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Waning Immunity after the BNT162b2 Vaccine in Israel
https://www.nejm.org/doi/full/10.1056/NEJMoa2114228?query=featured_home
The New England Journal of Medicine; Goldberg Y, .

Oct 27th, 2021 - In December 2020, Israel began a mass vaccination campaign against coronavirus disease 2019 (Covid-19) by administering the BNT162b2 vaccine, which led to a sharp curtailing of the outbreak. After a period with almost no cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a resurgent Covid-19 outbreak began in mid-June 2021. Possible reasons for...

Waning Immunity after the BNT162b2 Vaccine in Israel.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609604
The New England Journal of Medicine; Goldberg Y, Mandel M et. al.

Oct 28th, 2021 - In December 2020, Israel began a mass vaccination campaign against coronavirus disease 2019 (Covid-19) by administering the BNT162b2 vaccine, which led to a sharp curtailing of the outbreak. After a period with almost no cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a resurgent Covid-19 outbreak began in mid-June 2021. Possible reasons for...

Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522797
The New England Journal of Medicine; Levin EG, Lustig Y et. al.

Oct 7th, 2021 - Despite high vaccine coverage and effectiveness, the incidence of symptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been increasing in Israel. Whether the increasing incidence of infection is due to waning immunity after the receipt of two doses of the BNT162b2 vaccine is unclear. We conducted a 6-month longitud...

Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated he...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489881
Lancet (London, England); Tartof SY, Slezak JM et. al.

Oct 8th, 2021 - Vaccine effectiveness studies have not differentiated the effect of the delta (B.1.617.2) variant and potential waning immunity in observed reductions in effectiveness against SARS-CoV-2 infections. We aimed to evaluate overall and variant-specific effectiveness of BNT162b2 (tozinameran, Pfizer-BioNTech) against SARS-CoV-2 infections and COVID-19-related hospital admissions by tim...

Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months
https://www.nejm.org/doi/full/10.1056/NEJMoa2114583?query=featured_home
The New England Journal of Medicine; Levin EG, .

Oct 6th, 2021 - Despite high vaccine coverage and effectiveness, the incidence of symptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been increasing in Israel. Whether the increasing incidence of infection is due to waning immunity after the receipt of two doses of the BNT162b2 vaccine is unclear.

Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness again...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8548286
Clinical Microbiology and Infection : the Official Public... Fiolet T, Kherabi Y et. al.

Oct 30th, 2021 - Vaccines are critical cost-effective tools to control the COVID-19 pandemic. However, the emergence of SARS-CoV-2 variants may threaten the global impact of mass vaccination campaigns. The objective of this study was to provide an up-to-date comparative analysis of the characteristics, adverse events, efficacy, effectiveness and impact of the variants of concern for nineteen COVID-19 vaccine...

Pfizer Vax Immunity Waned in Israel, Regardless of Age
https://www.medpagetoday.com/infectiousdisease/covid19vaccine/95288

Oct 27th, 2021 - Immunity against the Delta variant from Pfizer's COVID-19 vaccine waned after a few months across age groups, Israeli researchers found. Not surprisingly, rates of infection in July were higher among adults ages 60 and up who were fully vaccinated in January compared with those who were fully vaccinated in March (rate ratio [RR] 1.6, 95% CI 1.3-2.0), reported Yair Goldberg, PhD, of the T...

Some Americans Could Need COVID-19 Vaccine Booster: Fauci
https://www.medscape.com/viewarticle/955361

Jul 27th, 2021 - WASHINGTON (Reuters) - Top infectious disease official Anthony Fauci said on Sunday that Americans who are immune compromised may end up needing COVID-19 vaccine booster shots as the United States deals with increasing cases from the Delta variant of the coronavirus. "Those who are transplant patients, cancer chemotherapy, auto-immune diseases, that are on immunosuppressant regimens, tho...

Humoral and T-Cell Response to SARS-CoV-2 Vaccination in Patients With Multiple Scleros...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461553
JAMA Neurology; Brill L, Rechtman A et. al.

Sep 24th, 2021 - B-cell-depleting therapies may affect the development of a protective immune response following vaccination. Understanding the ability to develop vaccine-specific immunity to COVID-19 in patients with multiple sclerosis (MS) treated with B-cell-depleting therapy is of importance for clinical decisions. To assess SARS-CoV-2 vaccine-specific humoral and cellular responses in ...

Pertussis Outbreak Among Soldiers During Basic Training: The Need for Updated Protocols.
https://doi.org/10.7205/MILMED-D-16-00083
Military Medicine; Halhal B, Glick Y et. al.

Mar 16th, 2017 - Pertussis is a highly contagious, vaccine preventable upper respiratory disease. The incidence of the disease has been rising in the past few decades. During the winter of 2015, an upper respiratory outbreak occurred in one of Israel Defense Forces basic training bases in northern Israel. Following the detection of the first primary cases, a suspected outbreak investigation...

Odds of Testing Positive for SARS-CoV-2 Following Receipt of 3 vs 2 Doses of the BNT162...
https://doi.org/10.1001/jamainternmed.2021.7382
JAMA Internal Medicine; Patalon T, Gazit S et. al.

