Drugs Fraguas-Sánchez, A. et. al.
Oct 28th, 2018 - Cannabinoid receptors, endocannabinoids and the enzymes responsible for their biosynthesis and degradation constitute the endocannabinoid system. In recent decades, the endocannabinoid system has attracted considerable interest as a potential therapeutic target in numerous pathological conditions. Its involvement in several physiological processes is well known, such as in energy balance...
JAMA Whiting PF, Wolff RF et. al.
Jun 23rd, 2015 - Cannabis and cannabinoid drugs are widely used to treat disease or alleviate symptoms, but their efficacy for specific indications is not clear. To conduct a systematic review of the benefits and adverse events (AEs) of cannabinoids. Twenty-eight databases from inception to April 2015. Randomized clinical trials of cannabinoids for the following indications: nausea and vomiting du...
Medical Cannabis and Cannabinoids; Hazekamp, A. et. al.
Aug 31st, 2018 - In just a few years, cannabidiol (CBD) has become immensely popular around the world. After initially being discovered as an effective self-medication for Dravet syndrome in children, CBD is now sold and used to treat a wide range of medical conditions and lifestyle diseases. The cannabinoid CBD, a non-psychoactive isomer of the more infamous tetrahydrocannabinol (THC), is available in a...
Pediatrics Wong SS, Wilens TE
Oct 24th, 2017 - Legalization of medical marijuana in many states has led to a widening gap between the accessibility and the evidence for cannabinoids as a medical treatment. To systematically review published reports to identify the evidence base of cannabinoids as a medical treatment in children and adolescents. Based on Preferred Reporting Items for Systematic Reviews and ...
Expert Review of Clinical Immunology; Sarzi-Puttini P, Batticciotto A et. al.
Sep 12th, 2019 - Introduction: Clinicians involved in pain management can finally include cannabis or cannabis-related products in their therapeutic armamentarium as a growing number of countries have approved them for pain relief. Despite the several benefits attributed to analgesic, anti-inflammatory and immunomodulatory properties of cannabinoids, there are still significant areas of uncertainty conce...
Jan 7th, 2019 - NEW YORK (Reuters Health) - While advocates of marijuana and cannabinoids promote its use for conditions ranging from nausea to cancer, the paucity of high-quality evidence demands caution regarding the use of these agents, according to 6 brief commentaries from physicians and other providers across the US. The editors of Annals of Internal Medicine earlier issued a call for readers' per...
European Journal of Internal Medicine; Abuhasira R, Shbiro L et. al.
Jan 13th, 2018 - In 1937, the United States of America criminalized the use of cannabis and as a result its use decreased rapidly. In recent decades, there is a growing interest in the wide range of medical uses of cannabis and its constituents; however, the laws and regulations are substantially different between countries. Laws differentiate between raw herbal cannabis, cannabis extracts, and cannabino...
Cancer Chemotherapy and Pharmacology; Badowski ME
Aug 6th, 2017 - Oral cannabinoids (i.e., dronabinol, nabilone) containing the active component of marijuana, delta(Δ)9-tetrahydrocannabinol (THC), are available for the treatment of chemotherapy-induced nausea and vomiting (CINV) in patients with cancer who have failed to adequately respond to conventional antiemetic therapy. The aim of this article is to provide an overview of the efficacy, pharmacokin...
Drugs Fraguas-Sánchez AI, Torres-Suárez AI
Oct 30th, 2018 - Cannabinoid receptors, endocannabinoids and the enzymes responsible for their biosynthesis and degradation constitute the endocannabinoid system. In recent decades, the endocannabinoid system has attracted considerable interest as a potential therapeutic target in numerous pathological conditions. Its involvement in several physiological processes is well known, such as in energy balance...
Drug and Alcohol Dependence; Goldenberg M, Reid MW et. al.
