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Rethinking Covid-19 Test Sensitivity — A Strategy for Containment
https://www.nejm.org/doi/10.1056/NEJMp2025631?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub 0pubmed
The New England Journal of Medicine; Minta, MJ et. al.

It’s time to change how we think about the sensitivity of testing for Covid-19. The Food and Drug Administration (FDA) and the scientific community are currently almost exclusively focused on test sensitivity, a measure of how well an individual assay can detect viral protein or RNA molecules.

Rethinking Covid-19 Test Sensitivity - A Strategy...
https://doi.org/10.1056/NEJMp2025631
The New England Journal of Medicine; Mina MJ, Parker R et. al.

Sep 30th, 2020 - Rethinking Covid-19 Test Sensitivity - A Strategy for Containment.|2020|Mina MJ,Parker R,Larremore DB,|diagnosis,methods,standards,

CDC Revises COVID-19 Test Criteria, Director Tells House Panel | MedPage Today
https://www.medpagetoday.com/infectiousdisease/covid19/85138

Feb 26th, 2020 - WASHINGTON--Criteria determining who's tested for the COVID-19 coronavirus has been expanded following the first possible case of community transmission in the U.S., CDC Director Robert Redfield, MD, told lawmakers during a House Foreign Affairs subcommittee hearing on Thursday. But subcommittee members expressed concern over healthcare providers' access to the tests and the time...

Controlling COVID-19 via test-trace-quarantine.
https://doi.org/10.1038/s41467-021-23276-9 10.1016/S1473-3099(20)30120-1 10.1126/science.abb4557 10.1016/S2468-2667(20)30157-2 10.1016/S1473-3099(20)30457-6 10.1016/S2214-109X(20)30074-7 10.1001/jamanetworkopen.2020.19217 10.1038/s41562-020-0931-9 10.1038/s41586-020-2405-7 10.1038/d41586-020-01248-1 10.5694/mja2.50786 10.1056/NEJMoa2001191 10.1001/jamainternmed.2020.2020 10.1016/S1473-3099(20)30471-0 10.1038/s41591-020-0869-5 10.1126/science.abb6936 10.1038/s41467-020-20325-7 10.1038/d41586-020-03518-4 10.12688/wellcomeopenres.16344.3 10.1038/s41591-020-1132-9 10.1001/jama.2020.3151 10.1038/s41467-020-20699-8 10.1126/science.abb8001 10.1016/S2352-4642(20)30250-9 10.1371/journal.pcbi.1005697 10.1001/jama.2020.9540 10.1056/NEJMoa2005412
Nature Communications; Kerr CC, Mistry D et. al.

May 21st, 2021 - Initial COVID-19 containment in the United States focused on limiting mobility, including school and workplace closures. However, these interventions have had enormous societal and economic costs. Here, we demonstrate the feasibility of an alternative control strategy, test-trace-quarantine: routine testing of primarily symptomatic individuals, tracing ...

Exit strategies: optimising feasible surveillance for detection, elimination, and ongoi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887417
BMC Medicine; Lokuge K, Banks E et. al.

Feb 18th, 2021 - Following implementation of strong containment measures, several countries and regions have low detectable community transmission of COVID-19. We developed an efficient, rapid, and scalable surveillance strategy to detect remaining COVID-19 community cases through exhaustive identification of every active transmission chain. We identified measures to en...

Editorial Perspective: Rethinking child and adolescent mental health care after ...
https://doi.org/10.1111/jcpp.13371
Journal of Child Psychology and Psychiatry, and Allied Di... Raballo A, Poletti M et. al.

Dec 28th, 2020 - While COVID-19 pandemic has allegedly passed its first peak in most western countries, health systems are progressively adapting to the 'new normality'. In child and adolescent mental health services (CAMHS), such organizational envisioning is needed to cope with the foreseeable psychological effects of prolonged social isolation induced by nation-wide public health measures such ...

Evaluation of the Effectiveness of Surveillance and Containment Measures for the...
https://doi.org/10.15585/mmwr.mm6911e1
MMWR. Morbidity and Mortality Weekly Report; Ng Y, Li Z et. al.

Mar 19th, 2020 - Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in December 2019, and has since spread globally, resulting in >95,000 confirmed COVID-19 cases worldwide by March 5, 2020 (1). Singapore adopted a multipronged surveillance strategy that included applying the case definition at medical consults, tracing contacts of patients w...

Sensitivity evaluation of 2019 novel coronavirus (SARS-CoV-2) RT-PCR detection k...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673793
PloS One; Zhou Y, Pei F et. al.

Nov 18th, 2020 - The early detection and differential diagnosis of respiratory infections increase the chances for successful control of COVID-19 disease. The nucleic acid RT-PCR test is regarded as the current standard for molecular diagnosis. However, the maximal specificity confirmation target ORF1ab gene is considered to be less sensitive than other targets in clinical application. In a...

The clinical sensitivity of a single SARS-CoV-2 upper respiratory tract RT-PCR ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687334
Clinical Medicine (London, England); Holborow A, Asad H et. al.

Sep 12th, 2020 - The clinical false negative rate of reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 on a single upper respiratory tract sample was calculated using convalescent antibody testing as a comparator. The sensitivity in symptomatic individuals was 86.2% (25/29). Of the missed cases, one (3.5%) was detected by repeat RT-PCR, one by CT thorax and two (7.1%) by con...

