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Cancer Screening Programs Influence Incidence and Causes of Cancer Deaths
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200141/full/

May 13th, 2020 - By 2040, there will be marked changes in the predicted landscape of cancer incidence and deaths, according to an analysis of demographic results from the Surveillance, Epidemiology, and End Results Program (2014-2016) and U.S. Census Bureau population growth projections (Abstract 1566).

New Kidney Cancer Research From the ASCO20 Virtual Scientific Program Demonstrates an Exciting, Evolving Field
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200216/full/

Jun 25th, 2020 - There used to be a paucity of options for managing advanced renal cell cancer (RCC) with a high toxicity profile including traditional chemotherapy, interferon, and interleukins. With the advent of tyrosine kinase inhibitors (TKIs) in 2007 followed by immunotherapy over the past few years, a paradigm shift emerged in managing this increasingly prevalent disease with its associated high m...

ECOG-ACRIN Trial Reassures Clinicians, Patients That Locoregional Therapy Is Not Beneficial for Stage IV Metastatic Breast Cancer
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200218/full/

Jun 24th, 2020 - For patients with stage IV metastatic breast cancer and an intact primary tumor (ITP), the early initiation of locoregional treatment (LRT) was not associated with longer survival or improvements in health-related quality of life (HRQoL) compared with systemic therapy alone, according to a phase III clinical trial (Abstract LBA2). These findings appear to add to a robust evidence base th...

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675422
Gastroenterology Hadjiliadis D, Khoruts A et. al.

Jan 1st, 2018 - Improved therapy has substantially increased survival of persons with cystic fibrosis (CF). But the risk of colorectal cancer (CRC) in adults with CF is 5-10 times greater compared to the general population, and 25-30 times greater in CF patients after an organ transplantation. To address this risk, the CF Foundation convened a multi-stakeholder task force to develop CRC screening recomm...

Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.
https://doi.org/10.1056/NEJMoa1612645
The New England Journal of Medicine; Masuda N, Lee SJ et. al.

Jun 1st, 2017 - Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)-negative breast cancer have poor prognoses. The benefit of adjuvant chemotherapy in these patients remains unclear. We randomly assigned 910 patients with HER2-negative residual invasive breast cancer after neoadjuvant chemotherapy (contai...

Alectinib versus crizotinib in patients with ALK-positive non-small-cell lung cancer...
https://doi.org/10.1016/S0140-6736(17)30565-2
Lancet (London, England); Hida T, Nokihara H et. al.

May 16th, 2017 - Alectinib, a potent, highly selective, CNS-active inhibitor of anaplastic lymphoma kinase (ALK), showed promising efficacy and tolerability in the single-arm phase 1/2 AF-001JP trial in Japanese patients with ALK-positive non-small-cell lung cancer. Given those promising results, we did a phase 3 trial to directly compare the efficacy and safety of alectinib and crizotinib. J-ALEX was a ...

Understanding the Public's Emotions about Cancer: Analysis of Social Media Data.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579657
International Journal of Environmental Research and Publi... Park SK, Park HA et. al.

Oct 4th, 2020 - Cancer survivors suffer from emotional distress, which varies depending on several factors. However, existing emotion management programs are insufficient and do not take into consideration all of the factors. Social media provides a platform for understanding the emotions of the public. The aim of this study was to explore the relationship between the public's emotions about cancer...

Adjuvant Therapy for Resected Gallbladder Cancer: Analysis of the National Ca...
https://doi.org/10.1093/jnci/djw202
Journal of the National Cancer Institute; Mantripragada KC, Hamid F et. al.

Oct 7th, 2016 - Management of resected gallbladder cancer relies on single-arm trials and retrospective observations. Our objective was to evaluate adjuvant therapy in a nationwide data set using causal inference methods to address sources of bias. We studied patients with T2-3 or node-positive, nonmetastatic gallbladder cancer, resected with grossly negative margins and reported to the National ...

Community-acquired bacterial meningitis in adults with cancer or a history of
https://doi.org/10.1212/WNL.0000000000002315
Neurology Costerus JM, Brouwer MC et. al.

Jan 24th, 2016 - To study the incidence, clinical presentation, causative bacteria, and outcome of community-acquired bacterial meningitis in adults with cancer. We evaluated incidence and characteristics of patients with cancer included in a nationwide prospective cohort study of adults with community-acquired meningitis performed in the Netherlands from March 1, 2006, to September 31, 2014. All ...

Incidence and mortality of colorectal cancer in individuals with a family histor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628587
Gastroenterology Schoen RE, Razzak A et. al.

Aug 10th, 2015 - Little is known about the change in risk conferred by family history of colorectal cancer (CRC) as a person ages. We evaluated the effect of family history on CRC incidence and mortality after 55 years of age, when the risk of early onset cancer had passed. We collected data from participants in the randomized, controlled Prostate, Lung, Colorectal and Ovarian cancer screen...

Clinical Practice Guideline on Screening for Colorectal Cancer in Individuals Wi...
https://doi.org/10.1053/j.gastro.2018.08.017
Gastroenterology Leddin D, Lieberman DA et. al.

