Apr 18th, 2017 - Cannabis is the most widely used illicit drug. The two most important natural cannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). The THC content of cannabis has been increasing during the last years and recently appeared in the market as a series of synthetic cannabinoids with potent agonist activity. Recreational users frequently combine cannabis with other drugs of abu...

Aug 25th, 2021 - There are currently three cannabinoids available on the pharmaceutical market. Dronabinol and nabilone are both synthetic tetrahydrocannabinol (THC) which the FDA has approved for the treatment of chemotherapy-induced nausea and vomiting (CINV) after the failure of a trial of first-line anti-emetics. Both are also FDA-approved to treat anorexia associated with AIDS. Recently, the ...

Aug 9th, 2021 - Trinucleotide repeat disorders are neuropsychiatric disorders caused due to abnormal trinucleotide repeat expansions. Accurate diagnosis, with knowledge of epidemiology and studying ongoing research, is beneficial in the management of these diseases. This activity reviews the clinical presentation, pathophysiology, and upcoming treatment of the five major trinucleotide repeat disorders and high...

INTRODUCTION — This topic discusses the epidemiology, pharmacology, toxicity, clinical manifestations, and management of acute intoxication with cannabis (marijuana). The clinical manifestations and management of toxicity from synthetic cannabinoids, medical uses of cannabinoids, and the manifestations and treatment of cannabis use disorder are provided separately: ●(See "...

Jul 5th, 2021 - Recent Major Changes Section Warnings and Precautions Nervous System Symptoms (5.6)                                        10/2019         Immune Reconstitution Syndrome (5.12)                           10/2019 Boxed Warning Section Severe acute exacerbations of hepatitis B virus (HBV) have been reported in patients who are coinfected with HIV-1 and HBV and have discontinued products containi...

Oct 30th, 2021 - The Path Forward: A Federal Perspective on the COVID-19 Response

Senate Health, Education, Labor, and Pensions Committee

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