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About 474 results

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.
https://doi.org/10.1016/S0140-6736(20)30183-5
Lancet (London, England); Huang C, Wang Y et. al.

Jan 27th, 2020 - A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively...

Drug treatment options for the 2019-new coronavirus (2019-nCoV).
https://www.ncbi.nlm.nih.gov/pubmed/31996494
Bioscience Trends; Lu H

Jan 27th, 2020 - As of January 22, 2020, a total of 571 cases of the 2019-new coronavirus (2019-nCoV) have been reported in 25 provinces (districts and cities) in China. At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak. Thre...

China Testing HIV Drug as Treatment for New Coronavirus, AbbVie Says
https://www.medscape.com/viewarticle/924263

Jan 27th, 2020 - (Reuters) - China is testing an HIV drug as a treatment for symptoms of the new coronavirus that is rapidly spreading, said drugmaker AbbVie Inc on Sunday. China health authorities requested the drug to help with the government's efforts to address the crisis, according to Adelle Infante, a spokeswoman for North Chicago, Illinois-based AbbVie. Aluvia, which is also known as Kaletr...

A systematic review of lopinavir therapy for SARS coronavirus and MERS corona...
https://doi.org/10.1002/jmv.25729
Journal of Medical Virology REFERENCES; Yao TT, Qian JD et. al.

Feb 27th, 2020 - In the past few decades, coronaviruses have risen as a global threat to public health. Currently, the outbreak of coronavirus disease-19 (COVID-19) from Wuhan caused a worldwide panic. There are no specific antiviral therapies for COVID-19. However, there are agents that were used during the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) epide...

Novel coronavirus treatment with ribavirin: Groundwork for evaluation con...
https://doi.org/10.1002/jmv.25798
Journal of Medical Virology; Khalili JS, Zhu H et. al.

Mar 29th, 2020 - Confronting the challenge of the outbreak of COVID-19 should sharpen our focus on global drug access as a key issue in anti-viral therapy testing. The testing and adoption of effective therapies for novel coronaviruses is hampered by the challenge of conducting controlled studies during a state of emergency. The access to direct anti-viral drugs such as ribavirin that have an existing inventory...

Timely Diagnosis and Treatment Shortens the Time to Resolution of Coronavirus...
https://doi.org/10.2214/AJR.20.23078
AJR. American Journal of Roentgenology; Huang G, Gong T et. al.

Mar 29th, 2020 - OBJECTIVE. This study aims to assess correlations of the time from symptom onset to diagnosis and treatment with the time to disease resolution and CT scores as based on findings from sequential chest CT examinations. MATERIALS AND METHODS. Thirty patients with coronavirus disease (COVID-19) confirmed by reverse transcription-polymerase chain reaction analysis underwent chest CT e...

Early antiviral treatment contributes to alleviate the severity and improve the ...
https://doi.org/10.1111/joim.13063
Journal of Internal Medicine; Wu J, Li W et. al.

Mar 26th, 2020 - At present, the severity of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a focal point. To assess the factors associated with severity and prognosis of patients infected with SARS-CoV-2, we retrospectively investigated the clinical, imaging, and laboratory characteristics of confirmed 280 cases of novel coronavirus disease (COVID-19)...

Anticoagulant treatment is associated with decreased mortality in severe coro...
https://doi.org/10.1111/jth.14817
Journal of Thrombosis and Haemostasis : JTH; Tang N, Bai H et. al.

Mar 26th, 2020 - A relatively high mortality of severe coronavirus disease 2019 (COVID-19) is worrying, the application of heparin in COVID-19 has been recommended by some expert consensus due to the risk of disseminated intravascular coagulation and venous thromboembolism. However, its efficacy remains to be validated. Coagulation results, medications and outcomes of consecutive patients being classifie...

Coronavirus Disease 2019 (COVID-19) Treatment & Management
https://emedicine.medscape.com/article/2500114-treatment

Mar 25th, 2020 - Investigational Drugs and Biologics No drugs or biologics have been proven to be effective for the prevention or treatment of COVID-19. Numerous antiviral agents, immunotherapies, and vaccines are being investigated and developed as potential therapies. Searching for effective therapies for COVID-19 infection is a complex process. Gordon et al identified 332 high-confidence SARS-CoV-2 hu...

The use of anti-inflammatory drugs in the treatment of people with severe cor...
https://doi.org/10.1016/j.clim.2020.108393
Clinical Immunology (Orlando, Fla.); Zhang W, Zhao Y et. al.

Mar 24th, 2020 - The pandemic outbreak of coronavirus disease 2019 (COVID-19) is rapidly spreading all over the world. Reports from China showed that about 20% of patients developed severe disease, resulting in a fatality of 4%. In the past two months, we clinical immunologists participated in multi-rounds of MDT (multidiscipline team) discussion on the anti-inflammation management of critical ill COVID-...

