Mar 18th, 2023 - Mass drug administration (MDA) based on two doses of ivermectin, one week apart, substantially reduces prevalence of both scabies and impetigo. The Regimens of Ivermectin for Scabies Elimination (RISE) trial assessed whether one-dose ivermectin-based MDA would be as effective. RISE was a cluster-randomised trial in Solomon Islands. We assigned 20 villages in a 1:1 ratio to ...

Mar 15th, 2023 - Ivermectin cream, 1% is indicated for the treatment of inflammatory lesions of rosacea. Ivermectin cream, 1% is indicated for the treatment of inflammatory lesions of rosacea. (1)

Mar 15th, 2023 - Sea louse ectoparasitosis is a major threat to fish aquaculture. Avermectins such as ivermectin and emamectin have been effectively used against sea louse infestation, but the emergence of resistance has limited their use. A better understanding of the molecular targets of avermectins is essential to the development of novel treatment strategies or new, more effective drugs. Avermectins ...

Mar 15th, 2023 - Glycine Receptors (GlyRs) provide inhibitory neuronal input in the spinal cord and brainstem, which is critical for muscle coordination and sensory perception. Synaptic GlyRs are a heteromeric assembly of α and β subunits. Here we present cryo-EM structures of full-length zebrafish α1βBGlyR in the presence of an antagonist (strychnine), agonist (glycine), or agonist with a positive allosteric m...

Mar 8th, 2023 - Early treatment with metformin reduced the risk of long COVID among outpatients, according to secondary results of a negative phase III trial. In the COVID-OUT study of over 1,100 randomized participants, the cumulative incidence of long COVID was 6.3% in the metformin group versus 10.6% in the placebo group over 10-month follow-up (HR 0.58, 95% CI 0.38-0.88, P=0.009), reported Carolyn Bramante...

Mar 7th, 2023 - Ivermectin, an antiparasitic drug, has been repurposed for COVID-19 treatment during the SARS-CoV-2 pandemic. Although its antiviral efficacy was confirmed early in vitro and in preclinical studies, its clinical efficacy remained ambiguous. Our purpose was to assess the efficacy of ivermectin in terms of time to viral clearance based on the meta-analysis of available clinical trials at t...

Mar 7th, 2023 - Oral ivermectin treatment for an infant with crusted scabies.|2023|Bourkas AN,Pope E,|therapeutic use,diagnosis,drug therapy,

Mar 7th, 2023 - Background Onchocerciasis is an infection caused by the nematode Onchocerca volvulus. Humans acquire onchocerciasis through the bite of Simulium blackflies.[1, 2, 3, 4] Because the fly develops and breeds in flowing water, onchocerciasis is commonly found along rivers and is sometimes referred to as river blindness. Simulium fly (black fly). In the human host, the adult nematodes live in subcut...

Mar 7th, 2023 - Background Onchocerciasis is an infection caused by the nematode Onchocerca volvulus. Humans acquire onchocerciasis through the bite of Simulium blackflies. [1, 2, 3, 4] Because the fly develops and breeds in flowing water, onchocerciasis is commonly found along rivers and is sometimes referred to as river blindness. Simulium fly (black fly). View Media Gallery In the human host, the adult nema...

Mar 7th, 2023 - Background Onchocerciasis is an infection caused by the nematode Onchocerca volvulus. Humans acquire onchocerciasis through the bite of Simulium blackflies. [1, 2, 3, 4] Because the fly develops and breeds in flowing water, onchocerciasis is commonly found along rivers and is sometimes referred to as river blindness. Simulium fly (black fly). View Media Gallery In the human host, the adult nema...

Feb 27th, 2023 - Note that some links may require subscriptions. Doctors who supported ivermectin as a treatment for COVID-19 -- despite all the evidence against it -- now claim it can treat flu and respiratory syncytial virus (RSV) as well. (Washington Post) Twelve attorneys general sued the FDA seeking to remove restrictions on the abortion pill mifepristone (Mifeprex). (New York Times) The CDC's indep...

Feb 26th, 2023 - Although single-dose ivermectin has been widely used in mass-drug administration programs for onchocerciasis and lymphatic filariasis for many years, ivermectin may have utility as an endectocide with mosquito-lethal effects at dosages greater and longer than those used to treat helminths. The final physiologically-based pharmacokinetic (PBPK) model for ivermectin described...

Feb 25th, 2023 - Onchocerciasis (river blindness) caused by the filarial worm Onchocerca volvulus is a neglected tropical disease that affects the skin and eyes of humans. Mass drug administration with ivermectin (IVM) to control the disease often suffers from severe adverse events in individuals co-injected with high loads of Loa loa microfilariae (mf). Thus loiasis animal models for counter-screening o...

Feb 23rd, 2023 - It is unknown whether ivermectin, with a maximum targeted dose of 600 μg/kg, shortens symptom duration or prevents hospitalization among outpatients with mild to moderate COVID-19. To evaluate the effectiveness of ivermectin at a maximum targeted dose of 600 μg/kg daily for 6 days, compared with placebo, for the treatment of early mild to moderate COVID-19. The ongoing Acceleratin...

Feb 23rd, 2023 - At a Higher Dose and Longer Duration, Ivermectin Still Not Effective Against COVID-19.|2023|Bibbins-Domingo K,Malani PN,|

Feb 23rd, 2023 - Ivermectin and moxidectin, two macrocyclic lactones, are potent antiparasitic drugs currently registered and mainly used against filarial diseases; however, their potential value for improved soil-transmitted helminth (STH) control has been acknowledged. This review provides insights on recent studies evaluating the efficacy of ivermectin and moxidectin as single or coadministered therap...

Feb 22nd, 2023 - HONOLULU – More often than not, patients with rosacea require a combination of treatments to optimize the management of the disease, according to Julie C. Harper, MD.

Feb 21st, 2023 - High doses of the drug ivermectin, controversially recommended by some high-profile political and media figures during the COVID-19 pandemic, is ineffective at treating the COVID-19 virus, say University of Oxford- affiliated researchers in a study published today in eLife. The study was conducted mainly in the Hospital for Tropical Diseases in Bangkok. It is part of the ongoing PLATCOV ...

Feb 16th, 2023 - Domesticated animals play a role in maintaining residual transmission of Plasmodium parasites of humans, by offering alternative blood meal sources for malaria vectors to survive on. However, the blood of animals treated with veterinary formulations of the anti-helminthic drug ivermectin can have an insecticidal effect on adult malaria vector mosquitoes. This study therefore assessed the...

Feb 15th, 2023 - Reply to "oral ivermectin to treat scabies: a comparison of two different regimens".|2023|Potestio L,Ruggiero A,Fabbrocini G,Martora F,Costanzo L,|