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ALLMedicine: Cannabis Center

Medicinal CannabisPotential Drug Interactions
https://www.mdpi.com/2305-6320/6/1/3/htm
Medicines

Nov 30th, 2018 - The endocannabinoids system (ECS) has garnered considerable interest as a potential therapeutic target in various carcinomas and cancer-related conditions alongside neurodegenerative diseases. Cannabinoids are implemented in several physiological processes such as appetite stimulation, energy balance, pain modulation and the control of chemotherapy-induced nausea and vomiting (CINV). How...

Evaluation of potential herb-drug interactions between oseltamivir...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125811
Journal of Ethnopharmacology; Zhang Y, Lyu C et. al.

Jul 22nd, 2019 - According to Traditional Chinese Medicine theory, influenza is categorized as a warm disease or Wen Bing. The Wen Bing formulas, such as Yin-Qiao-San and Sang-Ju-Yin, are still first-line herbal therapies in combating variant influenza virus. To continue our study on the pharmacokinetic and pharmacodynamic interactions between Wen Bing formulas and oseltamivir (OS), the first-line western drug ...

Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana i...
https://doi.org/10.1016/j.amjcard.2013.09.042
The American Journal of Cardiology; Thomas G, Kloner RA et. al.

Nov 2nd, 2013 - Marijuana is the most widely used illicit drug, with approximately 200 million users worldwide. Once illegal throughout the United States, cannabis is now legal for medicinal purposes in several states and for recreational use in 3 states. The current wave of decriminalization may lead to more widespread use, and it is important that cardiologists be made aware of the po...

The Potential for Pharmacokinetic Interactions Between Cannabis Products and Convention...
https://doi.org/10.1097/JCP.0000000000001089
Journal of Clinical Psychopharmacology; Qian Y, Gurley BJ et. al.

Aug 23rd, 2019 - Increased cannabis use and recent drug approvals pose new challenges for avoiding drug interactions between cannabis products and conventional medications. This review aims to identify drug-metabolizing enzymes and drug transporters that are affected by concurrent cannabis use and, conversely, those co-prescribed medications that may alter...

Cannabinoid disruption of learning mechanisms involved in reward processing.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097761
Learning & Memory (Cold Spring Harbor, N.Y.); Lupica CR, Hoffman AF

Aug 18th, 2018 - The increasing use of cannabis, its derivatives, and synthetic cannabinoids for medicinal and recreational purposes has led to burgeoning interest in understanding the addictive potential of this class of molecules. It is estimated that ∼10% of marijuana users will eventually show signs of dependence on the drug, and the diagnosis of cannabis use disorder (CUD...

Herb-Drug Interactions of Commonly Used Chinese Medicinal Herbs.
https://doi.org/10.1016/bs.irn.2017.02.010
International Review of Neurobiology; Singh A, Zhao K

Aug 16th, 2017 - With more and more popular use of traditional herbal medicines, in particular Chinese herbal medicines, herb-drug interactions have become a more and more important safety issue in the clinical applications of the conventional drugs. Researches in this area are increasing very rapidly. Herb-drug interactions are complicated due to the fact that multiple chemic...

Cannabinoids, insomnia, and other sleep disorders.
https://doi.org/10.1016/j.chest.2022.04.151
Chest Lavender I, McGregor IS et. al.

May 11th, 2022 - Sleep disturbances are often cited as a primary reason for medicinal cannabis use and there is increasing clinical interest in the therapeutic potential of cannabinoids in treating sleep disorders. Burgeoning evidence suggests a role of the endocannabinoid system in regulating the circadian sleep-wake cycle, highlighting a potential avenue for developing novel therap...

Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizi...
https://doi.org/10.3109/03602532.2013.849268
Drug Metabolism Reviews; Stout SM, Cimino NM

Oct 29th, 2013 - Exogenous cannabinoids are structurally and pharmacologically diverse compounds that are widely used. The purpose of this systematic review is to summarize the data characterizing the potential for these compounds to act as substrates, inhibitors, or inducers of human drug metabolizing enzymes, with the aim of clarifying the significance of these properties in clinical care and

Cannabis Use in Older Adults: A Perspective.
https://doi.org/10.1097/HRP.0000000000000289
Harvard Review of Psychiatry; Solomon HV, Greenstein AP et. al.

Mar 5th, 2021 - The prevalence of cannabis use among older adults (aged 65 and above) for both recreational and medicinal purposes has significantly increased in recent years. Information regarding the safety of cannabis in this population is important since aging is associated with metabolic changes, multiple morbidities, increases in prescription medication use, and an overall decline in...

Drug interactions between common illicit drugs and prescription therapies.
https://doi.org/10.3109/00952990.2011.643997
The American Journal of Drug and Alcohol Abuse; Lindsey WT, Stewart D et. al.

Jan 10th, 2012 - The aim was to summarize the clinical literature on interactions between common illicit drugs and prescription therapies. Medline, Iowa Drug Information Service, International Pharmaceutical Abstracts, EBSCO Academic Search Premier, and Google Scholar were searched from date of origin of database to March 2011. Search terms were cocaine, marijuana, cannabis, methamph...

Cannabis use could cause harmful drug interactions
https://www.eurekalert.org/news-releases/937642

Dec 13th, 2021 - SPOKANE, Wash.—Using cannabis alongside other drugs may come with a significant risk of harmful drug-drug interactions, new research by scientists at Washington State University suggests. The researchers looked at cannabinoids—a group of substances found in the cannabis plant—and their major metabolites found in cannabis users’ blood and found th...

Cannabinoids in treatment-resistant epilepsy: A review.
https://doi.org/10.1016/j.yebeh.2016.11.012
Epilepsy & Behavior : E&B; O'Connell BK, Gloss D et. al.

Feb 12th, 2017 - Treatment-resistant epilepsy (TRE) affects 30% of epilepsy patients and is associated with severe morbidity and increased mortality. Cannabis-based therapies have been used to treat epilepsy for millennia, but only in the last few years have we begun to collect data from adequately powered placebo-controlled, randomized trials (RCTs) with cannabidiol (CBD), a cannabis derivative. Previously, in...

Epileptic seizure frequency fell by 86% in kids treated with whole plant medicinal cannabis
https://www.eurekalert.org/news-releases/937576

Dec 14th, 2021 - Epileptic seizure frequency fell by an average of 86% among 10 children treated with whole plant medicinal cannabis, reveals a case series, published in the open access journal BMJ Paediatrics Open. None of the children had responded to other treatments, including the only cannabidiol (CBD) product licensed for their condition. The findings prompt the researchers to call for furth...

A Cross-sectional Survey of Health Professionals' Attitudes toward Medicinal Cannabis U...
https://www.ncbi.nlm.nih.gov/pubmed/31682359
Journal of Law and Medicine; Hewa-Gamage D, Blaschke S et. al.

Nov 4th, 2019 - This study aimed to evaluate the attitudes of health professionals toward the use of medicinal cannabis as part of the management of patients with cancer. A prospective, cross-sectional study was conducted using an anonymous survey, emailed out to health professionals at a public metropolitan hospital in Australia. One hundred and thirty-five responses were received. 62% of survey...

Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characte...
https://doi.org/10.1208/s12248-021-00616-7 10.1177/1060028018765159 10.2133/dmpk.DMPK-12-RG-129 10.2133/dmpk.DMPK-11-RG-107 10.1124/dmd.111.041384 10.1111/bcpt.13152 10.1111/epi.13060 10.1016/j.ebcr.2017.10.001 10.1111/ajt.15398 10.1124/jpet.120.000340 10.1002/dta.2092 10.1002/ptr.6891 10.1124/dmd.31.7.938 10.1124/dmd.117.078055 10.1124/dmd.120.000261 10.1124/dmd.106.010439 10.1007/978-1-4615-0667-6_56 10.1007/s002280050580 10.1124/dmd.116.073510 10.1124/dmd.30.12.1311 10.3109/00498254.2015.1036954 10.1097/00008571-199308000-00004 10.2133/dmpk.18.128 10.1124/dmd.108.021816 10.1016/0006-2952(73)90196-2 10.1124/dmd.120.000073 10.3390/jpm8010001 10.3390/ph14010059 10.1111/epi.13852 10.1002/cpdd.665 10.1021/acs.analchem.6b01750 10.1373/clinchem.2013.216507 10.1038/sj.bjp.0707467 10.1016/j.ejphar.2008.06.079 10.1017/S1461145709990848 10.1124/jpet.105.098541 10.1016/j.pharmthera.2019.05.001
The AAPS Journal; Doohan PT, Oldfield LD et. al.

Jun 29th, 2021 - Medicinal cannabis use has increased exponentially with widespread legalization around the world. Cannabis-based products are being used for numerous health conditions, often in conjunction with prescribed medications. The risk of clinically significant drug-drug interactions (DDIs) increases in this setting of polypharmacy, prompting concern among heal...

Medicinal Cannabis For Treatment Of Chronic Pain
https://www.ncbi.nlm.nih.gov/books/NBK574562/
StatPearls; Sukhdeep Bains, Taif Mukhdomi

Oct 9th, 2021 - Over the past few years, medicinal cannabis has increasingly become a topic of conversation regarding its role in treating chronic pain. Medicinal cannabis is not an FDA-approved medication, although a licensed practitioner can prescribe it. This activity highlights the mechanism of action, indications, contraindications, and pertinent clinical studies regarding the possibl...

Does Cannabidiol Have a Benefit as a Supportive Care Drug in Cancer?
https://doi.org/10.1007/s11864-021-00934-0
Current Treatment Options in Oncology; Lord S, Hardy J et. al.

Mar 23rd, 2022 - Cannabinoids have been purported as having a wide range of therapeutic uses although currently, there is minimal evidence to support these claims. Patients with advanced cancer experience many distressing symptoms, with some turning to medicinal cannabis to help alleviate these. Focus has fallen on cannabidiol (CBD) as a potential treatment for a variety of symptoms in adva...

Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methy...
https://doi.org/10.1124/dmd.121.000823
Drug Metabolism and Disposition: the Biological Fate of C... Qian Y, Markowitz JS

May 6th, 2022 - The use of cannabis products has increased substantially. Cannabis products have been perceived and investigated as potential treatments for attention-deficit/hyperactivity disorder (ADHD). Accordingly, co-administration of cannabis products and methylphenidate (MPH), a first-line medication for ADHD, is possible. Oral MPH undergoes extensive pre-systemic metabolism by carb...

Inhibition of UDP-Glucuronosyltransferase Enzymes by Major Cannabinoids and Their Metab...
https://doi.org/10.1124/dmd.121.000530
Drug Metabolism and Disposition: the Biological Fate of C... Nasrin S, Watson CJW et. al.

Sep 9th, 2021 - The UDP-glucuronosyltransferase (UGT) family of enzymes play a central role in the metabolism and detoxification of a wide range of endogenous and exogenous compounds. UGTs exhibit a high degree of structural similarity and display overlapping substrate specificity, often making estimations of potential drug-drug interactions difficult to fully elucidate. One such in...

Cannabis in medicine: Enormous therapeutic potential but reliable studies still lacking
https://www.eurekalert.org/news-releases/938373

Dec 17th, 2021 - For more than twenty years now, international research into the endocannabinoid system in the human body has been seeking to understand the mode of action of cannabis and its constituents. There is ample evidence of therapeutic success for the use of cannabinoids for indications such as epilepsy or pain therapy, not only as adjunctive but as first-line therapy. However, there is still in...