Could chloroquine /hydroxychloroquine be harmful in Coronavirus Disease 2019 (CO...
https://doi.org/10.1093/cid/ciaa321
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Guastalegname M, Vallone A

Mar 23rd, 2020 - Could chloroquine /hydroxychloroquine be harmful in Coronavirus Disease 2019 (COVID-19) treatment?|2020|Guastalegname M,Vallone A,|

Sanofi, Regeneron Begin Testing Arthritis Drug as Coronavirus Treatment
https://www.medscape.com/viewarticle/926853

Mar 16th, 2020 - (Reuters) - Sanofi SA and partner Regeneron Pharmaceuticals Inc have started a clinical trial of their rheumatoid arthritis drug Kevzara as a treatment for the coronavirus, the companies said on Monday. Enrolments for the mid-to-late stage trial will begin immediately, and the companies anticipate the trial will test up to 400 patients. Kevzara is an infection-fighting protein kno...

Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098036
International Journal of Biological Sciences; Yang Y, Islam MS et. al.

Mar 14th, 2020 - Currently, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, formerly known as 2019-nCoV, the causative pathogen of Coronavirus Disease 2019 (COVID-19)) has rapidly spread across China and around the world, causing an outbreak of acute infectious pneumonia. No specific anti-virus drugs or vaccines are available for the treatment of this sudden and lethal disease....

A report of clinical diagnosis and treatment of nine cases of coronavirus...
https://doi.org/10.1002/jmv.25755
Journal of Medical Virology REFERENCES; Chen Q, Quan B et. al.

Mar 12th, 2020 - Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 has become an important public health issue in the world. More than 118 000 cases were confirmed around the world. The main clinical manifestations were respiratory symptoms and occasional gastrointestinal symptoms. However, there is no unified standard for the diagnosis and treatm...

Teicoplanin: an alternative drug for the treatment of coronavirus COVID-19?
https://doi.org/10.1016/j.ijantimicag.2020.105944
International Journal of Antimicrobial Agents; Baron SA, Devaux C et. al.

Mar 12th, 2020 - In December 2019, a new coronavirus, named SARS-CoV-2, has emerged from China causing pneumonia outbreaks first in the Wuhan region and have now spread worldwide because of its probable high transmission efficiency. Due to the lack of efficient and specific treatments and the need to contain the epidemic, drug repurposing appears to be the best tool to find therapeutic solution. C...

Vir Biotech to Collaborate With Biogen for Developing Coronavirus Treatment
https://www.medscape.com/viewarticle/926696

Mar 12th, 2020 - Once the agreement is finalized, Biogen would use Vir's antibody platform to develop infection-fighting proteins known as monoclonal antibodies to treat COVID-19, the disease caused by coronavirus. Vir said it had identified a number of monoclonal antibodies that could target the coronavirus, and that it had begun its development efforts with Biogen. The coronavirus has inf...

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroq...
https://doi.org/10.1093/cid/ciaa237
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Yao X, Ye F et. al.

Mar 9th, 2020 - The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection. Hydroxychloroquine shares the same mechanism of action as chloroquine, but its more tolerable safety profile makes it the preferred drug to treat malaria and autoimmune conditions. We ...

A Systematic Review of therapeutic agents for the treatment of the Middle East R...
https://doi.org/10.1016/j.tmaid.2019.06.012
Travel Medicine and Infectious Disease; Momattin H, Al-Ali AY et. al.

Jun 29th, 2019 - The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks. The disease carries a high case fatality rate of 34.5%, and there is no internationally or nationally recommended therapy. We searched MEDLINE, Science Direct, Embase and Scopus databases for relevant papers...

China's coronavirus epicenter boosts medical waste treatment as new cases spike
https://www.reuters.com/article/us-china-health-waste/chinas-coronavirus-epicenter-boosts-medical-waste-treatment-as-new-cases-spike-idUSKBN207145

Feb 13th, 2020 - BEIJING (Reuters) - The Chinese province at the center of the coronavirus outbreak has almost doubled its medical waste handling capacity after media images of bags of garbage piling up uncovered in hospital yards raised public concerns over secondary infections. Adding to the pressure on authorities Hubei province, in central China, on Thursday reported a spike in new cases. Provincial ...

A rapid advice guideline for the diagnosis and treatment of 2019 novel corona...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003341
Military Medical Research; Jin YH, Cai L et. al.

Feb 7th, 2020 - In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named "2019 novel coronavirus (2019-nCoV)" by the World Health Organization (WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world's attention but without treatment and control manual. ...