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About 190 results

Medicinal CannabisPotential Drug Interactions
https://www.mdpi.com/2305-6320/6/1/3/htm
Medicines

Nov 29th, 2018 - The endocannabinoids system (ECS) has garnered considerable interest as a potential therapeutic target in various carcinomas and cancer-related conditions alongside neurodegenerative diseases. Cannabinoids are implemented in several physiological processes such as appetite stimulation, energy balance, pain modulation and the control of chemotherapy-induced nausea and vomiting (CINV). How...

The Potential for Pharmacokinetic Interactions Between Cannabis Pr...
https://doi.org/10.1097/JCP.0000000000001089
Journal of Clinical Psychopharmacology; Qian Y, Gurley BJ et. al.

Aug 22nd, 2019 - Increased cannabis use and recent drug approvals pose new challenges for avoiding drug interactions between cannabis products and conventional medications. This review aims to identify drug-metabolizing enzymes and drug transporters that are affected by concurrent cannabis use and, conversely, those co-prescribed medications that may alter...

Evaluation of potential herb-drug interactions between oseltamivir...
https://doi.org/10.1016/j.jep.2019.112097
Journal of Ethnopharmacology; Zhang Y, Lyu C et. al.

Jul 21st, 2019 - According to Traditional Chinese Medicine theory, influenza is categorized as a warm disease or Wen Bing. The Wen Bing formulas, such as Yin-Qiao-San and Sang-Ju-Yin, are still first-line herbal therapies in combating variant influenza virus. To continue our study on the pharmacokinetic and pharmacodynamic interactions between Wen Bing formulas and oseltamivir (OS), the first-line wester...

An Innovative, Collaborative, and Strategic Approach to Proactively Evaluate and Update...
https://doi.org/10.1177/2168479017706717
Therapeutic Innovation & Regulatory Science; Porcalla A, Barshteyn N et. al.

Sep 18th, 2018 - Drug-drug interaction (DDIs) are evaluated using pharmacokinetic (PK) simulation models, clinical studies, and scientific publications throughout drug development. DDIs with Norvir (ritonavir) and combination products (eg, Kaletra [lopinavir/ritonavir]) containing ritonavir as a PK enhancer are relevant, because these drugs could affect exposures of CYP3A4 substrates. Application of algorithms ...

Herb-Drug Interactions of Commonly Used Chinese Medicinal Herbs.
https://doi.org/10.1016/bs.irn.2017.02.010
International Review of Neurobiology; Singh A, Zhao K

Aug 15th, 2017 - With more and more popular use of traditional herbal medicines, in particular Chinese herbal medicines, herb-drug interactions have become a more and more important safety issue in the clinical applications of the conventional drugs. Researches in this area are increasing very rapidly. Herb-drug interactions are complicated due to the fact that multiple chemic...

Managing menopausal symptoms and depression in tamoxifen users: implications of drug...
https://doi.org/10.1016/j.maturitas.2010.08.005
Maturitas Desmarais JE, Looper KJ

Sep 30th, 2010 - Tamoxifen, a medication used in the treatment of breast cancer, often induces menopausal symptoms. Certain medications and natural supplements taken or prescribed to alleviate tamoxifen-induced hot flashes and depressive states in women with breast cancer interact with tamoxifen. This paper reviews potentially problematic interactions and offers treatment recommendations. Medline (1950-J...

Medicinal herbs and therapeutic drugs interactions.
https://doi.org/10.1097/FTD.0000000000000035
Therapeutic Drug Monitoring; Alissa EM

Jan 23rd, 2014 - People mistakenly think that all herbs are safe, because of the fact that they are natural, and the use of herbal medication is growing. Aspects of the efficacy, safety, and quality of herbal or natural products are the subjects of on-going debates. Concurrent administration of herbs may interfere with the effect of drugs. Lack of knowledge of the interaction potential together wi...

Herb-drug interactions: a novel algorithm-assisted information system for...
https://doi.org/10.1007/s00228-019-02700-6
European Journal of Clinical Pharmacology; Ziemann J, Lendeckel A et. al.

Jun 3rd, 2019 - To develop a system to estimate the risk of herb-drug interactions that includes the available evidence from clinical and laboratory studies, transparently delineates the algorithm for the risk estimation, could be used in practice settings and allows for adaptation and update. We systematically searched Drugbank, Transformer, Drug Information Handbook, European and ...

Pharmacological profile of the novel antiepileptic drug candidate padsevonil - ...
https://doi.org/10.1124/jpet.119.261149
The Journal of Pharmacology and Experimental Therapeutics; Wood M, Daniels V et. al.

Oct 15th, 2019 - Padsevonil is an antiepileptic drug (AED) candidate synthesized in a medicinal chemistry program initiated to rationally design compounds with high affinity for synaptic vesicle 2 (SV2) proteins and low-to-moderate affinity for the benzodiazepine binding site on GABAA receptors. The pharmacological profile of padsevonil was characterized in binding and electrophysiological experim...

Active-learning exercises to teach drug-receptor interactions in a med...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987287
American Journal of Pharmaceutical Education; Satyanarayanajois SD

Dec 23rd, 2010 - To incorporate structural biology, enzyme kinetics, and visualization of protein structures in a medicinal chemistry course to teach fundamental concepts of drug design and principles of drug action. Pedagogy for active learning was incorporated via hands-on experience with visualization software for drug-receptor interactions and concurrent laboratory session...

