonline.com/doi/full/10.1080/09273948.2020.1738501
Ocular Immunology and Inflammation;

In December 2019, a novel coronavirus (CoV) epidemic, caused by the severe acute respiratory syndrome coronavirus – 2 (SARS-CoV-2) emerged from China. This virus causes the coronavirus disease 2019 (COVID-19). Since then, there have been anecdotal reports of ocular infection. The ocular implications of human CoV infections ha...

Evaluating and Testing Persons for Coronavirus Disease 2019 (COVID-19)
https://www.cdc.gov/coronavirus/2019-nCoV/hcp/clinical-criteria.html

Clinicians considering diagnostic testing of people with possible COVID-19 should continue to work with their local and state health departments to coordinate testing through public health laboratories, or work with commercial or clinical laboratories using diagnostic tests authorized for emergency use by the U.S. Food and Drug Administration.

Guidelines for Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Korea
https://www.sfndt.org/sites/www.sfndt.org/files/medias/documents/Hong et al. Ann Lab Med Avril 2020.pdf
Annals of Laboratory Medicine;

The outbreak of coronavirus disease 2019 (COVID-19), which began in December 2019, is still ongoing in Korea, with >9,000 confirmed cases as of March 25, 2020. COVID-19 is a severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, and real-time reverse transcription-PCR is currently the most reliable ...

Changes in blood coagulation in patients with severe coronavirus disease 2019 (COVID19): a meta‐analysis
https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.16725

Development and Licensure of Vaccines to Prevent COVID-19: Guidance for Industry
https://www.fda.gov/media/139638/download

This guidance is being issued to address the coronavirus disease 2019 (COVID-19) public health emergency. This guidance is being implemented without prior public comment because the Food and Drug Administration (FDA or Agency) has determined that prior public participation for this guidance is not feasible or appropriate (see section 701(h)(1)...

Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases (WHO)
https://apps.who.int/iris/bitstream/handle/10665/331329/WHO-COVID-19-laboratory-2020.4-eng.pdf

The purpose of this document is to provide interim guidance to laboratories and stakeholders involved in COVID-19 virus laboratory testing of patients.

Cardiovascular disease and COVID-19
https://www.sciencedirect.com/science/article/pii/S1871402120300539
Diabetes & Metabolic Syndrome: Clinical Research & Reviews;

Many patients with coronavirus disease 2019 (COVID-19) have underlying cardiovascular (CV) disease or develop acute cardiac injury during the course of the illness. Adequate understanding of the interplay between COVID-19 and CV disease is required for optimum management of these patients.

Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19
https://www.nejm.org/doi/full/10.1056/NEJMoa2007621
The New England Journal of Medicine;

Coronavirus disease 2019 (Covid-19) may disproportionately affect people with cardiovascular disease. Concern has been aroused regarding a potential harmful effect of angiotensin-converting–enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) in this clinical context.

Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China
https://jamanetwork.com/journals/jamacardiology/fullarticle/2763524
JAMA Cardiology;

Importance Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. However, information on cardiac injury in patients affected by COVID-19 is limited. Objective To explore the association between cardiac injury and mortality in patients with COVID-...

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31042-4/fulltext
The Lancet;

Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVID-19) pandemic. We assessed the efficacy and safety of combined interferon beta-1b, lopinavir–ritonavir, and ribavirin for treating patients with COVID-19.

CDC Diagnostic Test for COVID-19
https://www.cdc.gov/coronavirus/2019-ncov/lab/testing.html

CDC has developed a new laboratory test kit for use in testing patient specimens for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19. The test kit is called the “Centers for Disease Control and Prevention (CDC) 2019-Novel Coronavirus (2019-nCoV) Real-Time Reverse Transcriptase (RT)-PCR Diagnostic Panel...

COVID-19 Mortality Shows Strong Correlation With Active Cancer
https://www.targetedonc.com/view/covid-19-mortality-shows-strong-correlation-with-active-cancer

May 27th, 2020 - Death in patients with progressive cancer within 30 days of the coronavirus disease 2019 (COVID-19) diagnosis was 5.2 times compared with patients in remission or with no evidence of disease, data from the COVID-19 and Cancer Consortium (CCC19) registry shows.

COVID-19-Related Mortality Risk Increases With Recent Chemotherapy in Thoracic Cancer
https://www.targetedonc.com/view/covid-19-related-mortality-risk-increases-with-recent-chemotherapy-in-thoracic-cancer

May 27th, 2020 - The risk of death in patients with thoracic cancer was inflated with the administration of chemotherapy within 3 months of a coronavirus disease 2019 (COVID-19) diagnosis, findings from the global TERAVOLT Consortium registry show.

Recent Chemotherapy Raises COVID-19-Related Mortality Risk for Patients With Thoracic Cancer
https://www.onclive.com/conference-coverage/asco-2020/recent-chemotherapy-raises-covid19related-mortality-risk-for-patients-with-thoracic-cancer

May 27th, 2020 - Chemotherapy administered within 3 months of a diagnosis of coronavirus disease 2019 (COVID-19) increased the risk of death in patients with thoracic cancer, according to findings from the global TERAVOLT Consortium registry.

COVID-19 Employer Information for Office Buildings
https://www.cdc.gov/coronavirus/2019-ncov/community/office-buildings.html

Workers in office buildings may be at risk for exposure to the virus that causes coronavirus disease 2019 (COVID-19). Office building employers, building owners and managers, and building operations specialists can take steps to create a safe and healthy workplace and protect workers and clients.

May statins and PCSK9 inhibitors be protective from COVID-19 in familial hypercholesterolemia subjects?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217767/

Early data from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic disease causing 2019 coronavirus disease (COVID-19) showed that the affected subjects were typically men aged 40–60 years with several comorbidities; in particular, 25% of subjects with COVID-19 treated in an intensive care unit (ICU) had a ...

Plasminogen improves lung lesions and hypoxemia in patients with COVID-19
https://academic.oup.com/qjmed/advance-article/doi/10.1093/qjmed/hcaa121/5818885

Lungs from patients with coronavirus disease 2019 (COVID-19) have shown typical signs of acute respiratory distress syndrome (ARDS), formation of hyaline membrane mainly composed of fibrin and ‘ground-glass’ opacity. Previously, we showed plasminogen itself is a key regulator in fibrin degradation, wound healing and infection.