Jan 9th, 2022 - The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered a global catastrophe that has overwhelmed health care systems. Since initiation of the pandemic, identification of characteristics that might influence risk of infection and poor disease outcomes have been of paramount interest. Blood group phenotypes are gen...

Jun 5th, 2017 - The Eunice Kennedy Shriver National Institute of Child Health and Human Development Stillbirth Collaborative Research Network previously demonstrated an association between stillbirth and maternal marijuana use as defined by the presence of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid in the umbilical cord homogenate. However, the relationship between marijuana use and pe...

Mar 3rd, 2022 - Peer-reviewed/Observational/People New research suggests a causal link between blood group and severe COVID-19 A new study has analysed over 3000 proteins to identify which are causally linked to the development of severe COVID-19. This is the first study to assess such a large number of proteins for their connection to COVID-19. The findings provide insight into pot...

Sep 5th, 2021 - Pott puffy tumor is a subperiosteal abscess due to associated frontal skull osteomyelitis. This usually occurs as a rare complication of frontal sinusitis or trauma to the forehead, that presents with tender forehead swelling associated with fever, headaches, nasal discharge, or symptoms of increased intracranial pressure. Including this in the differential diagnosis is important, as early diag...

Jun 26th, 2021 - History of Present Illness: A 33-year-old white female presents after admission to the general medical/surgical hospital ward with a chief complaint of shortness of breath on exertion. She reports that she was seen for similar symptoms previously at her primary care physician’s office six months ago. At that time, she was diagnosed with acute bronchitis and treated with bronchodilators, empiric...

Oct 10th, 2021 - Neonatal sepsis refers to an infection involving bloodstream in newborn infants less than 28 days old. It continues to remain a leading cause of morbidity and mortality among infants, especially in middle and lower-income countries. It is divided into early-onset sepsis (EOS) or late-onset sepsis (LOS) based on the age of presentation after birth with different experts using 72 hours or ...

Sep 30th, 2021 - Scrub typhus is one of the tropical rickettsial infections which if left untreated, can have fatal consequences. It is caused by Orientia tsutsugamushi and transmitted by the bite of the mite larvae or chiggers. It is a systemic illness and can present as a vasculitis-like infection. This activity focuses on the role of the interprofessional team in prompt diagnosis and early trea...

Aug 19th, 2021 - Fournier gangrene is a rapidly progressive, life-threatening infectious process that involves the genital and perineal areas. The disease is one of the few urological emergencies and requires prompt surgical debridement as well as antibiotic therapy. This activity reviews the evaluation and treatment and highlights the role of the healthcare team in evaluating and treating patients with this co...

Aug 9th, 2021 - Fahr disease is a rare neurological condition characterized by abnormal idiopathic calcification of basal ganglia and commonly has an autosomal dominant inheritance. This activity describes the pathophysiology, etiology, differential diagnosis, evaluation, and treatment of Fahr disease and highlights the role of the interprofessional team in improving the care of patients suffering from this di...

INTRODUCTION — Trauma to the extremities represents one of the most common injury patterns seen in emergency medical and surgical practice. Achieving an optimal outcome in patients with severe extremity injuries requires a multidisciplinary approach with oversight by the general or trauma surgeon and commitment from other specialists including orthopedic, vascular, and plastic surgeons a...

Nov 5th, 2022 - The primary goals of this research were to analyze the relationship between ABO blood types and the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and investigate the effect of vaccination in Iraq. Data and outcomes were gathered from the medical records of 200 patients. Patients were categorized by blood group and va...

Jan 13th, 2023 - Apelin is a cardioprotective biomarker while galectin-3 is a pro-inflammatory and profibrotic biomarker. Endothelial dysfunction, hyperinflammation, and pulmonary fibrosis are key mechanisms that contribute to the development of adverse outcomes in Coronavirus disease 2019 (COVID-19) infection. This study aims to analyze the prognostic value of serum apelin and galectin-3 l...

Oct 8th, 2021 - ITASCA, IL – An ongoing study is looking at the relationship between cytokines in saliva and COVID-19 infection to help predict the severity of infection. In a preliminary analysis of saliva samples from 150 children, the researchers found that levels of two cytokines were higher in those with severe COVID-19 compared to those without severe infection. The stu...

Jun 12th, 2021 - COVID-19 is a worldwide infection caused by SARS-CoV-2 and infects humans by binding to the ACE2 receptor. Blood group ABO glycoproteins can influence the binding of the virus to ACE2. The role of ABO blood system in the susceptibility to infection as well as in the clinical outcome of infected patients is still controversial and needs to be clarified. We conducted a retrospective...

Mar 10th, 2022 - The risk of developing more severe COVID-19 infection and a poor prognosis for patients with sickle cell disease (SCD) is increased with having a history of acute chest syndrome (ACS), lack of hydroxyurea usage before the infection, and homozygous genotype (HbSS), according to a new study published in the Journal of Investigative Medicine. Researchers retrospectively...

Mar 4th, 2022 - Approximately 5000 major lower-limb amputations (MLLA) for PAD occur per-annum in the UK with clinical outcomes being poor for this high-risk cohort of patients. Existing evidence suggests that anaemic surgical patients have an increased 30-day mortality, but this has not been explored in the context of MLLA. Recent prioritization processes suggested that MLLAs are a target area for rese...

Jun 17th, 2022 - During the latest pandemic, the RECOVERY study showed the benefits of dexamethasone (DEX) use in COVID-19 patients. Obesity has been proven to be an independent risk factor for severe forms of infection, but little information is available in the literature regarding DEX dose adjustment according to body weight. We conducted a prospective, observational, exploratory study a...

Sep 7th, 2022 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center. Two large studies out of the UK and Norway show vitamin D supplementation has no benefit — as low dose, high dose, or in the form of cod liver oil supplementation — in preventing COVID-19 or acute respiratory tract infections, regardless of whether individuals are deficient or not. The st...

Nov 15th, 2021 - The objective of this study was to compare maternal outcomes of women with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections who underwent cesarean births. This was a matched cohort study of pregnant women who had a cesarean birth between March 15, 2020, and May 20, 2020. Cases included women who tested positive for SARS-CoV-2. For every case, two...

Feb 7th, 2022 - COVID-19 is associated with increased morbidity and mortality in patients with chronic kidney disease (CKD) stages G4-G5, on dialysis or after kidney transplantation (kidney replacement therapy, KRT). SARS-CoV-2 vaccine trials do not elucidate if SARS-CoV-2 vaccination is effective in these patients. Vaccination against other viruses is known to be less effective in kidney patients. Our objecti...