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VA's Formulary May Have Curbed Misuse of Ivermectin for COVID-19
https://www.medpagetoday.com/infectiousdisease/covid19/102931

Feb 2nd, 2023 - In contrast to retail pharmacies, there was only a minimal increase in ivermectin dispensing at Veterans Administration (VA) pharmacies during the COVID-19 pandemic, possibly due to the VA national formulary restriction on the antiparasitic drug, a cohort study suggested. After March 2020, the slope change in retail pharmacies was greater than that seen in VA pharmacies, for a differenti...

Filariasis Treatment & Management
https://emedicine.medscape.com/article/217776-treatment

Feb 2nd, 2023 - Approach Considerations Medical Management The medical management of a filarial infection should be specific and based on the microfilariae isolated or antigenemia detected. Specific attention should be paid to the presence of coinfection with multiple filarial organisms, as this will alter the treatment regimen. Mass drug administration (MDA) reduces the transmission of filarial infection and ...

Filariasis Medication
https://emedicine.medscape.com/article/217776-medication

Feb 2nd, 2023 - Medication Summary Patients with asymptomatic microfilaremia in lymphatic filariasis can be treated on an outpatient basis. Supervision of oral DEC therapy is recommended for patient compliance with therapy and for the management of febrile reactions in heavily infected patients. Inpatient care may initially be required for adenolymphangitis (ADL) and chronic filariasis. Mass drug administratio...

Filariasis Treatment & Management
http://emedicine.medscape.com/article/217776-treatment

Feb 2nd, 2023 - Approach Considerations Medical Management The medical management of a filarial infection should be specific and based on the microfilariae isolated or antigenemia detected. Specific attention should be paid to the presence of coinfection with multiple filarial organisms, as this will alter the treatment regimen. Mass drug administration (MDA) reduces the transmission of filarial infection and ...

Filariasis Medication
http://emedicine.medscape.com/article/217776-medication

Feb 2nd, 2023 - Medication Summary Patients with asymptomatic microfilaremia in lymphatic filariasis can be treated on an outpatient basis. Supervision of oral DEC therapy is recommended for patient compliance with therapy and for the management of febrile reactions in heavily infected patients. Inpatient care may initially be required for adenolymphangitis (ADL) and chronic filariasis. Mass drug administratio...

Dispensing of Ivermectin From Veterans Administration Pharmacies During the COVI...
https://doi.org/10.1001/jamanetworkopen.2022.54859
JAMA Network Open; Becker NV, Seelye S et. al.

Feb 2nd, 2023 - Dispensing of Ivermectin From Veterans Administration Pharmacies During the COVID-19 Pandemic.|2023|Becker NV,Seelye S,Chua KP,Echevarria K,Conti RM,|

Use of a "tablet pole" for the administration of ivermectin for strongyloidiasis...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883947
Infectious Diseases of Poverty; Buonfrate D, Anselmi M et. al.

Jan 29th, 2023 - Establishment of efficient control programs for strongyloidiasis, the infection by Strongyloides stercoralis, is among the World Health Organization (WHO) targets for 2030. Ivermectin is a drug of choice for strongyloidiasis, but its weight-based administration can be unfeasible in remote areas. We evaluated a WHO tablet pole for administration of ivermectin in school-age children...

Erratum: Oral ivermectin to treat scabies: a comparison of two different regimens.
https://doi.org/10.1093/ced/llad029
Clinical and Experimental Dermatology;

Jan 27th, 2023 - Erratum: Oral ivermectin to treat scabies: a comparison of two different regimens.|2023||

Oral ivermectin to treat scabies: a comparison of two different regimens.
https://doi.org/10.1093/ced/llac092
Clinical and Experimental Dermatology; Balestri R, Magnano M et. al.

Jan 27th, 2023 - As Sarcoptes scabiei is becoming less sensitive to permethrin, clinicians have started to prescribe oral ivermectin (OI) as a first-line treatment. Guidelines suggest OI 200 µg kg-1 as two doses, 1 week apart. However, the black box of the ivermectin registered in Italy recommends a single dose. To compare these two regimens, we collected 71 cases of scabies and treated them accor...

Phenotypic Profiling of Macrocyclic Lactones on Parasitic Schistosoma Flatworms.
https://doi.org/10.1128/aac.01230-22
Antimicrobial Agents and Chemotherapy; Ryan KT, Wheeler NJ et. al.

Jan 26th, 2023 - Macrocyclic lactones are front-line therapies for parasitic roundworm infections; however, there are no comprehensive studies on the activity of this drug class against parasitic flatworms. Ivermectin is well known to be inactive against flatworms. However, the structure-activity relationship of macrocyclic lactones may vary across phyla, and it is entirely possible other members of this...

