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ALLMedicine: Dementia Center

Study suggests lithium may decrease risk of developing dementia
https://www.eurekalert.org/news-releases/946590

Mar 17th, 2022 - Researchers have identified a link suggesting that lithium could decrease the risk of developing dementia, which affects nearly one million people in the UK. The researchers, from the University of Cambridge, conducted a retrospective analysis of the health records of nearly 30,000 patients from Cambridgeshire and Peterborough NHS Foundation Trust. The patient...

Lithium Linked to Small Reduction in Dementia Onset
https://www.medscape.com/viewarticle/970478

Mar 17th, 2022 - Lithium could be linked to a decrease in the risk of developing dementia for some people, according to a small study. Researchers at the University of Cambridge described their preliminary findings as "promising" and said that they justified conducting larger, randomised trials to test the results. Lithium has been proposed as a possible preventa...

Fast Food Linked to Increased Dementia Risk
https://www.medscape.com/viewarticle/978125

Jul 27th, 2022 - A diet high in ultraprocessed foods (UPFs) is linked to an increased risk for dementia, new research suggests. In a prospective cohort study, individuals who consumed the highest amounts of soft drinks, chips, and other UPFs had the highest risk of developing dementia compared with their counterparts who consumed the lowest amounts of these foods...

Old Drug May Hold New Promise in Alzheimer's Disease
https://www.staging.medscape.com/viewarticle/741621

Apr 27th, 2011 - April 28, 2011 — Low-dose lithium appears to slow the progression of memory loss and cognitive decline in individuals with amnestic mild cognitive impairment (aMCI), a significant risk factor for Alzheimer's disease (AD), a new study suggests. A randomized, placebo-controlled trial showed treatment with lithium, an old drug historically used to treat bipolar d...

Automated analysis of propositional idea density in older adults.
https://doi.org/10.1016/j.cortex.2021.09.018
Cortex; a Journal Devoted to the Study of the Nervous Sys... Hill E, Alty J et. al.

Nov 15th, 2021 - Previous research suggests oral and written language can act as barometers of an individual's cognitive function, potentially providing a screening tool for the earliest stages of Alzheimer's disease (AD) and other forms of dementia. Idea density is a measure of the rate at which ideas, or elementary predications, are expressed and may provide an ideal measure for early detection ...

Lithium in Drinking Water May Lower Dementia Risk
https://emedicine.medscape.com/viewarticle/884607

Higher long-term lithium exposure from drinking water may be associated with a lower incidence of dementia, a large population-based study suggests. "This is the first study ever investigating the association between lithium in drinking water and onset of dementia," Lars Vedel Kessing, MD, DMSc, from the University of Copenhagen, Denmark, told Me...

Calcium Supplementation May Raise Dementia Risk in Older Women
https://www.neurologyadvisor.com/topics/neurodegenerative-diseases/calcium-supplementation-may-raise-dementia-risk-in-older-women/
Neurology Advisor

Aug 24th, 2016 - A recent study published in Neurology suggests that the use of calcium supplementation in elderly women with cerebrovascular disease may be associated with an increased risk of dementia development.1 Calcium supplementation is recognized as a gold standard to minimize the risk of bone loss or decrease the likelihood of osteoporosis in most if not all el...

Simple Language Test May Predict Alzheimer's Years Before Symptoms
https://www.staging.medscape.com/viewarticle/939618

Oct 22nd, 2020 - A simple language test developed using artificial intelligence (AI) is able to predict, with a high level of accuracy, which cognitively normal individuals will go on to develop Alzheimer's disease (AD), new research suggests. The findings show that the test has a 70% accuracy rate in predicting AD onset years before cognitive decline begins and is more accurate than traditional predictive meth...

Old Drug May Hold New Promise in Alzheimer's Disease
https://emedicine.medscape.com/viewarticle/741621

April 28, 2011 — Low-dose lithium appears to slow the progression of memory loss and cognitive decline in individuals with amnestic mild cognitive impairment (aMCI), a significant risk factor for Alzheimer's disease (AD), a new study suggests. A randomized, placebo-controlled trial showed treatment with lithium, an old drug historically used to treat bipolar d...

Olanzapine - olanzapine injection, powder, lyophilized, for solution-AuroMedics Pharma LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9c745e2e-89d3-44d4-906e-704705c33310

Nov 18th, 2021 - Boxed Warning Section Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death...

