JAMA Gonzalez DC, Nassau DE et. al.
Jun 18th, 2021 - Sperm Parameters Before and After COVID-19 mRNA Vaccination.|2021|Gonzalez DC,Nassau DE,Khodamoradi K,Ibrahim E,Blachman-Braun R,|adverse effects,drug effects,adverse effects,
JAMA Gonzalez DC, Nassau DE et. al.
Jun 17th, 2021 - Two mRNA vaccines, BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), received Emergency Use Authorization from the US Food and Drug Administration. Despite high efficacy and few adverse events found in clinical trials, only 56% of individuals in the US reported wanting to receive the vaccine.
Journal of Assisted Reproduction and Genetics; Freour T, Barragan M et. al.
Apr 27th, 2017 - WBP2NL/PAWP, a protein found in the post-acrosomal region of mammalian spermatozoa, has been proposed as a sperm-borne oocyte-activating factor (SOAF) contributing to Ca2+ release within the oocyte and subsequent fertilization and embryo development. However, its relevance as either a diagnostic or a prognostic marker of fertilization failure has been questioned in the recent literature. We ana...
May 14th, 2021 - (Reuters) - The COVID-19 mRNA vaccine from Pfizer Inc and BioNTech SE does not damage sperm, according to a study by Israeli researchers. They collected sperm samples from 43 male volunteers before and roughly a month after the men were vaccinated. None of their sperm parameters - volume, concentration, or motility - had changed significantly after vaccinat...
Reproductive Sciences (Thousand Oaks, Calif.); Santonastaso M, Mottola F et. al.
Apr 17th, 2021 - Cryopreservation causes decreased sperm fertility potential due to reactive oxygen species (ROS) production and physical-chemical damage, resulting in reduced sperm viability and motility. The addition of antioxidants to freezing media could protect sperm from cryo-damage, counteracting the harmful effects of ROS. The aim of this study was to assess the effects of curcumin ...
American Journal of Physiology. Endocrinology and Metabol... Suleiman JB, Abu Bakar AB et. al.
Jul 8th, 2021 - The pituitary-gonadal axis plays an important role in steroidogenesis and spermatogenesis, and by extension, fertility. The aim of this study was to investigate the protective role of bee bread, a natural bee product, against obesity-induced decreases in steroidogenesis and spermatogenesis. Thirty-two adult male Sprague-Dawley rats weighing between 200 and 300 g were divided into ...
Diabetes/metabolism Research and Reviews; Watanabe M, Balena A et. al.
May 7th, 2021 - To explore variables associated with the serological response following COVID-19 mRNA vaccine. Eighty-six healthcare workers adhering to the vaccination campaign against COVID-19 were enrolled in January-February 2021. All subjects underwent two COVID-19 mRNA vaccine inoculations (Pfizer/BioNTech) separated by 3 weeks. Blood samples were collected before the 1st and 1-4 wee...
The Journal of Urology; Ni K, Steger K et. al.
Jul 2nd, 2014 - We investigated the expression and the exact role of leptin under hypoxic conditions in the human testis. Five testes from patients treated with orchiectomy for prostate cancer were used to construct an in vitro hypoxic culture system for human testicular tissue. Immunohistochemistry was performed to analyze leptin protein expression. Leptin, leptin receptor and HIF-1α mRNA were examined...
Human Reproduction (Oxford, England); Zohni K, Zhang X et. al.
Nov 16th, 2011 - Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis and represent a crucial resource for male fertility restoration. It has not been well documented, however, whether the recovery of SSC population size after cytotoxic damage associates with the kinetics of male fertility restoration. We addressed this issue using the mouse as a model. Following single injections of bu...
Molecular Reproduction and Development; Sadakierska-Chudy A, Patrylak J et. al.
Nov 27th, 2020 - Preimplantation embryo development might be influenced by a specific set of transcripts that are delivered to the oocyte by the sperm. The aim of the study was to determine the relationship between the level of selected transcripts in spermatozoa and preimplantation development of the embryos in couples with severe oligozoospermia undergoing intracytoplasmic sperm in...
Andrology Amjad S, Mushtaq S et. al.
