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About 125 results

Sirolimus reduces the incidence and progression of UVB-induced skin cancer in SKH mice ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606089
The Journal of Investigative Dermatology; Wulff BC, Kusewitt DF et. al.

May 8th, 2008 - Transplant immunosuppressants have been implicated in the increased incidence of non-melanoma skin cancer in transplant recipients, most of whom harbor considerable UVB-induced DNA damage in their skin prior to transplantation. This study was designed to evaluate the effects of two commonly used immunosuppressive drugs, cyclosporine A (CsA) and sirolimus (SRL), on the development and progressio...

K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation ...
https://doi.org/10.1038/jid.2008.66
The Journal of Investigative Dermatology; Hong JH, Youm JK et. al.

Apr 3rd, 2008 - Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, regulates multiple cellular responses such as Ca(2+) signaling, growth, survival, and differentiation. Because sphingosine kinase (SphK) is the enzyme directly responsible for production of S1P, many factors have been identified that regulate its activity and subsequent S1P levels. Here we synthesized a previously unidentified ...

Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal...
https://doi.org/10.1038/jid.2008.13
The Journal of Investigative Dermatology; Jeong SK, Kim HJ et. al.

Feb 28th, 2008 - Protease-activated receptor-2 (PAR-2) is known to be involved in epidermal permeability barrier function homeostasis. PAR-2 activation occurs after barrier disruption and further activation of PAR-2 by activating peptide significantly delays barrier recovery rate. Cockroach and house dust mite allergens, both known to be associated with the development of asthma, allergic rhinitis, and atopic d...

Overexpression of extracellular epimorphin leads to impaired epidermal differentiation ...
https://doi.org/10.1038/jid.2008.22
The Journal of Investigative Dermatology; Okugawa Y, Hirai Y

Feb 14th, 2008 - Epimorphin (also known as syntaxin2) is a stromal signaling factor that is temporally secreted via a non-classical route to regulate the morphogenesis of various epithelia, including skin epidermis. In this study, we show that epimorphin signaling also regulates the differentiation program in the keratinocyte. The extracellular presentation of this molecule is detectable predominantly in the de...

Novel mutation in the human hairless gene once more erroneously diagnosed and treated a...
https://doi.org/10.1111/j.1365-2133.2007.08413.x
The British Journal of Dermatology; Roelandt T, Kraemer L et. al.

Feb 4th, 2008 - Novel mutation in the human hairless gene once more erroneously diagnosed and treated as 'alopecia areata'.|2008|Roelandt T,Kraemer L,Van Neste D,Lissens W,Roseeuw D,|genetics,therapy,genetics,methods,