Epilepsia Gaston TE, Bebin EM et. al.
Aug 6th, 2017 - To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study. Serum levels were monitored to identify interactions between CBD and AEDs. In 39 adults and 42 children, CBD dose was started at 5 mg/kg/day and inc...
Rheumatology (Oxford, England); Wilson-Morkeh H, Al-Abdulla A et. al.
Jul 28th, 2019 - Important drug interactions exist between cannabidiol oil and commonly prescribed drugs in rheumatology practice.|2019|Wilson-Morkeh H,Al-Abdulla A,Sien L,Mohamed H,Youngstein T,|
Clinical Pharmacology in Drug Development; Morrison G, Crockett J et. al.
Feb 22nd, 2019 - GW Pharmaceuticals' formulation of highly purified cannabidiol oral solution is approved in the United States for seizures associated with Lennox-Gastaut and Dravet syndromes in patients aged ≥2 years, for which clobazam, stiripentol, and valproate are commonly used antiepileptic drugs. This open-label, fixed-sequence, drug-drug interaction, healthy volunteer trial i...
Aug 17th, 2017 - Cannabidiol, a compound of cannabis that is being investigated as a potential treatment for epilepsy, may negatively interact with commonly used antiepileptic drugs (AEDs), new research suggests. Analysis from an ongoing, open-label compassionate-use study included 42 children and 39 adults given the cannabidiol (CBD) Epidiolex (GW Pharmaceuticals, plc) to aug...
Cannabis and Cannabinoid Research; Iffland, K. et. al.
May 31st, 2017 - Introduction: This literature survey aims to extend the comprehensive survey performed by Bergamaschi et al. in 2011 on cannabidiol (CBD) safety and side effects. Apart from updating the literature, this article focuses on clinical studies and CBD potential interactions with other drugs. Results: In general, the often described favorable safety profile of CBD in humans w...
Sep 3rd, 2019 - A number of medications commonly prescribed by rheumatologists may interact with cannabidiol oil, investigators at the Imperial College Healthcare NHS Trust, London, reported. “Patients are increasingly requesting information concerning the safety of CBD oil,” Taryn Youngstein, MD, and associates said in letter to the editor in Rheumatology, but current guidelines on the use of me.