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Why False Positives Merit Concern, Too
https://www.nytimes.com/2020/10/25/health/coronavirus-testing-false-positive.html
The New York Times; Katherine J. Wu

In the high-stakes world of coronavirus testing, one mistake has taken center stage: the dreaded false negative, wherein a test mistakenly deems an infected person to be virus-free. These troublesome results, experts have said, can deprive a person of treatment and embolden them to mingle with others, hastening the spread of disease.

Lung Cancer Screening Debate Bubbles Up
https://www.medpagetoday.com/hematologyoncology/lungcancer/767

Mar 24th, 2005 - Action Points Discuss the pros and cons with patients, particularly with smokers or ex-smokers, who request a helical CT scan for lung cancer screening. Patients should understand that false-positive results are common and can lead to unnecessary worry, additional testing, and surgery. Advise current smokers that the best way to prevent lung cancer is to quit smoking. ROCHESTER, Minn., M...

Fetal DNA in Mom's Blood Signals Down Syndrome
https://www.medpagetoday.com/genetics/genetictesting/50791

Apr 2nd, 2015 - Action Points Note that a series of studies published in the New England Journal of Medicine document that peripheral blood DNA analysis has superior test characteristics compared with traditional trisomy screening methods. Be aware that false-positive results did occur; women with positive results should consider amniocentesis for definitive diagnosis. A cell-free DNA (cfDNA) prenatal b...

'False-Positive' Cath Lab Activation for STEMI Up to 14%
https://www.mdedge.com/cardiology/article/41516/acute-coronary-syndromes/false-positive-cath-lab-activation-stemi-14
Mary Ann Moon

The prevalence of unnecessary activation of a cardiac catheterization laboratory for suspected ST-segment elevation myocardial infarction ranged from 9. 5% to 14% in one Midwestern coronary intervention network, depending on the diagnostic criteria used, researchers reported.

Low-Dose Aspirin Okay With Fecal Blood Tests
https://www.medpagetoday.com/hematologyoncology/coloncancer/23788

Dec 7th, 2010 - Action Points Note that colorectal cancer screening with fecal occult blood testing is typically done among age groups in which low-dose aspirin is often used for the prevention of cardiovascular disease. As aspirin increases the risk of GI bleeding, this could lead to false positives. Point however that, in this study, the use of low-dose aspirin was actually associated with incr...

Bedside Ultrasound: Sorting Shadows
https://www.medpagetoday.com/emergencymedicine/emergencymedicine/47598

Sep 10th, 2014 - Action Points In a prospective, randomized trial of patients presenting to an ER with respiratory symptoms, standard diagnostic tests supplemented with point-of-care ultrasonography compared with a standard diagnostic strategy alone were associated with a higher rate of correct presumptive diagnoses. Despite the increased percentage of patients who were given a correct presumptive diagnosis and...

Expert Shares Advantages, Challenges With Liquid Biopsies in Cancer Care
https://www.onclive.com/view/expert-shares-advantages-challenges-with-liquid-biopsies-in-cancer-care

Dec 4th, 2020 - Geoffrey R. Oxnard, MD The advent of liquid biopsies in oncology has led to a series of opportunities and challenges, explained Geoffrey R. Oxnard, MD. While the diagnostic approach is noninvasive in terms of cancer genotyping, false-negative and false-positive results continue to be obstacles. "We know that liquid biopsies have limitations; not all cancers shed tumor DNA, so

Cystoscopy Alone Most Cost-Effective for Monitoring Bladder Cancer Recurrence
https://www.onclive.com/view/cystoscopy_bladder_cancer_recurrence

Dec 5th, 2020 - Click here to view as PDF. A study presented at the ASCO 2010 Genitourinary Cancers Symposium found that adding urine testing to cystoscopy to monitor patients for bladder cancer recurrence greatly increases costs without a corresponding clinical benefit. Nearly 50% of patients treated for early stage or noninvasive bladder cancer experience relapse, and because of this high risk, they must ty...

PLA Testing Brings Nuance to the Diagnosis of Early-Stage Melanoma
https://www.medscape.com/viewarticle/971976

Apr 12th, 2022 - BOSTON – Although skin biopsy remains the gold standard for diagnosing early-stage melanoma, advances in genetic expression profiling are helping dermatologists provide a nuanced approach to managing suspicious lesions. One such test, the Pigmented Lesional Assay (PLA) uses adhesive patches applied to lesions of concern at the bedside to extract RNA from the stratum corneum to help determine th...

At-Home COVID-19 Testing: Convenience, Cost, and Some Caveats
https://www.medscape.com/viewarticle/947386

Mar 12th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. At-home testing for COVID-19 features great convenience, but pathology experts caution that false positives, false negatives, out-of-pocket costs, and the potential for inadequate sampling from people swabbing their own noses or mouths could compromise results. Screen but Verify At...

