About 1,458 results

ALLMedicine: Sars Center

The proximal origin of SARS-CoV-2
Nature Medicine; Andersen et al

Since the first reports of novel pneumonia (COVID-19) in Wuhan, Hubei province, China1,2, there has been considerable discussion on the origin of the causative virus, SARS-CoV-23 (also referred to as HCoV-19)4.

An update on the origin of SARS-CoV-2: Despite closest iden...
Journal of Medical Virology; Malaiyan J, Arumugam S et. al.

Jul 8th, 2020 - The initial cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) occurred in Wuhan, China, in December 2019 and swept the world by 23 June 2020 with 8 993 659 active cases, 469 587 deaths across 216 countries, areas or territories. This strongly implies global transmission occurred before...

Phylogenetic Analyses of Severe Acute Respiratory Syndrome ...
Clinical Infectious Diseases : an Official Publication Of... Chaillon A, Smith DM

Mar 28th, 2021 - The emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) herald a new phase of the pandemic. This study used state-of-the-art phylodynamic methods to ascertain that the rapid rise of B.1.1.7 "Variant of Concern" most likely occurred by global dispersal rather than convergent evolution from multiple sources.

Emergence of a Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2: Biol...
Journal of Clinical Microbiology; Khan S, Siddique R et. al.

Mar 13th, 2020 - The new decade of the 21st century (2020) started with the emergence of a novel coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease (COVID-19) in Wuhan, China. It is the third highly pathogenic and transmissible coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV)...

The origin of SARS-CoV-2 variants of concern.
The Lancet. Infectious Diseases; Burki T

Jan 17th, 2022 - The origin of SARS-CoV-2 variants of concern.|2022|Burki T,|transmission,virology,classification,genetics,physiology,

SARS-CoV-2, SARS-CoV, and MERS-CoV encode cir...
Journal of Medical Virology; Yang S, Zhou H et. al.

Mar 24th, 2022 - Circular RNAs (circRNAs) are a newly recognized component of the transcriptome with critical roles in autoimmune diseases and viral pathogenesis. To address the importance of circRNA in RNA viral transcriptome, we systematically identified and characterized circRNAs encoded by the RNA genomes of betacoronaviruses using both bioinformatical and experimental approaches. We predicted 351, 2...

SARS-CoV-2: tracing the origin, tracking the evolution.
BMC Medical Genomics; Voskarides K

Mar 20th, 2022 - The origin of SARS-CoV-2 is uncertain. Findings support a "bat origin" but results are not highly convincing. Studies found evidence that SARS-CoV-2 was around for many years before the pandemic outbreak. Evidence has been published that the progenitor of SARS-CoV-2 already had the capability to bind strongly to the hu...

Origin and Structural Biology of Novel Coronavirus (SARS-CoV-2...
https://doi.org/10.1007/978-3-030-85109-5_1 10.1007/978-1-4939-2438-7_1 10.1016/j.cell.2020.02.052 10.3390/v4112902 10.21203/rs.2.24016/v1 10.2139/ssrn.3542586
Advances in Experimental Medicine and Biology; Mallick R, Duttaroy AK

Feb 9th, 2022 - A recent rapid outbreak of infection around the globe has been caused by a novel coronavirus, now known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was first identified in December 2019 in Wuhan city of Hubei province, People's Republic of China. We reviewed the currently available literature on coronaviru...

The origin of SARS-CoV-2.
The Lancet. Infectious Diseases; Burki T

Aug 30th, 2020 - The origin of SARS-CoV-2.|2020|Burki T,|genetics,isolation & purification,virology,epidemiology,virology,epidemiology,virology,genetics,isolation & purification,

Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.
Nature Zhou P, Fan H et. al.

Apr 6th, 2018 - Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health 1 . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute ...