Mar 20th, 2017 - The use of cannabis or cannabinoids to treat medical conditions and/or alleviate symptoms is increasingly common. However, the impact of this use on patient reported outcomes, such as health-related quality of life (HRQoL), remains unclear. We conducted a systematic review and meta-analysis, employing guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analys...
Cannabis and Cannabinoid Research; Corroon, J. et. al.
Oct 17th, 2018 - Cannabidiol (CBD) is 1 of > 100 cannabinoids found in Cannabis sativa L. (Cannabis spp. or Cannabis). Despite its complex and rapidly evolving regulatory status in the United States, projected retail sales of CBD products—hemp, cannabis and pharmaceutical—are as high as $1.9 billion by 2020. CBD products can currently be purchased online, over the counter, and at cannabis-specific dispen...
CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne; McLeod SA, Lemay JF
Aug 1st, 2017 - Medical cannabinoids.|2017|McLeod SA,Lemay JF,|adverse effects,therapeutic use,adverse effects,therapeutic use,drug therapy,adverse effects,therapeutic use,
Ageing Research Reviews; van den Elsen GA, Ahmed AI et. al.
Feb 10th, 2014 - This systematic review aims to integrate the evidence on indications, efficacy, safety and pharmacokinetics of medical cannabinoids in older subjects. The literature search was conducted using PubMed, EMBASE, CINAHL and Cochrane Library. We selected controlled trials including solely older subjects (≥65 years) or reporting data on older subgroups. 105 (74%) papers, on controlled i...
Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses; Mallick-Searle T, St Marie B
Apr 29th, 2019 - The current landscape contains conflicting reports regarding the use of medical marijuana, creating fields of misinformation and lack of understanding by health care providers about cannabinoids. In this article we provide a dispassionate look at medical marijuana, while providing a clinical overview focusing on pain management. We examine the mechanisms of the endocannabin...
Jun 28th, 2016 - “Would you authorize its use for a 22-year-old patient with treatment-resistant epilepsy who is not a candidate for epilepsy surgery, is having two complex partial seizures a week and one tonic-clonic seizure per month, and is currently on three antiepileptic drugs [AEDs] at high doses,” asked Dr. Friedman.
Oct 28th, 2019 - Scant evidence exists to recommend medical cannabinoids and derivatives such as tetrahydrocannabinol and cannabidiol to patients with depressive disorders, anxiety, or other mental disorders, suggested research in a recent systematic review and meta-analysis published in The Lancet Psychiatry. In their review, Nicola Black, PhD, Emily Stockings, PhD,and colleagues performed a sear.
Autoimmunity Reviews; Sarzi-Puttini P, Ablin J et. al.
Oct 20th, 2019 - Medical cannabis is being increasingly used in the treatment of rheumatic diseases because, despite the paucity of evidence regarding its safety and efficacy, a growing number of countries are legalising its use for medical purposes in response to social pressure. Cannabinoids may be useful in the management of rheumatic disorders for two broad reasons: their anti-inflammat...
Oct 12th, 2019 - LAS VEGAS – Cannabinoids and stem cells may intrigue patients as potential treatments for osteoarthritis (OA), but evidence does not support their use. Planned clinical trials may clarify whether they benefit patients, said Joel A.
Mary Ann Moon
Jun 23rd, 2015 - At best, only moderate-quality evidence supports the use of medical cannabinoids, and for only two conditions. And low-quality evidence only “suggests” that these agents may improve other medical conditions, but that limited effectiveness applies only to the four conditions that have been studied, according to a report published online June 23 in JAMA.
Sexual Medicine Reviews; Lynn B, Gee A et. al.
Sep 15th, 2019 - With the legalization of both medical and recreational marijuana in some countries and a few US states, its use has become more widely prevalent. Both exogenous cannabinoids such as tetrahydrocannabinol (THC) and endogenous cannabinoids (endocannabinoids) have been shown to affect female gonadotropin pathways and female sexuality. Yet, our understanding of the mechan...