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COVID-19 Testing: The Threat of False-Negative Results
https://www.mayoclinicproceedings.org/article/S0025-6196(20)30365-7/fulltext
Mayo Clinic Proceedings;

As health care systems around the world attempt to cope with the coronavirus disease 2019 (COVID-19) “tsunami,” concerns about ongoing spread of disease from individuals who are infected without symptoms have been raised.

COVID-19 Myths vs. Realities
https://www.jhsph.edu/covid-19/articles/coronavirus-facts-vs-myths.html

The swiftly moving novel coronavirus continues its relentless spread around the world, upending life as we know it and creating a breeding ground for misinformation. Some rumors are harmless, while others can be dangerous, stoking fear and threatening health. Here, we separate true from false, based on the best science and expertise available.

Fraudulent Coronavirus Disease 2019 (COVID-19) Products
https://www.fda.gov/consumers/health-fraud-scams/fraudulent-coronavirus-disease-2019-covid-19-products

The U.S. Food and Drug Administration is issuing warning letters to firms for selling fraudulent products with claims to prevent, treat, mitigate, diagnose or cure coronavirus disease 2019 (COVID-19). We are actively monitoring for any firms marketing products with fraudulent COVID-19 prevention and treatment claims. The FDA is exercising its authority to prot...

COVID-19 and the potential long-term impact on antimicrobial resistance
https://academic.oup.com/jac/article/75/7/1681/5841159

The emergence of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has required an unprecedented response to control the spread of the infection and protect the most vulnerable within society. Whilst the pandemic has focused society on the threat of emerging infections and hand hygiene, certain infection control and antimicrobial stewardship policies may have to be relaxed. It is...

COVID-19 Testing: The Threat of False-Negative Results.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151274
Mayo Clinic Proceedings; West CP, Montori VM et. al.

May 8th, 2020 - COVID-19 Testing: The Threat of False-Negative Results.|2020|West CP,Montori VM,Sampathkumar P,|epidemiology,isolation & purification,classification,methods,classification,diagnosis,epidemiology,prevention & control,methods,organization & administration,diagnosis,epidemiology,methods,epidemiology,

New Method to Reduce COVID-19 Transmission - The Need for Medical Air Disinfection is Now
https://link.springer.com/content/pdf/10.1007/s10916-020-01585-8.pdf

The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) [1]. It has led to a pandemic worldwide due to its extremely infectious nature. At present, the route of transmission of SARS-CoV-2 is still controversial, but the major route of the COVID-19 to rapidly spread through indoor environments, is ca...

Comparison of nasopharyngeal and oropharyngeal swabs for SARS-CoV-2 detection in 353 patients received tests with both specimens simultaneously
https://www.ijidonline.com/article/S1201-9712(20)30235-6/pdf
International Journal of Infectious Diseases;

Since the outbreak of coronavirus disease (COVID-19) in Wuhan in December 2019, by March 10, 2020, a total of 80,932 confirmed cases have been reported in China. Two consecutively negative RTPCR test results in respiratory tract specimens is required for the evaluation of discharge from hospital, and oropharyngeal swabs were the most common sample. However, fals...

Fear of the False Negative COVID-19 Test
https://www.medpagetoday.com/infectiousdisease/covid19/86047

Apr 20th, 2020 - Infectious disease specialist Gonzalo Ballon-Landa, MD, of Scripps Health in San Diego, was a bit bewildered. One of his patients who had all the signs and symptoms of COVID-19 had tested negative with the nasopharyngeal swab RT-PCR assay. But when his hospital system's lab re-ran the sample, this time his patient was positive, just as he suspected. And while Ballon-Landa i...

Why False Positives Merit Concern, Too
https://www.nytimes.com/2020/10/25/health/coronavirus-testing-false-positive.html
The New York Times; Katherine J. Wu

In the high-stakes world of coronavirus testing, one mistake has taken center stage: the dreaded false negative, wherein a test mistakenly deems an infected person to be virus-free. These troublesome results, experts have said, can deprive a person of treatment and embolden them to mingle with others, hastening the spread of disease.

False Negative: COVID-19 Testing's Catch-22
https://www.medpagetoday.com/infectiousdisease/covid19/85717

Mar 31st, 2020 - In a physician WhatsApp group, a doctor posted he had a fever of 101 degrees Fahrenheit and muscle ache, gently confessing that it felt like his typical "man flu" which heals with rest and scotch. He worried that he had coronavirus. When the reverse transcription-polymerase chain reaction (RT-PCR) for the virus on his nasal swab came back negative, he jubilantly announced his relief. Lik...