Jul 9th, 2021 - The difficulties encountered in surgical spermatozoa retrieval for intracytoplasmic sperm injection procedure in azoospermic men have stressed the dire need for a robust biomarker for the prediction of spermatozoa retrieval. Data have highlighted the role of JMJD1A (Jumonji domain-containing 1A), a histone H3K9 demethylase, and other nuclear proteins, protamines (PRM...
Environmental Health and Preventive Medicine; Qin F, Liu N et. al.
Oct 13th, 2021 - Exposure to the ionizing radiation (IR) encountered outside the magnetic field of the Earth poses a persistent threat to the reproductive functions of astronauts. The potential effects of space IR on the circadian rhythms of male reproductive functions have not been well characterized so far. Here, we investigated the circadian effects of IR exposure (3 Gy X-rays) on reproductive functional mar...
Reproductive Toxicology (Elmsford, N.Y.); Bianchi E, Stermer A et. al.
Jun 27th, 2021 - Assessing male reproductive toxicity of environmental and therapeutic agents relies on the histopathology of the testis and epididymis in a pre-clinical setting. Animal histopathology poorly correlates with human sperm parameters, and none of these current methods are strong indicators of sperm health or reproductive potential. Therefore, there is an urgent need to identify...
Andrology Bucak MN, Keskin N et. al.
Nov 16th, 2021 - Sperm cryopreservation has been widely used in the field of reproductive biotechnology. It applies to certain males of economic and scientific values, including livestock breeds or endangered animal species. The development of a semen extender with a low cryoprotectant concentration and an appropriate amount of trehalose and boron can prevent the deterioration of sperm paramete...
The Journal of Clinical Endocrinology and Metabolism; Grigorova M, Punab M et. al.
Jul 8th, 2011 - The detailed role of FSH in contributing to male testicular function and fertility has been debated. We have previously identified the association between the T-allele of the FSHB promoter polymorphism (rs10835638; G/T, -211 bp from the mRNA start) and significantly reduced male serum FSH. In the current study, the T-allele carriers of the FSHB -211 G/T single nucleotide polymorphism represente...
Alcohol (Fayetteville, N.Y.); Fozooni R, Jafarzadeh Shirazi MR et. al.
Aug 31st, 2021 - Stressful conditions increase alcohol consumption in men. Clinical studies link disruption of the neuroendocrine stress system with alcoholism, but the effect of alcohol in a stress condition on male fertility is still relatively poorly understood. This project was undertaken to evaluate the effect of sub-chronic alcohol in a stress condition on male fertility in a rat model. Male Sprague-Dawle...
Fertility and Sterility; Yu B, Qi Y et. al.
Oct 12th, 2013 - To investigate the association between smoking, semen quality, and the histone-to-protamine transition ratio in mature sperm. Biochemical and molecular analysis in human samples and a cell line. Andrology laboratory in a university-affiliated hospital. Semen samples from 147 heavy smokers and 175 nonsmokers receiving infertility treatment. None. Basic semen parameters, histone-to-...
Urology Journal; Kumar V, Kaur M
Aug 5th, 2021 - As world is going through the COVID-19 pandemic, the mass vaccination of newly approved vaccines for COVID-19 has begun around the world. There has been some concern among the vaccine recipients regarding the potential effect of vaccine on male fertility. Does COVID-19 affect the male reproductive health? Does COVID-19 vaccine impair the sperm parameters?
Journal of Obstetrics and Gynaecology : the Journal of Th... Imani M, Talebi AR et. al.
Jul 25th, 2020 - Diabetes Mellitus (DM) is the most common endocrine disorder affecting many human physiological systems and tissues, including the reproductive organs in men. The age of individuals suffering from this disease has been falling rapidly in recent years. This study compared the effect of DM on sperm parameters, chromatin quality, and apoptosis, as well as the expression profile of pr...
Journal of Nuclear Medicine : Official Publication, Socie... Seban RD, Richard C et. al.
Dec 4th, 2021 - Rationale: We aimed to predict the presence of vaccine-induced hypermetabolic lymph nodes (v-HLN) on 18F-FDG PET/CT after Coronavirus disease 2019 (COVID-19) vaccination and determine their association with lymphocyte counts. Methods: In this retrospective single-center study, we included consecutive patients who underwent [18F]-FDG PET/CT imaging after mRNA- or viral vector-based...