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Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, this disease has spread rapidly around the globe. Considering the potential threat of a pandemic, scientists and physicians have been racing to understand this new virus and the pathophysiology of this disease to uncover possible treatment regimens and discover effective therapeutic agents and v...

Vaccines for COVID-19: Perspectives, Prospects, and Challenges Based on Candidate SARS, MERS, and Animal Coronavirus Vaccines

Development and Licensure of Vaccines to Prevent COVID-19: Guidance for Industry

This guidance is being issued to address the coronavirus disease 2019 (COVID-19) public health emergency. This guidance is being implemented without prior public comment because the Food and Drug Administration (FDA or Agency) has determined that prior public participation for this guidance is not feasible or appropriate (see section 701(h)(1)(C) of the Federal Food, Drug, and Cosmetic Act ...

11 coronavirus vaccines to keep an eye on

Federal officials have repeatedly expressed optimism that at least one vaccine against the coronavirus will be proven effective and ready for market by early 2021. As of this week, pharmaceutical companies worldwide were working on 160 candidates, including 21 that are being tested in people, according to the World Health Organization.

These 3 Covid-19 vaccines have been in the news. Here's what you need to know about them

The US government is pouring billions into Covid-19 vaccines, and candidates from three companies are moving along quickly: Moderna, Pfizer and Novavax. Here's what you need to know about them. These are among the dozens of Covid-19 vaccines in trials around the world as researchers rush to find a way to stop the pandemic. To help speed the process, the US government's Operat...

Coronavirus Q&A: Accelerating Therapies and Vaccines

US National Institutes of Health (NIH) Director Francis S. Collins, MD, discusses the agency’s new initiative to collaborate with other agencies and industry to accelerate development and testing of COVID-19 treatments and vaccines.

Can existing live vaccines prevent COVID-19?

An international physical activity and public health research agenda to inform COVID-19 policies and practices

Physical activity (PA) has strong relevance for limiting the harms to human health and well-being due to the COVID-19 pandemic.1 Active muscles produce chemicals that improve immune functioning, which in turn reduces the extent of infections, and decreases inflammation, and these are the main causes of the lung damage from SARS-CoV-2 infection. PA is a powerful preventive and therapeutic interv...

COVID-19 Treatment & Vaccine Tracker

FasterCures, a center of the Milken Institute, is currently tracking the development of treatments and vaccines for COVID-19 (coronavirus). This tracker contains an aggregation of publicly-available information from validated sources.

Will the shingles vaccine help me fight coronavirus? No. Here’s why

Got the shingles vaccine? The vaccine boosts a group of cells that trigger an immune response to the shingles virus, but don’t expect it to protect you against coronavirus. Shingles vaccines, like Shingrix, are recommended by the Centers of Disease Control and Prevention for people over 60. Doctors believe that as you age, your number of Cd4 cells, or T-cells, can decline.

Focus On Herpes Zoster

This resource is designed to offer pharmacists a concise and accurate tool to support assessing, recommending, and administering vaccines to protect against herpes zoster (often referred to as shingles). Information is included for addressing questions and concerns so that pharmacists are prepared to educate patients about herpes zoster and the risks and benefits of available vaccines...

Association of herpes zoster with dementia and effect of antiviral therapy on dementia: a population-based cohort study

We investigated the association between herpes zoster (HZ) and dementia, and the effects of antiviral therapy on the risk of dementia. We used the National Health Insurance Service-National Sample Cohort in South Korea to identify individuals that were followed from January 1, 2002, to December 31, 2013. Occurrences of HZ and dementia were identified using the relevant diagnostic codes. Shing...

Recommendations of the Advisory Committee on Immunization Practices (ACIP)

These recommendations represent the first statement by the Advisory Committee on Immunization Practices (ACIP) on the use of a live attenuated vaccine for the prevention of herpes zoster (zoster) (i.e., shingles) and its sequelae, which was licensed by the U.S. Food and Drug Administration (FDA) on May 25, 2006. This report summarizes the epidemiology of zoster and its sequelae, describes the z...

Biopharma Leaders Unite to Stand with Science

The CEOs of AstraZeneca (LSE/STO/NYSE: AZN), BioNTech (NASDAQ: BNTX), GlaxoSmithKline plc (LSE/NYSE: GSK), Johnson & Johnson (NYSE: JNJ), Merck (NYSE: MRK), known as MSD outside the United States and Canada, Moderna, Inc. (Nasdaq: MRNA), Novavax, Inc. (Nasdaq: NVAX), Pfizer Inc. (NYSE: PFE), and Sanofi (NASDAQ: SNY), today announced a historic pledge, outlining a united commitment to uphold the...

FDA and global partners to analyze coronavirus samples

The emergence of SARS-CoV-2 in 2019 and the associated COVID-19 pandemic, and prior SARS-CoV and MERS-CoV outbreaks, demonstrate the significant threat posed by coronaviruses. Since there are currently no licensed therapeutics or vaccines to prevent or treat infections from these specific viruses or coronaviruses in general, there is an urgent need to support development and evaluation o...

2020 U.S. Adult Immunization Schedule
NEJM Journal Watch;

Feb 10th, 2020 - The ACIP has made a few tweaks to its annual vaccine guidelines. Some recommended schedules and ages for various vaccines have been modified.

Principles of Vaccination - Immunology and Vaccine-Preventable Diseases

Jun 28th, 2020 - To understand how vaccines work and the basis of recommendations for their use, it is useful to have an understanding of the basic function of the human immune system. The following description is simplified. Many excellent immunology textbooks are available to provide additional detail.

COVID-19 Vaccines in People with Cancer
American Cancer Society;

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, continues to have a serious impact on many people, including cancer patients, their families, and caregivers.

General Recommendations on Immunization - Pink Book

This chapter discusses best practices related to vaccine administration, dosing, and contraindications and precautions for routinely recommended vaccines in the United States.

New HHS Regulations Expand Pharmacists’ Role in Childhood Immunizations
Pharmacy Times; Hanretty A

Nov 15th, 2020 - Following the national emergency declaration on March 13, 2020, due to the coronavirus disease 2019 (COVID-19) pandemic, there has been a drastic drop in childhood immunizations. According to a May 2020 CDC report, 2.5 million fewer doses of vaccines were ordered through the Vaccines for Children program in 2020 compared with the same time period in 2019. The decline in vaccinatio...