False-positive and false-negative COVID-19 cases: re...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074645
Expert Review of Respiratory Medicine; Mouliou DS, Gourgoulianis KI

Apr 27th, 2021 - Introduction: A novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was reported via nucleic acid identification in December, 2019. Accuracy of SARS-CoV-2 diagnostic assays has emerged as a major barrier to COVID-19 diagnosis, particularly in cases requiring urgent or emergent treatment.Areas covered: In this review, we explore the major reasons for false...

COVID-19 Data Dives: Claims About False COVID Deaths Are Reprehensible
https://www.staging.medscape.com/viewarticle/939833

Oct 27th, 2020 - Medscape asked top experts to weigh in on the most pressing scientific questions about COVID-19. Check back frequently for more COVID-19 Data Dives, and visit Medscape's Coronavirus Resource Center for complete coverage. Ashish K. Jha, MD, MPH President Trump and his advisor, Scott Atlas, MD, argue that there is a lot of false coding of COVID deaths. Th...

COVID-19 Data Dives: Claims About False COVID Deaths Are Reprehensible
https://www.medscape.com/viewarticle/939833

Oct 27th, 2020 - Medscape asked top experts to weigh in on the most pressing scientific questions about COVID-19. Check back frequently for more COVID-19 Data Dives, and visit Medscape's Coronavirus Resource Center for complete coverage. President Trump and his advisor, Scott Atlas, MD, argue that there is a lot of false coding of COVID deaths. This is junk news which, ...

Requirement for Proof of Negative COVID-19 Test or Documentation of Recovery from COVID-19
https://tools.cdc.gov/medialibrary/index.aspx#/media/id/512209

Information and frequently asked questions about requirement for proof of negative COVID-19 test or recovery from COVID-19 for all air passengers arriving in the United States

RT-PCR negative COVID-19.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841043
BMC Infectious Diseases; Parmar H, Montovano M et. al.

Feb 15th, 2022 - COVID-19 is a multi-system infection with emerging evidence-based antiviral and anti-inflammatory therapies to improve disease prognosis. However, a subset of patients with COVID-19 signs and symptoms have repeatedly negative RT-PCR tests, leading to treatment hesitancy. We used comparative serology early in the COVID-19 pandemic when background ...

Should Docs Be Punished for Spreading False COVID-19 Info?
https://www.medscape.com/viewarticle/957961

Sep 1st, 2021 - Across the country, state medical licensing boards and state and national medical associations are struggling with how to respond to physicians who make scientifically baseless public statements about COVID-19, often in a viral video. They fear such statements are increasing public confusion and are heightening political conflict, particularly regarding vaccines and the wearing of...

False negative rate of COVID-19 PCR testing: a discordant t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794619
Virology Journal; Kanji JN, Zelyas N et. al.

Jan 11th, 2021 - COVID-19 is diagnosed via detection of SARS-CoV-2 RNA using real time reverse-transcriptase polymerase chain reaction (rtRT-PCR). Performance of many SARS-CoV-2 rtRT-PCR assays is not entirely known due to the lack of a gold standard. We sought to evaluate the false negative rate (FNR) and sensitivity of our laboratory-developed SARS-CoV-2 rtRT-PCR targeting the enve...

Covid-19 Boosters - Where from Here?
https://doi.org/10.1056/NEJMe2203329
The New England Journal of Medicine; Offit PA

Apr 14th, 2022 - Covid-19 Boosters - Where from Here?|2022|Offit PA,|

What if a COVID-19 test is negative?
https://www.mdedge.com/neurology/article/220069/coronavirus-updates/what-if-covid-19-test-negative
Saurabh Jha, MBBS, MRCS

Apr 1st, 2020 - In a physician WhatsApp group, a doctor posted he had fever of 101 °F and muscle ache, gently confessing that it felt like his typical “man flu” which heals with rest and scotch. Nevertheless, he worried that he had coronavirus.

What If a COVID-19 Test Is Negative?
https://www.medscape.com/viewarticle/927800

Mar 30th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. In a physician WhatsApp group, a doctor posted he had fever of 101° F and muscle ache, gently confessing that it felt like his typical "man flu" which heals with rest and scotch. Nevertheless, he worried that he had coronavirus. When the reverse transcription polymerase chain react...