Protein-protein interactions as antibiotic targets: A medicinal chemistry...
https://doi.org/10.1002/med.21519
Medicinal Research Reviews; Cossar PJ, Lewis PJ et. al.

Jul 13th, 2018 - There are 27 small molecule protein-protein interaction (PPI) modulators in Phase I, II, and III clinical trials targeting cancer, viruses, autoimmune disorders, and as immune suppression agents. Targeting PPIs as an antibiotic drug discovery strategy remains in relative infancy by comparison. However, a number of molecules are in development which target PPI within the replisome, diviso...

Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana i...
https://doi.org/10.1016/j.amjcard.2013.09.042
The American Journal of Cardiology; Thomas G, Kloner RA et. al.

Nov 1st, 2013 - Marijuana is the most widely used illicit drug, with approximately 200 million users worldwide. Once illegal throughout the United States, cannabis is now legal for medicinal purposes in several states and for recreational use in 3 states. The current wave of decriminalization may lead to more widespread use, and it is important that cardiologists be made aware of the po...

Prevalence of drug-herb and drug-supplement interactions in older ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145997
The British Journal of General Practice : the Journal of the Royal College of General Practitioners; Agbabiaka TB, Spencer NH et. al.

Sep 26th, 2018 - Polypharmacy is common among older adults, with increasing numbers also using prescription drugs with herbal medicinal products (HMPs) and dietary supplements. There is no reliable evidence from the UK on concurrent use of HMPs and dietary supplements with prescription drugs in older adults. To establish prevalence of concurrent prescription drugs, HMPs, and dietary ...

Herb-drug interactions: an overview of systematic reviews.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575928
British Journal of Clinical Pharmacology; Posadzki P, Watson L et. al.

Jun 7th, 2012 - The aim of this overview of systematic reviews (SRs) is to evaluate critically the evidence regarding interactions between herbal medicinal products (HMPs) and synthetic drugs. Four electronic databases were searched to identify relevant SRs. Forty-six SRs of 46 different HMPs met our inclusion criteria. The vast majority of SRs were of poor methodological quality. The majo...

Herbal Medicinal Product Use During Pregnancy and the Postnatal Period: A System...
https://doi.org/10.1097/AOG.0000000000003217
Obstetrics and Gynecology; Muñoz Balbontín Y, Stewart D et. al.

Apr 10th, 2019 - To report the incidence and nature of herbal medicinal products' adverse events and herb-drug interactions used by some pregnant and postnatal women. The Allied and Complementary Medicine Database, the Cumulative Index to Nursing and Allied Health Literature, EMBASE, the Cochrane Library, MEDLINE, Scopus, Web of Science, and ClinicalTrials.gov were searched from inception u...

Clinically Relevant Pharmacokinetic Herb-drug Interactions in Antiretrovi...
https://doi.org/10.2174/1389200216666151103115053
Current Drug Metabolism; Fasinu PS, Gurley BJ et. al.

Nov 3rd, 2015 - For healthcare professionals, the volume of literature available on herb-drug interactions often makes it difficult to separate experimental/potential interactions from those deemed clinically relevant. There is a need for concise and conclusive information to guide pharmacotherapy in HIV/AIDS. In this review, the bases for potential interaction of medicina...

Cannabinoid disruption of learning mechanisms involved in reward processing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097761
Learning & Memory (Cold Spring Harbor, N.Y.); Lupica CR, Hoffman AF

Aug 17th, 2018 - The increasing use of cannabis, its derivatives, and synthetic cannabinoids for medicinal and recreational purposes has led to burgeoning interest in understanding the addictive potential of this class of molecules. It is estimated that ∼10% of marijuana users will eventually show signs of dependence on the drug, and the diagnosis of cannabis use disorder (CUD...

Interactions of Papua New Guinea medicinal plant extracts with antiretrov...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247785
Journal of Ethnopharmacology; Larson EC, Hathaway LB et. al.

Aug 20th, 2014 - A substantial proportion of the population in Papua New Guinea (PNG) lives with human immunodeficiency virus (HIV). Treatment requires lifelong use of antiretroviral therapy (ART). The majority of people in PNG use traditional medicines (TM) derived from plants for all types of health promotions. Consequently, there is a concern that herb-drug interactions may impact the efficacy ...

Stirring the Pot: Potential Drug Interactions With Marijuana
https://www.medscape.com/viewarticle/881059

Jun 7th, 2017 - Question What medications could potentially interact with marijuana? Response from Sarah T. Melton, PharmD Professor of Pharmacy Practice, Gatton College of Pharmacy, East Tennessee State University; Clinical Pharmacist, Johnson City Community Health Center, Johnson City, Tennessee Twenty-six states and the District of Columbia currently have laws broadly legalizing marijuana in some for...

Identifying the reactive metabolites of tyrosine kinase inhibitors in a comprehensive a...
https://doi.org/10.1002/med.21577
Medicinal Research Reviews; Paludetto MN, Puisset F et. al.

May 21st, 2019 - Tyrosine kinase inhibitors (TKI) are small heterocyclic molecules targeting transmembrane and cytoplasmic tyrosine kinases that have met with considerable success in clinical oncology. TKI are associated with toxicities including liver injury that may be serious and even life-threatening. Many of them require warnings in drug labeling against liver injury, and five of them have Black Box...