Can We Test Our Way Out of the COVID-19 Pandemic?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587108
Journal of Clinical Microbiology; Pettengill MA, McAdam AJ

Aug 27th, 2020 - Frequent, low-cost, universal testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with quarantine of those with a positive result has been suggested as a strategy to address the coronavirus disease 2019 (COVID-19) pandemic in the United States. Specifically, home or community use of tests that use paper strip detection devices, whic...

What If a COVID-19 Test Is Negative?
https://emedicine.medscape.com/viewarticle/927800

Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. In a physician WhatsApp group, a doctor posted he had fever of 101° F and muscle ache, gently confessing that it felt like his typical "man flu" which heals with rest and scotch. Nevertheless, he worried that he had coronavirus. When the reverse transcription polymerase chai...

What If a COVID-19 Test Is Negative?
https://www.medscape.com/viewarticle/927800

Mar 29th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. In a physician WhatsApp group, a doctor posted he had fever of 101° F and muscle ache, gently confessing that it felt like his typical "man flu" which heals with rest and scotch. Nevertheless, he worried that he had coronavirus. When the reverse transcription polymerase chai...

Rapid point-of-care testing for SARS-CoV-2 in a community screening setting shows low ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165286
Public Health; Döhla M, Boesecke C et. al.

Apr 25th, 2020 - With the current SARS-CoV2 outbreak, countless tests need to be performed on potential symptomatic individuals, contacts and travellers. The gold standard is a quantitative polymerase chain reaction (qPCR)-based system taking several hours to confirm positivity. For effective public health containment measures, this time span is too long. We therefore evaluated a rapid test...

Relationship of Test Positivity Rates with COVID-19 Epidemic Dynam...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125747
International Journal of Environmental Research and Publi... Furuse Y, Ko YK et. al.

Apr 30th, 2021 - Detection and isolation of infected people are believed to play an important role in the control of the COVID-19 pandemic. Some countries conduct large-scale screenings for testing, whereas others test mainly people with high prior probability of infection such as showing severe symptoms and/or having an epidemiological link with a known or suspected case or cluster ...

COVID-19 Pandemic 101: An Epidemiology and Public Health Primer for Oncol...
https://doi.org/10.1188/21.CJON.33-40
Clinical Journal of Oncology Nursing; Yackzan S, Mahon SM

Jan 22nd, 2021 - Understanding basic epidemiology and public health concepts is essential to the provision of safe care during a pandemic. These basic concepts and terms include containment, mitigation, predictive modeling, latent period, incubation period, reproduction number, case fatality rate, and test sensitivity and specificity. Public health concepts and terms are defined, described ...

Physical activity, dietary habits and sleep quality before and during COVID-1...
https://doi.org/10.1016/j.appet.2020.105019
Appetite Martínez-de-Quel Ó, Suárez-Iglesias D et. al.

Nov 8th, 2020 - The COVID-19 pandemic has forced the health public authorities to impose a lockdown as an epidemiological containment strategy. This study aimed to provide information regarding the impact of the mandatory confinement on the physical activity, eating disorders risk, sleep quality and well-being on a Spanish sample. An online survey that included the Minnesota Leisure...

Optimal uses of pooled testing for COVID-19 incorporating imperfec...
https://doi.org/10.1002/jmv.27054
Journal of Medical Virology; Nianogo RA, Emeruwa IO et. al.

Apr 30th, 2021 - Pooled testing is a potentially efficient alternative strategy for COVID-19 testing in congregate settings. We evaluated the utility and cost-savings of pooled testing based on imperfect test performance and potential dilution effect due to pooling and created a practical calculator for online use. We developed a 2-stage pooled testing mod...

The costs of an expanded screening criteria for COVID-19: A modelling study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422907
International Journal of Infectious Diseases : IJID : Off... Lim JT, Dickens BL et. al.

Aug 17th, 2020 - Nosocomial infection is an ongoing concern in the COVID-19 outbreak. The effective screening of suspected cases in the healthcare setting is therefore necessary, enabling the early identification and prompt isolation of cases for epidemic containment. We aimed to assess the cost and health outcomes of an extended screening strategy, implemented in Singapore on 07 Feb...

Evaluation of pooled sample analysis strategy in expediting case detection in ar...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508355
PloS One; Singh AK, Nema RK et. al.

Sep 22nd, 2020 - Timely diagnosis of COVID-19 infected individuals and their prompt isolation are essential for controlling the transmission of SARS-CoV-2. Though quantitative reverse transcriptase PCR (qRT-PCR) is the method of choice for COVID-19 diagnostics, the resource-intensive and time-consuming nature of the technique impairs its wide applicability in resource-constrained set...

A Web-Based Digital Contact Tracing Strategy Addresses Stigma Concerns Among Ind...
https://doi.org/10.1089/tmj.2021.0148
Telemedicine Journal and E-health : the Official Journal ... Trevino J, Keswani M et. al.

Jun 4th, 2021 - Background: Conventional contact tracing approaches have not kept pace with the scale of the coronavirus disease 2019 (COVID-19) pandemic and the highly anticipated smartphone applications for digital contact tracing efforts are plagued by low adoption rates attributed to privacy concerns; therefore, innovation is needed in this public health capability. Methods: This study...