About 2,006 results

A novel approach to the classification of epidermodysplasia verruciformis.
International Journal of Dermatology; Huang S, Wu JH et. al.

Aug 29th, 2018 - Epidermodysplasia verruciformis (EV) is a rare genodermatosis that causes disseminated eruptions of hypo- or hyperpigmented macules and wart-like papules that can coalesce and scale. It is uniquely characterized by an increased susceptibility to specific human papillomavirus (HPV) genotypes. Classically, EV is associated with mutations of the EVER1/TMC6 and EVER2/TMC8 genes. The term "acquired"...

Generalized basaloid follicular hamartoma syndrome versus Gorlin syndrome: A diagnostic...
Pediatric Dermatology; Shevchenko A, Durkin JR et. al.

Aug 28th, 2018 - Basaloid follicular hamartoma is a relatively rare benign neoplasm of follicular origin that can be mistaken histologically for basal cell carcinoma, but hereditary forms of basaloid follicular hamartoma are associated with nevoid basal cell carcinoma syndrome, or Gorlin syndrome. The pathophysiology of basaloid follicular hamartoma development involves mutations in the patched gene, which is a...

Cutaneous collagenous vasculopathy: development after coronary artery bypass surgery.
Dermatology Online Journal; Rahnama-Moghadam S, Burgin C et. al.

Aug 25th, 2018 - Cutaneous collagenous vasculopathy (CCV) is a rare benign microangiopathy of the superficial dermal vessels. Clinically, it is characterized by widespread, asymptomatic development of cutaneous telangiectasia in the absence of systemic symptoms. Morphologically, it most resembles generalized essential telangiectasia and other telangiectatic syndromes such as telangiectasia macularis eruptiva pe...

Severe cutaneous adverse reactions syndromes and prescribing autonomy.
The British Journal of Dermatology; Walsh S, Creamer D

Aug 24th, 2018 - Severe cutaneous adverse reactions syndromes and prescribing autonomy.|2018|Walsh S,Creamer D,|

A case of congenital self-healing Langerhans cell histiocytosis with two lesions.
European Journal of Dermatology : EJD; Xu C, Xiong J et. al.

Aug 21st, 2018 -

Spontaneous Keloids: A Literature Review.
Dermatology (Basel, Switzerland); Jfri A, Alajmi A

Aug 16th, 2018 - Keloids are benign fibroproliferative tumors that extend beyond the original wound. Spontaneous keloids are those that result without a significant history of trauma. There are multiple reported cases in the literature. This article provides a summary and review of the cases that have been reported with spontaneous keloids and organizes them according to their associated medical conditions. A l...

Varicella zoster virus reactivation antedating ipsilateral brainstem stroke.
Dermatology Online Journal; Galassi G, Genovese M et. al.

Aug 14th, 2018 - itor Title: Varicella zoster virus reactivation antedating ipsilateral brainstem stroke Authors: Giuliana Galassi1, Maurilio Genovese2, Marisa Meacci3, Marcella Malagoli2 Affiliations: 1Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Italy, 2Neuroradiology Service, University Hospital of Modena, Italy, 3Department of Laboratory Medicine and Patholgy, Microbi...

Alopecia in Association with Malignancy: A Review.
American Journal of Clinical Dermatology; Suchonwanit P, McMichael AJ

Aug 8th, 2018 - The interaction between hair and malignancy is complicated. Various hair abnormalities can manifest in oncology patients as a clinical manifestation, the result of cancer therapy, or due to a paraneoplastic condition. The mechanisms of these changes remain unclear. Alopecia is one of the common clinical presentations occurring in oncology patients that affects their quality of life. The conditi...

Tease out genetic and structural causes of children’s hair loss
Heidi Splete

Aug 8th, 2018 - When a child presents with hair loss, don’t rule out issues related to genetics and structural abnormalities of the hair itself, according to Maria Hordinsky, MD, of the University of Minnesota, Minneapolis. The ectodermal dysplasias are a heterogeneous group of disorders in which a main feature is the absent, incomplete, or delayed development of one or more of the appendages derived from ecto.

Oral drug seen preventing angioedema attacks
Dermatology News; Jennie Smith

Jul 27th, 2018 - An experimental agent reduced swelling episodes markedly in patients with hereditary angioedema, according to results from a phase 2 randomized, dose-ranging, placebo-controlled trial. The drug BCX7353, developed by BioCryst Pharmaceuticals, is taken orally and works by inhibiting plasma kallikrein, an enzyme overexpressed in hereditary angioedema, a rare genetic disease that causes severe tiss.

Dermatomyositis: Current concepts.
Clinics in Dermatology; Bogdanov I, Kazandjieva J et. al.