COVID-19 Raises Dementia Risk; Lithium Reduces Bipolar Mortality; and Early Eating, Fasting Leads to Weight Loss
https://www.medscape.com/viewarticle/984526

Nov 29th, 2022 - COVID-19 Raises Dementia Risk Older people who get COVID-19 are at higher risk of developing or worsening dementia, new research suggests. Those who live through COVID-19 have a higher risk for early- or late-onset dementia or a progressive decline in thinking skills compared with uninfected people, according to a study published in...

Exploring cognitive and brain oxygenation changes over a 1-year period in physically ac...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361664
BMC Geriatrics; Talamonti D, Gagnon C et. al.

Aug 9th, 2022 - Aging is associated with an increased likelihood of developing dementia, but a growing body of evidence suggests that certain modifiable risk factors may help prevent or delay dementia onset. Among these, physical activity (PA) has been linked to better cognitive performance and brain functions in healthy older adults and may contribute to preventing dement...

The Relationship Between Head Injury and Dementia Risk: Why It’s Complicated
https://www.psychiatryadvisor.com/home/topics/neurocognitive-disorders/alzheimers-disease-and-dementia/head-injury-tbi-alzheimer-disease-dementia-risk-relationship/
Psychiatry Advisor

Dec 14th, 2021 - In an effort to identify potentially modifiable risk factors for the development of dementia, there has been an increasing interest in the potential role of head injury on subsequent dementia risk. In a 2020 study published in Neurology, the authors found that the risk for dementia was roughly 2-3 times higher in patients with traumatic brain inj...

The Relationship Between Head Injury and Dementia Risk: Why It’s Complicated
https://www.neurologyadvisor.com/topics/alzheimers-disease-and-dementia/head-injury-tbi-alzheimer-disease-dementia-risk-relationship/
Neurology Advisor

Nov 19th, 2021 - In an effort to identify potentially modifiable risk factors for the development of dementia, there has been an increasing interest in the potential role of head injury on subsequent dementia risk. In a 2020 study published in Neurology, the authors found that the risk for dementia was roughly 2-3 times higher in patients with traumatic brain inj...

Old Drug May Hold New Promise in Alzheimer's Disease
https://www.medscape.com/viewarticle/741621

Apr 27th, 2011 - April 28, 2011 — Low-dose lithium appears to slow the progression of memory loss and cognitive decline in individuals with amnestic mild cognitive impairment (aMCI), a significant risk factor for Alzheimer's disease (AD), a new study suggests. A randomized, placebo-controlled trial showed treatment with lithium, an old drug historically used to treat bipolar d...

Does the SORG Orthopaedic Research Group Hip Fracture Delirium Algorithm Perform Well o...
https://doi.org/10.1097/CORR.0000000000002246
Clinical Orthopaedics and Related Research; Oosterhoff JHF, Oberai T et. al.

May 14th, 2022 - Postoperative delirium in patients aged 60 years or older with hip fractures adversely affects clinical and functional outcomes. The economic cost of delirium is estimated to be as high as USD 25,000 per patient, with a total budgetary impact between USD 6.6 to USD 82.4 billion annually in the United States alone. Forty percent of delirium episodes are preventable, and accurate risk stra...

Olanzapine - olanzapine tablet-Aurobindo Pharma Limited
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=636665be-9d7e-443a-8134-e8cc47e6ba24

Nov 8th, 2022 - Recent Major Changes Section Warnings and Precautions, Tardive Dyskinesia (5.6) 10/2019 Warnings and Precautions, Use in Patients with Concomitant Illness (5.14)                                    Removed 4/2020 Warnings and Precautions, Anticholinergic (antimuscarinic) Effects (5.14)                                                      4/2020 Boxed Warning Section Elderly patients with de...

Quetiapine fumarate - quetiapine fumarate tablet, film coated-A-S Medication Solutions
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=55018271-1f8f-4683-afee-8203c3bd9acc

Jan 23rd, 2023 - Boxed Warning Section Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death [see Warnings and Precautions (5.1)]. Quetiapine is not approved for the treatment of patients with dementia-related psychosis [see Warnings and Precautions (5...

Olanzapine - olanzapine tablet-Ascend Laboratories, LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e8626e68-088d-47ff-bf06-489a778815aa

Oct 31st, 2022 - Boxed Warning Section Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of deat...

Quetiapine fumarate - quetiapine fumarate tablet, film coated-Bryant Ranch Prepack
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=897184b1-de3c-4d59-91be-3069325fd5b2

Jan 17th, 2023 - SPL PRODUCT DATA ELEMENTS SECTION Chemical Structure Figure1 Figure2 Boxed Warning Section Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death [see Warnings and Precautions (5.1)]. Quetiapine is not approved for the treatment of patients ...