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About 2,060 results

Safety and pharmacokinetics of oral cannabidiol when adm...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449284
Journal of Addiction Medicine; Manini AF, Yiannoulos G et. al.

Mar 10th, 2015 - Cannabidiol (CBD) is hypothesized as a potential treatment for opioid addiction, with safety studies an important first step for medication development. We determined CBD safety and pharmacokinetics when administered concomitantly with a high-potency opioid in healthy subjects. This double-blind, placebo-controlled cross-over study of CBD, coadminist...

Preclinical assessment of the abuse potential of purified botanical cannabidiol: self-a...
https://doi.org/10.1124/jpet.121.000988
The Journal of Pharmacology and Experimental Therapeutics; Gray RA, Heal DJ et. al.

May 1st, 2022 - Cannabidiol (CBD) is a constituent of the cannabis plant with a diverse array of pharmacological activities as well as potential therapeutic uses. An oral formulation of CBD (Epidiolex® in the US; Epidyolex® in Europe) is approved for treating seizures associated with rare and severe forms of epilepsy. These studies, which supported the approval of the medication, investigated abu...

A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Inte...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275018
CNS Drugs; Ben-Menachem E, Gunning B et. al.

May 1st, 2020 - In recent randomized, placebo-controlled, phase III trials, highly purified cannabidiol demonstrated efficacy with an acceptable safety profile in patients with Lennox-Gastaut syndrome or Dravet syndrome. It is anticipated that antiepileptic drugs such as stiripentol and valproate will be administered concomitantly with cannabidiol. This trial evaluated the ef...

Effect of Phosphate Binders and a Dietary Iron Supplement on the Pharmacokinetics of a ...
https://doi.org/10.1002/cpdd.1033
Clinical Pharmacology in Drug Development; Paulson SK, Martinez J et. al.

Feb 17th, 2022 - Vadadustat is a hypoxia-inducible factor prolyl-hydroxylase inhibitor being developed for the treatment of anemia in patients with chronic kidney disease. Sequelae of chronic kidney disease include hyperphosphatemia and anemia, which are frequently treated with phosphate binders and iron supplements, respectively. Two studies evaluating the pharmacokinetics, safety, and tolerabili...

New oral anticoagulants: comparative pharmacology with vitamin K antagonists.
https://doi.org/10.1007/s40262-012-0030-9
Clinical Pharmacokinetics; Scaglione F

Jan 8th, 2013 - New oral anticoagulants (OACs) that directly inhibit Factor Xa (FXa) or thrombin have been developed for the long-term prevention of thromboembolic disorders. These novel agents provide numerous benefits over older vitamin K antagonists (VKAs) due to major pharmacological differences. VKAs are economical and very well characterized, but have important limitations that can outweigh these ...

Pharmacokinetics and Tolerability of Multiple Doses of Pharmaceutical-Grade Synthetic C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534520
CNS Drugs; Wheless JW, Dlugos D et. al.

May 3rd, 2019 - Prior studies have evaluated the use of various constituents of cannabis for their anti-seizure effects. Specifically, cannabidiol, a non-psychoactive component of cannabis, has been investigated for treatment-resistant epilepsy, but more information is needed particularly on its use in a pediatric population. The objective of this study was to evaluate the pharmacokinetics and

Effects of Repeated Oral Administration of Esaxerenone on the Pharmacokinetics of Midaz...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397627
European Journal of Drug Metabolism and Pharmacokinetics; Toyama K, Furuie H et. al.

Aug 13th, 2021 - Esaxerenone showed the potential to inhibit and induce activity against cytochrome P450 (CYP) 3A in in vitro studies. We investigated whether repeated administration of 5 mg/day esaxerenone for 14 days influences the pharmacokinetics of midazolam, a sensitive CYP3A substrate, in healthy Japanese males. This single-centre, open-label, single-sequence study had two administration periods: ...

Fluconazole - fluconazole powder, for suspension-NorthStar Rx LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=afde17e7-b95b-4cd5-97eb-e361724014bd

May 19th, 2022 - Description Section Fluconazole, the first of a new subclass of synthetic triazole antifungal agents, is available as a powder for oral suspension. Fluconazole is designated chemically as 2,4-difluoro-α,α1-bis(1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol with a molecular formula of C13H12F2N6O and molecular weight of 306.3. The structural formula is: Fluconazole USP is a white or almost w...

Fluconazole - fluconazole powder, for suspension-Aurobindo Pharma Limited
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bf588f7e-89de-4b4e-8d33-c1ff2be1b34e

Apr 14th, 2022 - Description Section Fluconazole, the first of a new subclass of synthetic triazole antifungal agents, is available as a powder for oral suspension. Fluconazole is designated chemically as 2,4-difluoro-α,α1-bis(1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol with a molecular formula of C13H12F2N6O and molecular weight of 306.3. The structural formula is: Fluconazole USP is a white or almost w...

Fluconazole - fluconazole tablet-Rising Health, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2ca7efcd-4a8d-4139-a3eb-930afd18b13f

May 13th, 2022 - Description Section Fluconazole, the first of a new subclass of synthetic triazole antifungal agents, is available as tablets for oral administration. Fluconazole is designated chemically as 2,4-difluoro-α,α1-bis(1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol with a molecular formula of C13H12F2N6O and molecular weight of 306.3. The structural formula is: Fluconazole USP is a white crystall...