Dec 1st, 2021 - With the evidence of waning immunity of the mRNA vaccine BNT162b2 (Pfizer-BioNTech), a nationwide third-dose (booster) vaccination campaign was initiated in Israel during August 2021; other countries have begun to administer a booster shot as well. To evaluate the initial short-term additional benefit of a 3-dose vs a 2-dose regimen against infection of SARS-C...

Effectiveness of BNT162b2 Vaccine in Adolescents during Outbreak of SARS-CoV-2 Delta Variant Infection, Israel, 2021
https://wwwnc.cdc.gov/eid/article/27/11/21-1886_article

Oct 19th, 2021 - Figure 1 Figure 1. Vaccine doses among adolescents and total severe acute respiratory syndrome coronavirus 2 infections, Israel, June 1–August 26, 2021. A) Daily frequency of administration of first and second dose of BNT162b2... In May 2021, the US Food and Drug Administration and the European Medicines Agency expanded existing authorization for BNT162b2 vaccine (Pf...

Israel Weighing COVID Booster Shots for Over 60s Before FDA Approval
https://www.medscape.com/viewarticle/955387

Jul 27th, 2021 - JERUSALEM (Reuters) - Israel is considering giving a third shot of the Pfizer/BioNTech COVID-19 vaccine to its elderly population even before FDA approval in order to help fend off the Delta coronavirus variant, a health official said on Monday. U.S. and European Union authorities are considering whether booster shots are needed for specific risk groups. "This is the big dilemma. ...

Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing seve...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555967
Lancet (London, England); Barda N, Dagan N et. al.

Nov 11th, 2021 - Many countries are experiencing a resurgence of COVID-19, driven predominantly by the delta (B.1.617.2) variant of SARS-CoV-2. In response, these countries are considering the administration of a third dose of mRNA COVID-19 vaccine as a booster dose to address potential waning immunity over time and reduced effectiveness against the delta variant. We aimed to use the data r...

Israel Extends COVID-19 Vaccine Boosters to People Over 40, Teachers
https://www.medscape.com/viewarticle/956932

Aug 20th, 2021 - TEL AVIV (Reuters) - Israelis over 40 and teachers are now eligible for a third dose of the Pfizer/BioNTech COVID-19 vaccine, the health minister said on Thursday, hoping an expansion of the booster campaign will fend off the coronavirus Delta variant. The expansion of booster eligibility, following a recommendation by Health Ministry experts, comes a day after the United States announce...

Accounting for the spread of vaccination behavior to optimize influenza vaccination pro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177529
PloS One; Kahana D, Yamin D

Jun 5th, 2021 - Vaccination is the most efficient means of preventing influenza infection and its complications. While previous studies have considered the externalities of vaccination that arise from indirect protection against influenza infection, they have often neglected another key factor-the spread of vaccination behavior among social contacts. We modeled influenza vaccination as a socially contagious pr...

Send Vaccines to Africa and Ditch Unproven Third Shot, AU Says
https://www.medscape.com/viewarticle/958409

Sep 10th, 2021 - JOHANNESBURG (Reuters) - Rich nations would do better to send vaccines to Africa to help fight the global COVID-19 pandemic rather than hoarding them for third-dose booster shots that scientific evidence does not back, the African Union's (AU) top health official said on Thursday. Africa Centres for Disease Control and Prevention (Africa CDC) director John Nkengasong told a news conference he w...

Cancer Patients See Sustained Response to COVID Vaccine
https://www.medpagetoday.com/hematologyoncology/othercancers/93991

Aug 11th, 2021 - Cancer patients on active treatment achieved sustained responses to the Pfizer/BioNTech COVID-19 vaccine, though at reduced antibody levels versus healthy controls, according to Israeli investigators. After about 4 months from the second dose of Pfizer's mRNA vaccine (BNT162b2), 87% of solid tumor patients who had been on active treatment remained seropositive for SA...

Delta Variant Acquitted in Need for Pfizer Boosters. Kind Of.
https://www.medpagetoday.com/infectiousdisease/covid19vaccine/94841

Oct 4th, 2021 - A decline in the effectiveness of the Pfizer COVID-19 vaccine (Comirnaty) against infection appeared to be due to waning immunity, not the Delta variant, researchers found. Examining sequenced infections, protection against infection with the Delta variant was 93% (95% CI 85-97) for the first month following full vaccination but then dropped to 53% (95% CI 39-65) after 4 mo...

Cancer Patients Develop 'Adequate' Immune Response to COVID Vax
https://www.medpagetoday.com/infectiousdisease/covid19vaccine/92845

May 28th, 2021 - The vast majority of patients undergoing active systemic therapy for cancer exhibited an adequate immune response to the Pfizer/BioNTech COVID-19 vaccine, according to a prospective cohort study. A total of 90% of patients with solid tumors undergoing active intravenous cancer treatment were seropositive for SARS-CoV-2 antispike IgG antibodies after a second dose of the vaccine (B...