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About 4 results

Safety and pharmacokinetics of oral cannabidiol when adm...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449284
Journal of Addiction Medicine; Manini AF, Yiannoulos G et. al.

Mar 9th, 2015 - Cannabidiol (CBD) is hypothesized as a potential treatment for opioid addiction, with safety studies an important first step for medication development. We determined CBD safety and pharmacokinetics when administered concomitantly with a high-potency opioid in healthy subjects. This double-blind, placebo-controlled cross-over study of CBD, coadminist...

Effect of rifampin on the pharmacokinetics of bosutinib, a dual Src/Abl tyrosine...
https://doi.org/10.1515/dmdi-2014-0026
Drug Metabolism and Personalized Therapy; Abbas R, Boni J et. al.

Mar 24th, 2015 - Bosutinib is an orally bioavailable dual Src/Abl tyrosine kinase inhibitor and a CYP3A4 enzyme substrate. This study assessed the safety, tolerability, and pharmacokinetics of bosutinib when coadministered with the CYP3A4 inducer rifampin in 24 healthy men. Subjects received single oral doses of bosutinib 500 mg (Days 1 and 14) and once-daily oral doses of rif...

Effects of multiple doses of albiglutide on the pharmacokinetics, pharmacodynami...
https://doi.org/10.3810/pgm.2012.11.2613
Postgraduate Medicine; Bush M, Scott R et. al.

Jan 16th, 2013 - Albiglutide is a glucagon-like peptide-1 analog that is currently under investigation for the treatment of type 2 diabetes mellitus as a once-weekly injection. Three open-label phase 1 studies were conducted in healthy human participants to investigate potential pharmacokinetic (PK) and/or pharmacodynamic (PD) interactions between albiglutide and medications that may be used concomitantly...

Absence of pharmacokinetic interaction between roflumilast and digoxin in healthy adults.
https://doi.org/10.1177/0091270010389467
Journal of Clinical Pharmacology; Eckermann G, Lahu G et. al.

Jan 24th, 2011 - Numerous interactions are known for digoxin, which is a drug with a narrow therapeutic index and a substrate of P-glycoprotein (P-gp). This study investigated potential effects of coadministration on pharmacokinetics and safety of both drugs when a single dose of digoxin was concomitantly administered with roflumilast under steady-state conditions. Sixteen healthy ma...