Fluconazole - fluconazole tablet-Aurobindo Pharma Limited
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6ebf24fd-41cd-4b3c-8176-a1436253ba2d

Apr 19th, 2022 - Description Section Fluconazole, the first of a new subclass of synthetic triazole antifungal agents, is available as tablets for oral administration. Fluconazole is designated chemically as 2,4-difluoro-α,α1-bis(1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol with a molecular formula of C13H12F2N6O and molecular weight of 306.3. The structural formula is: Fluconazole USP is a white crystall...

Fluconazole - fluconazole powder, for suspension-Rising Health, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ccbe0991-27a1-4ddb-bfc7-1b3422e53390

Jan 27th, 2022 - Description Section Fluconazole, the first of a new subclass of synthetic triazole antifungal agents, is available as a powder for oral suspension. Fluconazole is designated chemically as 2,4-difluoro-α,α1-bis(1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol with a molecular formula of C13H12F2N6O and molecular weight of 306.3. The structural formula is: Fluconazole USP is a white or almost w...

Pharmacokinetics and safety of neratinib during co-administration with loperamide in he...
https://doi.org/10.1007/s00280-019-03951-x
Cancer Chemotherapy and Pharmacology; Keyvanjah K, Cooke B et. al.

Sep 13th, 2019 - To evaluate the effects of multiple doses of loperamide on the pharmacokinetics and safety of a single oral dose of neratinib. This was an open-label, two-period, fixed-sequence study. Twenty healthy adult subjects received an oral dose of neratinib 240 mg daily on Days 1-4 of Period 1 followed by a 7-day washout. In Period 2, oral neratinib 240 mg was admi...

A phase 1, randomized, pharmacokinetic trial of the effect of different meal compositio...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065230
Epilepsia Crockett J, Critchley D et. al.

Feb 6th, 2020 - The pharmacokinetics (PK) and safety of single oral 750-mg doses of a plant-derived pharmaceutical formulation of highly purified cannabidiol (CBD; Epidiolex in the USA and Epidyolex in Europe; 100-mg/mL oral solution) were assessed in healthy adults following a high-fat/calorie meal (n = 15), a low-fat/calorie meal (n = 14), whole milk (n = 15), or alcohol (n...

Drug-Drug Interaction Study of Benznidazole and E1224 in Healthy Male Volunteers.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097458
Antimicrobial Agents and Chemotherapy; Ribeiro I, Blum B et. al.

Feb 10th, 2021 - E1224 is a prodrug of ravuconazole (RVZ), an antifungal drug with promising anti-Trypanosoma cruzi activity, the causative organism of Chagas disease (CD). This study was designed to assess the pharmacokinetics (PK) and safety interactions of benznidazole (BNZ), the drug of choice for treatment of CD, and E1224 in healthy volunteers. This open-label, single-center, sequential, single- an...

Absence of pharmacokinetic interaction between roflumilast and digoxin in healthy adults.
https://doi.org/10.1177/0091270010389467
Journal of Clinical Pharmacology; Eckermann G, Lahu G et. al.

Jan 25th, 2011 - Numerous interactions are known for digoxin, which is a drug with a narrow therapeutic index and a substrate of P-glycoprotein (P-gp). This study investigated potential effects of coadministration on pharmacokinetics and safety of both drugs when a single dose of digoxin was concomitantly administered with roflumilast under steady-state conditions. Sixteen healthy ma...

Fluconazole - fluconazole tablet-NorthStar Rx LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d2acccda-8068-46c1-8562-950d7f70ee06

Jan 7th, 2022 - Description Section Fluconazole, the first of a new subclass of synthetic triazole antifungal agents, is available as tablets for oral administration. Fluconazole is designated chemically as 2,4-difluoro-α,α1-bis(1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol with a molecular formula of C13H12F2N6O and molecular weight of 306.3. The structural formula is: Fluconazole USP is a white crystall...

Metacam - meloxicam suspension-Boehringer Ingelheim Animal Health USA Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c27c35d7-07e1-47d4-97cd-ed1fb17750ce

Apr 14th, 2022 - SPL UNCLASSIFIED SECTION (equivalent to 0.05 mg per drop) Non-steroidal anti-inflammatory drug for oral use in dogs only SPL UNCLASSIFIED SECTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. Boxed Warning section Repeated use of meloxicam in cats has been associated with acute renal failure and death. Do not administer additional injectable or oral m...

Montelukast sodium - montelukast sodium tablet, chewable-RPK Pharmaceuticals, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cf92d18d-02a9-4710-8b6c-65ac48dacf34

Mar 30th, 2022 - Recent Major Changes Section Boxed Warning 04/2020 Indications and Usage (1.3, 1.4)                                               02/2021 Dosage and Administration (2.1, 2.2, 2.3, 2.4)                         02/2021 Warnings and Precautions (5.1, 5.6)                                        02/2021 Boxed Warning Section Serious neuropsychiatric (NP) events have been reported with the use of m...

Pantoprazole sodium - pantoprazole sodium granule, delayed release-Sun Pharmaceutical Industries, Inc.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=38353b9e-63bd-47e8-b7cb-b198d1e901f9

Mar 29th, 2022 - Recent Major Changes Section Warnings and Precautions, Severe Cutaneous Adverse Reactions (5.5) 03/2022 Hypomagnesemia and Mineral Metabolism (5.8) 03/2022 Indications & Usage Section Pantoprazole sodium for delayed-release oral suspension is indicated for: Pantoprazole sodium is a proton pump inhibitor (PPI) indicated for the following: Short-Term Treatment of Erosive Esophagitis Associated ...