Holding out hope for ambroxol
https://www.mdedge.com/neurology/article/260728/business-medicine/holding-out-hope-ambroxol
Allan M. Block, MD

Jan 23rd, 2023 - How many of you hadn’t heard of ambroxol until the last few weeks? How many of you have gotten at least one call asking for a prescription for it in that time? I’ll raise my hand on both accounts. Dr.

ivermectin pour-on for cattle - ivermectin solution-Durvet
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b339a104-62b3-4bb8-95e8-41cbff08d754

Jan 19th, 2023 - Ivermectin Pour-On for Cattle applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi (including inhibited stage) (adults and L4) Haemonchus placei                                                (adults and L4) Trichostrongylus axei                                        ...

Perception of accountability decreases with age: observations from a clinical study of ...
https://doi.org/10.1007/s00403-023-02531-7
Archives of Dermatological Research; Cook MK, Kelly KA et. al.

Jan 19th, 2023 - Patient adherence to medications usually increases with age, however, it can also be impacted by other factors. Accountability is a psychosocial construct that is defined as the expectation for an individual to account for their actions. Accountability may also influence patients' motivation to adhere to their treatments. We assessed the relationship between age and perception of accountability...

Novel strategies to reverse chemoresistance in colorectal cancer.
https://doi.org/10.1002/cam4.5594
Cancer Medicine; Ma SC, Zhang JQ et. al.

Jan 17th, 2023 - Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect and greatly improved the survival of CRC patients. Nevertheless, chemoresistance is one of the major problems during chemotherapy for CRC and significantly limits the efficacy of the treatment and influences the prognos...

Is the antiparasitic drug ivermectin a suitable candidate for the treatment of e...
https://doi.org/10.1111/epi.17511
Epilepsia Löscher W

Jan 17th, 2023 - There are only a few drugs that can seriously lay claim to the title of "wonder drug," and ivermectin, the world's first endectocide and forerunner of a completely new class of antiparasitic agents, is among them. Ivermectin, a mixture of two macrolytic lactone derivatives (avermectin B1a and B1b in a ratio of 80:20), exerts its highly potent antiparasitic effect by activating the glutam...

Fluvoxamine Flops Again for Milder COVID-19
https://www.medpagetoday.com/infectiousdisease/covid19/102613

Jan 12th, 2023 - Adults with mild to moderate COVID-19 treated with 50 mg of fluvoxamine (Luvox) twice daily for 10 days did not recover more quickly than those taking placebo, the ACTIV-6 randomized controlled platform trial showed. Among nearly 1,300 adult outpatients, sustained recovery with no symptoms for at least 3 days in a row took a median of 12 days for those treated with fluvoxamine versus 13 days fo...

Effect of Ivermectin® on survivorship and fertility of Anopheles arabiensis in E...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9830892
Malaria Journal; Eba K, Habtewold T et. al.

Jan 10th, 2023 - Innovative vector control tools are needed to counteract insecticide resistance and residual malaria transmission. One of such innovative methods is an ivermectin (IVM) treatment to reduce vector survival. In this study, a laboratory experiment was conducted to investigate the effect of ivermectin on survivorship, fertility and egg hatchability rate of Anopheles arabiensis in Ethi...

COVID-19 vaccine acceptance increased globally in 2022
https://www.eurekalert.org/news-releases/976033

Jan 9th, 2023 - New York, NY, January 9 – Global willingness to accept a COVID-19 vaccine increased from 75.2% in 2021 to 79.1% in 2022, according to a new survey of 23 countries that represent more than 60% of the world’s population, published today in Nature Medicine. Vaccine acceptance decreased in eight countries however, and nearly one in eight vaccinated respondents were hesitant about receiving a booste...

A cellular and molecular biology-based update for ivermectin against COVID-19: i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823263
Inflammopharmacology Nabi-Afjadi M, Mohebi F et. al.

Jan 8th, 2023 - Despite community vaccination against coronavirus disease 2019 (COVID-19) and reduced mortality, there are still challenges in treatment options for the disease. Due to the continuous mutation of SARS-CoV-2 virus and the emergence of new strains, diversity in the use of existing antiviral drugs to combat the epidemic has become a crucial therapeutic chance. As a broad-spectrum antiparasitic and...

Ivermectin for COVID-19: The 2022 Update.
https://doi.org/10.1097/MJT.0000000000001577
American Journal of Therapeutics; Manu P

Jan 7th, 2023 - Ivermectin for COVID-19: The 2022 Update.|2023|Manu P,|