Aug 20th, 2018 - A family history (FH) of colorectal cancer (CRC) increases the risk of developing CRC. These consensus recommendations developed by the Canadian Association of Gastroenterology and endorsed by the American Gastroenterological Association, aim to provide guidance on screening these high-risk individuals. Multiple parallel systematic review streams, informed by 10 literature searches, asse...

Racial Differences in the Use and Outcome of Neoadjuvant Chemotherapy for Breast Can...
https://doi.org/10.1200/JCO.2015.63.7801
Journal of Clinical Oncology : Official Journal of the Am... Killelea BK, Yang VQ et. al.

Nov 26th, 2015 - To explore racial differences in the use and outcome of neoadjuvant chemotherapy for breast cancer. The National Cancer Data Base was queried to identify women with stage 1 to 3 breast cancer diagnosed in 2010 and 2011. Chemotherapy use and rate of pathologic complete response (pCR) was determined for various racial/ethnic groups. Of 278,815 patients with known race and eth...

Breast-Cancer Tumor Size, Overdiagnosis, and Mammography Screening Effectiveness.
https://doi.org/10.1056/NEJMoa1600249
The New England Journal of Medicine; Welch HG, Prorok PC et. al.

Oct 13th, 2016 - The goal of screening mammography is to detect small malignant tumors before they grow large enough to cause symptoms. Effective screening should therefore lead to the detection of a greater number of small tumors, followed by fewer large tumors over time. We used data from the Surveillance, Epidemiology, and End Results (SEER) program, 1975 through 2012, to calculate the tumor-size distributio...

Pediatric Outcome after Maternal Cancer Diagnosed during Pregnancy.
https://doi.org/10.1056/NEJMoa1508913
The New England Journal of Medicine; Amant F, Vandenbroucke T et. al.

Sep 29th, 2015 - Data on the long-term outcome of children who are exposed to maternal cancer with or without treatment during pregnancy are lacking. In this multicenter case-control study, we compared children whose mothers received a diagnosis of cancer during the pregnancy with matched children of women without a cancer diagnosis. We used a health questionnaire and medical files to colle...

Screening for Occult Cancer in Unprovoked Venous Thromboembolism.
https://doi.org/10.1056/NEJMoa1506623
The New England Journal of Medicine; Carrier M, Lazo-Langner A et. al.

Jun 23rd, 2015 - Venous thromboembolism may be the earliest sign of cancer. Currently, there is a great diversity in practices regarding screening for occult cancer in a person who has an unprovoked venous thromboembolism. We sought to assess the efficacy of a screening strategy for occult cancer that included comprehensive computed tomography (CT) of the abdomen and pelvis in patients who ...

Active Surveillance for the Management of Localized Prostate Cancer (Cancer...
https://doi.org/10.1200/JCO.2015.65.7759
Journal of Clinical Oncology : Official Journal of the Am... Chen RC, Rumble RB et. al.

Feb 18th, 2016 - To endorse Cancer Care Ontario's guideline on Active Surveillance for the Management of Localized Prostate Cancer. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing clinical practice guidelines developed by other professional organizations. The Active Surveillance for the Management of Localized Prostate Cancer guideline was r...

Long-term colorectal-cancer mortality after adenoma removal.
https://doi.org/10.1056/NEJMoa1315870
The New England Journal of Medicine; Løberg M, Kalager M et. al.

Aug 28th, 2014 - Although colonoscopic surveillance of patients after removal of adenomas is widely promoted, little is known about colorectal-cancer mortality among these patients. Using the linkage of the Cancer Registry and the Cause of Death Registry of Norway, we estimated colorectal-cancer mortality among patients who had undergone removal of colorectal adenomas during the period from 1993 through ...

Screening for Thyroid Cancer: US Preventive Services Task Force Recommendation S...
https://doi.org/10.1001/jama.2017.4011
JAMA , Bibbins-Domingo K et. al.

May 12th, 2017 - The incidence of thyroid cancer detection has increased by 4.5% per year over the last 10 years, faster than for any other cancer, but without a corresponding change in the mortality rate. In 2013, the incidence rate of thyroid cancer in the United States was 15.3 cases per 100 000 persons. Most cases of thyroid cancer have a good prognosis; the 5-year survival rate ...

Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer.
https://doi.org/10.1056/NEJMoa1415369
The New England Journal of Medicine; Poortmans PM, Collette S et. al.

Jul 23rd, 2015 - The effect of internal mammary and medial supraclavicular lymph-node irradiation (regional nodal irradiation) added to whole-breast or thoracic-wall irradiation after surgery on survival among women with early-stage breast cancer is unknown. We randomly assigned women who had a centrally or medially located primary tumor, irrespective of axillary involvement, or an externally located tum...

Breast Cancer Screening, Incidence, and Mortality Across US Counties.
https://doi.org/10.1001/jamainternmed.2015.3043
JAMA Internal Medicine; Harding C, Pompei F et. al.

Jul 7th, 2015 - Screening mammography rates vary considerably by location in the United States, providing a natural opportunity to investigate the associations of screening with breast cancer incidence and mortality, which are subjects of debate. To examine the associations between rates of modern screening mammography and the incidence of breast cancer, mortality from breast cancer, and t...