A call for an independent inquiry into the origin of the SARS-CoV-...
Proceedings of the National Academy of Sciences of the Un... Harrison NL, Sachs JD

May 20th, 2022 - A call for an independent inquiry into the origin of the SARS-CoV-2 virus.|2022|Harrison NL,Sachs JD,|transmission,virology,virology,genetics,isolation & purification,

Evidence for a mouse origin of the SARS-CoV-2 Omicron variant
BioRxiv Wei C, .

Dec 15th, 2021 - The rapid accumulation of mutations in the SARS-CoV-2 Omicron variant that enabled its outbreak raises questions as to whether its proximal origin occurred in humans or another mammalian host. Here, we identified 45 point mutations that Omicron acquired since divergence from the B.1.1 lineage.

Aromatic amino acids in the juxtamembrane domain of severe acute respiratory syndrome c...
Journal of Virology; Howard MW, Travanty EA et. al.

Jan 18th, 2008 - The severe acute respiratory syndrome coronavirus (SARS-CoV) spike glycoprotein (S) is a class I viral fusion protein that binds to its receptor glycoprotein, human angiotensin converting enzyme 2 (hACE2), and mediates virus entry and cell-cell fusion. The juxtamembrane domain (JMD) of S is an aromatic amino acid-rich region proximal...

SARS-CoV-2's origin should be investigated worldwide for pandemic prevention
The Lancet; Wu Z, .

Sep 17th, 2021 - The origin of SARS-CoV-2 has received intensive global attention since its spread was first reported to the international community in early January, 2020. Multiple studies1, 2, 3, 4, 5, 6, 7, 8, 9 conducted collaboratively by scientists around the world have found that animal-to-human cross-species spillover is the most likely source of ...

SARS-CoV-2 causes a specific dysfunction of the kidney proximal...
Kidney International; Werion A, Belkhir L et. al.

Aug 14th, 2020 - Coronavirus disease 2019 (COVID-19) is commonly associated with kidney damage, and the angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 is highly expressed in the proximal tubule cells. Whether patients with COVID-19 present specific manifestations of proximal tubule dysfunction remains unknown. To test this, we examined a co...

SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.
Journal of Virology; Chen DY, Khan N et. al.

Jul 15th, 2021 - SARS-CoV-2 can infect multiple organs, including lung, intestine, kidney, heart, liver, and brain. The molecular details of how the virus navigates through diverse cellular environments and establishes replication are poorly defined. Here, we generated a panel of phenotypically diverse, SARS-CoV-2-infectible human cell lines representing different body ...

Finding SARS-CoV-2 Origin a 'Critical Priority' for White House

May 25th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. The Biden administration will conduct a deep-dive investigation into the origin and initial transmission of the novel coronavirus, said the White House COVID-19 response team during a news conference Tuesday — just days after a US intelligence report found that three researchers at a lab in Chin...

Climate change and the origin of SARS-CoV-2.
Journal of Travel Medicine; Yan Yam EL

Dec 4th, 2020 - Climate change and the origin of SARS-CoV-2.|2020|Yan Yam EL,|

Origin of imported SARS-CoV-2 strains in The Gambia identif...
PloS One; Kanteh A, Manneh J et. al.

Sep 1st, 2021 - The SARS-CoV-2 disease, first detected in Wuhan, China, in December 2019 has become a global pandemic and is causing an unprecedented burden on health care systems and the economy globally. While the travel history of index cases may suggest the origin of infection, phylogenetic analysis of isolated strains from these cases and contacts will increase the under...

COVID-19, SARS -CoV-2, Origin, Transmission and Treatment A...
Infectious Disorders Drug Targets; Nawaz S

Oct 8th, 2020 - The emergence of Severe Acute Respiratory Syndrome (SARS) in named as corona virus disease 19(covid-19) caused by the novel corona virus SARS-CoV-2 has caused hundreds of thousands of mortalities across the world, while the mortality rate is in millions, leading it to be declared as a global pandemic. Numerous research activities are under...