Jul 26th, 2018 - Dermatomyositis (DM) is a multifactorial chronic autoimmune disorder with characteristic skin changes and involvement of different organ systems, including the muscles, blood vessels, joints, esophagus, and lungs. In terms of epidemiology, DM affects both children and adults. It is most often observed beyond the age of 40, but there is also a peak of incidence between 5 and 12 years of age. The...

Mosaicism due to postzygotic mutations in women with focal dermal hypoplasia.
The British Journal of Dermatology; Heinz L, Bourrat E et. al.

Jul 19th, 2018 - Focal dermal hypoplasia (FDH, Goltz syndrome, MIM #305600) constitutes a rare multisystem genetic disorder of the skin, skeleton, teeth and eyes with considerable variation in the clinical features. FDH is transmitted as an X-linked dominant trait and is caused by mutations in PORCN. In male children, hemizygous PORCN mutations are lethal in utero. Around 300 cases have been reported in the lit...

Identification of a novel PLCD1 mutation in Chinese Han pedigree with hereditary leukon...
Journal of Cosmetic Dermatology; Xue K, Zheng Y et. al.

Jul 13th, 2018 - Hereditary leukonychia is a rare nail dystrophy characterized by distinctive whitening of the nail plate. Mutations in the PLCD1 gene have been identified as a major causative factor in hereditary leukonychia (HL). However, few reports have analyzed the relationship between genotype and phenotype, especially in Chinese HL patients. Our study aims to explore the typical clinical features of here...

Infantile hemangioma with minimal or arrested growth as the skin manifestation of PHACE...
Pediatric Dermatology; Valdivielso-Ramos M, Torrelo A et. al.

Jul 9th, 2018 - Infantile hemangiomas with minimal or arrested growth are vascular tumors with a proliferative component involving < 25% of their total surface area. They are commonly described as localized lesions and are mainly located on the lower body. Little has been described about segmental forms on the face and their associations with PHACE syndrome. We carried out a multicenter, retrospective, case-se...

Single-nucleotide polymorphisms of VEGF-A and VEGFR-2 genes and risk of infantile heman...
International Journal of Dermatology; Oszajca K, Szemraj J et. al.

Jul 9th, 2018 - Infantile hemangioma (IH) is the most common vascular tumor of childhood and infancy. It is distinguished by rapid proliferation of endothelial cells during the first year of life followed by spontaneous regression thereafter. One of the possible factors responsible for the IH development is vascular endothelial grow factor (VEGF). The purpose of this study was to evaluate the influence of sele...

Clinical course of the first Japanese family with Marie Unna hereditary hypotrichosis: ...
European Journal of Dermatology : EJD; Masuda Y, Ito T et. al.

Jun 28th, 2018 - Clinical course of the first Japanese family with Marie Unna hereditary hypotrichosis: a follow-up report.|2018|Masuda Y,Ito T,Shimomura Y,Ogai M,Sakabe JI,|

Midface toddler excoriation syndrome (MiTES) can be caused by autosomal recessive biall...
The British Journal of Dermatology; Moss C, Srinivas SM et. al.

Jun 27th, 2018 - Midface toddler excoriation syndrome (MiTES) is a condition recently reported in three unrelated children. Habitual scratching from the first year of life inflicted deep, chronic, scarring wounds around the nose and eyes. One child had a mild neurological deficit but there was no other evidence of insensitivity to pain. Bilateral distribution and localization to the midface distinguish MiTES fr...

Clinical and histopathologic features of paraneoplastic granuloma annulare in associati...
Journal of the American Academy of Dermatology; Mangold AR, Cumsky HJL et. al.

Jun 19th, 2018 - Granuloma annulare (GA) is a granulomatous skin eruption rarely associated with cancer. We report seven cases of paraneoplastic GA in association with solid organ malignancy. To compare the clinical and histopathological features of paraneoplastic GA to case-matched controls of classic GA. Retrospective chart and histopathological review of 7 individuals and 13 age- and sex-matched controls. Pa...

Teledermatology leading to an important diagnosis in an underserved clinic.
Dermatology Online Journal; Da Silva DM, Roth RR et. al.

Jun 15th, 2018 - Cutaneous signs can be the first manifestation of important medical diagnoses, including inherited cancer syndromes, but access to dermatologic evaluation is especially challenging for uninsured patients. Herein, we present a case in which a volunteer academic teledermatology triage program was used by a community health clinic to make a diagnosis of multiple cutaneous leiomyomas, which confer ...

Is the humoral immunity dispensable for the pathogenesis of psoriasis?
Journal of the European Academy of Dermatology and Venereology : JEADV; Thomas J, Küpper M et. al.

Jun 1st, 2018 - Imbalances of T-cell subsets are hallmarks of disease-specific inflammation in psoriasis. However, the relevance of B cells for psoriasis remains poorly investigated. To analyse the role of B cells and immunoglobulins for the disease-specific immunology of psoriasis. We characterized B-cell subsets and immunoglobulin levels in untreated psoriasis patients (n = 37) and compared them to healthy c...