Surgery for Locally Advanced HNSCC
https://www.onclive.com/view/surgery-for-locally-advanced-hnscc

Apr 2nd, 2021 - Transcript: Ezra Cohen, MD: There is, of course, another way that we can de-escalate in a sense, and that is with new surgical techniques. Jared, I know this is something that you’re familiar with. What are some of the surgical options, or let’s say perioperative options, in patients with locally advanced disease? Jared Weiss, MD: Just as we do with radiation and chemoradiation approaches...

CRPC: Goals of Imaging for the Detection of Metastasis
https://www.onclive.com/view/crpc-goals-of-imaging-for-the-detection-of-metastasis

Apr 2nd, 2021 - Transcript: Raoul S. Concepcion, MD, FACS: Phil, one test that was being used quite a bit, that’s off the registry now, is sodium fluoride PET/CT. Phillip Koo, MD: Correct. Raoul S. Concepcion, MD, FACS: Where do we stand with that? I thought the NOPR registry ended for that recently, correct? Phillip Koo, MD: You’re absolutely right. The NOPR registry has been in effect for the pa...

Lung Cancer: To Screen or Not to Screen?
https://www.onclive.com/view/lung_cancer_screening

Dec 5th, 2020 - Click here to view as PDF. Annals of Internal Medicine Early-stage diagnosis gives patients their best chance against lung cancer. The rush to adopt lung cancer screening seems premature, however, because no randomized trials have definitively demonstrated that it improves survival outcomes. The National Lung Screening Trial (NLST), sponsored by the National Cancer Institute, aims to supply t...

Experts Disagree With USPSTF's Take on Pediatric Blood Pressure Screening
https://www.staging.medscape.com/viewarticle/941312

Nov 19th, 2020 - Current evidence is insufficient to assess the balance of benefits and harms of screening for high blood pressure in children and adolescents, the U.S. Preventive Services Task Force reported in JAMA. However, two experts in this area suggested there is evidence if you know where to look, and pediatric BP testing is crucial now. In this update to the 2013 statement, the USPSTF's systematic revi...

High Rate of Negative Cancer Trials Raises Concerns
https://www.medpagetoday.com/hematologyoncology/othercancers/94755

Sep 28th, 2021 - More than 80% of recent phase III trials in cancer conducted over a 10-year period failed to show clinically meaningful improvement in overall survival (OS), according to a review of the data. Among 187 trials with a primary endpoint of OS, 131 did not achieve statistically significant improvement. Of the 56 studies that met statistical significance, 33 failed to meet the new or experimental th...

The lost year – even for common respiratory viruses
http://www.mdedge.com/pediatrics/article/235967/infectious-diseases/lost-year-even-common-respiratory-viruses
Christopher J. Harrison, MD

Feb 16th, 2021 - In this column in September 2020, you read how common respiratory viruses’ seasons are usually so predictable, each virus arising, peaking, and then dying out in a predictable virus parade (Figure 1). 1 Well, the predictable virus seasonal pattern was lost in 2020.

The lost year – even for common respiratory viruses
https://www.mdedge.com/pediatrics/article/235967/infectious-diseases/lost-year-even-common-respiratory-viruses
Christopher J. Harrison, MD

Feb 16th, 2021 - In this column in September 2020, you read how common respiratory viruses’ seasons are usually so predictable, each virus arising, peaking, and then dying out in a predictable virus parade (Figure 1). 1 Well, the predictable virus seasonal pattern was lost in 2020.

Study: Prostate Cancer Surgery Without Prior Biopsy Possible
https://www.cancertherapyadvisor.com/home/cancer-topics/prostate-cancer/prostate-cancer-surgery-without-prior-biopsy-possible-treatment/

Jan 4th, 2022 - Performing radical prostatectomy (RP) based solely on radiographic findings and skipping conventional biopsies that are the standard of care for diagnosing prostate cancer may be a possible option for well-selected patients, according to a recent report. In a study of 25 men with a high suspicion for significant prostate cancer based on imaging with multiparametric magnetic resonance imaging (m...

Addressing substance use in patients with intellectual disability: 5 Steps
https://www.mdedge.com/psychiatry/article/195235/addiction-medicine/addressing-substance-use-patients-intellectual
Jessica Rivers Allen, MD

Mar 1st, 2019 - Approximately 5% of patients with intellectual disability (ID) have a comorbid substance use disorder (SUD). 1 These patients frequently abuse alcohol, tobacco, and cannabis, but are largely underdiagnosed and undertreated for SUDs.

The Lost Year – Even for Common Respiratory Viruses
https://www.medscape.com/viewarticle/945973

Feb 17th, 2021 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. In this column in September 2020, you read how common respiratory viruses' seasons are usually so predictable, each virus arising, peaking, and then dying out in a predictable virus parade (Figure 1).1 Well, the predictable virus seasonal pattern was lost in 2020. Since March of 2020, it is stri...